Search Results - "Johnson, Mai"

Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy by Priceman, Saul J., Sung, James L., Shaposhnik, Zory, Burton, Jeremy B., Torres-Collado, Antoni X., Moughon, Diana L., Johnson, Mai, Lusis, Aldons J., Cohen, Donald A., Iruela-Arispe, M. Luisa, Wu, Lily

“…Tumor-infiltrating myeloid cells (TIMs) support tumor growth by promoting angiogenesis and suppressing antitumor immune responses. CSF-1 receptor (CSF1R)…”
Get full text

Lentiviral vector retargeting to P-glycoprotein on metastatic melanoma through intravenous injection by Chen, Irvin S Y, Morizono, Kouki, Xie, Yiming, Ringpis, Gene-Errol, Johnson, Mai, Nassanian, Hoorig, Lee, Benhur, Wu, Lily

“…Targeted gene transduction to specific tissues and organs through intravenous injection would be the ultimate preferred method of gene delivery. Here, we…”
Get full text

Rapamycin enhances adenovirus-mediated cancer imaging and therapy in pre-immunized murine hosts by Jiang, Ziyue Karen, Johnson, Mai, Moughon, Diana L, Kuo, Jennifer, Sato, Makoto, Wu, Lily

“…Tumor-specific adenoviral vectors comprise a fruitful gene-based diagnostic imaging and therapy research area for advanced stage of cancer, including…”
Get full text

Visualization of advanced human prostate cancer lesions in living mice by a targeted gene transfer vector and optical imaging by Wu, Lily, Adams, Jason Y, Johnson, Mai, Sato, Makoto, Berger, Frank, Gambhir, Sanjiv S, Carey, Michael, Iruela-Arispe, M. Luisa

“…Non-invasive imaging and transcriptional targeting can improve the safety of therapeutic approaches in cancer. Here we demonstrate the ability to identify…”
Get full text

Applications of molecular imaging in cancer gene therapy by Iyer, Meera, Sato, Makoto, Johnson, Mai, Gambhir, Sanjiv S, Wu, Lily

“…Gene-based therapy is a promising and flexible therapeutic approach to manage diverse types of cancer. The lack of convincing therapeutic success of current…”
Get more information

Functionality of Androgen Receptor–Based Gene Expression Imaging in Hormone Refractory Prostate Cancer by SATO, Makoto, JOHNSON, Mai, LIQUN ZHANG, GAMBHIR, Sanjiv S, CAREY, Michael, WU, Lily

“…Purpose: A highly augmented, prostate-specific two-step transcriptional amplification (TSTA) method was developed with the ultimate goal of delivering an…”
Get full text

Optimization of adenoviral vectors to direct highly amplified prostate-specific expression for imaging and gene therapy by Sato, Makoto, Johnson, Mai, Zhang, Liqun, Zhang, Baohui, Le, Kim, Gambhir, Sanjiv S, Carey, Michael, Wu, Lily

“…Gene expression-based imaging coupled to gene therapy will permit the prediction of therapeutic outcome. A significant challenge for successful gene therapy is…”
Get full text

Light-activated tetrazines enable precision live-cell bioorthogonal chemistry by Liu, Luping, Zhang, Dongyang, Johnson, Mai, Devaraj, Neal K.

“…Bioorthogonal cycloaddition reactions between tetrazines and strained dienophiles are widely used for protein, lipid and glycan labelling because of their…”
Get full text

Micro-PET/CT Monitoring of Herpes Thymidine Kinase Suicide Gene Therapy in a Prostate Cancer Xenograft: The Advantage of a Cell-specific Transcriptional Targeting Approach by Johnson, Mai, Sato, Makoto, Burton, Jeremy, Gambhir, Sanjiv S., Carey, Michael, Wu, Lily

“…Cancer gene therapy based on tissue-restricted expression of cytotoxic gene should achieve superior therapeutic index over an unrestricted method. This study…”
Get full text

Temperature-Dependent Reversible Morphological Transformations in N‑Oleoyl β‑d‑Galactopyranosylamine by Johnson, Mai, Bhattacharya, Ahanjit, Brea, Roberto J, Podolsky, Kira A, Devaraj, Neal K

“…Amphiphilic molecules self-assemble into supramolecular structures of various sizes and morphologies depending on their molecular packing and external factors…”
Get full text

Inhibition of NRAS Signaling in Melanoma through Direct Depalmitoylation Using Amphiphilic Nucleophiles by Vora, Hetika D, Johnson, Mai, Brea, Roberto J, Rudd, Andrew K, Devaraj, Neal K

“…Activating mutations in the small GTPase NRAS are responsible for driving tumor growth in several cancers. Unfortunately, the development of NRAS inhibitors…”
Get full text

Differential biodistribution of adenoviral vector in vivo as monitored by bioluminescence imaging and quantitative polymerase chain reaction by Johnson, Mai, Huyn, Steve, Burton, Jeremy, Sato, Makoto, Wu, Lily

“…A better understanding of the in vivo biodistribution of adenoviral vectors would enable the researcher to anticipate potential side effects due to…”
Get more information

Non-invasive molecular imaging of prostate cancer lymph node metastasis by Pouliot, Frédéric, Johnson, Mai, Wu, Lily

“…Imaging in medicine has been classically based on the anatomical description of organs. In the past 15 years, new imaging techniques based on gene expression…”
Get full text

Abstract 4195: Activity of IMM-1-104 alone or in combination with chemotherapy in RAS-altered pancreatic cancer models by King, Peter, Funt, Jason, Kolitz, Sarah, Nair, Praveen, de Jong, Jan, Yamamura, Amy, Johnson, Mai, Zhang, Jenny, Fowler, Kevin, Travesa, Anna, Axel, Amy, Walker, Chris, Zeskind, Benjamin J., Hall, Brett M.

“…Introduction: Addiction to the MAPK pathway drives a large proportion of cancers, and pancreatic tumors almost universally display RAS mutations. IMM-1-104, a…”
Get full text

Abstract B021: Pan-RAS IMM-1-104 activity in humanized 3D tumor models is independent of specific amino acid substitution by Kolitz, Sarah, Nair, Praveen, Johnson, Mai, Funt, Jason, King, Peter J., Fowler, Kevin D., Travesa, Anna, Wang, Frank, II, John Brothers, Axel, Amy, Barrett, Scott, Zeskind, Benjamin J., Hall, Brett

“…Introduction: Novel dual-MEK inhibitor IMM-1-104 is under clinical investigation for use in RAS-addicted solid tumors. Approved KRAS G12C inhibitors are…”
Get full text

Modulating metastasis by a lymphangiogenic switch in prostate cancer by Brakenhielm, Ebba, Burton, Jeremy B., Johnson, Mai, Chavarria, Nelson, Morizono, Kouki, Chen, Irvin, Alitalo, Kari, Wu, Lily

“…Prostate cancer dissemination is difficult to detect in the clinic, and few treatment options exist for patients with advanced‐stage disease. Our aim was to…”
Get full text

Adenovirus-mediated gene expression imaging to directly detect sentinel lymph node metastasis of prostate cancer by Burton, Jeremy B, Koh, Sok Boon S, Johnson, Mai, Stout, David, Wu, Hong, Chatziioannou, Arion F, Phelps, Michael E, Wu, Lily, Sato, Makoto, Mulholland, David J

“…The degree of lymph-node metastasis in prostate cancer is crucial for both staging the disease and planning treatment. Here, Burton and colleagues describe a…”
Get full text

Corrigendum to “Engineering polypeptide coatings to augment gene transduction and in vivo stability of adenoviruses” [J. Control. Release 166 (2013) 75–85] by Jiang, Ziyue Karen, Koh, Sok Boon S., Sato, Makoto, Atanasov, Ivo C., Johnson, Mai, Zhou, Z. Hong, Deming, Timothy J., Wu, Lily

Get full text

Engineering polypeptide coatings to augment gene transduction and in vivo stability of adenoviruses by Jiang, Ziyue Karen, Koh, Sok Boon S., Sato, Makoto, Atanasov, Ivo C., Johnson, Mai, Zhou, Z. Hong, Deming, Timothy J., Wu, Lily

“…We sought to modify adenoviral (Ad) particles by incorporating the advantageous characteristics of non-viral gene delivery vehicles to complement the viral…”
Get full text

Transcriptionally targeted gene therapy to detect and treat cancer by Wu, Lily, Johnson, Mai, Sato, Makoto

“…The greatest challenge in cancer treatment is to achieve the highest levels of specificity and efficacy. Cancer gene therapy could be designed specifically to…”
Get full text