Search Results - "Johnson, Keith A"

Longitudinal Association of Amyloid Beta and Anxious-Depressive Symptoms in Cognitively Normal Older Adults by Donovan, Nancy J, Locascio, Joseph J, Marshall, Gad A, Gatchel, Jennifer, Hanseeuw, Bernard J, Rentz, Dorene M, Johnson, Keith A, Sperling, Reisa A

“…Objective:To understand the role of depressive symptoms in preclinical Alzheimer’s disease, it is essential to define their temporal relationship to…”
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Tau positron emission tomographic imaging in aging and early Alzheimer disease by Johnson, Keith A., Schultz, Aaron, Betensky, Rebecca A., Becker, J. Alex, Sepulcre, Jorge, Rentz, Dorene, Mormino, Elizabeth, Chhatwal, Jasmeer, Amariglio, Rebecca, Papp, Kate, Marshall, Gad, Albers, Mark, Mauro, Samantha, Pepin, Lesley, Alverio, Jonathan, Judge, Kelly, Philiossaint, Marlie, Shoup, Timothy, Yokell, Daniel, Dickerson, Bradford, Gomez-Isla, Teresa, Hyman, Bradley, Vasdev, Neil, Sperling, Reisa

“…Objective Detection of focal brain tau deposition during life could greatly facilitate accurate diagnosis of Alzheimer disease (AD), staging and monitoring of…”
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The A4 study: stopping AD before symptoms begin? by Sperling, Reisa A, Rentz, Dorene M, Johnson, Keith A, Karlawish, Jason, Donohue, Michael, Salmon, David P, Aisen, Paul

“…A new secondary prevention trial in older people with amyloid accumulation at high risk for Alzheimer's disease dementia should provide insights into whether…”
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Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals by Jacobs, Heidi I. L., Hedden, Trey, Schultz, Aaron P., Sepulcre, Jorge, Perea, Rodrigo D., Amariglio, Rebecca E., Papp, Kathryn V., Rentz, Dorene M., Sperling, Reisa A., Johnson, Keith A.

“…Animal models of Alzheimer’s disease have suggested that tau pathology propagation, facilitated by amyloid pathology, may occur along connected pathways. To…”
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Invited review: Frontotemporal dementia caused by microtubule-associated protein tau gene (MAPT) mutations: a chameleon for neuropathology and neuroimaging by Ghetti, Bernardino, Oblak, Adrian L., Boeve, Bradley F., Johnson, Keith A., Dickerson, Bradford C., Goedert, Michel

“…Hereditary frontotemporal dementia associated with mutations in the microtubule‐associated protein tau gene (MAPT) is a protean disorder. Three neuropathologic…”
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Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue by Marquié, Marta, Normandin, Marc D., Vanderburg, Charles R., Costantino, Isabel M., Bien, Elizabeth A., Rycyna, Lisa G., Klunk, William E., Mathis, Chester A., Ikonomovic, Milos D., Debnath, Manik L., Vasdev, Neil, Dickerson, Bradford C., Gomperts, Stephen N., Growdon, John H., Johnson, Keith A., Frosch, Matthew P., Hyman, Bradley T., Gómez-Isla, Teresa

“…Objective To examine region‐ and substrate‐specific autoradiographic and in vitro binding patterns of positron emission tomography tracer [F‐18]‐AV‐1451…”
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Cortical Hubs Revealed by Intrinsic Functional Connectivity: Mapping, Assessment of Stability, and Relation to Alzheimer's Disease by Buckner, Randy L, Sepulcre, Jorge, Talukdar, Tanveer, Krienen, Fenna M, Liu, Hesheng, Hedden, Trey, Andrews-Hanna, Jessica R, Sperling, Reisa A, Johnson, Keith A

“…Recent evidence suggests that some brain areas act as hubs interconnecting distinct, functionally specialized systems. These nexuses are intriguing because of…”
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Neurogenetic contributions to amyloid beta and tau spreading in the human cortex by Sepulcre, Jorge, Grothe, Michel J., d’Oleire Uquillas, Federico, Ortiz-Terán, Laura, Diez, Ibai, Yang, Hyun-Sik, Jacobs, Heidi I. L., Hanseeuw, Bernard J., Li, Quanzheng, El-Fakhri, Georges, Sperling, Reisa A., Johnson, Keith A.

“…Tau and amyloid beta (Aβ) proteins accumulate along neuronal circuits in Alzheimer’s disease. Unraveling the genetic background for the regional vulnerability…”
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The AHEAD 3‐45 Study: Design of a prevention trial for Alzheimer's disease by Rafii, Michael S., Sperling, Reisa A., Donohue, Michael C., Zhou, Jin, Roberts, Claire, Irizarry, Michael C., Dhadda, Shobha, Sethuraman, Gopalan, Kramer, Lynn D, Swanson, Chad J, Li, David, Krause, Stephen, Rissman, Robert A., Walter, Sarah, Raman, Rema, Johnson, Keith A., Aisen, Paul S.

“…Introduction The Alzheimer's disease (AD) continuum begins with a long asymptomatic or preclinical stage, during which amyloid beta (Aβ) is accumulating for…”
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Sex Differences in the Association of Global Amyloid and Regional Tau Deposition Measured by Positron Emission Tomography in Clinically Normal Older Adults by Buckley, Rachel F, Mormino, Elizabeth C, Rabin, Jennifer S, Hohman, Timothy J, Landau, Susan, Hanseeuw, Bernard J, Jacobs, Heidi I L, Papp, Kathryn V, Amariglio, Rebecca E, Properzi, Michael J, Schultz, Aaron P, Kirn, Dylan, Scott, Matthew R, Hedden, Trey, Farrell, Michelle, Price, Julie, Chhatwal, Jasmeer, Rentz, Dorene M, Villemagne, Victor L, Johnson, Keith A, Sperling, Reisa A

“…Mounting evidence suggests that sex differences exist in the pathologic trajectory of Alzheimer disease. Previous literature shows elevated levels of…”
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The Centiloid Project: Standardizing quantitative amyloid plaque estimation by PET by Klunk, William E, Koeppe, Robert A, Price, Julie C, Benzinger, Tammie L, Devous, Michael D, Jagust, William J, Johnson, Keith A, Mathis, Chester A, Minhas, Davneet, Pontecorvo, Michael J, Rowe, Christopher C, Skovronsky, Daniel M, Mintun, Mark A

“…Abstract Although amyloid imaging with PiB-PET ([C-11]Pittsburgh Compound-B positron emission tomography), and now with F-18-labeled tracers, has produced…”
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The impact of amyloid‐beta and tau on prospective cognitive decline in older individuals by Sperling, Reisa A., Mormino, Elizabeth C., Schultz, Aaron P., Betensky, Rebecca A., Papp, Kathryn V., Amariglio, Rebecca E., Hanseeuw, Bernard J., Buckley, Rachel, Chhatwal, Jasmeer, Hedden, Trey, Marshall, Gad A., Quiroz, Yakeel T., Donovan, Nancy J., Jackson, Jonathan, Gatchel, Jennifer R., Rabin, Jennifer S., Jacobs, Heidi, Yang, Hyun‐Sik, Properzi, Michael, Kirn, Dylan R., Rentz, Dorene M., Johnson, Keith A.

“…Objectives Amyloid‐beta (Aβ) and tau pathologies are commonly observed among clinically normal older individuals at postmortem and can now be detected with in…”
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Dedifferentiation of caudate functional connectivity and striatal dopamine transporter density predict memory change in normal aging by Rieckmann, Anna, Johnson, Keith A., Sperling, Reisa A., Buckner, Randy L., Hedden, Trey

“…Age-related changes in striatal function are potentially important for predicting declining memory performance over the adult life span. Here, we used fMRI to…”
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Flortaucipir tau PET imaging in semantic variant primary progressive aphasia by Makaretz, Sara J, Quimby, Megan, Collins, Jessica, Makris, Nikos, McGinnis, Scott, Schultz, Aaron, Vasdev, Neil, Johnson, Keith A, Dickerson, Bradford C

“…ObjectiveThe semantic variant of primary progressive aphasia (svPPA) is typically associated with frontotemporal lobar degeneration (FTLD) with longTAR…”
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Subjective Cognitive Concerns and Neuropsychiatric Predictors of Progression to the Early Clinical Stages of Alzheimer Disease by Donovan, Nancy J., M.D, Amariglio, Rebecca E., Ph.D, Zoller, Amy S., B.A, Rudel, Rebecca K., B.A, Gomez-Isla, Teresa, M.D, Blacker, Deborah, M.D., Sc.D, Hyman, Bradley T., M.D., Ph.D, Locascio, Joseph J., Ph.D, Johnson, Keith A., M.D, Sperling, Reisa A., M.D, Marshall, Gad A., M.D, Rentz, Dorene M., Psy.D

“…Objective To examine neuropsychiatric and neuropsychological predictors of progression from normal to early clinical stages of Alzheimer disease (AD). Methods…”
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Subjective cognitive complaints and amyloid burden in cognitively normal older individuals by Amariglio, Rebecca E., Becker, J. Alex, Carmasin, Jeremy, Wadsworth, Lauren P., Lorius, Natacha, Sullivan, Caroline, Maye, Jacqueline E., Gidicsin, Christopher, Pepin, Lesley C., Sperling, Reisa A., Johnson, Keith A., Rentz, Dorene M.

“…Accumulating evidence suggests that subjective cognitive complaints (SCC) may indicate subtle cognitive decline characteristic of individuals with preclinical…”
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Appropriate use criteria for amyloid PET: A report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer's Association by Johnson, Keith A, Minoshima, Satoshi, Bohnen, Nicolaas I, Donohoe, Kevin J, Foster, Norman L, Herscovitch, Peter, Karlawish, Jason H, Rowe, Christopher C, Carrillo, Maria C, Hartley, Dean M, Hedrick, Saima, Pappas, Virginia, Thies, William H

“…Abstract Positron emission tomography (PET) of brain amyloid β is a technology that is becoming more available, but its clinical utility in medical practice…”
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Pathological correlations of [F‐18]‐AV‐1451 imaging in non‐alzheimer tauopathies by Marquié, Marta, Normandin, Marc D., Meltzer, Avery C., Siao Tick Chong, Michael, Andrea, Nicolas V., Antón‐Fernández, Alejandro, Klunk, William E., Mathis, Chester A., Ikonomovic, Milos D., Debnath, Manik, Bien, Elizabeth A., Vanderburg, Charles R., Costantino, Isabel, Makaretz, Sara, DeVos, Sarah L., Oakley, Derek H., Gomperts, Stephen N., Growdon, John H., Domoto‐Reilly, Kimiko, Lucente, Diane, Dickerson, Bradford C., Frosch, Matthew P., Hyman, Bradley T., Johnson, Keith A., Gómez‐Isla, Teresa

“…Objective Recent studies have shown that positron emission tomography (PET) tracer AV‐1451 exhibits high binding affinity for paired helical filament (PHF)‐tau…”
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Plasma N-terminal tau fragment levels predict future cognitive decline and neurodegeneration in healthy elderly individuals by Chhatwal, Jasmeer P., Schultz, Aaron P., Dang, Yifan, Ostaszewski, Beth, Liu, Lei, Yang, Hyun-Sik, Johnson, Keith A., Sperling, Reisa A., Selkoe, Dennis J.

“…The availability of blood-based assays detecting Alzheimer’s disease (AD) pathology should greatly accelerate AD therapeutic development and improve clinical…”
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Disruption of Functional Connectivity in Clinically Normal Older Adults Harboring Amyloid Burden by Hedden, Trey, Van Dijk, Koene R. A, Becker, J. Alex, Mehta, Angel, Sperling, Reisa A, Johnson, Keith A, Buckner, Randy L

“…Amyloid deposition is present in 20-50% of nondemented older adults yet the functional consequences remain unclear. The current study found that amyloid…”
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