Search Results - "Johnson, Kari"

Parallel, but Dissociable, Processing in Discrete Corticostriatal Inputs Encodes Skill Learning by Kupferschmidt, David A., Juczewski, Konrad, Cui, Guohong, Johnson, Kari A., Lovinger, David M.

“…Changes in cortical and striatal function underlie the transition from novel actions to refined motor skills. How discrete, anatomically defined…”
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Glutamate receptors as therapeutic targets for Parkinson's disease by Johnson, Kari A, Conn, P Jeffrey, Niswender, Colleen M

“…Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor symptoms including tremor and bradykinesia. The primary pathophysiology…”
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Metabotropic glutamate receptor 2 inhibits thalamically-driven glutamate and dopamine release in the dorsal striatum by Johnson, Kari A., Mateo, Yolanda, Lovinger, David M.

“…The striatum plays critical roles in action control and cognition, and activity of striatal neurons is driven by glutamatergic input. Inhibition of…”
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G protein‐coupled receptor modulation of striatal dopamine transmission: Implications for psychoactive drug effects by Littlepage‐Saunders, Mydirah, Hochstein, Michael J., Chang, Doris S., Johnson, Kari A.

“…Dopamine transmission in the striatum is a critical mediator of the rewarding and reinforcing effects of commonly misused psychoactive drugs. G protein‐coupled…”
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Endocannabinoid Actions on Cortical Terminals Orchestrate Local Modulation of Dopamine Release in the Nucleus Accumbens by Mateo, Yolanda, Johnson, Kari A., Covey, Dan P., Atwood, Brady K., Wang, Hui-Ling, Zhang, Shiliang, Gildish, Iness, Cachope, Roger, Bellocchio, Luigi, Guzmán, Manuel, Morales, Marisela, Cheer, Joseph F., Lovinger, David M.

“…Dopamine (DA) transmission mediates numerous aspects of behavior. Although DA release is strongly linked to firing of DA neurons, recent developments indicate…”
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Local modulation by presynaptic receptors controls neuronal communication and behaviour by Lovinger, David M., Mateo, Yolanda, Johnson, Kari A., Engi, Sheila A., Antonazzo, Mario, Cheer, Joseph F.

“…Central nervous system neurons communicate via fast synaptic transmission mediated by ligand-gated ion channel (LGIC) receptors and slower neuromodulation…”
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Operant self-stimulation of thalamic terminals in the dorsomedial striatum is constrained by metabotropic glutamate receptor 2 by Johnson, Kari A, Voyvodic, Lucas, Loewinger, Gabriel C, Mateo, Yolanda, Lovinger, David M

“…Dorsal striatal manipulations including stimulation of dopamine release and activation of medium spiny neurons (MSNs) are sufficient to drive…”
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Reinforcing actions through the thalamostriatal circuit by Johnson, Kari A, Lovinger, David M

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Presynaptic G Protein-Coupled Receptors: Gatekeepers of Addiction? by Johnson, Kari A, Lovinger, David M

“…Drug abuse and addiction cause widespread social and public health problems, and the neurobiology underlying drug actions and drug use and abuse is an area of…”
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Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS by Yin, Shen, Noetzel, Meredith J, Johnson, Kari A, Zamorano, Rocio, Jalan-Sakrikar, Nidhi, Gregory, Karen J, Conn, P Jeffrey, Niswender, Colleen M

“…Metabotropic glutamate (mGlu) receptors play important roles in regulating CNS function and are known to function as obligatory dimers. Although recent studies…”
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Allosteric modulation of metabotropic glutamate receptors in alcohol use disorder: Insights from preclinical investigations by Johnson, Kari A, Lovinger, David M

“…Metabotropic glutamate (mGlu) receptors are family C G protein-coupled receptors (GPCRs) that modulate neuronal excitability and synaptic transmission…”
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Presynaptic Plasticity Found in Translation by Johnson, Kari A., Lovinger, David M.

“…In this issue of Neuron, Younts et al. (2016) demonstrate that activation of presynaptic CB1 receptors by retrograde endocannabinoid signaling stimulates…”
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Rapid and highly efficient morphogenic gene-mediated hexaploid wheat transformation by Johnson, Kari, Cao Chu, Uyen, Anthony, Geny, Wu, Emily, Che, Ping, Jones, Todd J

“…The successful employment of morphogenic regulator genes, ( ) and ( ), for -mediated transformation of maize ( L.) and sorghum ( L.) has been reported to…”
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Age-dependent impairment of metabotropic glutamate receptor 2-dependent long-term depression in the mouse striatum by chronic ethanol exposure by Johnson, Kari A., Liput, Daniel J., Homanics, Gregg E., Lovinger, David M.

“…Chronic alcohol exposure is associated with increased reliance on behavioral strategies involving the dorsolateral striatum (DLS), including habitual or…”
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Prefrontal cortex parvalbumin interneurons exhibit decreased excitability and potentiated synaptic strength after ethanol reward learning by Ferranti, Anthony S., Johnson, Kari A., Winder, Danny G., Conn, P. Jeffrey, Joffe, Max E.

“…The prefrontal cortex (PFC) is intimately associated with behavioral characteristics of alcohol use disorders, including high motivation to drink and…”
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Active Zone Proteins RIM1αβ Are Required for Normal Corticostriatal Transmission and Action Control by Kupferschmidt, David A, Augustin, Shana M, Johnson, Kari A, Lovinger, David M

“…Dynamic regulation of synaptic transmission at cortical inputs to the dorsal striatum is considered critical for flexible and efficient action learning and…”
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Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4 by Niswender, Colleen M, Johnson, Kari A, Weaver, C David, Jones, Carrie K, Xiang, Zixiu, Luo, Qingwei, Rodriguez, Alice L, Marlo, Joy E, de Paulis, Tomas, Thompson, Analisa D, Days, Emily L, Nalywajko, Tasha, Austin, Cheryl A, Williams, Michael Baxter, Ayala, Jennifer E, Williams, Richard, Lindsley, Craig W, Conn, P Jeffrey

“…Parkinson's disease (PD) is caused by the death of dopamine neurons in the basal ganglia and results in motor symptoms such as tremor and bradykinesia…”
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Metabotropic Glutamate Receptor 2 Positive Allosteric Modulators: Closing the Gate on Drug Abuse? by Johnson, Kari A, Lovinger, David M

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An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission by Shirey, Jana K, Xiang, Zixiu, Orton, Darren, Brady, Ashley E, Johnson, Kari A, Williams, Richard, Ayala, Jennifer E, Rodriguez, Alice L, Wess, Jürgen, Weaver, David, Niswender, Colleen M, Conn, P Jeffrey

“…Muscarinic acetylcholine receptors (mAChRs) provide viable targets for the treatment of multiple central nervous system disorders. We have used cheminformatics…”
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Climate influences thermal balance and water use in African and Asian elephants: physiology can predict drivers of elephant distribution by Dunkin, Robin C, Wilson, Dinah, Way, Nicolas, Johnson, Kari, Williams, Terrie M

“…Elephant movement patterns in relation to surface water demonstrate that they are a water-dependent species. Thus, there has been interest in using surface…”
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