Search Results - "Johnson, Kaitlyn E."

Cancer cell population growth kinetics at low densities deviate from the exponential growth model and suggest an Allee effect by Johnson, Kaitlyn E, Howard, Grant, Mo, William, Strasser, Michael K, Lima, Ernesto A B F, Huang, Sui, Brock, Amy

“…Most models of cancer cell population expansion assume exponential growth kinetics at low cell densities, with deviations to account for observed slowing of…”
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Effects of COVID-19 Vaccination Timing and Risk Prioritization on Mortality Rates, United States by Wang, Xutong, Du, Zhanwei, Johnson, Kaitlyn E, Pasco, Remy F, Fox, Spencer J, Lachmann, Michael, McLellan, Jason S, Meyers, Lauren Ancel

“…During rollout of coronavirus disease vaccination, policymakers have faced critical trade-offs. Using a mathematical model of transmission, we found that…”
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SARS-CoV-2 viral load is associated with risk of transmission to household and community contacts by Bhavnani, Darlene, James, Emily R, Johnson, Kaitlyn E, Beaudenon-Huibregtse, Sylvie, Chang, Patrick, Rathouz, Paul J, Weldon, Minda, Matouschek, Andreas, Young, Amy E

“…Factors that lead to successful SARS-CoV-2 transmission are still not well described. We investigated the association between a case's viral load and the risk…”
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Optimizing COVID-19 testing strategies on college campuses: Evaluation of the health and economic costs by Johnson, Kaitlyn E, Pasco, Remy, Woody, Spencer, Lachmann, Michael, Johnson-Leon, Maureen, Bhavnani, Darlene, Klima, Jessica, Paltiel, A David, Fox, Spencer J, Meyers, Lauren Ancel

“…Colleges and universities in the US struggled to provide safe in-person education throughout the COVID-19 pandemic. Testing coupled with isolation is a nimble…”
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Individually optimal choices can be collectively disastrous in COVID-19 disease control by Stoddard, Madison, Van Egeren, Debra, Johnson, Kaitlyn E, Rao, Smriti, Furgeson, Josh, White, Douglas E, Nolan, Ryan P, Hochberg, Natasha, Chakravarty, Arijit

“…The word 'pandemic' conjures dystopian images of bodies stacked in the streets and societies on the brink of collapse. Despite this frightening picture,…”
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Real-Time Projections of SARS-CoV-2 B.1.1.7 Variant in a University Setting, Texas, USA by Johnson, Kaitlyn E, Woody, Spencer, Lachmann, Michael, Fox, Spencer J, Klima, Jessica, Hines, Terrance S, Meyers, Lauren Ancel

“…We used the incidence of spike gene target failures identified during PCR testing to provide an early projection of the prevalence of severe acute respiratory…”
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In the long shadow of our best intentions: Model-based assessment of the consequences of school reopening during the COVID-19 pandemic by Johnson, Kaitlyn E, Stoddard, Madison, Nolan, Ryan P, White, Douglas E, Hochberg, Natasha S, Chakravarty, Arijit

“…As the world grapples with the ongoing COVID-19 pandemic, a particularly thorny set of questions surrounds the reopening of primary and secondary (K-12)…”
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Disproportionate impacts of COVID-19 in a large US city by Fox, Spencer J, Javan, Emily, Pasco, Remy, Gibson, Graham C, Betke, Briana, Herrera-Diestra, José L, Woody, Spencer, Pierce, Kelly, Johnson, Kaitlyn E, Johnson-León, Maureen, Lachmann, Michael, Meyers, Lauren Ancel

“…COVID-19 has disproportionately impacted individuals depending on where they live and work, and based on their race, ethnicity, and socioeconomic status…”
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Integrating Quantitative Assays with Biologically Based Mathematical Modeling for Predictive Oncology by Kazerouni, Anum S., Gadde, Manasa, Gardner, Andrea, Hormuth, David A., Jarrett, Angela M., Johnson, Kaitlyn E., Lima, Ernesto A.B. F., Lorenzo, Guillermo, Phillips, Caleb, Brock, Amy, Yankeelov, Thomas E.

“…We provide an overview on the use of biological assays to calibrate and initialize mechanism-based models of cancer phenomena. Although artificial intelligence…”
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A multi-state model of chemoresistance to characterize phenotypic dynamics in breast cancer by Howard, Grant R., Johnson, Kaitlyn E., Rodriguez Ayala, Areli, Yankeelov, Thomas E., Brock, Amy

“…The development of resistance to chemotherapy is a major cause of treatment failure in breast cancer. While mathematical models describing the dynamics of…”
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Multifunctional barcoding with ClonMapper enables high-resolution study of clonal dynamics during tumor evolution and treatment by Gutierrez, Catherine, Al'Khafaji, Aziz M, Brenner, Eric, Johnson, Kaitlyn E, Gohil, Satyen H, Lin, Ziao, Knisbacher, Binyamin A, Durrett, Russell E, Li, Shuqiang, Parvin, Salma, Biran, Anat, Zhang, Wandi, Rassenti, Laura, Kipps, Thomas J, Livak, Kenneth J, Neuberg, Donna, Letai, Anthony, Getz, Gad, Wu, Catherine J, Brock, Amy

“…Lineage-tracing methods have enabled characterization of clonal dynamics in complex populations, but generally lack the ability to integrate genomic,…”
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Integrating transcriptomics and bulk time course data into a mathematical framework to describe and predict therapeutic resistance in cancer by Johnson, Kaitlyn E, Howard, Grant R, Morgan, Daylin, Brenner, Eric A, Gardner, Andrea L, Durrett, Russell E, Mo, William, Al'Khafaji, Aziz, Sontag, Eduardo D, Jarrett, Angela M, Yankeelov, Thomas E, Brock, Amy

“…A significant challenge in the field of biomedicine is the development of methods to integrate the multitude of dispersed data sets into comprehensive…”
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Comparative effectiveness of dexamethasone in treatment of hospitalized COVID-19 patients in the United States during the first year of the pandemic: Findings from the National COVID Cohort Collaborative by Zhou, Richard, Johnson, Kaitlyn E, Rousseau, Justin F, Rathouz, Paul J

“…Background Dexamethasone was approved for use in hospitalized COVID-19 patients early in the pandemic based on the RECOVERY trial, but evidence is still needed…”
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Abstract 231: Evaluation of pharmacologic mechanisms to overcome IgG1 antibody (Ab) resistance via quantitative systems pharmacology (QSP) modeling of antibody-dependent cell mediated cytotoxicity (ADCC) by Johnson, Kaitlyn E., Ciocanel, Maria Veronica, Aponte, Josua, Bajeux, Nicolas, Meng, Fanwang, Bottino, Dean

“…Novel therapies that enhance ADCC have the potential to overcome Rituximab (RTX) resistance in lymphoma, which can occur due to e.g. CD20 loss,…”
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Abstract 11: An alternative time-to-event metric that is consistent with tumor response speed and depth, unlike RECIST time to progression by Johnson, Kaitlyn E., Gomez, Axel, Burton, Jackson, White, Douglas, Chakravarty, Arijit, Schmid, Annette, Bottino, Dean

“…Time to RECIST progression (TTP) is currently used as a surrogate for patient benefit for either accelerated regulatory approval or to study the effects of…”
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Abstract LB-011: Experimentally derived multi-state model of chemoresistance to characterize phenotypic dynamics in breast cancer by Johnson, Kaitlyn E., Howard, Grant, Brock, Amy, Yankeelov, Thomas

“…Although several molecular mechanisms of chemotherapeutic resistance are well studied, the ability to model and predict the dynamic development of resistance…”
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Comparative effectiveness of dexamethasone in treatment of hospitalized COVID-19 patients in the United States during the first year of the pandemic: Findings from the National COVID Cohort Collaborative (N3C) data repository by Zhou, Richard, Johnson, Kaitlyn E, Rousseau, Justin F, Rathouz, Paul J

“…Dexamethasone was approved for use in hospitalized COVID-19 patients early in the pandemic based on the RECOVERY trial, but evidence is still needed to support…”
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