Search Results - "Johnson, James D."

The quest to make fully functional human pancreatic beta cells from embryonic stem cells: climbing a mountain in the clouds by Johnson, James D.

“…The production of fully functional insulin-secreting cells to treat diabetes is a major goal of regenerative medicine. In this article, I review progress…”
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Mild Suppression of Hyperinsulinemia to Treat Obesity and Insulin Resistance by Page, Melissa M., Johnson, James D.

“…Insulin plays roles in lipid uptake, lipolysis, and lipogenesis, in addition to controlling blood glucose levels. Excessive circulating insulin is associated…”
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Genetic Basis for Red Coloration in Birds by Lopes, Ricardo J., Johnson, James D., Toomey, Matthew B., Ferreira, Mafalda S., Araujo, Pedro M., Melo-Ferreira, José, Andersson, Leif, Hill, Geoffrey E., Corbo, Joseph C., Carneiro, Miguel

“…The yellow and red feather pigmentation of many bird species [1] plays pivotal roles in social signaling and mate choice [2, 3]. To produce red pigments, birds…”
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The Vitamin A–Redox Hypothesis: A Biochemical Basis for Honest Signaling via Carotenoid Pigmentation by Hill, Geoffrey E., Johnson, James D.

“…Trade-offs in resource allocation have been widely stated as the means by which the honesty of ornamental traits is maintained, but an alternative to this…”
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Hyperinsulinemia in Obesity, Inflammation, and Cancer by Zhang, Anni M Y, Wellberg, Elizabeth A, Kopp, Janel L, Johnson, James D

“…The relative insufficiency of insulin secretion and/or insulin action causes diabetes. However, obesity and type 2 diabetes mellitus can be associated with an…”
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Adaptation and validation of the Johnson-Lecci scale to assess anti-white bias among black UK minority group members by Dierckx, Kim, Van Hiel, Alain, Johnson, James D, Lecci, Len, Valcke, Barbara, Sekwena, Eva Kefilwe

“…The present study (total N = 901) set out to construct and validate a culturally sensitive instrument to examine anti-White bias among Black UK minority group…”
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A causal role for hyperinsulinemia in obesity by Templeman, Nicole M, Skovsø, Søs, Page, Melissa M, Lim, Gareth E, Johnson, James D

“…Insulin modulates the biochemical pathways controlling lipid uptake, lipolysis and lipogenesis at multiple levels. Elevated insulin levels are associated with…”
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Reduced Circulating Insulin Enhances Insulin Sensitivity in Old Mice and Extends Lifespan by Templeman, Nicole M., Flibotte, Stephane, Chik, Jenny H.L., Sinha, Sunita, Lim, Gareth E., Foster, Leonard J., Nislow, Corey, Johnson, James D.

“…The causal relationships between insulin levels, insulin resistance, and longevity are not fully elucidated. Genetic downregulation of insulin/insulin-like…”
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Neoepitopes in Type 1 Diabetes: Etiological Insights, Biomarkers and Therapeutic Targets by Rodriguez-Calvo, Teresa, Johnson, James D, Overbergh, Lut, Dunne, Jessica L

“…The mechanisms underlying type 1 diabetes (T1D) pathogenesis remain largely unknown. While autoantibodies to pancreatic beta-cell antigens are often the first…”
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A randomized controlled trial of pharmacist-led therapeutic carbohydrate and energy restriction in type 2 diabetes by Durrer, Cody, McKelvey, Sean, Singer, Joel, Batterham, Alan M., Johnson, James D., Gudmundson, Kelsey, Wortman, Jay, Little, Jonathan P.

“…Type 2 diabetes can be treated, and sometimes reversed, with dietary interventions; however, strategies to implement these interventions while addressing…”
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Reduced Insulin Production Relieves Endoplasmic Reticulum Stress and Induces β Cell Proliferation by Szabat, Marta, Page, Melissa M., Panzhinskiy, Evgeniy, Skovsø, Søs, Mojibian, Majid, Fernandez-Tajes, Juan, Bruin, Jennifer E., Bround, Michael J., Lee, Jason T.C., Xu, Eric E., Taghizadeh, Farnaz, O’Dwyer, Shannon, van de Bunt, Martijn, Moon, Kyung-Mee, Sinha, Sunita, Han, Jun, Fan, Yong, Lynn, Francis C., Trucco, Massimo, Borchers, Christoph H., Foster, Leonard J., Nislow, Corey, Kieffer, Timothy J., Johnson, James D.

“…Pancreatic β cells are mostly post-mitotic, but it is unclear what locks them in this state. Perturbations including uncontrolled hyperglycemia can drive β…”
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Effects of Mineral Trioxide Aggregate on Human Dental Pulp Cells after Pulp-capping Procedures by Paranjpe, Avina, BDS, MS, PhD, MSD, Zhang, Hai, DMD, PhD, Johnson, James D., DDS, MS

“…Abstract Introduction Pulp-capping procedures are routinely performed. The control of infection and biocompatibility of the pulp-capping materials are…”
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Disinfection Efficacy of Current Regenerative Endodontic Protocols in Simulated Necrotic Immature Permanent Teeth by Latham, Jason, DMD, MS, Fong, Hanson, PhD, Jewett, Anahid, PhD, Johnson, James D., DDS, MS, Paranjpe, Avina, BDS, MS, MSD, PhD

“…Abstract Introduction The lack of mechanical debridement and reduced concentrations suggested for chemical debridement to maintain stem cell viability call…”
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PDX1+ cell budding morphogenesis in a stem cell-derived islet spheroid system by Zhao, Jia, Liang, Shenghui, Cen, Haoning Howard, Li, Yanjun, Baker, Robert K., Ruprai, Balwinder, Gao, Guang, Zhang, Chloe, Ren, Huixia, Tang, Chao, Chen, Liangyi, Liu, Yanmei, Lynn, Francis C., Johnson, James D., Kieffer, Timothy J.

“…Remarkable advances in protocol development have been achieved to manufacture insulin-secreting islets from human pluripotent stem cells (hPSCs). Distinct from…”
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Specialized Hub Beta Cells Trade Maximal Insulin Production for Perfect Timing by Kolic, Jelena, Johnson, James D.

“…The pulsatility of insulin release is disturbed early in type 2 diabetes, but it is not clear whether specialized pacemaker cells drive islet oscillations. In…”
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Is dynamic autocrine insulin signaling possible? A mathematical model predicts picomolar concentrations of extracellular monomeric insulin within human pancreatic islets by Wang, Minghu, Li, Jiaxu, Lim, Gareth E, Johnson, James D

“…Insulin signaling is essential for β-cell survival and proliferation in vivo. Insulin also has potent mitogenic and anti-apoptotic actions on cultured β-cells,…”
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Folding mutations suppress early beta-cell proliferation by Modi, Honey, Johnson, James D

“…Exploring how proliferation and maturation of beta-cells can be impaired after birth will shed light on the origins of various forms of diabetes…”
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Presynaptic Boutons That Contain Mitochondria Are More Stable by Lees, Robert M, Johnson, James D, Ashby, Michael C

“…The addition and removal of presynaptic terminals reconfigures neuronal circuits of the mammalian neocortex, but little is known about how this presynaptic…”
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Evaluation of the Resistance to Cyclic Fatigue among ProTaper Next, ProTaper Universal, and Vortex Blue Rotary Instruments by Nguyen, Harrison H., DDS, MSD, Fong, Hanson, PhD, Paranjpe, Avina, BDS, MS, PhD, MSD, Flake, Natasha M., DDS, PhD, MSD, Johnson, James D., DDS, MS, Peters, Ove A., DMD, MS, PhD

“…Abstract Introduction The purpose of this study was to compare the fracture resistance to cyclic fatigue of ProTaper Next (PTN; Dentsply Tulsa Dental…”
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On the causal relationships between hyperinsulinaemia, insulin resistance, obesity and dysglycaemia in type 2 diabetes by Johnson, James D.

“…Hundreds of millions of people are affected by hyperinsulinaemia, insulin resistance, obesity and the dysglycaemia that mark a common progression from…”
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