Search Results - "Johnson, J. P."

Development and application of an eDNA method to detect and quantify a pathogenic parasite in aquatic ecosystems by Huver, J. R, Koprivnikar, J, Johnson, P. T. J, Whyard, S

“…Approaches based on organismal DNA found in the environment (eDNA) have become increasingly utilized for ecological studies and biodiversity inventories as an…”
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Expanding the genotype-phenotype spectrum in SCN8A-related disorders by Hebbar, Malavika, Al-Taweel, Nawaf, Gill, Inderpal, Boelman, Cyrus, Dean, Richard A, Goodchild, Samuel J, Mezeyova, Janette, Shuart, Noah Gregory, Johnson, Jr, J P, Lee, James, Michoulas, Aspasia, Huh, Linda L, Armstrong, Linlea, Connolly, Mary B, Demos, Michelle K

“…SCN8A-related disorders are a group of variable conditions caused by pathogenic variations in SCN8A. Online Mendelian Inheritance in Man (OMIM) terms them as…”
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Power output and columbic efficiencies from biofilms of Geobacter sulfurreducens comparable to mixed community microbial fuel cells by Nevin, K.P, Richter, H, Covalla, S.F, Johnson, J.P, Woodard, T.L, Orloff, A.L, Jia, H, Zhang, M, Lovley, D.R

“…It has been previously noted that mixed communities typically produce more power in microbial fuel cells than pure cultures. If true, this has important…”
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Activity patterns and temporal avoidance by prey in response to Sunda clouded leopard predation risk by Ross, J., Hearn, A. J., Johnson, P. J., Macdonald, D. W.

“…Little is known about the activity patterns of Bornean ungulates, or the temporal interactions of these species with the Sunda clouded leopard Neofelis diardi…”
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Variable patterns of mutation density among NaV1.1, NaV1.2 and NaV1.6 point to channel-specific functional differences associated with childhood epilepsy by Encinas, Alejandra C., Watkins, Joseph C., Longoria, Iris Arenas, Johnson, J. P., Hammer, Michael F.

“…Variants implicated in childhood epilepsy have been identified in all four voltage-gated sodium channels that initiate action potentials in the central nervous…”
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On-road and laboratory evaluation of combustion aerosols—Part1: Summary of diesel engine results by Kittelson, D.B., Watts, W.F., Johnson, J.P.

“…The objective was to characterize diesel exhaust aerosols on road and to duplicate the results in the laboratory without altering the physical characteristics…”
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Nanoparticle emissions on Minnesota highways by Kittelson, D.B., Watts, W.F., Johnson, J.P.

“…The objective of this project was to characterize on-road aerosol on highways surrounding the Minneapolis area. Data were collected under varying on-road…”
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Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective NaV1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy by Focken, Thilo, Burford, Kristen, Grimwood, Michael E, Zenova, Alla, Andrez, Jean-Christophe, Gong, Wei, Wilson, Michael, Taron, Matt, Decker, Shannon, Lofstrand, Verner, Chowdhury, Sultan, Shuart, Noah, Lin, Sophia, Goodchild, Samuel J, Young, Clint, Soriano, Maegan, Tari, Parisa K, Waldbrook, Matthew, Nelkenbrecher, Karen, Kwan, Rainbow, Lindgren, Andrea, de Boer, Gina, Lee, Stephanie, Sojo, Luis, DeVita, Robert J, Cohen, Charles J, Wesolowski, Steven S, Johnson, J. P, Dehnhardt, Christoph M, Empfield, James R

“…Nonselective antagonists of voltage-gated sodium (NaV) channels have been long used for the treatment of epilepsies. The efficacy of these drugs is thought to…”
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Structure- and Ligand-Based Discovery of Chromane Arylsulfonamide Nav1.7 Inhibitors for the Treatment of Chronic Pain by McKerrall, Steven J, Nguyen, Teresa, Lai, Kwong Wah, Bergeron, Philippe, Deng, Lunbin, DiPasquale, Antonio, Chang, Jae H, Chen, Jun, Chernov-Rogan, Tania, Hackos, David H, Maher, Jonathan, Ortwine, Daniel F, Pang, Jodie, Payandeh, Jian, Proctor, William R, Shields, Shannon D, Vogt, Jennifer, Ji, Pengfei, Liu, Wenfeng, Ballini, Elisa, Schumann, Lilia, Tarozzo, Glauco, Bankar, Girish, Chowdhury, Sultan, Hasan, Abid, Johnson, J. P, Khakh, Kuldip, Lin, Sophia, Cohen, Charles J, Dehnhardt, Christoph M, Safina, Brian S, Sutherlin, Daniel P

“…Using structure- and ligand-based design principles, a novel series of piperidyl chromane arylsulfonamide Nav1.7 inhibitors was discovered. Early optimization…”
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Discovery of Aryl Sulfonamides as Isoform-Selective Inhibitors of NaV1.7 with Efficacy in Rodent Pain Models by Focken, Thilo, Liu, Shifeng, Chahal, Navjot, Dauphinais, Maxim, Grimwood, Michael E, Chowdhury, Sultan, Hemeon, Ivan, Bichler, Paul, Bogucki, David, Waldbrook, Matthew, Bankar, Girish, Sojo, Luis E, Young, Clint, Lin, Sophia, Shuart, Noah, Kwan, Rainbow, Pang, Jodie, Chang, Jae H, Safina, Brian S, Sutherlin, Daniel P, Johnson, J. P, Dehnhardt, Christoph M, Mansour, Tarek S, Oballa, Renata M, Cohen, Charles J, Robinette, C. Lee

“…We report on a novel series of aryl sulfonamides that act as nanomolar potent, isoform-selective inhibitors of the human sodium channel hNaV1.7. The…”
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Identification of serum biomarkers for colon cancer by proteomic analysis by WARD, D. G, SUGGETT, N, CHENG, Y, WEI, W, JOHNSON, H, BILLINGHAM, L. J, ISMAIL, T, WAKELAM, M. J. O, JOHNSON, P. J, MARTIN, A

“…Colorectal cancer (CRC) is often diagnosed at a late stage with concomitant poor prognosis. Early detection greatly improves prognosis; however, the invasive,…”
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Biomarker-based prognosis in hepatocellular carcinoma: validation and extension of the BALAD model by Fox, R, Berhane, S, Teng, M, Cox, T, Tada, T, Toyoda, H, Kumada, T, Kagebayashi, C, Satomura, S, Johnson, P J

“…Background: The Japanese ‘BALAD’ model offers the first objective, biomarker-based, tool for assessment of prognosis in hepatocellular carcinoma, but relies on…”
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Comprehensive analysis of risk factors associating with Hepatitis B virus (HBV) reactivation in cancer patients undergoing cytotoxic chemotherapy by YEO, W, ZEE, B, ZHONG, S, CHAN, P. K. S, WONG, W-L, HO, W. M, LAM, K. C, JOHNSON, P. J

“…For cancer patients with chronic hepatitis B virus (HBV) infection, who receive cytotoxic chemotherapy, HBV reactivation is a well-described complication,…”
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Modelling prognostic factors in advanced pancreatic cancer by Stocken, D D, Hassan, A B, Altman, D G, Billingham, L J, Bramhall, S R, Johnson, P J, Freemantle, N

“…Pancreatic cancer is the fifth most common cause of cancer death. Identification of defined patient groups based on a prognostic index may improve the…”
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Hepatocellular carcinoma: is current therapy really altering outcome? by Johnson, P J

“…Progress in the management of hepatocellular carcinoma (HCC) has been slow and has limited impact on outcome. Most patients with HCC have two diseases—chronic…”
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Nasopharyngeal carcinoma by Chan, A. T. C., Teo, P. M. L., Johnson, P. J.

“…Nasopharyngeal carcinoma (NPC) is endemic in southern China where genetic abnormalities and Epstein–Barr virus (EBV) infection are critical in the pathogenesis…”
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From avengers to hunters: Leveraging collective action for the conservation of endangered lions by Fitzherbert, E., Caro, T., Johnson, P.J., Macdonald, D.W., Borgerhoff Mulder, M.

“…[Display omitted] •East Africans, including Tanzanian Sukuma, traditionally kill lions to retaliate for loss or avert future attacks.•Contemporary lion killers…”
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Molecular Pharmacology of Selective NaV1.6 and Dual NaV1.6/NaV1.2 Channel Inhibitors that Suppress Excitatory Neuronal Activity Ex Vivo by Goodchild, Samuel J., Shuart, Noah Gregory, Williams, Aaron D., Ye, Wenlei, Parrish, R. Ryley, Soriano, Maegan, Thouta, Samrat, Mezeyova, Janette, Waldbrook, Matthew, Dean, Richard, Focken, Thilo, Ghovanloo, Mohammad-Reza, Ruben, Peter C., Scott, Fiona, Cohen, Charles J., Empfield, James, Johnson, JP

“…Voltage-gated sodium channel (NaV) inhibitors are used to treat neurological disorders of hyperexcitability such as epilepsy. These drugs act by attenuating…”
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Combined proteome and transcriptome analyses for the discovery of urinary biomarkers for urothelial carcinoma by Shimwell, N J, Bryan, R T, Wei, W, James, N D, Cheng, K K, Zeegers, M P, Johnson, P J, Martin, A, Ward, D G

“…Background: Proteomic discovery of cancer biomarkers in body fluids is challenging because of their low abundance in a complex background. Altered gene…”
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Groundwater drainage from fissures as a source for lahars by Johnson, P. J., Valentine, G. A., Stauffer, P. H., Lowry, C. S., Sonder, I., Pulgarín, B. A., Santacoloma, C. C., Agudelo, A.

“…One mechanism for generating lahars at volcanoes experiencing unrest is the disruption of internal aquifers. These disruptions can trigger releases of large…”
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