Search Results - "Johnson, Fraser D."

Epithelial tumor suppressor ELF3 is a lineage-specific amplified oncogene in lung adenocarcinoma by Enfield, Katey S. S., Marshall, Erin A., Anderson, Christine, Ng, Kevin W., Rahmati, Sara, Xu, Zhaolin, Fuller, Megan, Milne, Katy, Lu, Daniel, Shi, Rocky, Rowbotham, David A., Becker-Santos, Daiana D., Johnson, Fraser D., English, John C., MacAulay, Calum E., Lam, Stephen, Lockwood, William W., Chari, Raj, Karsan, Aly, Jurisica, Igor, Lam, Wan L.

“…Gene function in cancer is often cell type-specific. The epithelial cell-specific transcription factor ELF3 is a documented tumor suppressor in many epithelial…”
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Extracellular signal-regulated kinase mediates chromatin rewiring and lineage transformation in lung cancer by Inoue, Yusuke, Nikolic, Ana, Farnsworth, Dylan, Shi, Rocky, Johnson, Fraser D, Liu, Alvin, Ladanyi, Marc, Somwar, Romel, Gallo, Marco, Lockwood, William W

“…Lineage transformation between lung cancer subtypes is a poorly understood phenomenon associated with resistance to treatment and poor patient outcomes. Here,…”
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Characterization of a small molecule inhibitor of disulfide reductases that induces oxidative stress and lethality in lung cancer cells by Johnson, Fraser D., Ferrarone, John, Liu, Alvin, Brandstädter, Christina, Munuganti, Ravi, Farnsworth, Dylan A., Lu, Daniel, Luu, Jennifer, Sihota, Tianna, Jansen, Sophie, Nagelberg, Amy, Shi, Rocky, Forcina, Giovanni C., Zhang, Xu, Cheng, Grace S.W., Spencer Miko, Sandra E., de Rappard-Yuswack, Georgia, Sorensen, Poul H., Dixon, Scott J., Guha, Udayan, Becker, Katja, Djaballah, Hakim, Somwar, Romel, Varmus, Harold, Morin, Gregg B., Lockwood, William W.

“…Phenotype-based screening can identify small molecules that elicit a desired cellular response, but additional approaches are required to characterize their…”
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Characterizing the secretome of EGFR mutant lung adenocarcinoma by Luu, Jennifer K, Johnson, Fraser D, Jajarmi, Jana, Sihota, Tianna, Shi, Rocky, Lu, Daniel, Farnsworth, Dylan, Spencer, Sandra E, Negri, Gian Luca, Morin, Gregg B, Lockwood, William W

“…Lung cancer is the leading cause of cancer related death worldwide, mainly due to the late stage of disease at the time of diagnosis. Non-invasive biomarkers…”
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Tandem mass tag-based thermal proteome profiling for the discovery of drug-protein interactions in cancer cells by Johnson, Fraser D., Hughes, Christopher S., Liu, Alvin, Lockwood, William W., Morin, Gregg B.

“…Identification of effector targets is imperative to the characterization of the mechanisms of action of novel small molecules. Here, we describe steps to…”
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MEK inhibitor resistance in lung adenocarcinoma is associated with addiction to sustained ERK suppression by Farnsworth, Dylan A., Inoue, Yusuke, Johnson, Fraser D., de Rappard-Yuswack, Georgia, Lu, Daniel, Shi, Rocky, Ma, Lok In Josephine, Mattar, Marissa S., Somwar, Romel, Ladanyi, Marc, Unni, Arun M., Lockwood, William W.

“…MEK inhibitors (MEKi) have limited efficacy in KRAS mutant lung adenocarcinoma (LUAD) patients, and this is attributed to both intrinsic and adaptive…”
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Loss of ATG4B and ATG4A results in two-stage cell cycle defects in pancreatic ductal adenocarcinoma cells by Sathiyaseelan, Paalini, Chittaranjan, Suganthi, Kalloger, Steve E, Chan, Jennifer, Go, Nancy E, Jardon, Mario A, Ho, Cally J, Hui, Theodore, Xu, Jing, Chow, Christine, Gao, Dongxia, Johnson, Fraser D, Lockwood, William W, Morin, Gregg B, Renouf, Daniel J, Schaeffer, David F, Gorski, Sharon M

“…Pancreatic ductal adenocarcinoma (PDAC) exhibits elevated levels of autophagy, which promote tumor progression and treatment resistance. ATG4B is an…”
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Methionine-producing tumor micro(be) environment fuels growth of solid tumors by Vega, Alexis A., Marshall, Erin A., Noonan, Avery J. C., Filho, Fernando Sergio Leitao, Yang, Julia, Stewart, Greg L., Johnson, Fraser D., Vucic, Emily A., Pewarchuk, Michelle E., Shah, Parag P., Clem, Brian F., Nislow, Corey, Lam, Stephen, Lockwood, William W., Hallam, Steven J., Leung, Janice M., Beverly, Levi J., Lam, Wan L.

“…Background Recent studies have uncovered the near-ubiquitous presence of microbes in solid tumors of diverse origins. Previous literature has shown the impact…”
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