Search Results - "Johnson, E.F"

Leukocytoclastic vasculitis in children: clinical characteristics, subtypes, causes and direct immunofluorescence findings of 56 biopsy‐confirmed cases by Johnson, E.F., Wetter, D.A., Lehman, J.S., Hand, J.L., Davis, D.M.R., Tollefson, M.M.

“…Background Leukocytoclastic vasculitis (LCV) in children is a complex group of conditions. Objectives This study presents the demographics, clinical features,…”
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Microsomal cytochrome P450 2C5: comparison to microbial P450s and unique features by Williams, P.A, Cosme, J, Sridhar, V, Johnson, E.F, McRee, D.E

“…Although microsomal P450s represent the majority of P450s, only microbial P450s have been amenable to crystal structure solution. We have recently solved the…”
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The peroxisome proliferator-activated receptor mediates the induction of CYP4A6, a cytochrome P450 fatty acid omega-hydroxylase, by clofibric acid by SCOTT MUERHOFF, A, GRIFFIN, K. J, JOHNSON, E. F

“…Gene transfer experiments indicate that induction by the peroxisome proliferators, clofibric acid and WY-14,643, of luciferase expression driven by the…”
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A Major CYP2D6 Autoepitope in Autoimmune Hepatitis Type 2 and Chronic Hepatitis C is a Three-dimensional Structure Homologous to Other Cytochrome P450 Autoantigens by Sugimura, T., Obermayer-Straub, P., Kayser, A., Braun, S., Loges, S., Alex, B., Lüttig, B., Johnson, E.F., Manns, Michael P., Strassburg, Christian P.

“…Liver-kidney microsomal antibodies type 1 (LKM) are a diagnostic marker for autoimmune hepatitis type 2 (AIH-2), however, LKM autoantibodies are also detected…”
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Reactive granulomatous dermatitis as a clinically relevant and unifying term: a retrospective review of clinical features, associated systemic diseases, histopathology and treatment for a series of 65 patients at Mayo Clinic by Bangalore Kumar, A., Lehman, J.S., Johnson, E.F., Cantwell, H.M., Sartori Valinotti, J.C., Sokumbi, O., Davis, M.D.P., Wetter, D.A.

“…Background Reactive granulomatous dermatitis (RGD) is an umbrella term used to describe interstitial granulomatous dermatitis (IGD), palisaded neutrophilic and…”
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Henoch-Schönlein purpura and systemic disease in children: retrospective study of clinical findings, histopathology and direct immunofluorescence in 34 paediatric patients by Johnson, E.F., Lehman, J.S., Wetter, D.A., Lohse, C.M., Tollefson, M.M.

“…Summary Background Henoch–Schönlein purpura (HSP), an IgA‐mediated small vessel vasculitis, is the most common form of vasculitis in children. HSP is commonly…”
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Determinants of Cytochrome P450 2C8 Substrate Binding: Structures of Complexes With Montelukast, Troglitazone, Felodipine And 9-CIS-Retinoic Acid by Schoch, G.A., Yano, J.K., Dansette, P.M., Stout, C.D., Johnson, E.F.

“…Although a crystal structure and a pharmacophore model are available for cytochrome P450 2C8, the role of protein flexibility and specific ligand-protein…”
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Structural insight into the altered substrate specificity of human cytochrome P450 2A6 mutants by Sansen, Stefaan, Hsu, Mei-Hui, Stout, C. David, Johnson, Eric F.

“…Human P450 2A6 displays a small active site that is well adapted for the oxidation of small planar substrates. Mutagenesis of CYP2A6 resulted in an increased…”
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Crystal Structures of Substrate-Bound And Substrate-Free Cytochrome P450 46A1, the Principal Cholesterol Hydroxylase in the Brain by Mast, N., White, M.A., Bjorkhem, I., Johnson, E.F., Stout, C.D., Pikuleva, I.A.

“…By converting cholesterol to 24S-hydroxycholesterol, cytochrome P450 46A1 (CYP46A1) initiates the major pathway for cholesterol removal from the brain. Two…”
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Specificity in the activation and inhibition by flavonoids of benzo[a]pyrene hydroxylation by cytochrome P-450 isozymes from rabbit liver microsomes by Huang, M T, Johnson, E F, Muller-Eberhard, U, Koop, D R, Coon, M J, Conney, A H

“…The effect of flavone and 7,8-benzoflavone on the metabolism of benzo[a]pyrene to fluorescent phenols by five cytochrome P-450 isozymes obtained from rabbit…”
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Amino acid sequence of an analogous peptide from two forms of cytochrome P-450 by Ozols, J, Heinemann, F S, Johnson, E F

“…Two cytochrome P-450 preparations, a constitutive isozyme, form 3b, and a phenobarbital-induced isozyme, form 2, were isolated from rabbit liver microsomes and…”
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Reactor-scale cultivation of the hyperthermophilic methanarchaeon Methanococcus jannaschii to high cell densities by MUKHOPADHYAY, B, JOHNSON, E. F, WOLFE, R. S

“…For the hyperthermophilic and barophilic methanarchaeon Methanococcus jannaschii, we have developed a medium and protocols for reactor-scale cultivation that…”
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Use of Complementary Cation And Anion Heavy Atom-Atom Salt Derivatives to Solve the Structure of Cytochrome P450 46a1 by White, M.A., Mast, N., Bjorkhem, I., Johnson, E.F., Stout, C.D., Pikuleva, I.A.

“…Human cytochrome P450 46A1 (CYP46A1) is one of the key enzymes in cholesterol homeostasis in the brain. The crystallization and heavy-atom structure solution…”
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Interaction of the peroxisome proliferator-activated receptor alpha with the retinoid X receptor alpha unmasks a cryptic peroxisome proliferator response element that overlaps an ARP-1-binding site in the CYP4A6 promoter by Palmer, C N, Hsu, M H, Muerhoff, A S, Griffin, K J, Johnson, E F

“…P450 4A6 is highly induced by peroxisome proliferators in vivo. Gene transfer experiments indicate that this induction can be mediated by the mouse peroxisome…”
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Alterations of the regiospecificity of progesterone metabolism by the mutagenesis of two key amino acid residues in rabbit cytochrome P450 2C3v by Richardson, T H, Johnson, E F

“…A Ser/Thr difference at position 364 underlies a phenotypic difference between naturally occurring variants of microsomal cytochrome P450 2C3 in their capacity…”
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Conditions for Vigorous Growth on Sulfide and Reactor-Scale Cultivation Protocols for the Thermophilic Green Sulfur Bacterium Chlorobium tepidum by MUKHOPADHYAY, B, JOHNSON, E. F, ASCANO, M. JR

“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Expression of rabbit cytochromes P4504A which catalyze the omega-hydroxylation of arachidonic acid, fatty acids, and prostaglandins by Roman, L J, Palmer, C N, Clark, J E, Muerhoff, A S, Griffin, K J, Johnson, E F, Masters, B S

“…The omega-hydroxylation product of arachidonic acid is thought to be a potent vasoconstrictor or a precursor thereof in kidney. In this report, we have…”
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A single amino acid substitution confers progesterone 6 beta-hydroxylase activity to rabbit cytochrome P450 2C3 by MEI-HUI HSU, GRIFFIN, K. J, YAN WANG, KEMPER, B, JOHNSON, E. F

“…A cDNA encoding a naturally occurring variant of cytochrome P450 (P450) 2C3 that catalyzes the 6 beta- and 16 alpha-hydroxylation of progesterone exhibits six…”
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Cassette mutagenesis of a potential substrate recognition region of cytochrome P450 2C2 by STRAUB, P, LLOYD, M, JOHNSON, E. F, KEMPER, B

“…Cassette mutagenesis was used to analyze the effects of mutations at amino acid positions 107-120 in cytochrome P450 2C2 which are part of a predicted…”
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Hydrophobic side chain requirements for lauric acid and progesterone hydroxylation at amino acid 113 in cytochrome P450 2C2, a potential determinant of substrate specificity by Straub, P, Johnson, E F, Kemper, B

“…To determine the requirements for hydrophobic amino acids at position 113 in cytochrome P450 2C2, a series of hydrophobic and uncharged polar amino acids was…”
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