Search Results - "Johnson, Dale J."

Partial Reduction of Pyridinium Salts as a Versatile Route to Dihydropyridones by Donohoe, Timothy J., Johnson, Dale J., Mace, Laura H., Bamford, Mark J., Ichihara, Osamu

“…The addition of two electrons to a pyridinium salt turns it into a nucleophile. The intermediate generated by the reduction of such salts can be reacted…”
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The discovery of a series of N-substituted 3-(4-piperidinyl)-1,3-benzoxazolinones and oxindoles as highly brain penetrant, selective muscarinic M1 agonists by JOHNSON, Dale J, FORBES, Ian T, MURKITT, Graham S, LUCAS, Adam J, MOOKHERJEE, Claudette R, WATSON, Jeannette M, GARTLON, Jane E, BRADFORD, Andrea M, BROWN, Fiona, WATSON, Steve P, GARZYA, Vincenzo, STEVENSON, Graeme I, WALKER, Graham R, MUDHAR, Harminder S, FLYNN, Sean T, WYMAN, Paul A, SMITH, Paul W

“…A series of N-substituted 3-(4-piperidinyl)-1,3-benzoxazolinones and oxindoles are reported which were found to be potent and selective muscarinic M1 agonists…”
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The ammonia-free partial reduction of substituted pyridinium salts by Donohoe, Timothy J, Johnson, Dale J, Mace, Laura H, Thomas, Rhian E, Chiu, Jessica Y K, Rodrigues, Jason S, Compton, Richard G, Banks, Craig E, Tomcik, Peter, Bamford, Mark J, Ichihara, Osamu

“…This paper reports a study into the partial reduction of N-alkylpyridinium salts together with subsequent elaboration of the intermediates thus produced…”
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Low temperature electrochemistry as a mechanistic probe for the partial reduction of heterocycles by Donohoe, Timothy J, Johnson, Dale J, Compton, Richard G, Wadhawan, Jay D

“…The reduction of a series of electron deficient aromatic heterocycles has been examined using electrochemical techniques: the analysis was performed under…”
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The discovery of a series of N-substituted 3-(4-piperidinyl)-1,3-benzoxazolinones and oxindoles as highly brain penetrant, selective muscarinic M 1 agonists by Johnson, Dale J., Forbes, Ian T., Watson, Steve P., Garzya, Vincenzo, Stevenson, Graeme I., Walker, Graham R., Mudhar, Harminder S., Flynn, Sean T., Wyman, Paul A., Smith, Paul W., Murkitt, Graham S., Lucas, Adam J., Mookherjee, Claudette R., Watson, Jeannette M., Gartlon, Jane E., Bradford, Andrea M., Brown, Fiona

“…A series of N-substituted 3-(4-piperidinyl)-1,3-benzoxazolinones and oxindoles are reported which were found to be potent and selective muscarinic M 1…”
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The discovery of a series of N-substituted 3-(4-piperidinyl)-1,3-benzoxazolinones and oxindoles as highly brain penetrant, selective muscarinic M sub(1) agonists by Johnson, Dale J, bes, Ian T, Watson, Steve P, Garzya, Vincenzo, Stevenson, Graeme I, Walker, Graham R, Mudhar, Harminder S, Flynn, Sean T, Wyman, Paul A, Smith, Paul W, Murkitt, Graham S, Lucas, Adam J, Mookherjee, Claudette R, Watson, Jeannette M, Gartlon, Jane E, Bradford, Andrea M, Brown, Fiona

“…A series of N-substituted 3-(4-piperidinyl)-1,3-benzoxazolinones and oxindoles are reported which were found to be potent and selective muscarinic M sub(1)…”
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The discovery of an orally efficacious positive allosteric modulator of the calcium sensing receptor containing a dibenzylamine core by Harrington, Paul E., St. Jean, David J., Clarine, Jeffrey, Coulter, Thomas S., Croghan, Michael, Davenport, Adam, Davis, James, Ghiron, Chiara, Hutchinson, Jonathan, Kelly, Michael G., Lott, Fred, Lu, Jenny Ying-Lin, Martin, David, Morony, Sean, Poon, Steve F., Portero-Larragueta, Elena, Reagan, Jeff D., Regal, Kelly A., Tasker, Andrew, Wang, Minghan, Yang, Yuhua, Yao, Guomin, Zeng, Qingping, Henley, Charles, Fotsch, Christopher

“…Compound 22 suppressed plasma PTH levels relative to vehicle when dosed orally in a rat pharmacodynamic model. The discovery of a series of novel and orally…”
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Individual variation in ballooning dispersal by black widow spiderlings： The effects of family and social rearing by Johnson, J. Chadwick, Halpin, Rebecca, Stevens, Dale, Vannan, Annika, Lam, Jesse, Bratsch, Katie

“…Individual behavioral variation is ubiquitous across taxa and important to understand if we wish to fully use beha- vioral data to understand the ecology and…”
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