Search Results - "Johnson, Colin P"

Otoferlin is a multivalent calcium-sensitive scaffold linking SNAREs and calcium channels by Hams, Nicole, Padmanarayana, Murugesh, Qiu, Weihong, Johnson, Colin P.

“…Sensory hair cells rely on otoferlin as the calcium sensor for exocytosis and encoding of sound preferentially over the neuronal calcium sensor synaptotagmin…”
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Quantitation of the Calcium and Membrane Binding Properties of the C2 Domains of Dysferlin by Abdullah, Nazish, Padmanarayana, Murugesh, Marty, Naomi J., Johnson, Colin P.

“…Dysferlin is a large membrane protein involved in calcium-triggered resealing of the sarcolemma after injury. Although it is generally accepted that dysferlin…”
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Forced Unfolding of Proteins Within Cells by Johnson, Colin P, Tang, Hsin-Yao, Carag, Christine, Speicher, David W, Discher, Dennis E

“…To identify cytoskeletal proteins that change conformation or assembly within stressed cells, in situ labeling of sterically shielded cysteines with…”
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Otoferlin Depletion Results in Abnormal Synaptic Ribbons and Altered Intracellular Calcium Levels in Zebrafish by Manchanda, Aayushi, Chatterjee, Paroma, Bonventre, Josephine A., Haggard, Derik E., Kindt, Katie S., Tanguay, Robert L., Johnson, Colin P.

“…The protein otoferlin plays an essential role at the sensory hair cell synapse. Mutations in otoferlin result in deafness and depending on the species, mild to…”
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Mechanism and function of synaptotagmin-mediated membrane apposition by Chapman, Edwin R, Hui, Enfu, Gaffaney, Jon D, Wang, Zhao, Johnson, Colin P, Evans, Chantell S

“…Synaptotagmin-1 aggregates membranes in response to Ca 2+ . Using a variety of approaches, it was discovered that synaptotagmin-mediated membrane aggregation…”
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Direct Evidence That Neural Cell Adhesion Molecule (NCAM) Polysialylation Increases Intermembrane Repulsion and Abrogates Adhesion by Johnson, Colin P., Fujimoto, Ichiro, Rutishauser, Urs, Leckband, Deborah E.

“…Molecular force measurements quantified the impact of polysialylation on the adhesive properties both of membrane-bound neural cell adhesion molecule (NCAM)…”
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Two Pathway-Specific Transcriptional Regulators, PltR and PltZ, Coordinate Autoinduction of Pyoluteorin in Pseudomonas protegens Pf-5 by Yan, Qing, Liu, Mary, Kidarsa, Teresa, Johnson, Colin P., Loper, Joyce E.

“…Antibiotic biosynthesis by microorganisms is commonly regulated through autoinduction, which allows producers to quickly amplify the production of antibiotics…”
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Emerging Functional Differences between the Synaptotagmin and Ferlin Calcium Sensor Families by Johnson, Colin P

“…The ferlin family proteins have emerged as multi-C2 domain regulators of calcium-triggered membrane fusion and fission events. While initially determined to…”
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New Otoferlin Studies Advances Gene Therapy for Congenital Hearing Loss by P. Johnson, Colin

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Otoferlin is a calcium sensor that directly regulates SNARE-mediated membrane fusion by Johnson, Colin P, Chapman, Edwin R

“…Otoferlin is a large multi-C2 domain protein proposed to act as a calcium sensor that regulates synaptic vesicle exocytosis in cochlear hair cells. Although…”
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Stable Silver Clusters and Nanoparticles Prepared in Polyacrylate and Inverse Micellar Solutions by Zhang, Zhiqiang, Patel, Ramesh C, Kothari, Rajshree, Johnson, Colin P, Friberg, Stig E, Aikens, Patricia A

“…Silver clusters and nanoparticles were prepared by reduction of silver nitrate by sodium borohydride in water, in the presence of polyacrylate ions, and in…”
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Synaptotagmin-mediated bending of the target membrane is a critical step in Ca(2+)-regulated fusion by Hui, Enfu, Johnson, Colin P, Yao, Jun, Dunning, F Mark, Chapman, Edwin R

“…Decades ago it was proposed that exocytosis involves invagination of the target membrane, resulting in a highly localized site of contact between the bilayers…”
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Orientation of the Dysferlin C2A Domain is Responsive to the Composition of Lipid Membranes by Carpenter, Andrew P., Khuu, Patricia, Weidner, Tobias, Johnson, Colin P., Roeters, Steven J., Baio, Joe E.

“…Dysferlin is a 230 kD protein that plays a critical function in the active resealing of micron-sized injuries to the muscle sarcolemma by recruiting vesicles…”
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Dysferlin Binds SNAREs (Soluble N-Ethylmaleimide-sensitive Factor (NSF) Attachment Protein Receptors) and Stimulates Membrane Fusion in a Calcium-sensitive Manner by Codding, Sara J., Marty, Naomi, Abdullah, Nazish, Johnson, Colin P.

“…Resealing of tears in the sarcolemma of myofibers is a necessary step in the repair of muscle tissue. Recent work suggests a critical role for dysferlin in the…”
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Embryonic cardiomyocytes beat best on a matrix with heart-like elasticity: scar-like rigidity inhibits beating by Engler, Adam J, Carag-Krieger, Christine, Johnson, Colin P, Raab, Matthew, Tang, Hsin-Yao, Speicher, David W, Sanger, Joseph W, Sanger, Jean M, Discher, Dennis E

“…Fibrotic rigidification following a myocardial infarct is known to impair cardiac output, and it is also known that cardiomyocytes on rigid culture substrates…”
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Truncation of the otoferlin transmembrane domain alters the development of hair cells and reduces membrane docking by Manchanda, Aayushi, Bonventre, Josephine A, Bugel, Sean M, Chatterjee, Paroma, Tanguay, Robyn, Johnson, Colin P

“…Release of neurotransmitter from sensory hair cells is regulated by otoferlin. Despite the importance of otoferlin in the auditory and vestibular pathways, the…”
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Otoferlin C2F Domain-Induced Changes in Membrane Structure Observed by Sum Frequency Generation by Golbek, Thaddeus W., Padmanarayana, Murugesh, Roeters, Steven J., Weidner, Tobias, Johnson, Colin P., Baio, Joe E.

“…Proteins that contain C2 domains are involved in a variety of biological processes, including encoding of sound, cell signaling, and cell membrane repair. Of…”
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Direct Evidence That Mutations within Dysferlin's C2A Domain Inhibit Lipid Clustering by Golbek, Thaddeus W, Otto, Shauna C, Roeters, Steven J, Weidner, Tobias, Johnson, Colin P, Baio, Joe E

“…Mechanical stress on sarcolemma can create small tears in the muscle cell membrane. Within the sarcolemma resides the multidomain dysferlin protein. Mutations…”
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The Dysferlin C2A Domain Binds PI(4,5)P2 and Penetrates Membranes by Kwok, Ethiene, Otto, Shauna C., Khuu, Patricia, Carpenter, Andrew P., Codding, Sara J., Reardon, Patrick N., Vanegas, Juan, Kumar, Tanushri M., Kuykendall, Chapman J., Mehl, Ryan A., Baio, Joe, Johnson, Colin P.

“…[Display omitted] •Dysferlin is a multi-C2 domain protein that regulates sarcolemma repair.•Dysferlin function is dependent on C2A through an unknown…”
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Otoferlin Deficiency in Zebrafish Results in Defects in Balance and Hearing: Rescue of the Balance and Hearing Phenotype with Full-Length and Truncated Forms of Mouse Otoferlin by Chatterjee, Paroma, Padmanarayana, Murugesh, Abdullah, Nazish, Holman, Chelsea L., LaDu, Jane, Tanguay, Robert L., Johnson, Colin P.

“…Sensory hair cells convert mechanical motion into chemical signals. Otoferlin, a six-C2 domain transmembrane protein linked to deafness in humans, is…”
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