Search Results - "Johnson, Barry C"

Molecular Dynamics Approaches Estimate the Binding Energy of HIV-1 Integrase Inhibitors and Correlate with In Vitro Activity by JOHNSON, Barry C, METIFIOT, Mathieu, POMMIER, Yves, HUGHES, Stephen H

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

A comparison of the ability of rilpivirine (TMC278) and selected analogues to inhibit clinically relevant HIV-1 reverse transcriptase mutants by Johnson, Barry C, Pauly, Gary T, Rai, Ganesha, Patel, Disha, Bauman, Joseph D, Baker, Heather L, Das, Kalyan, Schneider, Joel P, Maloney, David J, Arnold, Eddy, Thomas, Craig J, Hughes, Stephen H

“…The recently approved anti-AIDS drug rilpivirine (TMC278, Edurant) is a nonnucleoside inhibitor (NNRTI) that binds to reverse transcriptase (RT) and…”
Get full text

Call Bell Usage: Tracking the Effect of Hourly Staff Rounding by Johnson, Barry C, Bryant, Laurie

“…Hourly rounding by nursing staff helps to proactively manage patient needs and minimize the number of unscheduled calls from patients. The focus of this study…”
Get full text

ROADMAPS: An Online Database of Response Data, Dosing Regimens, and Toxicities of Approved Oncology Drugs as Single Agents to Guide Preclinical In Vivo Studies by Hollingshead, Melinda G, Greenberg, Nathaniel, Gottholm-Ahalt, Michelle, Camalier, Richard, Johnson, Barry C, Collins, Jerry M, Doroshow, James H

“…Preclinical studies provide valuable data in the early development of novel drugs for patients with cancer. Many cancer treatment regimens now utilize multiple…”
Get full text

A Homology Model of HIV-1 Integrase and Analysis of Mutations Designed to Test the Model by Johnson, Barry C., Métifiot, Mathieu, Ferris, Andrea, Pommier, Yves, Hughes, Stephen H.

“…Although there are structures of the different domains of human immunodeficiency virus type 1 (HIV-1) integrase (IN), there is no structure of the entire…”
Get full text

Bicyclic 1‑Hydroxy-2-oxo-1,2-dihydropyridine-3-carboxamide-Containing HIV‑1 Integrase Inhibitors Having High Antiviral Potency against Cells Harboring Raltegravir-Resistant Integrase Mutants by Zhao, Xue Zhi, Smith, Steven J, Métifiot, Mathieu, Johnson, Barry C, Marchand, Christophe, Pommier, Yves, Hughes, Stephen H, Burke, Terrence R

“…Integrase (IN) inhibitors are the newest class of antiretroviral agents developed for the treatment of HIV-1 infections. Merck’s Raltegravir (RAL) (October…”
Get full text

Isoform- and Phosphorylation-specific Multiplexed Quantitative Pharmacodynamics of Drugs Targeting PI3K and MAPK Signaling in Xenograft Models and Clinical Biopsies by Herrick, William G, Kilpatrick, Casey L, Hollingshead, Melinda G, Esposito, Dominic, O'Sullivan Coyne, Geraldine, Gross, Andrea M, Johnson, Barry C, Chen, Alice P, Widemann, Brigitte C, Doroshow, James H, Parchment, Ralph E, Srivastava, Apurva K

“…Ras/Raf/MEK/ERK (MAPK) and PI3K/AKT signaling pathways influence several cell functions involved in oncogenesis, making them attractive drug targets. We…”
Get full text

Selectivity for strand-transfer over 3'-processing and susceptibility to clinical resistance of HIV-1 integrase inhibitors are driven by key enzyme-DNA interactions in the active site by Métifiot, Mathieu, Johnson, Barry C, Kiselev, Evgeny, Marler, Laura, Zhao, Xue Zhi, Burke, Jr, Terrence R, Marchand, Christophe, Hughes, Stephen H, Pommier, Yves

“…Integrase strand transfer inhibitors (INSTIs) are highly effective against HIV infections. Co-crystal structures of the prototype foamy virus intasome have…”
Get full text

Combination therapy with pazopanib and tivantinib modulates VEGF and c-MET levels in refractory advanced solid tumors by Kummar, Shivaani, Srivastava, Apurva K., Navas, Tony, Cecchi, Fabiola, Lee, Young H., Bottaro, Donald P., Park, Sook Ryun, Do, Khanh T., Jeong, Woondong, Johnson, Barry C., Voth, Andrea R., Rubinstein, Larry, Wright, John J., Parchment, Ralph E., Doroshow, James H., Chen, Alice P.

“…Summary The vascular endothelial growth factor (VEGF)/VEGFR and hepatocyte growth factor (HGF)/c-MET signaling pathways act synergistically to promote…”
Get full text

Phase 1 study of Z-endoxifen in patients with advanced gynecologic, desmoid, and hormone receptor-positive solid tumors by Takebe, Naoko, Coyne, Geraldine O'Sullivan, Kummar, Shivaani, Collins, Jerry, Reid, Joel M, Piekarz, Richard, Moore, Nancy, Juwara, Lamin, Johnson, Barry C, Bishop, Rachel, Lin, Frank I, Mena, Esther, Choyke, Peter L, Lindenberg, M Liza, Rubinstein, Larry V, Bonilla, Cecilia Monge, Goetz, Matthew P, Ames, Matthew M, McGovern, Renee M, Streicher, Howard, Covey, Joseph M, Doroshow, James H, Chen, Alice P

“…Differential responses to tamoxifen may be due to inter-patient variability in tamoxifen metabolism into pharmacologically active Z-endoxifen. Z-endoxifen…”
Get full text

Mutagenesis of Human Immunodeficiency Virus Reverse Transcriptase p51 Subunit Defines Residues Contributing to Vinylogous Urea Inhibition of Ribonuclease H Activity by Chung, Suhman, Miller, Jennifer T., Johnson, Barry C., Hughes, Stephen H., Le Grice, Stuart F.J.

“…The vinylogous urea, NSC727447, was proposed to allosterically inhibit ribonuclease H (RNase H) activity of human immunodeficiency virus type 1 reverse…”
Get full text

6,7-Dihydroxy-1-oxoisoindoline-4-sulfonamide-containing HIV-1 integrase inhibitors by Zhao, Xue Zhi, Maddali, Kasthuraiah, Smith, Steven J., Métifiot, Mathieu, Johnson, Barry C., Marchand, Christophe, Hughes, Stephen H., Pommier, Yves, Burke, Terrence R.

“…Although an extensive body of scientific and patent literature exists describing the development of HIV-1 integrase (IN) inhibitors, Merck’s raltegravir and…”
Get full text

The effect of die attach voiding on the thermal resistance of chip level packages by Fleischer, Amy S., Chang, Li-hsin, Johnson, Barry C.

“…The presence of voids in the die bond region is known to adversely affect the thermal resistance of the packaged chip-level device. Unfortunately, such voids…”
Get full text

Activities, Crystal Structures, and Molecular Dynamics of Dihydro‑1H‑isoindole Derivatives, Inhibitors of HIV‑1 Integrase by Métifiot, Mathieu, Maddali, Kasthuraiah, Johnson, Barry C, Hare, Stephen, Smith, Steven J, Zhao, Xue Zhi, Marchand, Christophe, Burke, Terrence R, Hughes, Stephen H, Cherepanov, Peter, Pommier, Yves

“…On the basis of a series of lactam and phthalimide derivatives that inhibit HIV-1 integrase, we developed a new molecule, XZ-259, with biochemical and…”
Get full text

Call Bell Usage by Johnson, Barry C, Bryant, Laurie

“…Hourly rounding by nursing staff helps to proactively manage patient needs and minimize the number of unscheduled calls from patients. The focus of this study…”
Get full text

Phase 1 study of indenoisoquinoline LMP744 in adults with relapsed solid tumors and lymphomas by Ko, Brian, Chen, Alice P., Kummar, Shivaani, Hogu, Murielle, Rubinstein, Larry V., Takebe, Naoko, Piekarz, Richard, Sharon, Elad, Beumer, Jan Hendrik, Wilsker, Deborah, Ketchum, Donna, Ferry-Galow, Katherine V., Parchment, Ralph E., Holleran, Julianne L., Deppas, Joshua J., Collins, Jerry M., Johnson, Barry C., Ivy, S. Percy, Doroshow, James H., O'Sullivan Coyne, Geraldine Helen

“…3022 Background: Indenoisoquinolines (IIQ) are non-camptothecin inhibitors of topoisomerase 1 (TOP1) that have improved characteristics over camptothecin TOP1…”
Get full text

Activities, Crystal Structures, and Molecular Dynamics of Dihydro-1 H -isoindole Derivatives, Inhibitors of HIV-1 Integrase by Métifiot, Mathieu, Maddali, Kasthuraiah, Johnson, Barry C., Hare, Stephen, Smith, Steven J., Zhao, Xue Zhi, Marchand, Christophe, Burke, Terrence R., Hughes, Stephen H., Cherepanov, Peter, Pommier, Yves

Get full text

Solved: The "Mystery" of Lt. Lovell Jerome by Johnson, Barry C

Get full text

The Future of High Density Packaging by Johnson, Barry C.

“…A general overview is presented of high density packaging methods earmarked for use with future leading edge integrated circuits. Pertinent design, performance…”
Get full text

Democratic Convention of 1924 and Some Reminiscences of a Participant; Comments on DeTrobriand and Officer Inebriates by Wheeler, Burton K., M. F. Keller, Barry C. Johnson, John R. Sibbald

Get full text