Search Results - "Johnsen, Steven A"

DeltaNp63-dependent super enhancers define molecular identity in pancreatic cancer by an interconnected transcription factor network by Hamdan, Feda H., Johnsen, Steven A.

“…Molecular subtyping of cancer offers tremendous promise for the optimization of a precision oncology approach to anticancer therapy. Recent advances in…”
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The enigmatic role of H2Bub1 in cancer by Johnsen, Steven A.

“…The post-translational modification of histone proteins plays an important role in controlling cell fate by directing essentially all DNA-associated nuclear…”
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The Histone H2B Monoubiquitination Regulatory Pathway Is Required for Differentiation of Multipotent Stem Cells by Karpiuk, Oleksandra, Najafova, Zeynab, Kramer, Frank, Hennion, Magali, Galonska, Christina, König, Annekatrin, Snaidero, Nicolas, Vogel, Tanja, Shchebet, Andrei, Begus-Nahrmann, Yvonne, Kassem, Moustapha, Simons, Mikael, Shcherbata, Halyna, Beissbarth, Tim, Johnsen, Steven A.

“…Extensive changes in posttranslational histone modifications accompany the rewiring of the transcriptional program during stem cell differentiation. However,…”
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Bromodomain Protein BRD4 Is Required for Estrogen Receptor-Dependent Enhancer Activation and Gene Transcription by Nagarajan, Sankari, Hossan, Tareq, Alawi, Malik, Najafova, Zeynab, Indenbirken, Daniela, Bedi, Upasana, Taipaleenmäki, Hanna, Ben-Batalla, Isabel, Scheller, Marina, Loges, Sonja, Knapp, Stefan, Hesse, Eric, Chiang, Cheng-Ming, Grundhoff, Adam, Johnsen, Steven A.

“…The estrogen receptor α (ERα) controls cell proliferation and tumorigenesis by recruiting various cofactors to estrogen response elements (EREs) to control…”
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Stem-Cell-like Properties and Epithelial Plasticity Arise as Stable Traits after Transient Twist1 Activation by Schmidt, Johanna M., Panzilius, Elena, Bartsch, Harald S., Irmler, Martin, Beckers, Johannes, Kari, Vijayalakshmi, Linnemann, Jelena R., Dragoi, Diana, Hirschi, Benjamin, Kloos, Uwe J., Sass, Steffen, Theis, Fabian, Kahlert, Steffen, Johnsen, Steven A., Sotlar, Karl, Scheel, Christina H.

“…Master regulators of the epithelial-mesenchymal transition such as Twist1 and Snail1 have been implicated in invasiveness and the generation of cancer stem…”
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USP22 promotes HER2-driven mammary carcinoma aggressiveness by suppressing the unfolded protein response by Prokakis, Evangelos, Dyas, Anna, Grün, Regina, Fritzsche, Sonja, Bedi, Upasana, Kazerouni, Zahra B., Kosinsky, Robyn L., Johnsen, Steven A., Wegwitz, Florian

“…The Ubiquitin-Specific Protease 22 (USP22) is a deubiquitinating subunit of the mammalian SAGA transcriptional co-activating complex. USP22 was identified as a…”
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Loss of CHD1 causes DNA repair defects and enhances prostate cancer therapeutic responsiveness by Kari, Vijayalakshmi, Mansour, Wael Yassin, Raul, Sanjay Kumar, Baumgart, Simon J, Mund, Andreas, Grade, Marian, Sirma, Hüseyin, Simon, Ronald, Will, Hans, Dobbelstein, Matthias, Dikomey, Ekkehard, Johnsen, Steven A

“…The CHD1 gene, encoding the chromo‐domain helicase DNA‐binding protein‐1, is one of the most frequently deleted genes in prostate cancer. Here, we examined the…”
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Histone deacetylase class-I inhibition promotes epithelial gene expression in pancreatic cancer cells in a BRD4- and MYC-dependent manner by Mishra, Vivek Kumar, Wegwitz, Florian, Kosinsky, Robyn Laura, Sen, Madhobi, Baumgartner, Roland, Wulff, Tanja, Siveke, Jens T, Schildhaus, Hans-Ulrich, Najafova, Zeynab, Kari, Vijayalakshmi, Kohlhof, Hella, Hessmann, Elisabeth, Johnsen, Steven A

“…Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with a particularly dismal prognosis. Histone deacetylases (HDAC) are epigenetic…”
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Super enhancer regulation of cytokine-induced chemokine production in alcoholic hepatitis by Liu, Mengfei, Cao, Sheng, He, Li, Gao, Jinhang, Arab, Juan P., Cui, Huarui, Xuan, Weixia, Gao, Yandong, Sehrawat, Tejasav S., Hamdan, Feda H., Ventura-Cots, Meritxell, Argemi, Josepmaria, Pomerantz, William C. K., Johnsen, Steven A., Lee, Jeong-Heon, Gao, Fei, Ordog, Tamas, Mathurin, Philippe, Revzin, Alexander, Bataller, Ramon, Yan, Huihuang, Shah, Vijay H.

“…Alcoholic hepatitis (AH) is associated with liver neutrophil infiltration through activated cytokine pathways leading to elevated chemokine expression…”
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SAGA-Dependent Histone H2Bub1 Deubiquitination Is Essential for Cellular Ubiquitin Balance during Embryonic Development by El-Saafin, Farrah, Devys, Didier, Johnsen, Steven A., Vincent, Stéphane D., Tora, László

“…Ubiquitin (ub) is a small, highly conserved protein widely expressed in eukaryotic cells. Ubiquitination is a post-translational modification catalyzed by…”
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The glucocorticoid receptor and FOXO1 synergistically activate the skeletal muscle atrophy-associated MuRF1 gene by Waddell, David S, Baehr, Leslie M, van den Brandt, Jens, Johnsen, Steven A, Reichardt, Holger M, Furlow, J David, Bodine, Sue C

“…The muscle specific ubiquitin E3 ligase MuRF1 has been implicated as a key regulator of muscle atrophy under a variety of conditions, such as during synthetic…”
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Egr2-guided histone H2B monoubiquitination is required for peripheral nervous system myelination by Wüst, Hannah M, Wegener, Amélie, Fröb, Franziska, Hartwig, Anna C, Wegwitz, Florian, Kari, Vijayalakshmi, Schimmel, Margit, Tamm, Ernst R, Johnsen, Steven A, Wegner, Michael, Sock, Elisabeth

“…Abstract Schwann cells are the nerve ensheathing cells of the peripheral nervous system. Absence, loss and malfunction of Schwann cells or their myelin sheaths…”
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Estrogen-Dependent Gene Transcription in Human Breast Cancer Cells Relies upon Proteasome-Dependent Monoubiquitination of Histone H2B by PRENZEL, Tanja, BEGUS-NAHRMANN, Yvonne, BEISSBARTH, Tim, JOHNSEN, Steven A, KRAMER, Frank, HENNION, Magali, HSU, Chieh, GORSLER, Theresa, HINTERMAIR, Corinna, EICK, Dirk, KREMMER, Elisabeth, SIMONS, Mikael

“…The estrogen receptor-α (ERα) determines the phenotype of breast cancers where it serves as a positive prognostic indicator. ERα is a well-established target…”
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NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar–Ductal Transdifferentiation in the Pancreas by Chen, Nai-Ming, Singh, Garima, Koenig, Alexander, Liou, Geou-Yarh, Storz, Peter, Zhang, Jin-San, Regul, Lisanne, Nagarajan, Sankari, Kühnemuth, Benjamin, Johnsen, Steven A, Hebrok, Matthias, Siveke, Jens, Billadeau, Daniel D, Ellenrieder, Volker, Hessmann, Elisabeth

“…Background & Aims Oncogenic mutations in KRAS contribute to the development of pancreatic ductal adenocarcinoma, but are not sufficient to initiate…”
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RNF40 epigenetically modulates glycolysis to support the aggressiveness of basal-like breast cancer by Prokakis, Evangelos, Jansari, Shaishavi, Boshnakovska, Angela, Wiese, Maria, Kusch, Kathrin, Kramm, Christof, Dullin, Christian, Rehling, Peter, Glatzel, Markus, Pantel, Klaus, Wikman, Harriet, Johnsen, Steven A., Gallwas, Julia, Wegwitz, Florian

“…Triple-negative breast cancer (TNBC) is the most difficult breast cancer subtype to treat due to the lack of targeted therapies. Cancer stem cells (CSCs) are…”
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The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression by Shema, Efrat, Tirosh, Itay, Aylon, Yael, Huang, Jing, Ye, Chaoyang, Moskovits, Neta, Raver-Shapira, Nina, Minsky, Neri, Pirngruber, Judith, Tarcic, Gabi, Hublarova, Pavla, Moyal, Lilach, Gana-Weisz, Mali, Shiloh, Yosef, Yarden, Yossef, Johnsen, Steven A, Vojtesek, Borivoj, Berger, Shelley L, Oren, Moshe

“…Histone monoubiquitylation is implicated in critical regulatory processes. We explored the roles of histone H2B ubiquitylation in human cells by reducing the…”
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The H2B ubiquitin ligase RNF40 cooperates with SUPT16H to induce dynamic changes in chromatin structure during DNA double-strand break repair by Kari, Vijayalakshmi, Shchebet, Andrei, Neumann, Heinz, Johnsen, Steven A.

“…Many anticancer therapies function largely by inducing DNA double-strand breaks (DSBs) or altering the ability of cancer cells to repair them. Proper and…”
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USP22 supports the aggressive behavior of basal-like breast cancer by stimulating cellular respiration by Prokakis, Evangelos, Bamahmoud, Husam, Jansari, Shaishavi, Fritsche, Lena, Dietz, Alexander, Boshnakovska, Angela, Rehling, Peter, Johnsen, Steven A, Gallwas, Julia, Wegwitz, Florian

“…Breast cancer (BC) is the most frequent tumor entity in women worldwide with a high chance of therapeutic response in early- and non-metastatic disease stages…”
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SIRT2 directs the replication stress response through CDK9 deacetylation by Zhang, Hui, Park, Seong-Hoon, Pantazides, Brooke G., Karpiuk, Oleksandra, Warren, Matthew D., Hardy, Claire W., Duong, Due M., Park, So-Jeong, Kim, Hyun-Seok, Vassilopoulos, Athanassios, Seyfried, Nicholas T., Johnsen, Steven A., Gius, David, Yu, David S.

“…Sirtuin 2 (SIRT2) is a sirtuin family deacetylase that directs acetylome signaling, protects genome integrity, and is a murine tumor suppressor. We show that…”
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CDK9 directs H2B monoubiquitination and controls replication-dependent histone mRNA 3′-end processing by Pirngruber, Judith, Shchebet, Andrei, Schreiber, Lisa, Shema, Efrat, Minsky, Neri, Chapman, Rob D, Eick, Dirk, Aylon, Yael, Oren, Moshe, Johnsen, Steven A

“…Post‐translational histone modifications have essential roles in controlling nuclear processes; however, the specific mechanisms regulating these modifications…”
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