Search Results - "Johnsen, Pål Jarle"

Bacterial natural transformation by highly fragmented and damaged DNA by Overballe-Petersen, Søren, Harms, Klaus, Orlando, Ludovic A. A., Mayar, J. Victor Moreno, Rasmussen, Simon, Dahl, Tais W., Rosing, Minik T., Poole, Anthony M., Sicheritz-Ponten, Thomas, Brunak, Søren, Inselmann, Sabrina, de Vries, Johann, Wackernagel, Wilfried, Pybus, Oliver G., Nielsen, Rasmus, Johnsen, Pål Jarle, Nielsen, Kaare Magne, Willerslev, Eske

“…DNA molecules are continuously released through decomposition of organic matter and are ubiquitous in most environments. Such DNA becomes fragmented and…”
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OXA-48-Mediated Ceftazidime-Avibactam Resistance Is Associated with Evolutionary Trade-Offs by Fröhlich, Christopher, Sørum, Vidar, Thomassen, Ane Molden, Johnsen, Pål Jarle, Leiros, Hanna-Kirsti S, Samuelsen, Ørjan

“…Infections due to carbapenemase-producing Gram-negative pathogens are associated with limited treatment options and consequently lead to increased mortality…”
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Improved burns therapy: liposomes-in-hydrogel delivery system for mupirocin by Hurler, Julia, Berg, Ole Aleksander, Skar, Merete, Conradi, Anne Hilde, Johnsen, Pål Jarle, Skalko-Basnet, Nataša

“…Wounds, particularly burns, are prone to colonization of potentially life-threatening bacteria. Local delivery of antimicrobial agents in sufficient quantities…”
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Persistence of a pKPN3-like CTX-M-15-encoding IncFIIK plasmid in a Klebsiella pneumonia ST17 host during two years of intestinal colonization by Löhr, Iren Høyland, Hülter, Nils, Bernhoff, Eva, Johnsen, Pål Jarle, Sundsfjord, Arnfinn, Naseer, Umaer

“…To characterize the CTX-M-15-encoding plasmid in a Klebsiella pneumoniae ST17 strain, responsible for an outbreak at a Norwegian neonatal intensive care unit…”
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Substitutions of short heterologous DNA segments of intragenomic or extragenomic origins produce clustered genomic polymorphisms by Harms, Klaus, Lunnan, Asbjørn, Hülter, Nils, Mourier, Tobias, Vinner, Lasse, Andam, Cheryl P., Marttinen, Pekka, Fridholm, Helena, Hansen, Anders Johannes, Hanage, William P., Nielsen, Kaare Magne, Willerslev, Eske, Johnsen, Pål Jarle

“…In a screen for unexplained mutation events we identified a previously unrecognized mechanism generating clustered DNA polymorphisms such as microindels and…”
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No effect of natural transformation on the evolution of resistance to bacteriophages in the Acinetobacter baylyi model system by McLeman, Amy, Sierocinski, Pawel, Hesse, Elze, Buckling, Angus, Perron, Gabriel, Hülter, Nils, Johnsen, Pål Jarle, Vos, Michiel

“…The adaptive benefits of natural transformation, the active uptake of free DNA molecules from the environment followed by incorporation of this DNA into the…”
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Mge-cluster: a reference-free approach for typing bacterial plasmids by Arredondo-Alonso, Sergio, Gladstone, Rebecca A, Pöntinen, Anna K, Gama, João A, Schürch, Anita C, Lanza, Val F, Johnsen, Pål Jarle, Samuelsen, Ørjan, Tonkin-Hill, Gerry, Corander, Jukka

“…Abstract Extrachromosomal elements of bacterial cells such as plasmids are notorious for their importance in evolution and adaptation to changing ecology…”
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Antimicrobial resistance acquisition via natural transformation: context is everything by Winter, Macaulay, Buckling, Angus, Harms, Klaus, Johnsen, Pål Jarle, Vos, Michiel

“…•Natural transformation mediates the spread of antibiotic resistance genes.•Natural transformation can aid gene transfer between unrelated taxa.•Natural…”
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Transfer of plasmid and chromosomal glycopeptide resistance determinants occurs more readily in the digestive tract of mice than in vitro and exconjugants can persist stably in vivo in the absence of glycopeptide selection by Dahl, Kristin Hegstad, Mater, Denis D. G., Flores, María José, Johnsen, Pål Jarle, Midtvedt, Tore, Corthier, Gerard, Sundsfjord, Arnfinn

“…Objectives and methods The transferability of vanA and vanB glycopeptide resistance determinants with a defined plasmid (n = 9) or chromosomal (n = 4) location…”
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Testing for the fitness benefits of natural transformation during community-embedded evolution by Winter, Macaulay, Harms, Klaus, Johnsen, Pål Jarle, Buckling, Angus, Vos, Michiel

“…Natural transformation is a process where bacteria actively take up DNA from the environment and recombine it into their genome or reconvert it into…”
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Evolution of β-lactamase-mediated cefiderocol resistance by Fröhlich, Christopher, Sørum, Vidar, Tokuriki, Nobuhiko, Johnsen, Pål Jarle, Samuelsen, Ørjan

“…Cefiderocol is a novel siderophore β-lactam with improved hydrolytic stability toward β-lactamases, including carbapenemases, achieved by combining structural…”
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Distribution of class 1 integrons in a highly impacted catchment by Borruso, Luigimaria, Harms, Klaus, Johnsen, Pål Jarle, Nielsen, Kaare Magne, Brusetti, Lorenzo

“…Polluted compounds into freshwater sediments may select and enrich bacteria carrying specific genetic compositions. Here we examine the possible use of class 1…”
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Gene transfer potential of outer membrane vesicles of Acinetobacter baylyi and effects of stress on vesiculation by Fulsundar, Shweta, Harms, Klaus, Flaten, Gøril E, Johnsen, Pål J, Chopade, Balu Ananda, Nielsen, Kaare M

“…Outer membrane vesicles (OMVs) are continually released from a range of bacterial species. Numerous functions of OMVs, including the facilitation of horizontal…”
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Piggybacking on Niche Adaptation Improves the Maintenance of Multidrug‐Resistance Plasmids by Kloos, Julia, Gama, João A, Hegstad, Joachim, Samuelsen, Ørjan, Johnsen, Pål J

“…Abstract The persistence of plasmids in bacterial populations represents a puzzling evolutionary problem with serious clinical implications due to their role…”
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Tn1 transposition in the course of natural transformation enables horizontal antibiotic resistance spread in Acinetobacter baylyi by Kloos, Julia, Johnsen, Pål J., Harms, Klaus

“…Transposons are genetic elements that change their intracellular genomic position by transposition and are spread horizontally between bacteria when located on…”
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Conserved collateral antibiotic susceptibility networks in diverse clinical strains of Escherichia coli by Podnecky, Nicole L., Fredheim, Elizabeth G. A., Kloos, Julia, Sørum, Vidar, Primicerio, Raul, Roberts, Adam P., Rozen, Daniel E., Samuelsen, Ørjan, Johnsen, Pål J.

“…There is urgent need to develop novel treatment strategies to reduce antimicrobial resistance. Collateral sensitivity (CS), where resistance to one…”
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Effect of chemotherapeutic agents on natural transformation frequency in Acinetobacter baylyi by Winter, Macaulay, Vos, Michiel, Buckling, Angus, Johnsen, Pål Jarle, Harms, Klaus

“…Natural transformation is the ability of a bacterial cell to take up extracellular DNA which is subsequently available for recombination into the chromosome…”
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Strong pathogen competition in neonatal gut colonisation by Mäklin, Tommi, Thorpe, Harry A., Pöntinen, Anna K., Gladstone, Rebecca A., Shao, Yan, Pesonen, Maiju, McNally, Alan, Johnsen, Pål J., Samuelsen, Ørjan, Lawley, Trevor D., Honkela, Antti, Corander, Jukka

“…Opportunistic bacterial pathogen species and their strains that colonise the human gut are generally understood to compete against both each other and the…”
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Steady at the wheel: conservative sex and the benefits of bacterial transformation by Ambur, Ole Herman, Engelstädter, Jan, Johnsen, Pål J., Miller, Eric L., Rozen, Daniel E.

“…Many bacteria are highly sexual, but the reasons for their promiscuity remain obscure. Did bacterial sex evolve to maximize diversity and facilitate adaptation…”
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Strong pathogen competition in neonatal gut colonisation by Mäklin, Tommi, Thorpe, Harry Arthur Frank Wright, Pöntinen, Anna Kaarina, Gladstone, Rebecca Ashley, Shao, Yan, Pesonen, Maiju, McNally, Alan, Johnsen, Pål Jarle, Samuelsen, Ørjan, Lawley, Trevor D, Honkela, Antti, Corander, Jukka

“…Abstract Opportunistic bacterial pathogen species and their strains that colonise the human gut are generally understood to compete against both each other and…”
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