Search Results - "Johns, Scott C"

The Anti-inflammatory Protein TSG-6 Regulates Chemokine Function by Inhibiting Chemokine/Glycosaminoglycan Interactions by Dyer, Douglas P., Salanga, Catherina L., Johns, Scott C., Valdambrini, Elena, Fuster, Mark M., Milner, Caroline M., Day, Anthony J., Handel, Tracy M.

“…TNF-stimulated gene-6 (TSG-6) is a multifunctional protein secreted in response to pro-inflammatory stimuli by a wide range of cells, including neutrophils,…”
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Pulsed Low-Frequency Magnetic Fields Induce Tumor Membrane Disruption and Altered Cell Viability by Ashdown, Christopher P., Johns, Scott C., Aminov, Edward, Unanian, Michael, Connacher, William, Friend, James, Fuster, Mark M.

“…Tumor cells express a unique cell surface glycocalyx with upregulation of sulfated glycosaminoglycans and charged glycoproteins. Little is known about how…”
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Targeting glycan sulfation in a CD11c+ myeloid population inhibits early KRAS-mutant lung neoplasia by Kim, So Young, Johns, Scott C., Gupta, Purva, Varki, Nissi, Fuster, Mark M

“…Early lung carcinoma development may be modulated by innate host cellular mechanisms that promote tumor growth and invasion. We recently identified how a…”
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Genetic alteration of heparan sulfate in CD11c + immune cells inhibits inflammation and facilitates pathogen clearance during influenza A virus infection by Kim, So Young, Gupta, Purva, Johns, Scott C., Zuniga, Elina I., Teijaro, John R., Fuster, Mark M.

“…Survival from influenza A virus (IAV) infection largely depends on an intricate balance between pathogen clearance and immunomodulation in the lung. We…”
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Functional Cellular Anti-Tumor Mechanisms are Augmented by Genetic Proteoglycan Targeting by Gupta, Purva, Johns, Scott C., Kim, So Young, El Ghazal, Roland, Zuniga, Elina I., Fuster, Mark M.

“…While recent research points to the importance of glycans in cancer immunity, knowledge on functional mechanisms is lacking. In lung carcinoma among other…”
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Glycan Sulfation Modulates Dendritic Cell Biology and Tumor Growth by El Ghazal, Roland, Yin, Xin, Johns, Scott C, Swanson, Lee, Macal, Monica, Ghosh, Pradipta, Zuniga, Elina I, Fuster, Mark M

“…Abstract In cancer, proteoglycans have been found to play roles in facilitating the actions of growth factors, and effecting matrix invasion and remodeling…”
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IL‐33/ST2 receptor‐dependent signaling in the development of pulmonary hypertension in Sugen/hypoxia mice by Indralingam, Cynthia S., Gutierrez‐Gonzalez, Alma K., Johns, Scott C., Tsui, Tzuhan, Cannon, Daniel T., Fuster, Mark M., Bigby, Timothy D., Jennings, Patricia A., Breen, Ellen C.

“…Pulmonary arterial hypertension (PAH) is associated with significant morbidity and mortality. PAH is characterized by pulmonary artery remodeling, elevated…”
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A critical role for lymphatic endothelial heparan sulfate in lymph node metastasis by Yin, Xin, Truty, Jadwiga, Lawrence, Roger, Johns, Scott C, Srinivasan, R Sathish, Handel, Tracy M, Fuster, Mark M

“…Lymph node metastasis constitutes a key event in tumor progression. The molecular control of this process is poorly understood. Heparan sulfate is a linear…”
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Glycocalyx transduces membrane leak in brain tumor cells exposed to sharp magnetic pulsing by Johns, Scott C, Gupta, Purva, Lee, Yi-Hung, Friend, James, Fuster, Mark M

“…Mechanisms by which electric (E) or magnetic (B) fields might be harnessed to affect tumor cell behavior remain poorly defined, presenting a barrier to…”
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Functional Importance of a Proteoglycan Coreceptor in Pathologic Lymphangiogenesis by Johns, Scott C, Yin, Xin, Jeltsch, Michael, Bishop, Joseph R, Schuksz, Manuela, El Ghazal, Roland, Wilcox-Adelman, Sarah A, Alitalo, Kari, Fuster, Mark M

“…RATIONALE:Lymphatic vessel growth is mediated by major prolymphangiogenic factors, such as vascular endothelial growth factor (VEGF-C) and VEGF-D, among other…”
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Lipopolysaccharide Down-Regulates the Leukotriene C4 Synthase Gene in the Monocyte-Like Cell Line, THP-1 by Serio, Kenneth J, Johns, Scott C, Luo, Linda, Hodulik, Craig R, Bigby, Timothy D

“…We studied the effects of LPS on cysteinyl leukotriene (LT) synthesis and LTC(4) synthase expression in mononuclear phagocytes. Conditioning of the…”
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Examining Roles of Glycans in Chemokine-Mediated Dendritic-Endothelial Cell Interactions by Yin, Xin, Johns, Scott C, El Ghazal, Roland, Salanga, Catherina L, Handel, Tracy M, Fuster, Mark M

“…Interactions between glycosaminoglycans (GAGs) and chemokines play a critical role in multiple physiological and pathological processes, including tumor…”
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Lymphatic specific disruption in the fine structure of heparan sulfate inhibits dendritic cell traffic and functional T cell responses in the lymph node by Yin, Xin, Johns, Scott C, Kim, Daniel, Mikulski, Zbigniew, Salanga, Catherina L, Handel, Tracy M, Macal, Mónica, Zúñiga, Elina I, Fuster, Mark M

“…Dendritic cells (DCs) are potent APCs essential for initiating adaptive immunity. Following pathogen exposure, trafficking of DCs to lymph nodes (LNs) through…”
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Lymphatic Endothelial Heparan Sulfate Deficiency Results in Altered Growth Responses to Vascular Endothelial Growth Factor-C (VEGF-C) by Yin, Xin, Johns, Scott C., Lawrence, Roger, Xu, Ding, Reddi, Krisanavane, Bishop, Joseph R., Varner, Judith A., Fuster, Mark M.

“…Growth and remodeling of lymphatic vasculature occur during development and during various pathologic states. A major stimulus for this process is the unique…”
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Lipopolysaccharide down-regulates leukotriene C4 synthase gene expression in a cell-specific manner in the monocyte-like cell line, THP-1 by Serio, Kenneth J, Johns, Scott C, Luo, Linda, Hodulik, Craig R, Bigby, Timothy D

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Targeting glycan sulfation in a CD11c+ myeloid population inhibits early KRAS-mutant lung neoplasia1 by Kim, So Young, Johns, Scott C., Gupta, Purva, Varki, Nissi, Fuster, Mark M

“…Early lung carcinoma development may be modulated by innate host cellular mechanisms that promote tumor growth and invasion. We recently identified how a…”
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Interleukin‐33 Dependent Endothelial Cell Hyperproliferation and Vascular Remodeling in Sugen/Hypoxia Mice by Indralingam, Cynthia, Johns, Scott C., Fuster, Mark M., Jennings, Patricia A., Breen, Ellen C.

“…Abstract only…”
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Glycan Sulfation Modulates Dendritic Cell Biology and Tumor Growth1 by El Ghazal, Roland, Yin, Xin, Johns, Scott C., Swanson, Lee, Macal, Monica, Ghosh, Pradipta, Zuniga, Elina I., Fuster, Mark M.

“…In cancer, proteoglycans have been found to play roles in facilitating the actions of growth factors, and effecting matrix invasion and remodeling. However,…”
Get full text