Search Results - "Johns, Malcolm"

A Miniaturized Screen of a Schistosoma mansoni Serotonergic G Protein-Coupled Receptor Identifies Novel Classes of Parasite-Selective Inhibitors by Chan, John D, McCorvy, John D, Acharya, Sreemoyee, Johns, Malcolm E, Day, Timothy A, Roth, Bryan L, Marchant, Jonathan S

“…Schistosomiasis is a tropical parasitic disease afflicting ~200 million people worldwide and current therapy depends on a single drug (praziquantel) which…”
Get full text

Unique pharmacological properties of serotoninergic G-protein coupled receptors from cestodes by Camicia, Federico, Celentano, Ana M, Johns, Malcolm E, Chan, John D, Maldonado, Lucas, Vaca, Hugo, Di Siervi, Nicolás, Kamentezky, Laura, Gamo, Ana M, Ortega-Gutierrez, Silvia, Martin-Fontecha, Mar, Davio, Carlos, Marchant, Jonathan S, Rosenzvit, Mara C

“…Cestodes are a diverse group of parasites, some of them being agents of neglected diseases. In cestodes, little is known about the functional properties of G…”
Get full text

Methylene blue dose-dependently induces cutaneous inflammation and heat hyperalgesia in a novel rat model by Banik, Ratan K, Sia, Twan, Johns, Malcolm E, Tran, Phu V, Cheng, Andrew Y, Setty, Sudarshan, Simone, Donald

“…Methylene blue (MB) has been shown to reduce mortality and morbidity in vasoplegic patients after cardiac surgery. Though MB is considered to be safe,…”
Get full text

Inhibition of DAGLβ as a therapeutic target for pain in sickle cell disease by Khasabova, Iryna A, Gable, Jacob, Johns, Malcolm, Khasabov, Sergey G, Kalyuzhny, Alexander E, Golovko, Mikhail Y, Golovko, Svetlana A, Kiven, Stacy, Gupta, Kalpna, Seybold, Virginia S, Simone, Donald A

“…Sickle cell disease (SCD) is the most common inherited disease. Pain is a key morbidity of SCD and opioids are the main treatment but their side effects…”
Get full text

A screening campaign in sea urchin egg homogenate as a platform for discovering modulators of NAADP-dependent Ca2+ signaling in human cells by Gunaratne, Gihan S., Johns, Malcolm E., Hintz, Hallie M., Walseth, Timothy F., Marchant, Jonathan S.

“…[Display omitted] •Nicotinic acid adenine dinucleotide phosphate (NAADP) releases Ca2+ from acidic organelles.•Modulators of NAADP signaling are useful…”
Get full text

Adverse effects of methylene blue in peripheral neurons: An in vitro electrophysiology and cell culture study by Uhelski, Megan L, Johns, Malcolm E, Horrmann, Alec, Mohamed, Sadiq, Sohail, Ayesha, Khasabova, Iryna A, Simone, Donald A, Banik, Ratan K

“…Methylene blue (MB) is an effective treatment for methemoglobinemia, ifosfamide-induced encephalopathy, cyanide poisoning, and refractory vasoplegia. However,…”
Get full text

Lack of relationship between epidermal denervation by capsaicin and incisional pain behaviours: A laser scanning confocal microscopy study in rats by Uhelski, Megan L., McAdams, Brian, Johns, Malcolm E., Kabadi, Rajiv A., Simone, Donald A., Banik, Ratan K.

“…Background Spontaneous pain after surgical incision is a significant problem for most post‐operative patients. Pain management that relies on opioids is…”
Get full text

The synthesis and characterization of a clickable-photoactive NAADP analog active in human cells by Asfaha, Timnit Yosef, Gunaratne, Gihan S., Johns, Malcolm E., Marchant, Jonathan S., Walseth, Timothy F., Slama, James T.

“…[Display omitted] •A clickable-photoactive NAADP analog was synthesized from simple materials.•This analog was recognized at low concentration by human NAADP…”
Get full text

Global transcriptome analysis of rat dorsal root ganglia to identify molecular pathways involved in incisional pain by Tran, Phu V, Johns, Malcolm E, McAdams, Brian, Abrahante, Juan E, Simone, Donald A, Banik, Ratan K

“…To develop non-opioid therapies for postoperative incisional pain, we must understand its underlying molecular mechanisms. In this study, we assessed global…”
Get full text

Preemptive Morphine Analgesia Attenuates the Long-Term Consequences of Neonatal Inflammation in Male and Female Rats by Laprairie, Jamie L, Johns, Malcolm E, Murphy, Anne Z

“…Despite mounting evidence on the importance of pain management in preterm infants, clinical use of analgesics in this population is limited. Our previous…”
Get full text

Persistent inflammatory pain decreases the antinociceptive effects of the mu opioid receptor agonist DAMGO in the locus coeruleus of male rats by Jongeling, Amy C., Johns, Malcolm E., Murphy, Anne Z., Hammond, Donna L.

“…Persistent inflammatory nociception increases levels of endogenous opioids with affinity for delta opioid receptors in the ventromedial medulla and enhances…”
Get full text

Rosette-type tegumental glands associated with aesthetasc sensilla in the olfactory organ of the Caribbean spiny lobster, Panulirus argus by Schmidt, Manfred, Chien, Hsin, Tadesse, Tizeta, Johns, Malcolm E, Derby, Charles D

“…The lateral antennular flagellum of decapod crustaceans bears unique olfactory sensilla, namely the aesthetascs, and other sensilla types. In this study, we…”
Get full text

A Single Residue at the Active Site of CD38 Determines Its NAD Cyclizing and Hydrolyzing Activities by Graeff, Richard, Munshi, Cyrus, Aarhus, Robert, Johns, Malcolm, Lee, Hon Cheung

“…CD38 is a multifunctional enzyme involved in metabolizing two Ca2+ messengers, cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate…”
Get full text

Identification of Bioaminergic Lead Compounds to Treat Parasitic Blood Flukes ( Schistosoma Spp. ) through High Throughput Screening Natural Product Libraries by Chan, John D, Johns, Malcolm, Marchant, Jonathan S

“…Abstract only Parasitic blood flukes ( Schistosoma species of flatworms) infect over 200 million people worldwide, making them the second most costly parasite…”
Get full text

Exosome-associated lysophosphatidic acid signaling contributes to cancer pain by Khasabova, Iryna A., Khasabov, Sergey G., Johns, Malcolm, Juliette, Joe, Zheng, Aunika, Morgan, Hannah, Flippen, Alyssa, Allen, Kaje, Golovko, Mikhail Y., Golovko, Svetlana A., Zhang, Wei, Marti, James, Cain, David, Seybold, Virginia S., Simone, Donald A.

“…Pain associated with bone cancer remains poorly managed, and chemotherapeutic drugs used to treat cancer usually increase pain. The discovery of dual-acting…”
Get full text

Sex differences in the activation of the spinoparabrachial circuit by visceral pain by Murphy, Anne Z, Suckow, Shelby K, Johns, Malcolm, Traub, Richard J

“…Abstract Women are more sensitive to most noxious visceral stimuli, both in terms of intensity and frequency. The spinoparabrachial (spino-PBn) pathway is an…”
Get full text

A screening campaign in sea urchin egg homogenate as a platform for discovering modulators of NAADP-dependent Ca 2+ signaling in human cells by Gunaratne, Gihan S, Johns, Malcolm E, Hintz, Hallie M, Walseth, Timothy F, Marchant, Jonathan S

“…The Ca mobilizing second messenger nicotinic acid adenine dinucleotide phosphate (NAADP) regulates intracellular trafficking events, including translocation of…”
Get full text

AOAC SMPR 2016.010:Standard Method Performance Requirements (SMPRs) for DNA-Based Methods of Detecting Burkholderia pseudomallei in Field-Deployable, Department of Defense Aerosol Collection Devices by Gee, Jay, Arce, Jennifer, Beck, Linda C, Blank, Thomas R, Blyn, Larry, Cahall, Ryan, Clark, Amanda J, Currie, Bart, Damer, Kenneth, Davenport, Matthew, DeShazer, David, Johns, Malcolm, Keim, Paul S, Kiss, Katalin, Lesho, Matthew, Lin, Nancy, Morse, Stephen A, Naraghi-Arani, Pejman, Ozanich, Rich, Roberto, Frank, Rozak, David, Sahl, Jason, Schaefer, Frank, Schutzer, Steven, Schweizer, Herbert P, Sozhamannan, Shanmuga, Tuanyok, Apichai, Coates, Scott

Get full text

AOAC SMPR(®) 2016.008 by Lindler, Luther, Appler, Jessica, Ballin, Jeff, Bauer, Timothy, Beck, Linda, Boylan, Julie, Bull, Robert, Cahall, Ryan, Damer, Kenneth, Davenport, Matthew, Egan, Christina, Gage, Ken, Gibbons, Jennifer, Hadfield, Ted L, Johns, Malcolm, Lesho, Matthew, Maple, Laura, Pals, Traci, Perry, Robert, Retford, Michael, Scheckelhoff, Mark, Shah, Sanjiv, Sozhamannan, Shanmuga, Wagner, David, Watson, David, Worsham, Patricia, Coates, Scott G

Get full text

AOAC SMPR(®) 2016.006 by Hadfield, Ted L, Jackson, Paul J, Appler, Jessica, Baillie, Les, Bailor, Ed, Ballin, Jeff, Beck, Linda, Blanke, Steven Robert, Cahall, Ryan, Damer, Kenneth, Dragon, Dan, Forsman, Mats, Jaing, Crystal, Johns, Malcolm, Lin, Nancy, Maple, Laura, Morse, Stephen A, New, Dallas, Retford, Michael, Shah, Sanjiv, Sozhamannan, Shanmuga, Trudil, David, Welkos, Susan, Coates, Scott G

Get full text