Search Results - "Johns, Deidre M."

Improved Total Synthesis of the Potent HDAC Inhibitor FK228 (FR-901228) by Greshock, Thomas J, Johns, Deidre M, Noguchi, Yasuo, Williams, Robert M

“…A scaleable synthesis of the potent histone deacetylase (HDAC) inhibitor FK228 is described. A reliable strategy for preparing the key β-hydroxy mercapto…”
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Synthetic Studies on Quinine:  Quinuclidine Construction via a Ketone Enolate Regio- and Diastereoselective Pd-Mediated Allylic Alkylation by Johns, Deidre M, Mori, Makoto, Williams, Robert M

“…7-Hydroxy-quinine was synthesized by an asymmetric aldol reaction that establishes the C8 and C9 stereochemistry, followed by construction of the…”
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A semi-synthetic neolignan derivative from dihydrodieugenol B selectively affects the bioenergetic system of Leishmania infantum and inhibits cell division by Amaral, Maiara, de Sousa, Fernanda S., Silva, Thais A. Costa, Junior, Andrés Jimenez G., Taniwaki, Noemi N., Johns, Deidre M., Lago, João Henrique G., Anderson, Edward A., Tempone, Andre G.

“…Leishmaniasis is a neglected disease that affects more than 12 million people, with a limited therapy. Plant-derived natural products represent a useful source…”
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Dehydrodieugenol B derivatives as antiparasitic agents: Synthesis and biological activity against Trypanosoma cruzi by Ferreira, Daiane D., Sousa, Fernanda S., Costa-Silva, Thais A., Reimão, Juliana Q., Torrecilhas, Ana C., Johns, Deidre M., Sear, Claire E., Honorio, Kathia M., Lago, João Henrique G., Anderson, Edward A., Tempone, Andre G.

“…Chagas disease is a neglected protozoan disease that affects more than eight million people in developing countries. Due to the limited number and toxicity…”
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Antitrypanosomal activity of isololiolide isolated from the marine hydroid Macrorhynchia philippina (Cnidaria, Hydrozoa) by Lima, Marta L., Romanelli, Maiara M., Borborema, Samanta E.T., Johns, Deidre M., Migotto, Alvaro Esteves, Lago, João Henrique G., Tempone, Andre G.

“…[Display omitted] •The novel occurrence of the isololiolide was described in a marine cnidarian, Macrorhynchia philippina.•Isololiolide exhibited anti-T. cruzi…”
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Remote Asymmetric Induction in an Intramolecular Ionic Diels−Alder Reaction:  Application to the Total Synthesis of (+)-Dihydrocompactin by Sammakia, Tarek, Johns, Deidre M, Kim, Ganghyeok, Berliner, Martin A

“…The total synthesis of (+)-dihydrocompactin via an intramolecular ionic Diels−Alder reaction that proceeds with remote stereocontrol is described. This…”
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Remote stereocontrol in the intramolecular Diels-Alder reaction: Application to the total synthesis of (+)-dihydrocompactin by Johns, Deidre M

“…Methods for using remote stereocenters to induce asymmetry in the intramolecular Diels-Alder reaction were studied and used in the total synthesis of…”
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Remote stereocontrol in the intramolecular Diels -Alder reaction: Application to the total synthesis of (+)-dihydrocompactin by Johns, Deidre M

“…Methods for using remote stereocenters to induce asymmetry in the intramolecular Diels-Alder reaction were studied and used in the total synthesis of…”
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