Search Results - "Johns, D. G."
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1
Regional Climate Change and Harmful Algal Blooms in the Northeast Atlantic
Published in Limnology and oceanography (01-03-2006)“…We investigated long-term spatial variability in a number of Harmful Algal Blooms (HABs) in the northeast Atlantic and North Sea using data from the Continuous…”
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2
Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide
Published in American journal of physiology. Heart and circulatory physiology (01-12-2001)“…Angiotensin II (ANG II) is a pleiotropic vasoactive peptide that binds to two distinct receptors: the ANG II type 1 (AT(1)) and type 2 (AT(2)) receptors…”
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3
Dewatering of mine tailings using electrokinetic geosynthetics
Published in Canadian geotechnical journal (01-02-2007)“…Many mining operations produce tailings that dewater very slowly under self-weight consolidation. One way of reducing the water content of such tailings is by…”
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4
Urotensin II and renal function in the rat
Published in Kidney international (01-04-2006)“…Urotensin II (UII) is a potent vasoactive hormone in mammals. However, despite its well-known effects on epithelial sodium transport in fish, little is known…”
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5
Increased blooms of a dinoflagellate in the NW Atlantic
Published in Marine ecology. Progress series (Halstenbek) (31-12-2003)“…Sampling by the Continuous Plankton Recorder (CPR) over the NW Atlantic from 1960 to 2000 has enabled long-term studies of the larger components of the…”
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6
Differential phosphorylation of azidothymidine, dideoxycytidine, and dideoxyinosine in resting and activated peripheral blood mononuclear cells
Published in The Journal of clinical investigation (01-05-1993)“…The antiviral activity of azidothymidine (AZT), dideoxycytidine (ddC), and dideoxyinosine (ddI) against HIV-1 was comparatively evaluated in PHA-stimulated…”
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Continuous Plankton Records: Plankton Atlas of the North Atlantic Ocean (1958–1999). II. Biogeographical charts
Published in Marine ecology. Progress series (Halstenbek) (01-01-2004)“…The following CPR Atlas contains the biogeographical distribution of 240 common pelagic plankton taxa of the North Sea and North Atlantic Ocean. The…”
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Mechanism of 'bystander effect' killing in the herpes simplex thymidine kinase gene therapy model of cancer treatment
Published in Gene therapy (01-03-1997)“…'Bystander' killing of adjacent wild-type tumor cells was seen when tumors transduced with the herpes thymidine kinase gene were treated with the antiviral…”
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The novel endocannabinoid receptor GPR55 is activated by atypical cannabinoids but does not mediate their vasodilator effects
Published in British journal of pharmacology (01-11-2007)“…Background and purpose: Atypical cannabinoids are thought to cause vasodilatation through an as‐yet unidentified ‘CBx’ receptor. Recent reports suggest GPR55…”
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10
Selective depletion of DNA precursors : An evolving strategy for potentiation of dideoxynucleoside activity against human immunodeficiency virus
Published in Biochemical pharmacology (15-05-1998)“…Human immunodeficiency virus type 1 (HIV-1) is wholly dependent on its host cell for a variety of essential metabolites. Among the latter are the…”
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11
Avascular necrosis in HIV infection
Published in AIDS (London) (01-10-1999)“…Protease-based, highly active antiretroviral therapy (HAART) has had a major beneficial impact on both the survival and the short-term outcomes of HIV-infected…”
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Replication of human immunodeficiency virus in monocytes: granulocyte/macrophage colony-stimulating factor (GM-CSF) potentiates viral production yet enhances the antiviral effect mediated by 3'-azido-2'3'-dideoxythymidine (AZT) and other-dideoxynucleoside congeners of thymidine
Published in The Journal of experimental medicine (01-03-1989)“…We have investigated the influence of granulocyte-macrophage CSF (GM-CSF) on the replication of HIV-1 in cells of monocyte/macrophage (M/M) lineage, and its…”
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Long-term toxicity/activity profile of 2',3'-dideoxyinosine in AIDS or AIDS-related complex
Published in The Lancet (British edition) (01-09-1990)“…To evaluate the long-term toxicity and activity profile of 2',3'-dideoxyinosine (ddI), a potent inhibitor of human immunodeficiency virus (HIV) replication, in…”
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Marked in vivo Antiretrovirus Activity of 9-(2-phosphonylmethoxyethyl)adenine, a Selective Anti-Human Immunodeficiency Virus Agent
Published in Proceedings of the National Academy of Sciences - PNAS (01-01-1989)“…9-(2-Phosphonylmethoxyethyl)adenine (PMEA) is a potent and selective inhibitor of the replication of human immunodeficiency virus (HIV) in vitro in human…”
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The anti-HTLV-III (anti-HIV) and cytotoxic activity of 2',3'-didehydro-2',3'-dideoxyribonucleosides: a comparison with their parental 2',3'-dideoxyribonucleosides
Published in Molecular pharmacology (01-07-1987)“…A series of 2',3'-didehydro-2',3'-dideoxyribonucleosides (ddeNs) [i.e., 2',3'-dideoxythymidinene (ddeThd), 2',3'-dideoxyuridinene (ddeUrd),…”
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16
Anti-human immunodeficiency virus type 1 activity of hydroxyurea in combination with 2',3'-dideoxynucleosides
Published in Molecular pharmacology (01-10-1994)“…The effects of hydroxyurea (HU), an inhibitor of ribonucleotide reductase, on the replication of human immunodeficiency virus type 1 (HIV-1) in activated…”
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Metabolic pathways for the activation of the antiretroviral agent 2',3'-dideoxyadenosine in human lymphoid cells
Published in The Journal of biological chemistry (25-10-1988)“…The pathways of 2',3'-dideoxyadenosine (ddAdo) metabolism, a selective inhibitor of the replication of human immunodeficiency virus, were investigated with use…”
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9-[(2RS)-3-Fluoro-2-Phosphonylmethoxypropyl] Derivatives of Purines: A Class of Highly Selective Antiretroviral Agents In vitro and In vivo
Published in Proceedings of the National Academy of Sciences - PNAS (01-06-1991)“…A new class of compounds, 9-[(2RS)-3-fluoro-2-phosphonylmethoxypropyl] [(RS)-FPMP] derivatives of purines, is described that has selective activity against a…”
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In vivo Activity against HIV and Favorable Toxicity Profile of 2$^{\prime}$,3$^{\prime}$-Dideoxyinosine
Published in Science (American Association for the Advancement of Science) (28-07-1989)“…The purine analog 2$^{\prime}$,3$^{\prime}$-dideoxyinosine (ddI), which has anti-retroviral activity in vitro was administered for up to 42 weeks to 26…”
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Factors determining the activity of 2',3'-dideoxynucleosides in suppressing human immunodeficiency virus in vitro
Published in Molecular pharmacology (01-10-1988)“…Mitsuya and Broder [Proc. Natl. Acad. Sci. USA 83:1911-1915 (1986)] demonstrated that every purine (adenosine, guanosine, and inosine) and pyrimidine (cytidine…”
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