Search Results - "Johns, D C"

Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets by CHAN, C. B, MACDONALD, P. E, SALEH, M. C, JOHNS, D. C, MARBAN, E, WHEELER, M. B

“…Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets. C B Chan , P E MacDonald , M C Saleh , D C Johns , E…”
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Absence of direct delivery for single transmembrane apical proteins or their "Secretory" forms in polarized hepatic cells by Bastaki, M, Braiterman, L T, Johns, D C, Chen, Y-H, Hubbard, A L

“…The absence of a direct route to the apical plasma membrane (PM) for single transmembrane domain (TMD) proteins in polarized hepatic cells has been inferred…”
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Phenotypic characterization of a novel long-QT syndrome mutation (R1623Q) in the cardiac sodium channel by KAMBOURIS, N. G, NUSS, H. B, JOHNS, D. C, TOMASELLI, G. F, MARBAN, M. E, BALSER, J. R

“…A heritable form of the long-QT syndrome (LQT3) has been linked to mutations in the cardiac sodium channel gene (SCN5A). Recently, a sporadic SCN5A mutation…”
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A functional assay for paralytic shellfish toxins that uses recombinant sodium channels by VELEZ, P, SIERRALTA, J, ALCAYAGA, C, FONSECA, M, LOYOLA, H, JOHNS, D. C, TOMASELLI, G. F, MARBAN, E, SUAREZ-ISLA, B. A

“…Saxitoxin (STX) and its derivatives are highly toxic natural compounds produced by dinoflagellates commonly present in marine phytoplankton. During algal…”
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Complete correction of acid α-glucosidase deficiency in pompe disease fibroblasts in vitro, and lysosomally targeted expression in neonatal rat cardiac and skeletal muscle by PAULY, D. F, JOHNS, D. C, MATELIS, L. A, LAWRENCE, J. H, BYRNE, B. J, KESSLER, P. D

“…The enzyme acid alpha-glucosidase catalyzes the breakdown of lysosomal glycogen. Absence of this enzyme results in infantile Pompe disease, characterized by…”
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Distinct Gene-Specific Mechanisms of Arrhythmia Revealed by Cardiac Gene Transfer of Two Long QT Disease Genes, HERG and KCNE1 by Hoppe, Uta C., Marbán, Eduardo, Johns, David C.

“…The long QT syndrome (LQTS) is a heritable disorder that predisposes to sudden cardiac death. LQTS is caused by mutations in ion channel genes including HERG…”
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Reversal of potassium channel deficiency in cells from failing hearts by adenoviral gene transfer: a prototype for gene therapy for disorders of cardiac excitability and contractility by Nuss, H B, Johns, D C, Kääb, S, Tomaselli, G F, Kass, D, Lawrence, J H, Marban, E

“…Heart failure is a common, often lethal disorder in which conventional pharmacologic strategies have achieved limited success. Failing hearts exhibit a delay…”
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Cell-specific promoter in adenovirus vector for transgenic expression of SERCA1 ATPase in cardiac myocytes by Inesi, G, Lewis, D, Sumbilla, C, Nandi, A, Strock, C, Huff, K W, Rogers, T B, Johns, D C, Kessler, P D, Ordahl, C P

“…Adenovirus-mediated transfer of cDNA encoding the chicken skeletal muscle sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA1) yielded selective expression in…”
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Manipulation of Cellular Excitability by Cell Fusion: Effects of Rapid Introduction of Transient Outward K+ Current on the Guinea Pig Action Potential by Hoppe, Uta C, Johns, David C, Marban, Eduardo, O'Rourke, Brian

“…To investigate the still-undetermined role of the Ca transient outward current (Ito1) on repolarization of the cardiac action potential, we used cell fusion to…”
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A revised view of cardiac sodium channel "blockade" in the long-QT syndrome by Kambouris, N G, Nuss, H B, Johns, D C, Marbán, E, Tomaselli, G F, Balser, J R

“…Mutations in SCN5A, encoding the cardiac sodium (Na) channel, are linked to a form of the congenital long-QT syndrome (LQT3) that provokes lethal ventricular…”
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Inward rectifier K+ channel from human heart and brain: cloning and stable expression in a human cell line by Ashen, M D, O'Rourke, B, Kluge, K A, Johns, D C, Tomaselli, G F

“…We have cloned the human homologue of the inward rectifier K+ channel from both heart and brain tissue (HHBIRK1). The human clones were identical to each other…”
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Cyclin D1 Repression of Peroxisome Proliferator-Activated Receptor γ Expression and Transactivation by Wang, Chenguang, Pattabiraman, Nagarajan, Zhou, Jian Nian, Fu, Maofu, Sakamaki, Toshiyuki, Albanese, Chris, Li, Zhiping, Wu, Kongming, Hulit, James, Neumeister, Peter, Novikoff, Phyllis M., Brownlee, Michael, Scherer, Philipp E., Jones, Joan G., Whitney, Kathleen D., Donehower, Lawrence A., Harris, Emily L., Rohan, Thomas, Johns, David C., Pestell, Richard G.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Inducible Genetic Suppression of Neuronal Excitability by Johns, David C, Marx, Ruth, Mains, Richard E, O'Rourke, Brian, Marban, Eduardo

“…Graded, reversible suppression of neuronal excitability represents a logical goal of therapy for epilepsy and intractable pain. To achieve such suppression, we…”
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Suppression of Neuronal and Cardiac Transient Outward Currents by Viral Gene Transfer of Dominant-Negative Kv4.2 Constructs by Johns, David C., Nuss, H. Bradley, Marban, Eduardo

“…To probe the molecular identity of transient outward (A-type) potassium currents, we expressed a truncated version of Kv4.2 in heart cells and neurons. The rat…”
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Overexpression of a human potassium channel suppresses cardiac hyperexcitability in rabbit ventricular myocytes by Nuss, H B, Marbán, E, Johns, D C

“…The high incidence of sudden death in heart failure may reflect abnormalities of repolarization and heightened susceptibility to arrhythmogenic early…”
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Identification of a highly conserved region at the 5' flank of the phospholamban gene by Johns, D C, Feldman, A M

“…Phospholamban is a protein that regulates the activity of the sarcoplasmic reticulum Ca(2+)-ATPase. The rat phospholamban gene contains a single intron of 6.5…”
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Adenovirus-Mediated Inducible Gene Expression in Vivo by a Hybrid Ecdysone Receptor by Hoppe, Uta C, Marbán, Eduardo, Johns, David C

“…Precise control of transgene expression would markedly facilitate certain applications of gene therapy. To regulate expression of a transferred gene in…”
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Ultrarapid, Highly Efficient Viral Gene Transfer to the Heart by Donahue, J. Kevin, Kikkawa, Kohei, Johns, David C., Marban, Eduardo, Lawrence, John H.

“…Gene therapy for common myocardial diseases will require effective and homogeneous gene delivery throughout the intact heart. We created two experimental…”
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Molecular dissection of cardiac repolarization by in vivo Kv4.3 gene transfer by Hoppe, U C, Marbán, E, Johns, D C

“…Heart failure leads to marked suppression of the Ca(2+)-independent transient outward current (I(to1)), but it is not clear whether I(to1) downregulation…”
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Molecular Composition of Mitochondrial ATP-sensitive Potassium Channels Probed by Viral Kir Gene Transfer by Seharaseyon, Jegatheesan, Ohler, Andreas, Sasaki, Norihito, Fraser, Heather, Sato, Toshiaki, Johns, David C., O»Rourke, Brian, Marbán, Eduardo

“…Heart cells contain ATP-sensitive potassium (KATP) channels in both the sarcolemma and the inner mitochondrial membrane. The sarcolemmal channels are believed…”
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