Search Results - "Johne, Marie"

Systematic evaluation of rationally chosen multitargeted drug combinations: a combination of low doses of levetiracetam, atorvastatin and ceftriaxone exerts antiepileptogenic effects in a mouse model of acquired epilepsy by Welzel, Lisa, Bergin, David H., Schidlitzki, Alina, Twele, Friederike, Johne, Marie, Klein, Pavel, Löscher, Wolfgang

“…Epileptogenesis, the gradual process that leads to epilepsy after brain injury or genetic mutations, is a complex network phenomenon, involving a variety of…”
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Deletion of the Na-K-2Cl cotransporter NKCC1 results in a more severe epileptic phenotype in the intrahippocampal kainate mouse model of temporal lobe epilepsy by Hampel, Philip, Johne, Marie, Gailus, Björn, Vogel, Alexandra, Schidlitzki, Alina, Gericke, Birthe, Töllner, Kathrin, Theilmann, Wiebke, Käufer, Christopher, Römermann, Kerstin, Kaila, Kai, Löscher, Wolfgang

“…Increased neuronal expression of the Na-K-2Cl cotransporter NKCC1 has been implicated in the generation of seizures and epilepsy. However, conclusions from…”
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Processing of auditory information in forebrain regions after hearing loss in adulthood: Behavioral and electrophysiological studies in a rat model by Johne, Marie, Helgers, Simeon O. A., Alam, Mesbah, Jelinek, Jonas, Hubka, Peter, Krauss, Joachim K., Scheper, Verena, Kral, Andrej, Schwabe, Kerstin

“…BackgroundHearing loss was proposed as a factor affecting development of cognitive impairment in elderly. Deficits cannot be explained primarily by…”
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Hearing loss in juvenile rats leads to excessive play fighting and hyperactivity, mild cognitive deficits and altered neuronal activity in the prefrontal cortex by Jelinek, Jonas, Johne, Marie, Alam, Mesbah, Krauss, Joachim K., Kral, Andrej, Schwabe, Kerstin

“…In children, hearing loss has been associated with hyperactivity, disturbed social interaction, and risk of cognitive disturbances. Mechanistic explanations of…”
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Bumetanide potentiates the anti-seizure and disease-modifying effects of midazolam in a noninvasive rat model of term birth asphyxia by Welzel, Björn, Johne, Marie, Löscher, Wolfgang

“…•Birth asphyxia often causes hypoxic-ischemic encephalopathy, and neonatal seizures, and later-life adverse outcome.•In most cases, current therapies cannot…”
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Midazolam Prevents the Adverse Outcome of Neonatal Asphyxia by Welzel, Björn, Schmidt, Ricardo, Johne, Marie, Löscher, Wolfgang

“…Objective Birth asphyxia (BA) is the most frequent cause of neonatal death as well as central nervous system (CNS) injury. BA is often associated with neonatal…”
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A combination of phenobarbital and the bumetanide derivative bumepamine prevents neonatal seizures and subsequent hippocampal neurodegeneration in a rat model of birth asphyxia by Johne, Marie, Käufer, Christopher, Römermann, Kerstin, Gailus, Björn, Gericke, Birthe, Löscher, Wolfgang

“…Objectives Bumetanide was suggested as an adjunct to phenobarbital for suppression of neonatal seizures. This suggestion was based on the idea that bumetanide,…”
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Long‐term outcome in a noninvasive rat model of birth asphyxia with neonatal seizures: Cognitive impairment, anxiety, epilepsy, and structural brain alterations by Gailus, Björn, Naundorf, Hannah, Welzel, Lisa, Johne, Marie, Römermann, Kerstin, Kaila, Kai, Löscher, Wolfgang

“…Objective Birth asphyxia is a major cause of hypoxic–ischemic encephalopathy (HIE) in neonates and often associated with mortality, neonatal seizures, brain…”
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Exploring the cognitive effects of hearing loss in adult rats: Implications for visuospatial attention, social behavior, and prefrontal neural activity by Stenzel, Mariele, Alam, Mesbah, Witte, Marla, Jelinek, Jonas, Armbrecht, Nina, Armstrong, Adrian, Kral, Andrej, Krauss, Joachim K., Land, Rüdiger, Schwabe, Kerstin, Johne, Marie

“…[Display omitted] •Hearing loss in adult deafened rats leads to mild attention deficits and temporary social deficits.•Neuronal activity in the cingulum…”
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Phenobarbital and midazolam suppress neonatal seizures in a noninvasive rat model of birth asphyxia, whereas bumetanide is ineffective by Johne, Marie, Römermann, Kerstin, Hampel, Philip, Gailus, Björn, Theilmann, Wiebke, Ala‐Kurikka, Tommi, Kaila, Kai, Löscher, Wolfgang

“…Objective Neonatal seizures are the most frequent type of neurological emergency in newborn infants, often being a consequence of prolonged perinatal asphyxia…”
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Effects of the NKCC1 inhibitors bumetanide, azosemide, and torasemide alone or in combination with phenobarbital on seizure threshold in epileptic and nonepileptic mice by Hampel, Philip, Römermann, Kerstin, Gailus, Björn, Johne, Marie, Gericke, Birthe, Kaczmarek, Edith, Löscher, Wolfgang

“…The sodium-potassium-chloride (Na–K–Cl) cotransporter NKCC1 is found in the plasma membrane of a wide variety of cell types, including neurons, glia and…”
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