Search Results - "John Withnall, W"

Design of novel and potent cPLA2α inhibitors containing an α-methyl-2-ketothiazole as a metabolically stable serine trap by METE, Antonio, ANDREWS, Glen, ROBINSON, David H, SMITH, Gill M, WELLS, Edward, WITHNALL, W. John, BERNSTEIN, Mike, CONNOLLY, Stephen, HARTOPP, Paul, JACKSON, Clive G, LEWIS, Richard, MARTIN, Lain, MURRAY, David, RILEY, Rob

“…We report the design of novel, potent cPLA(2)α inhibitors that possess an α-methyl-2-ketothiazole that acts as a serine-reactive moiety. We describe the…”
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Design and Synthesis of a Novel and Potent Series of Inhibitors of Cytosolic Phospholipase A2 Based on a 1,3-Disubstituted Propan-2-one Skeleton by Connolly, Stephen, Bennion, Colin, Botterell, Sarah, Croshaw, Pamela J, Hallam, Catherine, Hardy, Kim, Hartopp, Paul, Jackson, Clive G, King, Sarah J, Lawrence, Louise, Mete, Antonio, Murray, David, Robinson, David H, Smith, Gillian M, Stein, Linda, Walters, Iain, Wells, Edward, Withnall, W. John

“…Using knowledge of the substrate specificity of cPLA2 (phospholipases A2), a novel series of inhibitors of this enzyme were designed based upon a three point…”
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Synthesis and evaluation of substrate-mimicking cytosolic phospholipase A2 inhibitors: reducing the lipophilicity of the arachidonyl chain isostere by WALTERS, Lain, BENNION, Colin, MURRAY, David, ROBINSON, David H, STEIN, Linda, WELLS, Edward, WITHNALL, W. John, CONNOLLY, Stephen, CROSHAW, Pamela J, HARDY, Kim, HARTOPP, Paul, JACKSON, Clive G, KING, Sarah J, LAWRENCE, Louise, METE, Antonio

“…The high lipophilicity of a series of cytosolic phospholipase A(2) inhibitors has been reduced by the modification of a decyloxyphenyl chain designed to mimic…”
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Design of novel and potent cPLA 2α inhibitors containing an α-methyl-2-ketothiazole as a metabolically stable serine trap by Mete, Antonio, Andrews, Glen, Bernstein, Mike, Connolly, Stephen, Hartopp, Paul, Jackson, Clive G., Lewis, Richard, Martin, Iain, Murray, David, Riley, Rob, Robinson, David H., Smith, Gill M., Wells, Edward, Withnall, W. John

“…We report the design of novel, potent cPLA 2α inhibitors that possess an α-methyl-2-ketothiazole that acts as a serine-reactive moiety. We describe the…”
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Design and synthesis of a novel and potent series of inhibitors of cytosolic phospholipase A(2) based on a 1,3-disubstituted propan-2-one skeleton by Connolly, Stephen, Bennion, Colin, Botterell, Sarah, Croshaw, Pamela J, Hallam, Catherine, Hardy, Kim, Hartopp, Paul, Jackson, Clive G, King, Sarah J, Lawrence, Louise, Mete, Antonio, Murray, David, Robinson, David H, Smith, Gillian M, Stein, Linda, Walters, Iain, Wells, Edward, Withnall, W John

“…Using knowledge of the substrate specificity of cPLA(2) (phospholipases A(2)), a novel series of inhibitors of this enzyme were designed based upon a three…”
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Synthesis and evaluation of substrate-mimicking cytosolic phospholipase A 2 inhibitors––reducing the lipophilicity of the arachidonyl chain isostere by Walters, Iain, Bennion, Colin, Connolly, Stephen, Croshaw, Pamela J, Hardy, Kim, Hartopp, Paul, Jackson, Clive G, King, Sarah J, Lawrence, Louise, Mete, Antonio, Murray, David, Robinson, David H, Stein, Linda, Wells, Edward, John Withnall, W

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Design and Synthesis of a Novel and Potent Series of Inhibitors of Cytosolic Phospholipase A 2 Based on a 1,3-Disubstituted Propan-2-one Skeleton by Connolly, Stephen, Bennion, Colin, Botterell, Sarah, Croshaw, Pamela J., Hallam, Catherine, Hardy, Kim, Hartopp, Paul, Jackson, Clive G., King, Sarah J., Lawrence, Louise, Mete, Antonio, Murray, David, Robinson, David H., Smith, Gillian M., Stein, Linda, Walters, Iain, Wells, Edward, Withnall, W. John

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