Search Results - "John Walker"

The ATP synthase: the understood, the uncertain and the unknown by Walker, John E

“…The ATP synthases are multiprotein complexes found in the energy-transducing membranes of bacteria, chloroplasts and mitochondria. They employ a transmembrane…”
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Structure of the dimeric ATP synthase from bovine mitochondria by Spikes, Tobias E., Montgomery, Martin G., Walker, John E.

“…The structure of the dimeric ATP synthase from bovine mitochondria determined in three rotational states by electron cryo-microscopy provides evidence that the…”
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My path to citrin deficiency by Walker, John E.

“…Citrin belongs to the SLC25 transport protein family found mostly in inner mitochondrial membranes. The family prototype, the ADP–ATP carrier, delivers ATP…”
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Lessons from the Chemical Weapons Convention Negotiations and Implementation for the Diplomatic Challenges of Negotiating ‘Irreversibility’ by Walker, John

“…ABSTRACTNegotiating an international disarmament treaty that has as one of its core requirements the concept of “irreversibility” will be a major task,…”
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Drag-and-drop genome insertion of large sequences without double-strand DNA cleavage using CRISPR-directed integrases by Yarnall, Matthew T. N., Ioannidi, Eleonora I., Schmitt-Ulms, Cian, Krajeski, Rohan N., Lim, Justin, Villiger, Lukas, Zhou, Wenyuan, Jiang, Kaiyi, Garushyants, Sofya K., Roberts, Nathaniel, Zhang, Liyang, Vakulskas, Christopher A., Walker, John A., Kadina, Anastasia P., Zepeda, Adrianna E., Holden, Kevin, Ma, Hong, Xie, Jun, Gao, Guangping, Foquet, Lander, Bial, Greg, Donnelly, Sara K., Miyata, Yoshinari, Radiloff, Daniel R., Henderson, Jordana M., Ujita, Andrew, Abudayyeh, Omar O., Gootenberg, Jonathan S.

“…Programmable genome integration of large, diverse DNA cargo without DNA repair of exposed DNA double-strand breaks remains an unsolved challenge in genome…”
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In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels by Rothgangl, Tanja, Dennis, Melissa K., Lin, Paulo J. C., Oka, Rurika, Witzigmann, Dominik, Villiger, Lukas, Qi, Weihong, Hruzova, Martina, Kissling, Lucas, Lenggenhager, Daniela, Borrelli, Costanza, Egli, Sabina, Frey, Nina, Bakker, Noëlle, Walker, John A., Kadina, Anastasia P., Victorov, Denis V., Pacesa, Martin, Kreutzer, Susanne, Kontarakis, Zacharias, Moor, Andreas, Jinek, Martin, Weissman, Drew, Stoffel, Markus, van Boxtel, Ruben, Holden, Kevin, Pardi, Norbert, Thöny, Beat, Häberle, Johannes, Tam, Ying K., Semple, Sean C., Schwank, Gerald

“…Most known pathogenic point mutations in humans are C•G to T•A substitutions, which can be directly repaired by adenine base editors (ABEs). In this study, we…”
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Advances in abscission signaling by Patharkar, O Rahul, Walker, John C

“…A mechanistic overview of abscission signaling is presented to provide an easy entry point into the exciting field of research on how plants control shedding…”
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Permeability transition in human mitochondria persists in the absence of peripheral stalk subunits of ATP synthase by He, Jiuya, Carroll, Joe, Ding, Shujing, Fearnley, Ian M., Walker, John E.

“…The opening of a nonspecific channel, known as the permeability transition pore (PTP), in the inner membranes of mitochondria can be triggered by calcium ions,…”
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Persistence of the permeability transition pore in human mitochondria devoid of an assembled ATP synthase by Carroll, Joe, He, Jiuya, Ding, Shujing, Fearnley, Ian M., Walker, John E.

“…The opening of the permeability transition pore, a nonspecific channel in inner mitochondrial membranes, is triggered by an elevated total concentration of…”
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Concise Review: Wharton's Jelly: The Rich, but Enigmatic, Source of Mesenchymal Stromal Cells by Davies, John E., Walker, John T., Keating, Armand

“…The umbilical cord has become an increasingly used source of mesenchymal stromal cells for preclinical and, more recently, clinical studies. Despite the…”
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The Human Islet: Mini-Organ With Mega-Impact by Walker, John T, Saunders, Diane C, Brissova, Marcela, Powers, Alvin C

“…Abstract This review focuses on the human pancreatic islet—including its structure, cell composition, development, function, and dysfunction. After providing a…”
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Cardiolipin binds selectively but transiently to conserved lysine residues in the rotor of metazoan ATP synthases by Duncan, Anna L., Robinson, Alan J., Walker, John E.

“…The anionic lipid cardiolipin is an essential component of active ATP synthases. In metazoans, their rotors contain a ring of eight c-subunits consisting of…”
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Persistence of the mitochondrial permeability transition in the absence of subunit c of human ATP synthase by Jiuya He, Holly C. Ford, Carroll, Joe, Ding, Shujing, Fearnley, Ian M., Walker, John E.

“…The permeability transition in human mitochondria refers to the opening of a nonspecific channel, known as the permeability transition pore (PTP), in the inner…”
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A Closer Look at the Hippocampus and Memory by Voss, Joel L, Bridge, Donna J, Cohen, Neal J, Walker, John A

“…Current interpretations of hippocampal memory function are blind to the fact that viewing behaviors are pervasive and complicate the relationships among…”
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Increasing importance of deposition of reduced nitrogen in the United States by Li, Yi, Schichtel, Bret A., Walker, John T., Schwede, Donna B., Chen, Xi, Lehmann, Christopher M. B., Puchalski, Melissa A., Gay, David A., Collett, Jeffrey L.

“…Rapid development of agriculture and fossil fuel combustion greatly increased US reactive nitrogen emissions to the atmosphere in the second half of the 20th…”
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Leaf shedding as an anti-bacterial defense in Arabidopsis cauline leaves by Patharkar, O Rahul, Gassmann, Walter, Walker, John C

“…Plants utilize an innate immune system to protect themselves from disease. While many molecular components of plant innate immunity resemble the innate…”
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Assembly of the membrane domain of ATP synthase in human mitochondria by He, Jiuya, Ford, Holly C., Carroll, Joe, Douglas, Corsten, Gonzales, Evvia, Ding, Shujing, Fearnley, Ian M., Walker, John E.

“…The ATP synthase in human mitochondria is a membrane-bound assembly of 29 proteins of 18 kinds. All but two membrane components are encoded in nuclear genes,…”
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Core Mechanisms Regulating Developmentally Timed and Environmentally Triggered Abscission by Patharkar, O.Rahul, Walker, John C.

“…Drought-triggered abscission is a strategy used by plants to avoid the full consequences of drought; however, it is poorly understood at the molecular genetic…”
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Separate and cumulative effects of adverse childhood experiences in predicting adult health and health care utilization by Chartier, Mariette J, Walker, John R, Naimark, Barbara

“…Abstract Objectives Objectives of this population-based study were: (1) to examine the relative contribution of childhood abuse and other adverse childhood…”
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Is biochar-manure co-compost a better solution for soil health improvement and N2O emissions mitigation? by Yuan, Yinghong, Chen, Huaihai, Yuan, Wenqiao, Williams, David, Walker, John T., Shi, Wei

“…Land application of compost has been a promising remediation strategy for soil health and environmental quality, but substantial emissions of greenhouse gases,…”
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