Search Results - "John R. Jacob"

NNMT Silencing Activates Tumor Suppressor PP2A, Inactivates Oncogenic STKs, and Inhibits Tumor Forming Ability by Palanichamy, Kamalakannan, Kanji, Suman, Gordon, Nicolaus, Thirumoorthy, Krishnan, Jacob, John R, Litzenberg, Kevin T, Patel, Disha, Chakravarti, Arnab

“…To identify potential molecular hubs that regulate oncogenic kinases and target them to improve treatment outcomes for glioblastoma patients. Data mining of…”
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Methionine and Kynurenine Activate Oncogenic Kinases in Glioblastoma, and Methionine Deprivation Compromises Proliferation by Palanichamy, Kamalakannan, Thirumoorthy, Krishnan, Kanji, Suman, Gordon, Nicolaus, Singh, Rajbir, Jacob, John R, Sebastian, Nikhil, Litzenberg, Kevin T, Patel, Disha, Bassett, Emily, Ramasubramanian, Brinda, Lautenschlaeger, Tim, Fischer, Steven M, Ray-Chaudhury, Abhik, Chakravarti, Arnab

“…We employed a metabolomics-based approach with the goal to better understand the molecular signatures of glioblastoma cells and tissues, with an aim toward…”
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Early dose of Adenosine, postRadiofrequency abLation of accessory pathwaY in determining acute procedural success (EARLY study) by Manickavasagam, Anand, Guttikonda, Siva Nageswara Rao, Bootla, Dinakar, Patloori, Sirish Chandra Srinath, Jain, Ashish, Chase, David, Selvaraj, Raja, Jacob, John R.

“…Introduction Post ablation of the accessory pathway (AP), the patient is observed in the catheterization laboratory for a variable period for resumption of…”
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Altered Gemcitabine and Nab-paclitaxel Scheduling Improves Therapeutic Efficacy Compared with Standard Concurrent Treatment in Preclinical Models of Pancreatic Cancer by Wolfe, Adam R, Robb, Ryan, Hegazi, Ahmad, Abushahin, Laith, Yang, Linlin, Shyu, Duan-Liang, Trevino, Jose G, Cruz-Monserrate, Zobeida, Jacob, John R, Palanichamy, Kamalakannan, Chakravarti, Arnab, Williams, Terence M

“…Concurrent gemcitabine and nab-paclitaxel treatment is one of the preferred chemotherapy regimens for metastatic and locally advanced pancreatic ductal…”
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Abstract 1113: Mir-194-3p suppresses tumorigenic potential of glioblastoma stem cells by targeting the canonical NF-kB pathway by Singh, Rajbir, Palanichamy, Kamalakannan, Jacob, John R., Chakravarti, Arnab

“…Glioblastoma (GBM) is the most common tumor of the central nervous system, with its deadly nature owing to high rates of invasion and angiogenesis. A key…”
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Lack of Constitutively Active DNA Repair Sensitizes Glioblastomas to Akt Inhibition and Induces Synthetic Lethality with Radiation Treatment in a p53-Dependent Manner by Palanichamy, Kamalakannan, Patel, Disha, Jacob, John R, Litzenberg, Kevin T, Gordon, Nicolaus, Acus, Kirstin, Noda, Shin-Ei, Chakravarti, Arnab

“…Treatment refractory glioblastoma (GBM) remains a major clinical problem globally, and targeted therapies in GBM have not been promising to date. The Cancer…”
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Cells isolated from residual intracranial tumors after treatment express iPSC genes and possess neural lineage differentiation plasticity by Palanichamy, Kamalakannan, Jacob, John R., Litzenberg, Kevin T., Ray-Chaudhury, Abhik, Chakravarti, Arnab

“…The goal of this study is to identify and characterize treatment resistant tumor initiating cells (TRTICs) using orthotopic xenografts. TRTICs were enriched…”
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Abstract 2383: Nicotinamide N-methyltransferase inhibits Protein Phosphatase 2A activity by promoting Y307 phosphorylation by Jacob, John R., Chakravarti, Arnab, Palanichamy, Kamalakannan

“…Recent evidence indicates that suppression of protein phosphatase 2A (PP2A) activity plays an essential role in malignant transformation and cancer cell…”
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Cells isolated from residual intracranial tumors after treatment express iPSC genes and possess neural lineage differentiation plasticityResearch in context by Kamalakannan Palanichamy, John R. Jacob, Kevin T. Litzenberg, Abhik Ray-Chaudhury, Arnab Chakravarti

“…Background: The goal of this study is to identify and characterize treatment resistant tumor initiating cells (TRTICs) using orthotopic xenografts. Methods:…”
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Eye care in ICU by Sivasankar S, Jasper S, Simon S, Jacob P, John George, Raju R

“…Context: Patients in intensive care units have impaired ocular protective mechanisms, resulting in a high risk of developing eye complications. Various eye…”
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