Search Results - "John Okombo"

Genomic and Genetic Approaches to Studying Antimalarial Drug Resistance and Plasmodium Biology by Okombo, John, Kanai, Mariko, Deni, Ioanna, Fidock, David A.

“…Recent progress in genomics and molecular genetics has empowered novel approaches to study gene functions in disease-causing pathogens. In the human malaria…”
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Genetic screens reveal a central role for heme metabolism in artemisinin susceptibility by Harding, Clare R., Sidik, Saima M., Petrova, Boryana, Gnädig, Nina F., Okombo, John, Herneisen, Alice L., Ward, Kurt E., Markus, Benedikt M., Boydston, Elizabeth A., Fidock, David A., Lourido, Sebastian

“…Artemisinins have revolutionized the treatment of Plasmodium falciparum malaria; however, resistance threatens to undermine global control efforts. To broadly…”
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Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual blood stages by Okombo, John, Mok, Sachel, Qahash, Tarrick, Yeo, Tomas, Bath, Jade, Orchard, Lindsey M, Owens, Edward, Koo, Imhoi, Albert, Istvan, Llinás, Manuel, Fidock, David A

“…The emergence of Plasmodium falciparum parasite resistance to dihydroartemisinin + piperaquine (PPQ) in Southeast Asia threatens plans to increase the global…”
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Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum by Kümpornsin, Krittikorn, Kochakarn, Theerarat, Yeo, Tomas, Okombo, John, Luth, Madeline R., Hoshizaki, Johanna, Rawat, Mukul, Pearson, Richard D., Schindler, Kyra A., Mok, Sachel, Park, Heekuk, Uhlemann, Anne-Catrin, Jana, Gouranga P., Maity, Bikash C., Laleu, Benoît, Chenu, Elodie, Duffy, James, Moliner Cubel, Sonia, Franco, Virginia, Gomez-Lorenzo, Maria G., Gamo, Francisco Javier, Winzeler, Elizabeth A., Fidock, David A., Chookajorn, Thanat, Lee, Marcus C. S.

“…In vitro evolution of drug resistance is a powerful approach for identifying antimalarial targets, however, key obstacles to eliciting resistance are the…”
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4-Aminoquinoline Antimalarials Containing a Benzylmethylpyridylmethylamine Group Are Active against Drug Resistant Plasmodium falciparum and Exhibit Oral Activity in Mice by Joshi, Mukesh C, Okombo, John, Nsumiwa, Samkele, Ndove, Jeffrey, Taylor, Dale, Wiesner, Lubbe, Hunter, Roger, Chibale, Kelly, Egan, Timothy J

“…Emergence of drug resistant Plasmodium falciparum including artemisinin-tolerant parasites highlights the need for new antimalarials. We have previously shown…”
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Additional PfCRT mutations driven by selective pressure for improved fitness can result in the loss of piperaquine resistance and altered Plasmodium falciparum physiology by Hagenah, Laura M, Dhingra, Satish K, Small-Saunders, Jennifer L, Qahash, Tarrick, Willems, Andreas, Schindler, Kyra A, Rangel, Gabriel W, Gil-Iturbe, Eva, Kim, Jonathan, Akhundova, Emiliya, Yeo, Tomas, Okombo, John, Mancia, Filippo, Quick, Matthias, Roepe, Paul D, Llinás, Manuel, Fidock, David A

“…Our study leverages gene editing techniques in asexual blood stage parasites to profile novel mutations in mutant PfCRT, an important mediator of piperaquine…”
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Repeat Polymorphisms in the Low-Complexity Regions of Plasmodium falciparum ABC Transporters and Associations with In Vitro Antimalarial Responses by OKOMBO, John, ABDI, Abdirahman I, KIARA, Steven M, MWAI, Leah, POLE, Lewa, SUTHERLAND, Colin J, NZILA, Alexis, OCHOLA-OYIER, Lynette Isabella

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In Vitro Activity of Antifolate and Polymorphism in Dihydrofolate Reductase of Plasmodium falciparum Isolates from the Kenyan Coast: Emergence of Parasites with Ile-164-Leu Mutation by KIARA, Steven M, OKOMBO, John, MASSENO, Victor, MWAI, Leah, OCHOLA, Isabella, BORRMANN, Steffen, NZILA, Alexis

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Baseline In Vitro Activities of the Antimalarials Pyronaridine and Methylene Blue against Plasmodium falciparum Isolates from Kenya by Okombo, John, Kiara, Steven M, Mwai, Leah, Pole, Lewa, Ohuma, Eric, Ochola, Lynette Isabella, Nzila, Alexis

“…We have analyzed the in vitro activities of pyronaridine and methylene blue against 59 Plasmodium falciparum isolates from Kenya in association with…”
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A genome wide association study of Plasmodium falciparum susceptibility to 22 antimalarial drugs in Kenya by Wendler, Jason P, Okombo, John, Amato, Roberto, Miotto, Olivo, Kiara, Steven M, Mwai, Leah, Pole, Lewa, O'Brien, John, Manske, Magnus, Alcock, Dan, Drury, Eleanor, Sanders, Mandy, Oyola, Samuel O, Malangone, Cinzia, Jyothi, Dushyanth, Miles, Alistair, Rockett, Kirk A, MacInnis, Bronwyn L, Marsh, Kevin, Bejon, Philip, Nzila, Alexis, Kwiatkowski, Dominic P

“…Drug resistance remains a chief concern for malaria control. In order to determine the genetic markers of drug resistant parasites, we tested the genome-wide…”
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Temporal trends in prevalence of Plasmodium falciparum drug resistance alleles over two decades of changing antimalarial policy in coastal Kenya by Okombo, John, Kamau, Alice W., Marsh, Kevin, Sutherland, Colin J., Ochola-Oyier, Lynette Isabella

“…•Genomic changes in malaria parasites over 2 decades of drug pressure were assessed.•Chloroquine-sensitive and antifolate-resistant parasite populations rose…”
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In Vitro Activities of Quinine and Other Antimalarials and pfnhe Polymorphisms in Plasmodium Isolates from Kenya by OKOMBO, John, KIARA, Steven M, RONO, Josea, MWAI, Leah, POLE, Lewa, OHUMA, Eric, BORRMANN, Steffen, OCHOLA, Lynette Isabella, NZILA, Alexis

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Anticancer agents against malaria: time to revisit? by Nzila, Alexis, Okombo, John, Becker, Ruy Perez, Chilengi, Roma, Lang, Trudie, Niehues, Tim

“…The emergence of artemisinin resistance could adversely impact the current strategy for malaria treatment; thus, new drugs are urgently needed. A possible…”
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Early metabolic profiling of pyrido[1,2-a]benzimidazoles in mouse liver microsomes by LC-MS/MS by Brunschwig, Christel, Singh, Kawaljit, Barnard, Linley, Ndubi, Ferdinand, Okombo, John, Njoroge, Mathew, Wiesner, Lubbe, Chibale, Kelly

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The Polymorphic Linker Domain of pfmdr1 Is Associated with Resistance-Conferring Mutations in Plasmodium falciparum Populations from East and West Africa by OKOMBO, John, ZONGO, Issaka, GADALLA, Nahla, BOUSEMA, Teun, BESHIR, Khalid B, ROPER, Cally, HALLETT, Rachel, OCHOLA-OYIER, Lynette Isabella, SUTHERLAND, Colin J

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Insights into Integrated Lead Generation and Target Identification in Malaria and Tuberculosis Drug Discovery by Okombo, John, Chibale, Kelly

“…New, safe and effective drugs are urgently needed to treat and control malaria and tuberculosis, which affect millions of people annually. However, financial…”
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Recent updates in the discovery and development of novel antimalarial drug candidates by Okombo, John, Chibale, Kelly

“…Though morbidity and mortality due to malaria have declined in the last 15 years, emerging resistance to first-line artemisinin-based antimalarials, absence of…”
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Towards next-generation treatment options to combat Plasmodium falciparum malaria by Okombo, John, Fidock, David A

“…Malaria, which is caused by infection of red blood cells with Plasmodium parasites, can be fatal in non-immune individuals if left untreated. The recent…”
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Plasmepsin Inhibitors in Antimalarial Drug Discovery: Medicinal Chemistry and Target Validation (2000 to Present) by Cheuka, Peter Mubanga, Dziwornu, Godwin, Okombo, John, Chibale, Kelly

“…Plasmepsins represent novel antimalarial drug targets. However, plasmepsin-based antimalarial drug discovery efforts in the past 2 decades have generally…”
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Antiplasmodial drug targets: a patent review (2000 - 2013) by Okombo, John, Chibale, Kelly

“…New antimalarials with novel modes of action are crucial in countering the challenge of emerging drug-resistant Plasmodium falciparum. Equally significant is…”
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