Search Results - "John O Trent"

G‐Quadruplex Secondary Structure Obtained from Circular Dichroism Spectroscopy by del Villar‐Guerra, Rafael, Trent, John O., Chaires, Jonathan B.

“…A curated library of circular dichroism spectra of 23 G‐quadruplexes of known structure was built and analyzed. The goal of this study was to use this…”
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Folding and Unfolding Pathways of the Human Telomeric G-Quadruplex by Gray, Robert D., Trent, John O., Chaires, Jonathan B.

“…Sequence analogs of human telomeric DNA such as d[AGGG(TTAGGG)3] (Tel22) fold into monomeric quadruplex structures in the presence of a suitable cation. To…”
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The hTERT core promoter forms three parallel G-quadruplexes by Monsen, Robert C, DeLeeuw, Lynn, Dean, William L, Gray, Robert D, Sabo, T Michael, Chakravarthy, Srinivas, Chaires, Jonathan B, Trent, John O

“…The structure of the 68 nt sequence with G-quadruplex forming potential within the hTERT promoter is disputed. One model features a structure with three…”
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Long promoter sequences form higher-order G-quadruplexes: an integrative structural biology study of c-Myc, k-Ras and c-Kit promoter sequences by Monsen, Robert C, DeLeeuw, Lynn W, Dean, William L, Gray, Robert D, Chakravarthy, Srinivas, Hopkins, Jesse B, Chaires, Jonathan B, Trent, John O

“…Abstract We report on higher-order G-quadruplex structures adopted by long promoter sequences obtained by an iterative integrated structural biology approach…”
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Hydration Is a Major Determinant of the G-Quadruplex Stability and Conformation of the Human Telomere 3′ Sequence of d(AG3(TTAG3)3) by Miller, M. Clarke, Buscaglia, Robert, Chaires, Jonathan B, Lane, Andrew N, Trent, John O

“…The factors that determine the conformation and stability of G-quadruplex forming sequences remain poorly understood. Here we demonstrate the influence of…”
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Structure of a 28.5 kDa duplex-embedded G-quadruplex system resolved to 7.4 Å resolution with cryo-EM by Monsen, Robert C, Chua, Eugene Y D, Hopkins, Jesse B, Chaires, Jonathan B, Trent, John O

“…Genomic regions with high guanine content can fold into non-B form DNA four-stranded structures known as G-quadruplexes (G4s). Extensive in vivo investigations…”
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Targeting 6-phosphofructo-2-kinase (PFKFB3) as a therapeutic strategy against cancer by Clem, Brian F, O'Neal, Julie, Tapolsky, Gilles, Clem, Amy L, Imbert-Fernandez, Yoannis, Kerr, 2nd, Daniel A, Klarer, Alden C, Redman, Rebecca, Miller, Donald M, Trent, John O, Telang, Sucheta, Chesney, Jason

“…In human cancers, loss of PTEN, stabilization of hypoxia inducible factor-1α, and activation of Ras and AKT converge to increase the activity of a key…”
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Drug discovery of small molecules targeting the higher-order hTERT promoter G-quadruplex by Monsen, Robert C, Maguire, Jon M, DeLeeuw, Lynn W, Chaires, Jonathan B, Trent, John O

“…DNA G-quadruplexes (G4s) are now widely accepted as viable targets in the pursuit of anticancer therapeutics. To date, few small molecules have been identified…”
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Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer by Bates, Paula J., Laber, Damian A., Miller, Donald M., Thomas, Shelia D., Trent, John O.

“…Certain guanine-rich (G-rich) DNA and RNA molecules can associate intermolecularly or intramolecularly to form four stranded or “quadruplex” structures, which…”
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Structure and Stability of Higher-Order Human Telomeric Quadruplexes by Petraccone, Luigi, Spink, Charles, Trent, John O, Garbett, Nichola C, Mekmaysy, Chongkham S, Giancola, Concetta, Chaires, Jonathan B

“…G-quadruplex formation in the sequences 5′-(TTAGGG) n and 5′(TTAGGG) n TT (n = 4, 8, 12) was studied using circular dichroism, sedimentation velocity,…”
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Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth by Clem, Brian, Telang, Sucheta, Clem, Amy, Yalcin, Abdullah, Meier, Jason, Simmons, Alan, Rasku, Mary Ann, Arumugam, Sengodagounder, Dean, William L, Eaton, John, Lane, Andrew, Trent, John O, Chesney, Jason

“…6-Phosphofructo-1-kinase, a rate-limiting enzyme of glycolysis, is activated in neoplastic cells by fructose-2,6-bisphosphate (Fru-2,6-BP), a product of four…”
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POT1 stability and binding measured by fluorescence thermal shift assays by DeLeeuw, Lynn W, Monsen, Robert C, Petrauskas, Vytautas, Gray, Robert D, Baranauskiene, Lina, Matulis, Daumantas, Trent, John O, Chaires, Jonathan B

“…The protein POT1 (Protection of Telomeres 1) is an integral part of the shelterin complex that protects the ends of human chromosomes from degradation or end…”
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Activation of the Proapoptotic Bcl-2 Protein Bax by a Small Molecule Induces Tumor Cell Apoptosis by Zhao, Guoping, Zhu, Yanglong, Eno, Colins O., Liu, Yanlong, DeLeeuw, Lynn, Burlison, Joseph A., Chaires, Jonathan B., Trent, John O., Li, Chi

“…The proapoptotic Bcl-2 protein Bax by itself is sufficient to initiate apoptosis in almost all apoptotic paradigms. Thus, compounds that can facilitate…”
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Targeting the Nuclear Import Receptor Kpnβ1 as an Anticancer Therapeutic by van der Watt, Pauline J, Chi, Alicia, Stelma, Tamara, Stowell, Catherine, Strydom, Erin, Carden, Sarah, Angus, Liselotte, Hadley, Kate, Lang, Dirk, Wei, Wei, Birrer, Michael J, Trent, John O, Leaner, Virna D

“…Karyopherin beta 1 (Kpnβ1) is a nuclear transport receptor that imports cargoes into the nucleus. Recently, elevated Kpnβ1 expression was found in certain…”
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Resolution and characterization of the structural polymorphism of a single quadruplex-forming sequence by Dailey, Magdalena M, Miller, M. Clarke, Bates, Paula J, Lane, Andrew N, Trent, John O

“…The remarkable structural polymorphism of quadruplex-forming sequences has been a considerable impediment in the elucidation of quadruplex folds. Sequence…”
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Identification of a Heme Activation Site on the MD-2/TLR4 Complex by Belcher, John D, Zhang, Ping, Nguyen, Julia, Kiser, Zachary M, Nath, Karl A, Hu, Jianjun, Trent, John O, Vercellotti, Gregory M

“…Myeloid differentiation factor-2 (MD-2) binds lipopolysaccharide (LPS) and initiates toll-like receptor-4 (TLR4) pro-inflammatory signaling. Heme also…”
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An improved model for the hTERT promoter quadruplex by Chaires, Jonathan B, Trent, John O, Gray, Robert D, Dean, William L, Buscaglia, Robert, Thomas, Shelia D, Miller, Donald M

“…Mutations occur at four specific sites in the hTERT promoter in >75% of glioblastomas and melanomas, but the mechanism by which the mutations affect gene…”
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IKK2 inhibition using TPCA-1-loaded PLGA microparticles attenuates laser-induced choroidal neovascularization and macrophage recruitment by Gaddipati, Subhash, Lu, Qingxian, Kasetti, Ramesh Babu, Miller, M Clarke, Lu, Qingjun, Trent, John O, Kaplan, Henry J, Li, Qiutang

“…The inhibition of NF-κB by genetic deletion or pharmacological inhibition of IKK2 significantly reduces laser-induced choroid neovascularization (CNV). To…”
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A Novel, Macrophage Migration Inhibitory Factor Suicide Substrate Inhibits Motility and Growth of Lung Cancer Cells by WINNER, Millicent, MEIER, Jason, TRENT, John O, MITCHELL, Robert A, ZIEROW, Swen, RENDON, Beatriz E, CRICHLOW, Gregg V, RIGGS, Randall, BUCALA, Richard, LIN LENG, SMITH, Ned, LOLIS, Elias

“…Although chemokine and growth factor receptors are attractive and popular targets for cancer therapeutic intervention, structure-based targeting of the ligands…”
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The Golgi-Associated Protein p115 Mediates the Secretion of Macrophage Migration Inhibitory Factor by Merk, Melanie, Baugh, John, Zierow, Swen, Leng, Lin, Pal, Utpal, Lee, Seung Joon, Ebert, Antje D, Mizue, Yuka, Trent, John O, Mitchell, Robert, Nickel, Walter, Kavathas, Paula B, Bernhagen, Jurgen, Bucala, Richard

“…Macrophage migration inhibitory factor (MIF) is a leaderless protein that is secreted from cells by a specialized, nonclassical export pathway. The release of…”
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