Search Results - "John M. Dye"

Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2 by Chan, Kui K, Dorosky, Danielle, Sharma, Preeti, Abbasi, Shawn A, Dye, John M, Kranz, David M, Herbert, Andrew S, Procko, Erik

“…The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds angiotensin-converting enzyme 2 (ACE2) on host cells to initiate…”
Get full text

A Serological Point-of-Care Test for the Detection of IgG Antibodies against Ebola Virus in Human Survivors by Brangel, Polina, Sobarzo, Ariel, Parolo, Claudio, Miller, Benjamin S, Howes, Philip D, Gelkop, Sigal, Lutwama, Julius J, Dye, John M, McKendry, Rachel A, Lobel, Leslie, Stevens, Molly M

“…Ebola virus disease causes widespread and highly fatal epidemics in human populations. Today, there is still great need for point-of-care tests for diagnosis,…”
Get full text

Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody by Rappazzo, C Garrett, Tse, Longping V, Kaku, Chengzi I, Wrapp, Daniel, Sakharkar, Mrunal, Huang, Deli, Deveau, Laura M, Yockachonis, Thomas J, Herbert, Andrew S, Battles, Michael B, O'Brien, Cecilia M, Brown, Michael E, Geoghegan, James C, Belk, Jonathan, Peng, Linghang, Yang, Linlin, Hou, Yixuan, Scobey, Trevor D, Burton, Dennis R, Nemazee, David, Dye, John M, Voss, James E, Gunn, Bronwyn M, McLellan, Jason S, Baric, Ralph S, Gralinski, Lisa E, Walker, Laura M

“…The recurrent zoonotic spillover of coronaviruses (CoVs) into the human population underscores the need for broadly active countermeasures. We employed a…”
Get full text

A Replication-Competent Vesicular Stomatitis Virus for Studies of SARS-CoV-2 Spike-Mediated Cell Entry and Its Inhibition by Dieterle, M. Eugenia, Haslwanter, Denise, Bortz, Robert H., Wirchnianski, Ariel S., Lasso, Gorka, Vergnolle, Olivia, Abbasi, Shawn A., Fels, J. Maximilian, Laudermilch, Ethan, Florez, Catalina, Mengotto, Amanda, Kimmel, Duncan, Malonis, Ryan J., Georgiev, George, Quiroz, Jose, Barnhill, Jason, Pirofski, Liise-anne, Daily, Johanna P., Dye, John M., Lai, Jonathan R., Herbert, Andrew S., Chandran, Kartik, Jangra, Rohit K.

“…There is an urgent need for vaccines and therapeutics to prevent and treat COVID-19. Rapid SARS-CoV-2 countermeasure development is contingent on the…”
Get full text

Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects by Bekerman, Elena, Neveu, Gregory, Shulla, Ana, Brannan, Jennifer, Pu, Szu-Yuan, Wang, Stanley, Xiao, Fei, Barouch-Bentov, Rina, Bakken, Russell R, Mateo, Roberto, Govero, Jennifer, Nagamine, Claude M, Diamond, Michael S, De Jonghe, Steven, Herdewijn, Piet, Dye, John M, Randall, Glenn, Einav, Shirit

“…Global health is threatened by emerging viral infections, which largely lack effective vaccines or therapies. Targeting host pathways that are exploited by…”
Get full text

Lassa virus entry requires a trigger-induced receptor switch by Jae, Lucas T., Raaben, Matthijs, Herbert, Andrew S., Kuehne, Ana I., Wirchnianski, Ariel S., Soh, Timothy K., Stubbs, Sarah H., Janssen, Hans, Damme, Markus, Saftig, Paul, Whelan, Sean P., Dye, John M., Brummelkamp, Thijn R.

“…Lassa virus spreads from a rodent to humans and can lead to lethal hemorrhagic fever. Despite its broad tropism, chicken cells were reported 30 years ago to…”
Get full text

A Role for Fc Function in Therapeutic Monoclonal Antibody-Mediated Protection against Ebola Virus by Gunn, Bronwyn M., Yu, Wen-Han, Karim, Marcus M., Brannan, Jennifer M., Herbert, Andrew S., Wec, Anna Z., Halfmann, Peter J., Fusco, Marnie L., Schendel, Sharon L., Gangavarapu, Karthik, Krause, Tyler, Qiu, Xiangguo, He, Shinhua, Das, Jishnu, Suscovich, Todd J., Lai, Jonathan, Chandran, Kartik, Zeitlin, Larry, Crowe, James E., Lauffenburger, Douglas, Kawaoka, Yoshihiro, Kobinger, Gary P., Andersen, Kristian G., Dye, John M., Saphire, Erica Ollmann, Alter, Galit

“…The recent Ebola virus (EBOV) epidemic highlighted the need for effective vaccines and therapeutics to limit and prevent outbreaks. Host antibodies against…”
Get full text

Postexposure antibody prophylaxis protects nonhuman primates from filovirus disease by Dye, John M, Herbert, Andrew S, Kuehne, Ana I, Barth, James F, Muhammad, Majidat A, Zak, Samantha E, Ortiz, Ramon A, Prugar, Laura I, Pratt, William D

“…Antibody therapies to prevent or limit filovirus infections have received modest interest in recent years, in part because of early negative experimental…”
Get full text

NRP2 and CD63 Are Host Factors for Lujo Virus Cell Entry by Raaben, Matthijs, Jae, Lucas T., Herbert, Andrew S., Kuehne, Ana I., Stubbs, Sarah H., Chou, Yi-ying, Blomen, Vincent A., Kirchhausen, Tomas, Dye, John M., Brummelkamp, Thijn R., Whelan, Sean P.

“…Arenaviruses cause fatal hemorrhagic disease in humans. Old World arenavirus glycoproteins (GPs) mainly engage α-dystroglycan as a cell-surface receptor, while…”
Get full text

Antibodies from a Human Survivor Define Sites of Vulnerability for Broad Protection against Ebolaviruses by Wec, Anna Z., Herbert, Andrew S., Murin, Charles D., Nyakatura, Elisabeth K., Abelson, Dafna M., Fels, J. Maximilian, He, Shihua, James, Rebekah M., de La Vega, Marc-Antoine, Zhu, Wenjun, Bakken, Russell R., Goodwin, Eileen, Turner, Hannah L., Jangra, Rohit K., Zeitlin, Larry, Qiu, Xiangguo, Lai, Jonathan R., Walker, Laura M., Ward, Andrew B., Dye, John M., Chandran, Kartik, Bornholdt, Zachary A.

“…Experimental monoclonal antibody (mAb) therapies have shown promise for treatment of lethal Ebola virus (EBOV) infections, but their species-specific…”
Get full text

Longitudinal proteome-wide antibody profiling in Marburg virus survivors identifies wing domain immunogen for vaccine design by Khurana, Surender, Grubbs, Gabrielle, Ravichandran, Supriya, Cluff, Emily, Kim, JungHyun, Kuehne, Ana I., Zak, Samantha, Dye, John M., Lutwama, Julius J., Herbert, Andrew S.

“…Limited knowledge exists on the quality of polyclonal antibody responses generated following Marburg virus (MARV) infection and its evolution in survivors. In…”
Get full text

A "Trojan horse" bispecific-antibody strategy for broad protection against ebolaviruses by Wec, Anna Z., Nyakatura, Elisabeth K., Herbert, Andrew S., Howell, Katie A., Holtsberg, Frederick W., Bakken, Russell R., Mittler, Eva, Christin, John R., Shulenin, Sergey, Jangra, Rohit K., Bharrhan, Sushma, Kuehne, Ana I., Bornholdt, Zachary A., Flyak, Andrew I., Saphire, Erica Ollmann, Crowe, James E., Aman, M. Javad, Dye, John M., Lai, Jonathan R., Chandran, Kartik

“…There is an urgent need for monoclonal antibody (mAb) therapies that broadly protect against Ebola virus and other filoviruses. The conserved, essential…”
Get full text

Protective neutralizing antibodies from human survivors of Crimean-Congo hemorrhagic fever by Fels, J. Maximilian, Maurer, Daniel P., Herbert, Andrew S., Wirchnianski, Ariel S., Vergnolle, Olivia, Cross, Robert W., Abelson, Dafna M., Moyer, Crystal L., Mishra, Akaash K., Aguilan, Jennifer T., Kuehne, Ana I., Pauli, Noel T., Bakken, Russell R., Nyakatura, Elisabeth K., Hellert, Jan, Quevedo, Gregory, Lobel, Leslie, Balinandi, Stephen, Lutwama, Julius J., Zeitlin, Larry, Geisbert, Thomas W., Rey, Felix A., Sidoli, Simone, McLellan, Jason S., Lai, Jonathan R., Bornholdt, Zachary A., Dye, John M., Walker, Laura M., Chandran, Kartik

“…Crimean-Congo hemorrhagic fever virus (CCHFV) is a World Health Organization priority pathogen. CCHFV infections cause a highly lethal hemorrhagic fever for…”
Get full text

Longitudinal Human Antibody Repertoire against Complete Viral Proteome from Ebola Virus Survivor Reveals Protective Sites for Vaccine Design by Khurana, Surender, Ravichandran, Supriya, Hahn, Megan, Coyle, Elizabeth M, Stonier, Spencer W, Zak, Samantha E, Kindrachuk, Jason, Davey, Jr, Richard T, Dye, John M, Chertow, Daniel S

“…Evolution of antibody repertoire against the Ebola virus (EBOV) proteome was characterized in an acutely infected patient receiving supportive care alone to…”
Get full text

Homologous and heterologous protection of nonhuman primates by Ebola and Sudan virus-like particles by Warfield, Kelly L, Dye, John M, Wells, Jay B, Unfer, Robert C, Holtsberg, Frederick W, Shulenin, Sergey, Vu, Hong, Swenson, Dana L, Bavari, Sina, Aman, M Javad

“…Filoviruses cause hemorrhagic fever resulting in significant morbidity and mortality in humans. Several vaccine platforms that include multiple virus-vectored…”
Get full text

Post-exposure immunotherapy for two ebolaviruses and Marburg virus in nonhuman primates by Brannan, Jennifer M., He, Shihua, Howell, Katie A., Prugar, Laura I., Zhu, Wenjun, Vu, Hong, Shulenin, Sergey, Kailasan, Shweta, Raina, Henna, Wong, Gary, Rahim, Md Niaz, Banadyga, Logan, Tierney, Kevin, Zhao, Xuelian, Li, Yuxing, Holtsberg, Frederick W., Dye, John M., Qiu, Xiangguo, Aman, M. Javad

“…The 2013–2016 Ebola virus (EBOV) disease epidemic demonstrated the grave consequences of filovirus epidemics in the absence of effective therapeutics. Besides…”
Get full text

Emergence of Ebola Virus Escape Variants in Infected Nonhuman Primates Treated with the MB-003 Antibody Cocktail by Kugelman, Jeffrey R., Kugelman-Tonos, Johanny, Ladner, Jason T., Pettit, James, Keeton, Carolyn M., Nagle, Elyse R., Garcia, Karla Y., Froude, Jeffrey W., Kuehne, Ana I., Kuhn, Jens H., Bavari, Sina, Zeitlin, Larry, Dye, John M., Olinger, Gene G., Sanchez-Lockhart, Mariano, Palacios, Gustavo F.

“…MB-003, a plant-derived monoclonal antibody cocktail used effectively in treatment of Ebola virus infection in non-human primates, was unable to protect two of…”
Get full text

Pan-ebolavirus and Pan-filovirus Mouse Monoclonal Antibodies: Protection against Ebola and Sudan Viruses by Holtsberg, Frederick W, Shulenin, Sergey, Vu, Hong, Howell, Katie A, Patel, Sonal J, Gunn, Bronwyn, Karim, Marcus, Lai, Jonathan R, Frei, Julia C, Nyakatura, Elisabeth K, Zeitlin, Larry, Douglas, Robin, Fusco, Marnie L, Froude, Jeffrey W, Saphire, Erica Ollmann, Herbert, Andrew S, Wirchnianski, Ariel S, Lear-Rooney, Calli M, Alter, Galit, Dye, John M, Glass, Pamela J, Warfield, Kelly L, Aman, M Javad

“…The unprecedented 2014-2015 Ebola virus disease (EVD) outbreak in West Africa has highlighted the need for effective therapeutics against filoviruses…”
Get full text

Characterization of Ebola convalescent plasma donor immune response and psoralen treated plasma in the United States by Dean, Christina L., Hooper, Jay W., Dye, John M., Zak, Samantha E., Koepsell, Scott A., Corash, Laurence, Benjamin, Richard J., Kwilas, Steve, Bonds, Shannon, Winkler, Anne M., Kraft, Colleen S.

“…BACKGROUND In 2014, passive immunization by transfusion of Ebola convalescent plasma (ECP) was considered for treating patients with acute Ebola virus disease…”
Get full text

A novel compound active against SARS-CoV-2 targeting uridylate-specific endoribonuclease (NendoU/NSP15): in silico and in vitro investigations by Kumar, Sumit, Gupta, Yash, Zak, Samantha E., Upadhyay, Charu, Sharma, Neha, Herbert, Andrew S., Durvasula, Ravi, Potemkin, Vladimir, Dye, John M., Poonam, Kempaiah, Prakasha, Rathi, Brijesh

“…NendoU (NSP15) is an Mn(2+)-dependent, uridylate-specific enzyme, which leaves 2′-3′-cyclic phosphates 5′ to the cleaved bond. Our in-house library was…”
Get full text