Search Results - "John C. Vederas"

Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication by Vuong, Wayne, Khan, Muhammad Bashir, Fischer, Conrad, Arutyunova, Elena, Lamer, Tess, Shields, Justin, Saffran, Holly A., McKay, Ryan T., van Belkum, Marco J., Joyce, Michael A., Young, Howard S., Tyrrell, D. Lorne, Vederas, John C., Lemieux, M. Joanne

“…The main protease, M pro (or 3CL pro ) in SARS-CoV-2 is a viable drug target because of its essential role in the cleavage of the virus polypeptide. Feline…”
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The expanding structural variety among bacteriocins from Gram-positive bacteria by Acedo, Jeella Z, Chiorean, Sorina, Vederas, John C, van Belkum, Marco J

“…Bacteria use various strategies to compete in an ecological niche, including the production of bacteriocins. Bacteriocins are ribosomally synthesized…”
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Drug Discovery and Natural Products: End of an Era or an Endless Frontier? by Li, Jesse W.-H, Vederas, John C

“…Historically, the majority of new drugs have been generated from natural products (secondary metabolites) and from compounds derived from natural products…”
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Simplified cloning and isolation of peptides from "sandwiched" SUMO-peptide-intein fusion proteins by Lamer, Tess, Vederas, John C

“…Some peptides are targets for degradation when heterologously expressed as fusion proteins in E. coli, which can limit yields after isolation and purification…”
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Targeting the apelin pathway as a novel therapeutic approach for cardiovascular diseases by Zhong, Jiu-Chang, Zhang, Zhen-Zhou, Wang, Wang, McKinnie, Shaun M.K., Vederas, John C., Oudit, Gavin Y.

“…The apelin/apelin receptor system is widely distributed and has a dominant role in cardiovascular homeostasis and disease. The apelin gene is X-linked and is…”
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Enzymatic Synthesis of Resorcylic Acid Lactones by Cooperation of Fungal Iterative Polyketide Synthases Involved in Hypothemycin Biosynthesis by Zhou, Hui, Qiao, Kangjian, Gao, Zhizeng, Meehan, Michael J, Li, Jesse W.-H, Zhao, Xiling, Dorrestein, Pieter C, Vederas, John C, Tang, Yi

“…Hypothemycin is a macrolide protein kinase inhibitor from the fungus Hypomyces subiculosus. During biosynthesis, its carbon framework is assembled by two…”
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Thuricin CD, a posttranslationally modified bacteriocin with a narrow spectrum of activity against Clostridium difficile by Rea, Mary C, Sit, Clarissa S, Clayton, Evelyn, O'Connor, Paula M, Whittal, Randy M, Zheng, Jing, Vederas, John C, Ross, R. Paul, Hill, Colin

“…The last decade has seen numerous outbreaks of Clostridium difficile-associated disease (CDAD), which presented significant challenges for healthcare…”
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Catalytic mechanism and properties of pyridoxal 5'-phosphate independent racemases: how enzymes alter mismatched acidity and basicity by Fischer, Conrad, Ahn, Yeong-Chan, Vederas, John C

“…Covering: up to March 2019 Amino acid racemases and epimerases are key enzymes that invert the configuration of common amino acids and supply many…”
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Diacylglycerol Acyltransferase 1 Is Regulated by Its N-Terminal Domain in Response to Allosteric Effectors by Caldo, Kristian Mark P., Acedo, Jeella Z., Panigrahi, Rashmi, Vederas, John C., Weselake, Randall J., Lemieux, M. Joanne

“…Diacylglycerol acyltransferase 1 (DGAT1) is an integral membrane enzyme catalyzing the final and committed step in the acylcoenzyme A (CoA)-dependent…”
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Biosynthesis of lovastatin and related metabolites formed by fungal iterative PKS enzymes by Campbell, Chantel D., Vederas, John C.

“…The fungal polyketide lovastatin is a cholesterol lowering agent that is an immediate precursor to a multi‐billion dollar drug, simvastatin (Zocor™)…”
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LovG: The Thioesterase Required for Dihydromonacolin L Release and Lovastatin Nonaketide Synthase Turnover in Lovastatin Biosynthesis by Xu, Wei, Chooi, Yit-Heng, Choi, Jin W., Li, Shuang, Vederas, John C., Da Silva, Nancy A., Tang, Yi

“…No Lov lost: The cryptic thioesterase LovG was found to be responsible for product release from the lovastatin nonaketide synthase (LNKS or LovB; see scheme)…”
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Complete Reconstitution of a Highly Reducing Iterative Polyketide Synthase by Ma, Suzanne M, Li, Jesse W.-H, Choi, Jin W, Zhou, Hui, Lee, K.K. Michael, Moorthie, Vijayalakshmi A, Xie, Xinkai, Kealey, James T, Da Silva, Nancy A, Vederas, John C, Tang, Yi

“…Highly reducing iterative polyketide synthases are large, multifunctional enzymes that make important metabolites in fungi, such as lovastatin, a…”
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Biosynthesis of Aminovinyl-Cysteine-Containing Peptides and Its Application in the Production of Potential Drug Candidates by Sit, Clarissa S, Yoganathan, Sabesan, Vederas, John C

“…Bacteria produce a wide array of metabolites to protect themselves from competing microbes. These antimicrobial compounds include peptides with an…”
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Understanding Programming of Fungal Iterative Polyketide Synthases: The Biochemical Basis for Regioselectivity by the Methyltransferase Domain in the Lovastatin Megasynthase by Cacho, Ralph A, Thuss, Justin, Xu, Wei, Sanichar, Randy, Gao, Zhizeng, Nguyen, Allison, Vederas, John C, Tang, Yi

“…Highly reducing polyketide synthases (HR-PKSs) from fungi synthesize complex natural products using a single set of domains in a highly programmed, iterative…”
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Peptidomimetic nitrile warheads as SARS-CoV-2 3CL protease inhibitors by Bai, Bing, Arutyunova, Elena, Khan, Muhammad Bashir, Lu, Jimmy, Joyce, Michael A, Saffran, Holly A, Shields, Justin A, Kandadai, Appan Srinivas, Belovodskiy, Alexandr, Hena, Mostofa, Vuong, Wayne, Lamer, Tess, Young, Howard S, Vederas, John C, Tyrrell, D. Lorne, Lemieux, M. Joanne, Nieman, James A

“…Tragically, the death toll from the COVID-19 pandemic continues to rise, and with variants being observed around the globe new therapeutics, particularly…”
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The Metalloprotease Neprilysin Degrades and Inactivates Apelin Peptides by McKinnie, Shaun M. K., Fischer, Conrad, Tran, Kelvin M. H., Wang, Wang, Mosquera, Fabricio, Oudit, Gavin Y., Vederas, John C.

“…The apelinergic system is a mammalian peptide hormone network with key physiological roles. Apelin isoforms and analogues are believed to be promising…”
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Biochemical and Structural Basis for Controlling Chemical Modularity in Fungal Polyketide Biosynthesis by Winter, Jaclyn M, Cascio, Duilio, Dietrich, David, Sato, Michio, Watanabe, Kenji, Sawaya, Michael R, Vederas, John C, Tang, Yi

“…Modular collaboration between iterative fungal polyketide synthases (IPKSs) is an important mechanism for generating structural diversity of polyketide natural…”
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Genetic determinants of reutericyclin biosynthesis in Lactobacillus reuteri by Lin, Xiaoxi B, Lohans, Christopher T, Duar, Rebbeca, Zheng, Jinshui, Vederas, John C, Walter, Jens, Gänzle, Michael

“…Reutericyclin is a unique antimicrobial tetramic acid produced by some strains of Lactobacillus reuteri. This study aimed to identify the genetic determinants…”
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Genomic virulence features of Beauveria bassiana as a biocontrol agent for the mountain pine beetle population by Li, Janet X, Fernandez, Kleinberg X, Ritland, Carol, Jancsik, Sharon, Engelhardt, Daniel B, Coombe, Lauren, Warren, René L, van Belkum, Marco J, Carroll, Allan L, Vederas, John C, Bohlmann, Joerg, Birol, Inanc

“…The mountain pine beetle, Dendroctonus ponderosae, is an irruptive bark beetle that causes extensive mortality to many pine species within the forests of…”
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A carbonate-forming Baeyer-Villiger monooxygenase by Hu, Youcai, Dietrich, David, Xu, Wei, Patel, Ashay, Thuss, Justin A J, Wang, Jingjing, Yin, Wen-Bing, Qiao, Kangjian, Houk, K N, Vederas, John C, Tang, Yi

“…Carbonates exist in a few natural products, but their biosynthetic origins have been unclear. Genetic and biochemical characterization of a flavin-dependent…”
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