Search Results - "John Burn"

Transforming the care of people with Lynch syndrome: a system-wide approach by John Burn

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Direct oral anticoagulants versus warfarin: is new always better than the old? by Burn, John, Pirmohamed, Munir

“…About 1.4 British million people are at risk of strokes due to non-valvular atrial fibrillation (AF) necessitating long-term anticoagulation. The vitamin K…”
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Three molecular pathways model colorectal carcinogenesis in Lynch syndrome by Ahadova, Aysel, Gallon, Richard, Gebert, Johannes, Ballhausen, Alexej, Endris, Volker, Kirchner, Martina, Stenzinger, Albrecht, Burn, John, von Knebel Doeberitz, Magnus, Bläker, Hendrik, Kloor, Matthias

“…Lynch syndrome is caused by germline mutations of DNA mismatch repair (MMR) genes. MMR deficiency has long been regarded as a secondary event in the…”
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Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database by Møller, Pål, Seppälä, Toni T, Bernstein, Inge, Holinski-Feder, Elke, Sala, Paulo, Gareth Evans, D, Lindblom, Annika, Macrae, Finlay, Blanco, Ignacio, Sijmons, Rolf H, Jeffries, Jacqueline, Vasen, Hans F A, Burn, John, Nakken, Sigve, Hovig, Eivind, Rødland, Einar Andreas, Tharmaratnam, Kukatharmini, de Vos Tot Nederveen Cappel, Wouter H, Hill, James, Wijnen, Juul T, Jenkins, Mark A, Green, Kate, Lalloo, Fiona, Sunde, Lone, Mints, Miriam, Bertario, Lucio, Pineda, Marta, Navarro, Matilde, Morak, Monika, Renkonen-Sinisalo, Laura, Valentin, Mev Dominguez, Frayling, Ian M, Plazzer, John-Paul, Pylvanainen, Kirsi, Genuardi, Maurizio, Mecklin, Jukka-Pekka, Moeslein, Gabriela, Sampson, Julian R, Capella, Gabriel

“…Most patients with gene variants (Lynch syndrome (LS)) now survive both their first and subsequent cancers, resulting in a growing number of older patients…”
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Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression by Cunnington, Michael S, Santibanez Koref, Mauro, Mayosi, Bongani M, Burn, John, Keavney, Bernard

“…Single nucleotide polymorphisms (SNPs) on chromosome 9p21 are associated with coronary artery disease, diabetes, and multiple cancers. Risk SNPs are mainly…”
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The Manchester International Consensus Group recommendations for the management of gynecological cancers in Lynch syndrome by Crosbie, Emma J., Ryan, Neil A. J., Arends, Mark J., Bosse, Tjalling, Burn, John, Cornes, Joanna M., Crawford, Robin, Eccles, Diana, Frayling, Ian M., Ghaem-Maghami, Sadaf, Hampel, Heather, Kauff, Noah D., Kitchener, Henry C., Kitson, Sarah J., Manchanda, Ranjit, McMahon, Raymond F. T., Monahan, Kevin J., Menon, Usha, Møller, Pål, Möslein, Gabriela, Rosenthal, Adam, Sasieni, Peter, Seif, Mourad W., Singh, Naveena, Skarrott, Pauline, Snowsill, Tristan M., Steele, Robert, Tischkowitz, Marc, Evans, D. Gareth

“…Purpose There are no internationally agreed upon clinical guidelines as to which women with gynecological cancer would benefit from Lynch syndrome screening or…”
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Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts by Vasen, Hans F A, Blanco, Ignacio, Aktan-Collan, Katja, Gopie, Jessica P, Alonso, Angel, Aretz, Stefan, Bernstein, Inge, Bertario, Lucio, Burn, John, Capella, Gabriel, Colas, Chrystelle, Engel, Christoph, Frayling, Ian M, Genuardi, Maurizio, Heinimann, Karl, Hes, Frederik J, Hodgson, Shirley V, Karagiannis, John A, Lalloo, Fiona, Lindblom, Annika, Mecklin, Jukka-Pekka, Møller, Pal, Myrhoj, Torben, Nagengast, Fokko M, Parc, Yann, Ponz de Leon, Maurizio, Renkonen-Sinisalo, Laura, Sampson, Julian R, Stormorken, Astrid, Sijmons, Rolf H, Tejpar, Sabine, Thomas, Huw J W, Rahner, Nils, Wijnen, Juul T, Järvinen, Heikki Juhani, Möslein, Gabriela

“…Lynch syndrome (LS) is characterised by the development of colorectal cancer, endometrial cancer and various other cancers, and is caused by a mutation in one…”
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Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial by Burn, John, Prof Sir, Gerdes, Anne-Marie, Prof, Macrae, Finlay, Prof, Mecklin, Jukka-Pekka, Prof, Moeslein, Gabriela, MD, Olschwang, Sylviane, MD, Eccles, Diane, Prof, Evans, D Gareth, Prof, Maher, Eamonn R, Prof, Bertario, Lucio, MD, Bisgaard, Marie-Luise, MD, Dunlop, Malcolm G, Prof, Ho, Judy WC, MD, Hodgson, Shirley V, Prof, Lindblom, Annika, Prof, Lubinski, Jan, Prof, Morrison, Patrick J, Prof, Murday, Victoria, MD, Ramesar, Raj, Prof, Side, Lucy, MD, Scott, Rodney J, Prof, Thomas, Huw JW, Prof, Vasen, Hans F, Prof, Barker, Gail, Crawford, Gillian, Elliott, Faye, Movahedi, Mohammad, PhD, Pylvanainen, Kirsi, Wijnen, Juul T, PhD, Fodde, Riccardo, Prof, Lynch, Henry T, Prof, Mathers, John C, Prof, Bishop, D Timothy, Prof

“…Summary Background Observational studies report reduced colorectal cancer in regular aspirin consumers. Randomised controlled trials have shown reduced risk of…”
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Association of stroke and bleed events in non-valvular atrial fibrillation patients with direct oral anticoagulant prescriptions in NHS England between 2013 and 2016 by Sheth, Harsh, McNally, Daniel, Santibanez-Koref, Mauro, Burn, John

“…Prescription of direct oral anticoagulants (DOAC) compared to warfarin for treating atrial fibrillation patients have increased substantially since their…”
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The “unnatural” history of colorectal cancer in Lynch syndrome: Lessons from colonoscopy surveillance by Ahadova, Aysel, Seppälä, Toni T., Engel, Christoph, Gallon, Richard, Burn, John, Holinski‐Feder, Elke, Steinke‐Lange, Verena, Möslein, Gabriela, Nielsen, Maartje, Broeke, Sanne W., Laghi, Luigi, Dominguez‐Valentin, Mev, Capella, Gabriel, Macrae, Finlay, Scott, Rodney, Hüneburg, Robert, Nattermann, Jacob, Hoffmeister, Michael, Brenner, Hermann, Bläker, Hendrik, Knebel Doeberitz, Magnus, Sampson, Julian R., Vasen, Hans, Mecklin, Jukka‐Pekka, Møller, Pål, Kloor, Matthias

“…Individuals with Lynch syndrome (LS), one of the most common inherited cancer syndromes, are at increased risk of developing malignancies, in particular…”
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Aspirin and non-steroidal anti-inflammatory drugs for cancer prevention: an international consensus statement by Cuzick, Jack, Prof, Otto, Florian, MD, Baron, John A, Prof, Brown, Powel H, Prof, Burn, John, Prof, Greenwald, Peter, MD, Jankowski, Janusz, Prof, La Vecchia, Carlo, Prof, Meyskens, Frank, Prof, Senn, Hans Jörg, MD, Thun, Michael, Prof

“…Summary Evidence clearly shows a chemopreventive effect for aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) on colorectal cancer and probably…”
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Eflornithine plus Sulindac for Prevention of Progression in Familial Adenomatous Polyposis by Burke, Carol A, Dekker, Evelien, Lynch, Patrick, Samadder, N. Jewel, Balaguer, Francesc, Hüneburg, Robert, Burn, John, Castells, Antoni, Gallinger, Steven, Lim, Ramona, Stoffel, Elena M, Gupta, Samir, Henderson, Alex, Kallenberg, Frank G, Kanth, Priyanka, Roos, Victorine H, Ginsberg, Gregory G, Sinicrope, Frank A, Strassburg, Christian P, Van Cutsem, Eric, Church, James, Lalloo, Fiona, Willingham, Field F, Wise, Paul E, Grady, William M, Ford, Molly, Weiss, Jennifer M, Gryfe, Robert, Rustgi, Anil K, Syngal, Sapna, Cohen, Alfred

“…In randomized trial involving 171 adults with familial adenomatous polyposis, the incidence of disease progression was not significantly lower with combination…”
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Aspirin in the chemoprevention of colorectal neoplasia: an overview by Chan, Andrew T, Arber, Nadir, Burn, John, Chia, Whay Kuang, Elwood, Peter, Hull, Mark A, Logan, Richard F, Rothwell, Peter M, Schrör, Karsten, Baron, John A

“…Considerable evidence supports the effectiveness of aspirin for chemoprevention of colorectal cancer (CRC) in addition to its well-established benefits in the…”
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Obesity, Aspirin, and Risk of Colorectal Cancer in Carriers of Hereditary Colorectal Cancer: A Prospective Investigation in the CAPP2 Study by Movahedi, Mohammad, Bishop, D Timothy, Macrae, Finlay, Mecklin, Jukka-Pekka, Moeslein, Gabriela, Olschwang, Sylviane, Eccles, Diana, Evans, D Gareth, Maher, Eamonn R, Bertario, Lucio, Bisgaard, Marie-Luise, Dunlop, Malcolm G, Ho, Judy W C, Hodgson, Shirley V, Lindblom, Annika, Lubinski, Jan, Morrison, Patrick J, Murday, Victoria, Ramesar, Raj S, Side, Lucy, Scott, Rodney J, Thomas, Huw J W, Vasen, Hans F, Burn, John, Mathers, John C

“…In the general population, increased adiposity is a significant risk factor for colorectal cancer (CRC), but whether obesity has similar effects in those with…”
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Alison’s Story—A Cautionary Tale in the Age of Genomic Medicine by Burn, John, MD

“…Alison’s story illustrates the disastrous consequences of not securing an accurate family history when evaluating a patient for solid tumor malignancy; this is…”
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Celecoxib for the Prevention of Sporadic Colorectal Adenomas by Bertagnolli, Monica M, Eagle, Craig J, Zauber, Ann G, Redston, Mark, Solomon, Scott D, Kim, KyungMann, Tang, Jie, Rosenstein, Rebecca B, Wittes, Janet, Corle, Donald, Hess, Timothy M, Woloj, G. Mabel, Boisserie, Frédéric, Anderson, William F, Viner, Jaye L, Bagheri, Donya, Burn, John, Chung, Daniel C, Dewar, Thomas, Foley, T. Raymond, Hoffman, Neville, Macrae, Finlay, Pruitt, Ronald E, Saltzman, John R, Salzberg, Bruce, Sylwestrowicz, Thomas, Gordon, Gary B, Hawk, Ernest T

“…In this placebo-controlled trial of patients who had had colonic adenomas removed before study entry, celecoxib reduced the risk of recurrence of adenomas…”
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Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects by Saunders, Sean P., PhD, Goh, Christabelle S.M., BSc, Brown, Sara J., MD, Palmer, Colin N.A., PhD, Porter, Rebecca M., PhD, Cole, Christian, PhD, Campbell, Linda E., MSc, Gierlinski, Marek, PhD, Barton, Geoffrey J., PhD, Schneider, Georg, PhD, Balmain, Allan, PhD, Prescott, Alan R., PhD, Weidinger, Stephan, MD, PhD, Baurecht, Hansjörg, PhD, Kabesch, Michael, MD, Gieger, Christian, PhD, Lee, Young-Ae, MD, Tavendale, Roger, PhD, Mukhopadhyay, Somnath, MD, Turner, Stephen W., MD, Madhok, Vishnu B., MD, Sullivan, Frank M., MD, Relton, Caroline, PhD, Burn, John, MD, Meggitt, Simon, MD, Smith, Catherine H., MD, Allen, Michael A., PhD, Barker, Jonathan N.W. N., MD, Reynolds, Nick J., MD, Cordell, Heather J., DPhil, Irvine, Alan D., MD, McLean, W.H. Irwin, DSc, Sandilands, Aileen, PhD, Fallon, Padraic G., PhD

“…Background Atopic dermatitis (AD) is a major inflammatory condition of the skin caused by inherited skin barrier deficiency, with mutations in the filaggrin…”
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Acceptability of aspirin for cancer preventive therapy: a survey and qualitative study exploring the views of the UK general population by Lloyd, Kelly E, Hall, Louise H, Ziegler, Lucy, Foy, Robbie, Green, Sophie M C, MacKenzie, Mairead, Taylor, David G, Smith, Samuel G, Cuzick, Jack, Balkwill, Frances, Bishop, Tim, Burn, John, Chan, Andrew T, Crooks, Colin, Hawkey, Chris, Langley, Ruth, McKenzie, Mairead, Nedjai, Belinda, Patrignani, Paola, Patrono, Carlo, Rocca, Bianca, Smith, Samuel, Greaves, Laura

“…ObjectivesAspirin could be offered for colorectal cancer prevention for the UK general population. To ensure the views of the general population are considered…”
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Spectrum, risk factors and outcomes of neurological and psychiatric complications of COVID-19: a UK-wide cross-sectional surveillance study by Ross Russell, Amy L, Hardwick, Marc, Jeyanantham, Athavan, White, Laura M, Deb, Saumitro, Burnside, Girvan, Joy, Harriet M, Smith, Craig J, Pollak, Thomas A, Nicholson, Timothy R, Davies, Nicholas W S, Manji, Hadi, Easton, Ava, Ray, Stephen, Zandi, Michael S, Coles, Jonathan P, Menon, David K, Varatharaj, Aravinthan, McCausland, Beth, Ellul, Mark A, Thomas, Naomi, Breen, Gerome, Keddie, Stephen, Lunn, Michael P, Burn, John P S, Quattrocchi, Graziella, Dixon, Luke, Rice, Claire M, Pengas, George, Al-Shahi Salman, Rustam, Carson, Alan, Joyce, Eileen M, Turner, Martin R, Benjamin, Laura A, Solomon, Tom, Kneen, Rachel, Pett, Sarah, Thomas, Rhys H, Michael, Benedict D, Galea, Ian

“…Abstract SARS-CoV-2 is associated with new-onset neurological and psychiatric conditions. Detailed clinical data, including factors associated with recovery,…”
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Mismatch repair deficiency testing in Lynch syndrome-associated urothelial tumors by Rasmussen, Maria, Sowter, Peter, Gallon, Richard, Durhuus, Jon Ambæk, Hayes, Christine, Andersen, Ove, Nilbert, Mef, Schejbel, Lone, Høgdall, Estrid, Santibanez-Koref, Mauro, Jackson, Michael S, Burn, John, Therkildsen, Christina

“…Lynch syndrome-associated cancer develops due to germline pathogenic variants in one of the mismatch repair (MMR) genes, , , or . Somatic second hits in tumors…”
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