Search Results - "John B. Porter"

The Pathophysiology of Transfusional Iron Overload by Porter, John B., MD, Garbowski, Maciej, MD

“…The pathophysiologic consequences of transfusional iron overload (TIO) as well as the benefits of iron chelation therapy are best described in thalassemia…”
Get full text

Intravenous iron preparations transiently generate non-transferrin-bound iron from two proposed pathways by Garbowski, Maciej W, Bansal, Sukhvinder, Porter, John B, Mori, Claudio, Burckhardt, Susanna, Hider, Robert C

“…Intravenous iron-carbohydrate complex preparations (IVIPs) are non-interchangeable pro-drugs: their pharmacokinetics (PK) varies determined by semi-crystalline…”
Get full text

On T2 Magnetic Resonance and Cardiac Iron by CARPENTER, John-Paul, TAIGANG HE, GALANELLO, Renzo, FORNI, Gianluca, CATANI, Gualtiero, MATTA, Gildo, FUCHAROEN, Suthat, FLEMING, Adam, HOUSE, Michael J, BLACK, Greg, FIRMIN, David N, PIERRE, Timothy G. St, KIRK, Paul, PENNELL, Dudley J, ROUGHTON, Michael, ANDERSON, Lisa J, DE NORONHA, Sofia V, SHEPPARD, Mary N, PORTER, John B, WALKER, J. Malcolm, WOOD, John C

“…Measurement of myocardial iron is key to the clinical management of patients at risk of siderotic cardiomyopathy. The cardiovascular magnetic resonance…”
Get full text

Phytosterol, Lipid and Phenolic Composition, and Biological Activities of Guava Seed Oil by Prommaban, Adchara, Utama-Ang, Niramon, Chaikitwattana, Anan, Uthaipibull, Chairat, Porter, John B, Srichairatanakool, Somdet

“…Plant seeds have been found to contain bioactive compounds that have potential nutraceutical benefits. Guava seeds ( ) are by-products in the beverage and…”
Get full text

Anti-Platelet Aggregation and Anti-Cyclooxygenase Activities for a Range of Coffee Extracts ( Coffea arabica ) by Hutachok, Nuntouchaporn, Angkasith, Pongsak, Chumpun, Chaiwat, Fucharoen, Suthat, Mackie, Ian J, Porter, John B, Srichairatanakool, Somdet

“…Coffee is rich in caffeine (CF), chlorogenic acid (CGA) and phenolics. Differing types of coffee beverages and brewing procedures may result in differences in…”
Get full text

Effects of green tea extract treatment on erythropoiesis and iron parameters in iron-overloaded β-thalassemic mice by Settakorn, Kornvipa, Kongkarnka, Sarawut, Chompupoung, Anchan, Svasti, Saovaros, Fucharoen, Suthat, Porter, John B, Srichairatanakool, Somdet, Koonyosying, Pimpisid

“…β-Thalassemia is characterized by ineffective erythropoiesis leading to chronic anemia. Thus, increased iron absorption from the duodenum and via blood…”
Get full text

Iron overload across the spectrum of non‐transfusion‐dependent thalassaemias: role of erythropoiesis, splenectomy and transfusions by Porter, John B., Cappellini, Maria Domenica, Kattamis, Antonis, Viprakasit, Vip, Musallam, Khaled M., Zhu, Zewen, Taher, Ali T.

“…Summary Non‐transfusion‐dependent thalassaemias (NTDT) encompass a spectrum of anaemias rarely requiring blood transfusions. Increased iron absorption, driven…”
Get full text

Extracts of Thai Perilla frutescens nutlets attenuate tumour necrosis factor-α-activated generation of microparticles, ICAM-1 and IL-6 in human endothelial cells by Paradee, Narisara, Utama-Ang, Niramon, Uthaipibull, Chairat, Porter, John B, Garbowski, Maciej W, Srichairatanakool, Somdet

“…Elevation of endothelial microparticles (EMPs) play an important role in the progression of inflammation-related vascular diseases such as cardiovascular…”
Get full text

Real-time national survey of COVID-19 in hemoglobinopathy and rare inherited anemia patients by Telfer, Paul, De la Fuente, Josu, Sohal, Mamta, Brown, Ralph, Eleftheriou, Perla, Roy, Noémi, Piel, Frédéric B, Chakravorty, Subarna, Gardner, Kate, Velangi, Mark, Drasar, Emma, Shah, Farrukh, Porter, John B, Trompeter, Sara, Atoyebi, Wale, Szydlo, Richard, Anie, Kofi A, Ryan, Kate, Sharif, Joseph, Wright, Josh, Astwood, Emma, Nicolle, C Sarah, Webster, Amy, Roberts, David J, Lugthart, Sanne, Kaya, Banu, Awogbade, Moji, Rees, David C, Hollingsworth, Rob, Inusa, Baba, Howard, Jo, Layton, D Mark

Get full text

Residual erythropoiesis protects against myocardial hemosiderosis in transfusion-dependent thalassemia by lowering labile plasma iron via transient generation of apotransferrin by Garbowski, Maciej W, Evans, Patricia, Vlachodimitropoulou, Evangelia, Hider, Robert, Porter, John B

“…Cardiosiderosis is a leading cause of mortality in transfusion-dependent thalassemias. Plasma non-transferrin-bound iron and its redox-active component, labile…”
Get full text

Interaction of Transfusion and Iron Chelation in Thalassemias by Porter, John B., MA, MD, FRCP, FRCPath, Garbowski, Maciej W., MD, PhD

“…The relationship between blood transfusion intensity, chelatable iron pools, and extrahepatic iron distribution is described in thalassemia. Risk factors for…”
Get full text

Deferasirox for up to 3 years leads to continued improvement of myocardial T2 in patients with β-thalassemia major by PENNELL, Dudley J, PORTER, John B, KATTAMIS, Antonis, SMITH, Gillian, HABR, Dany, DOMOKOS, Gabor, ROUBERT, Bernard, TAHER, Ali, DOMENICA CAPPELLINI, Maria, LEE LEE CHAN, EL-BESHLAWY, Amal, AYDINOK, Yesim, IBRAHIM, Hishamshah, LI, Chi-Kong, VIPRAKASIT, Vip, ELALFY, Mohsen S

“…Prospective data on cardiac iron removal are limited beyond one year and longer-term studies are, therefore, important. Seventy-one patients in the EPIC…”
Get full text

Second international round robin for the quantification of serum non-transferrin-bound iron and labile plasma iron in patients with iron-overload disorders by de Swart, Louise, Hendriks, Jan C M, van der Vorm, Lisa N, Cabantchik, Z Ioav, Evans, Patricia J, Hod, Eldad A, Brittenham, Gary M, Furman, Yael, Wojczyk, Boguslaw, Janssen, Mirian C H, Porter, John B, Mattijssen, Vera E J M, Biemond, Bart J, MacKenzie, Marius A, Origa, Raffaella, Galanello, Renzo, Hider, Robert C, Swinkels, Dorine W

“…Non-transferrin-bound iron and its labile (redox active) plasma iron component are thought to be potentially toxic forms of iron originally identified in the…”
Get full text

Genetic and Clinical Heterogeneity in Thirteen New Cases with Aceruloplasminemia. Atypical Anemia as a Clue for an Early Diagnosis by Vila Cuenca, Marc, Marchi, Giacomo, Barqué, Anna, Esteban-Jurado, Clara, Marchetto, Alessandro, Giorgetti, Alejandro, Chelban, Viorica, Houlden, Henry, Wood, Nicholas W, Piubelli, Chiara, Dorigatti Borges, Marina, Martins de Albuquerque, Dulcinéia, Yotsumoto Fertrin, Kleber, Jové-Buxeda, Ester, Sanchez-Delgado, Jordi, Baena-Díez, Neus, Burnyte, Birute, Utkus, Algirdas, Busti, Fabiana, Kaubrys, Gintaras, Suku, Eda, Kowalczyk, Kamil, Karaszewski, Bartosz, Porter, John B, Pollard, Sally, Eleftheriou, Perla, Bignell, Patricia, Girelli, Domenico, Sanchez, Mayka

“…Aceruloplasminemia is a rare autosomal recessive genetic disease characterized by mild microcytic anemia, diabetes, retinopathy, liver disease, and progressive…”
Get full text

Patient-reported outcomes from a randomized phase II study of the deferasirox film-coated tablet in patients with transfusion-dependent anemias by Taher, Ali T, Origa, Raffaella, Perrotta, Silverio, Kouraklis, Alexandra, Ruffo, Giovan Battista, Kattamis, Antonis, Goh, Ai-Sim, Huang, Vicky, Zia, Aiesha, Herranz, Raquel Merino, Porter, John B

“…Adherence to long-term chelation therapy in transfusion-dependent patients is critical to prevent iron overload-related complications. Once-daily deferasirox…”
Get full text

Untreated Anemia in Nontransfusion‐dependent β‐thalassemia: Time to Sound the Alarm by Musallam, Khaled M., Taher, Ali T., Cappellini, Maria Domenica, Hermine, Olivier, Kuo, Kevin H. M., Sheth, Sujit, Viprakasit, Vip, Porter, John B.

Get full text

The challenges of adherence and persistence with iron chelation therapy by Porter, John B., Evangeli, Michael, El-Beshlawy, Amal

“…Due to advances in medical sciences, many chronic diseases that formerly resulted in early death can now be effectively managed with long-term treatment…”
Get full text

Utility of labile plasma iron and transferrin saturation in addition to serum ferritin as iron overload markers in different underlying anemias before and after deferasirox treatment by Porter, John B., El-Alfy, Mohsen, Viprakasit, Vip, Giraudier, Stephane, Chan, Lee Lee, Lai, Yongrong, El-Ali, Ali, Han, Jackie, Cappellini, Maria D.

“…Objectives Plasma markers in addition to serum ferritin (SF) may be useful for the assessment of iron overload; however, predictive utility may differ…”
Get full text

Guidelines on red cell transfusion in sickle cell disease Part II: indications for transfusion by Davis, Bernard A, Allard, Shubha, Qureshi, Amrana, Porter, John B, Pancham, Shivan, Win, Nay, Cho, Gavin, Ryan, Kate

Get full text

Nature of non-transferrin-bound iron: studies on iron citrate complexes and thalassemic sera by Evans, Robert W., Rafique, Roozina, Zarea, Adel, Rapisarda, Chiara, Cammack, Richard, Evans, Patricia J., Porter, John B., Hider, Robert C.

“…Despite its importance in iron-overload diseases, little is known about the composition of plasma non-transferrin-bound iron (NTBI). Using 30-kDa…”
Get full text