Search Results - "John A. Denman"

l-Leucine as an excipient against moisture on in vitro aerosolization performances of highly hygroscopic spray-dried powders by Li, Liang, Sun, Siping, Parumasivam, Thaigarajan, Denman, John A., Gengenbach, Thomas, Tang, Patricia, Mao, Shirui, Chan, Hak-Kim

“…[Display omitted] l-Leucine (LL) has been widely used to enhance the dispersion performance of powders for inhalation. LL can also protect powders against…”
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Protection of hydrophobic amino acids against moisture-induced deterioration in the aerosolization performance of highly hygroscopic spray-dried powders by Yu, Jiaqi, Chan, Hak-Kim, Gengenbach, Thomas, Denman, John A.

“…[Display omitted] Inhalable particles containing amorphous form of drugs or excipients may absorb atmospheric moisture, causing powder aggregation and…”
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Chemical nature of alkaline polyphosphate boundary film at heated rubbing surfaces by Wan, Shanhong, Tieu, A. Kiet, Zhu, Qiang, Zhu, Hongtao, Cui, Shaogang, Mitchell, David R. G., Kong, Charlie, Cowie, Bruce, Denman, John A., Liu, Rong

“…Alkaline polyphosphate has been demonstrated to be able to reduce significant wear and friction of sliding interfaces under heavy loads (>1 GPa) and elevated…”
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Influence of coating material on the flowability and dissolution of dry-coated fine ibuprofen powders by Qu, Li, Zhou, Qi (Tony), Denman, John A., Stewart, Peter J., Hapgood, Karen P., Morton, David A.V.

“…[Display omitted] This study investigates the effects of a variety of coating materials on the flowability and dissolution of dry-coated cohesive ibuprofen…”
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Characterization of chemoselective surface attachment of the cationic peptide melimine and its effects on antimicrobial activity by Chen, Renxun, Willcox, Mark D.P., Cole, Nerida, Ho, Kitty K.K., Rasul, Riaz, Denman, John A., Kumar, Naresh

“…Antimicrobial peptides (AMPs) are promising alternatives to current treatments for bacterial infections. However, our understanding of the…”
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Discrimination of pencil markings on paper using elemental analysis: An initial investigation by Denman, John A, Kempson, Ivan M, Skinner, William M, Kirkbride, K. Paul

“…Abstract The characterisation and comparison of pencil markings on paper is an area of questioned document analysis that has previously not received much…”
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The Vroman effect: Competitive protein exchange with dynamic multilayer protein aggregates by Hirsh, Stacey L., McKenzie, David R., Nosworthy, Neil J., Denman, John A., Sezerman, Osman U., Bilek, Marcela M.M.

“…[Display omitted] ► We establish that competitive protein exchange on surfaces (“Vroman effect”) can occur through the turning of multilayer protein…”
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Co-spray drying of hygroscopic kanamycin with the hydrophobic drug rifampicin to improve the aerosolization of kanamycin powder for treating respiratory infections by Momin, Mohammad A.M., Tucker, Ian G., Doyle, Colin S., Denman, John A., Sinha, Shubhra, Das, Shyamal C.

“…[Display omitted] High dose delivery of drugs to the lung using a dry powder inhaler (DPI) is an emerging approach to combat drug-resistant local infections…”
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Manipulation of spray-drying conditions to develop dry powder particles with surfaces enriched in hydrophobic material to achieve high aerosolization of a hygroscopic drug by Momin, Mohammad A.M., Tucker, Ian G., Doyle, Colin S., Denman, John A., Das, Shyamal C.

“…[Display omitted] This study aimed to develop dry powder particles with surfaces enriched in hydrophobic material by manipulation of spray-drying conditions…”
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The Adsorption of n-Octanohydroxamate Collector on Cu and Fe Oxide Minerals Investigated by Static Secondary Ion Mass Spectrometry by Alan N. Buckley, John A. Denman, Gregory A. Hope

“…The feasibility of investigating the adsorption of n-octanohydroxamate collector on copper and iron oxide minerals with static secondary ion mass spectrometry…”
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Synergistic Antibiotic Combination Powders of Colistin and Rifampicin Provide High Aerosolization Efficiency and Moisture Protection by Zhou, Qi (Tony), Gengenbach, Thomas, Denman, John A., Yu, Heidi H., Li, Jian, Chan, Hak Kim

“…For many respiratory infections caused by multidrug-resistant Gram-negative bacteria, colistin is the only effective antibiotic despite its nephrotoxicity. A…”
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Composite particle formulations of colistin and meropenem with improved in-vitro bacterial killing and aerosolization for inhalation by Mangal, Sharad, Park, Heejun, Zeng, Lingfei, Yu, Heidi H., Lin, Yu-wei, Velkov, Tony, Denman, John A., Zemlyanov, Dmitry, Li, Jian, Zhou, Qi (Tony)

“…[Display omitted] Antibiotic combination therapy is promising for the treatment of lower respiratory tract infections caused by multi-drug resistant…”
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How Much Surface Coating of Hydrophobic Azithromycin Is Sufficient to Prevent Moisture-Induced Decrease in Aerosolisation of Hygroscopic Amorphous Colistin Powder? by Zhou, Qi (Tony), Loh, Zhi Hui, Yu, Jiaqi, Sun, Si-ping, Gengenbach, Thomas, Denman, John A., Li, Jian, Chan, Hak-Kim

“…ABSTRACT Aerosolisation performance of hygroscopic particles of colistin could be compromised at elevated humidity due to increased capillary forces. Co-spray…”
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A novel dry powder inhalable formulation incorporating three first-line anti-tubercular antibiotics by Chan, John Gar Yan, Chan, Hak-Kim, Prestidge, Clive A., Denman, John A., Young, Paul M., Traini, Daniela

“…Treatment for tuberculosis (TB) using the standard oral antibiotic regimen is effective but inefficient, requiring high drug dosing and lengthy treatment…”
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Effects of Surface Composition on the Aerosolisation and Dissolution of Inhaled Antibiotic Combination Powders Consisting of Colistin and Rifampicin by Wang, Wenbo, Zhou, Qi Tony, Sun, Si-Ping, Denman, John A., Gengenbach, Thomas R., Barraud, Nicolas, Rice, Scott A., Li, Jian, Yang, Mingshi, Chan, Hak-Kim

“…ABSTRACT Colistin is often the only effective antibiotic against the respiratory infections caused by multidrug-resistant Gram-negative bacteria. However,…”
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Investigation of the potential for direct compaction of a fine ibuprofen powder dry-coated with magnesium stearate by Qu, Li, Zhou, Qi (Tony), Gengenbach, Thomas, Denman, John A., Stewart, Peter J., Hapgood, Karen P., Gamlen, Michael, Morton, David A. V.

“…Abstract Intensive dry powder coating (mechanofusion) with tablet lubricants has previously been shown to give substantial powder flow improvement. This study…”
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Characterization of the surface properties of a model pharmaceutical fine powder modified with a pharmaceutical lubricant to improve flow via a mechanical dry coating approach by Zhou, Qi Tony, Denman, John A, Gengenbach, Thomas, Das, Shyamal, Qu, Li, Zhang, Hailong, Larson, Ian, Stewart, Peter J, Morton, David A V

“…The aim of this study is to investigate the changes in physical and chemical surface properties of a fine lactose powder, which has been processed by a…”
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Organic and inorganic discrimination of ballpoint pen inks by ToF-SIMS and multivariate statistics by Denman, John A., Skinner, William M., Kirkbride, K. Paul, Kempson, Ivan M.

“…Surface analysis by ToF-SIMS analysis of ballpoint pen ink markings was performed for discrimination. ToF-SIMS provided non-destructive analysis of ink's…”
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Investigation of the extent of surface coating via mechanofusion with varying additive levels and the influences on bulk powder flow properties by Zhou, Qi (Tony), Qu, Li, Gengenbach, Thomas, Denman, John A., Larson, Ian, Stewart, Peter J., Morton, David A.V.

“…The objective of this study was to investigate if the coating extent created by a mechanofusion process corresponded with observed changes in bulk powder…”
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Robust and Flexible Fabrication of Chemical Micropatterns for Tumor Spheroid Preparation by Liu, Tianqing, Yang, Chih-Tsung, Dieguez, Lorena, Denman, John A, Thierry, Benjamin

“…A robust and flexible approach is described for the straightforward preparation of multicellular tumor spheroids of controllable dimensions. The approach is…”
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