Search Results - "John, Varghese"

Behavioral Deficits and Brain α-Synuclein and Phosphorylated Serine-129 α-Synuclein in Male and Female Mice Overexpressing Human α-Synuclein by Gabrielyan, Lilit, Liang, Honghui, Minalyan, Artem, Hatami, Asa, John, Varghese, Wang, Lixin

“…Alpha-synuclein (α-syn) is involved in pathology of Parkinson's disease, and 90% of α-syn in Lewy bodies is phosphorylated at serine 129 (pS129 α-syn). To…”
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Multi-Omics Analysis of Microglial Extracellular Vesicles From Human Alzheimer's Disease Brain Tissue Reveals Disease-Associated Signatures by Cohn, Whitaker, Melnik, Mikhail, Huang, Calvin, Teter, Bruce, Chandra, Sujyoti, Zhu, Chunni, McIntire, Laura Beth, John, Varghese, Gylys, Karen H, Bilousova, Tina

“…Alzheimer's disease (AD) is the most common cause of dementia, yet there is no cure or diagnostics available prior to the onset of clinical symptoms…”
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Exosomal tau with seeding activity is released from Alzheimer's disease synapses, and seeding potential is associated with amyloid beta by Miyoshi, Emily, Bilousova, Tina, Melnik, Mikhail, Fakhrutdinov, Danyl, Poon, Wayne W., Vinters, Harry V., Miller, Carol A., Corrada, Maria, Kawas, Claudia, Bohannan, Ryan, Caraway, Chad, Elias, Chris, Maina, Katherine N., Campagna, Jesus J., John, Varghese, Gylys, Karen Hoppens

“…Synaptic transfer of tau has long been hypothesized from the human pathology pattern and has been demonstrated in vitro and in vivo, but the precise mechanisms…”
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Integrated Multiomics Analysis of Salivary Exosomes to Identify Biomarkers Associated with Changes in Mood States and Fatigue by Cohn, Whitaker, Zhu, Chunni, Campagna, Jesus, Bilousova, Tina, Spilman, Patricia, Teter, Bruce, Li, Feng, Guo, Rong, Elashoff, David, Cole, Greg M, Avidan, Alon, Faull, Kym Francis, Whitelegge, Julian, Wong, David T W, John, Varghese

“…Fatigue and other deleterious mood alterations resulting from prolonged efforts such as a long work shift can lead to a decrease in vigilance and cognitive…”
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Sustainability and inclusiveness in a competitive market: A study of faith-based hospitals in India by Thekkekara, John Varghese

“…Introduction: The Christian Healthcare Network is the largest faith-based healthcare network in India, functioning, most often, in the hard-to-reach and…”
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Laminar burning velocities of LCV syngas-air mixtures at high temperature and pressure conditions by John Varghese, Robin, Kumar, Sudarshan

“…•Burning velocities of LCV syngas-air at elevated pressures and temperatures.•A modified power-law correlation for burning velocity is proposed.•Effect of…”
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Pharmacological inhibition of nSMase2 reduces brain exosome release and α-synuclein pathology in a Parkinson's disease model by Zhu, Chunni, Bilousova, Tina, Focht, Samantha, Jun, Michael, Elias, Chris Jean, Melnik, Mikhail, Chandra, Sujyoti, Campagna, Jesus, Cohn, Whitaker, Hatami, Asa, Spilman, Patricia, Gylys, Karen Hoppens, John, Varghese

“…We have previously reported that cambinol (DDL-112), a known inhibitor of neutral sphingomyelinase-2 (nSMase2), suppressed extracellular vesicle (EV)/exosome…”
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Human beta-secretase (BACE) and BACE inhibitors: progress report by John, Varghese

“…A key step in the processing of the integral membrane protein APP, or Amyloid Precursor Protein is through the proteolytic cleavage by the enzyme…”
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Designing Physical Human-Robot Interaction Interfaces: A Scalable Method for Simulation Based Design by John Varghese, Rohit, Mukherjee, Gaurav, Deshpande, Ashish

“…Designing the physical coupling between the human body and the wearable robot is a challenging endeavor. The typical approach of tightening the wearable robot…”
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Mechanism of bisphosphonate-related osteonecrosis of the jaw (BRONJ) revealed by targeted removal of legacy bisphosphonate from jawbone using competing inert hydroxymethylene diphosphonate by Okawa, Hiroko, Kondo, Takeru, Hokugo, Akishige, Cherian, Philip, Campagna, Jesus J, Lentini, Nicholas A, Sung, Eric C, Chiang, Samantha, Lin, Yi-Ling, Ebetino, Frank H, John, Varghese, Sun, Shuting, McKenna, Charles E, Nishimura, Ichiro

“…Bisphosphonate-related osteonecrosis of the jaw (BRONJ) presents as a morbid jawbone lesion in patients exposed to a nitrogen-containing bisphosphonate (N-BP)…”
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Next generation therapeutics for Alzheimer's disease by Bredesen, Dale E., John, Varghese

“…To date, no truly effective therapy has been developed for Alzheimer's disease or mild cognitive impairment. In searching for new approaches that may succeed…”
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B187 Successful outcome of spinal anaesthesia in a patient with a history of scorpion sting and failed spinal anaesthesia by John Varghese, R, Dhulkhed, V

“…Background and AimsScorpion stings can cause failure of spinal anaesthesia(1). We report a case of successful spinal anaesthesia with bupivacaine laced with…”
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Neuroprotective Sirtuin ratio reversed by ApoE4 by Theendakara, Veena, Patent, Alexander, Libeu, Clare A. Peters, Philpot, Brittany, Flores, Sonia, Descamps, Olivier, Poksay, Karen S., Zhang, Qiang, Cailing, Gabriellee, Hart, Matthew, John, Varghese, Rao, Rammohan V., Bredesen, Dale E.

“…The canonical pathogenesis of Alzheimer’s disease links the expression of apolipoprotein E ε4 allele (ApoE) to amyloid precursor protein (APP) processing and…”
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A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer’s disease mouse model by Campagna, Jesus, Spilman, Patricia, Jagodzinska, Barbara, Bai, Dongsheng, Hatami, Asa, Zhu, Chunni, Bilousova, Tina, Jun, Michael, Elias, Chris Jean, Pham, Johnny, Cole, Gregory, LaDu, Mary Jo, Jung, Michael E., Bredesen, Dale E., John, Varghese

“…We describe here the results from the testing of a small molecule first-in-class apolipoprotein E4 (ApoE4)-targeted sirtuin1 (SirT1) enhancer, A03, that…”
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Correction to: Pharmacological inhibition of nSMase2 reduces brain exosome release and α-synuclein pathology in a Parkinson’s disease model by Zhu, Chunni, Bilousova, Tina, Focht, Samantha, Jun, Michael, Elias, Chris Jean, Melnik, Mikhail, Chandra, Sujyoti, Campagna, Jesus, Cohn, Whitaker, Hatami, Asa, Spilman, Patricia, Gylys, Karen Hoppens, John, Varghese

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Bayesian tuned kinetic Monte Carlo modeling of polystyrene pyrolysis: Unraveling the pathways to its monomer, dimers, and trimers formation by Dogu, Onur, Eschenbacher, Andreas, John Varghese, Robin, Dobbelaere, Maarten, D'hooge, Dagmar R., Van Steenberge, Paul H.M., Van Geem, Kevin M.

“…•A kMC model is presented for the pyrolysis of polydisperse low-molar mass PS.•In-house Bayesian optimization tool allowed to fine-tune the rate…”
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Strongyloides stercoralis hyperinfection syndrome by Jacob, Lemna, Basu, Ayan, Paul, Dipankar, Ray, Yogiraj, Begam, Nazneen Nahar, John, Christy Varghese

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Selective catalytic conversion of model olefin and diolefin compounds of waste plastic pyrolysis oil: Insights for light olefin production and coke minimization by Goshayeshi, Bahman, Alexandros Theofanidis, Stavros, Abbas-Abadi, Mehrdad Seifali, Mahmoudi, Ehsan, Akin, Oguzhan, John Varghese, Robin, Lemonidou, Angeliki, Van Geem, Kevin M.

“…[Display omitted] •Examined the catalytic cracking of model compounds 1-decene and 1,9-decadiene.•Steam treatment reduces Brønsted acid sites in HZSM-5…”
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High-throughput screening identifies modulators of sarcospan that stabilize muscle cells and exhibit activity in the mouse model of Duchenne muscular dystrophy by Shu, Cynthia, Parfenova, Liubov, Mokhonova, Ekaterina, Collado, Judd R, Damoiseaux, Robert, Campagna, Jesus, John, Varghese, Crosbie, Rachelle H

“…Duchenne muscular dystrophy (DMD) is a degenerative muscle disease caused by mutations in the dystrophin gene. Loss of dystrophin prevents the formation of a…”
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Nanoscale Extracellular Vesicle Analysis in Alzheimer’s Disease Diagnosis and Therapy by John, Varghese, Campagna, Jesus, Bilousova, Tina, Heinzelman, Pete

“…Diagnostic assays that leverage bloodborne neuron-derived (neuronal) nanoscale extracellular vesicles (nsEVs) as “windows into the brain” can predict incidence…”
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