Search Results - "John, Sumi Elsa"

SARS-CoV-2: Possible recombination and emergence of potentially more virulent strains by Haddad, Dania, John, Sumi Elsa, Mohammad, Anwar, Hammad, Maha M, Hebbar, Prashantha, Channanath, Arshad, Nizam, Rasheeba, Al-Qabandi, Sarah, Al Madhoun, Ashraf, Alshukry, Abdullah, Ali, Hamad, Thanaraj, Thangavel Alphonse, Al-Mulla, Fahd

“…COVID-19 is challenging healthcare preparedness, world economies, and livelihoods. The infection and death rates associated with this pandemic are strikingly…”
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Identification of Maturity-Onset-Diabetes of the Young (MODY) mutations in a country where diabetes is endemic by Al-Kandari, Hessa, Al-Abdulrazzaq, Dalia, Davidsson, Lena, Nizam, Rasheeba, Jacob, Sindhu, Melhem, Motasem, John, Sumi Elsa, Al-Mulla, Fahd

“…Genetic variants responsible for Maturity-Onset-Diabetes of the Young (MODY) in Kuwait were investigated. A newly established a National Referral Clinic, the…”
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Genome-wide association study identifies novel recessive genetic variants for high TGs in an Arab population by Hebbar, Prashantha, Nizam, Rasheeba, Melhem, Motasem, Alkayal, Fadi, Elkum, Naser, John, Sumi Elsa, Tuomilehto, Jaakko, Alsmadi, Osama, Thanaraj, Thangavel Alphonse

“…Abnormal blood lipid levels are influenced by genetic and lifestyle/dietary factors. Although many genetic variants associated with blood lipid traits have…”
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Genetic substructure of Kuwaiti population reveals migration history by Alsmadi, Osama, Thareja, Gaurav, Alkayal, Fadi, Rajagopalan, Ramakrishnan, John, Sumi Elsa, Hebbar, Prashantha, Behbehani, Kazem, Thanaraj, Thangavel Alphonse

“…The State of Kuwait is characterized by settlers from Saudi Arabia, Iran, and other regions of the Arabian Peninsula. The settlements and subsequent admixtures…”
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Genome-wide landscape establishes novel association signals for metabolic traits in the Arab population by Hebbar, Prashantha, Abubaker, Jehad Ahmed, Abu-Farha, Mohamed, Alsmadi, Osama, Elkum, Naser, Alkayal, Fadi, John, Sumi Elsa, Channanath, Arshad, Iqbal, Rasheeba, Pitkaniemi, Janne, Tuomilehto, Jaakko, Sladek, Robert, Al-Mulla, Fahd, Thanaraj, Thangavel Alphonse

“…While the Arabian population has a high prevalence of metabolic disorders, it has not been included in global studies that identify genetic risk loci for…”
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Linkage analysis using whole exome sequencing data implicates SLC17A1, SLC17A3, TATDN2 and TMEM131L in type 1 diabetes in Kuwaiti families by Hebbar, Prashantha, Nizam, Rasheeba, John, Sumi Elsa, Antony, Dinu, Dashti, Mohammad, Channanath, Arshad, Shaltout, Azza, Al-Khandari, Hessa, Koistinen, Heikki A., Tuomilehto, Jaakko, Alsmadi, Osama, Thanaraj, Thangavel Alphonse, Al-Mulla, Fahd

“…Type 1 diabetes (T1D) is characterized by the progressive destruction of pancreatic β-cells, leading to insulin deficiency and lifelong dependency on exogenous…”
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Differentially methylated and expressed genes in familial type 1 diabetes by Dashti, Mohammed, Nizam, Rasheeba, Hebbar, Prashantha, Jacob, Sindhu, John, Sumi Elsa, Channanath, Arshad, Al-Kandari, Hessa, Thanaraj, Thangavel Alphonse, Al-Mulla, Fahd

“…There has recently been a growing interest in examining the role of epigenetic modifications, such as DNA methylation, in the etiology of type 1 diabetes…”
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Genetic risk variants for metabolic traits in Arab populations by Hebbar, Prashantha, Elkum, Naser, Alkayal, Fadi, John, Sumi Elsa, Thanaraj, Thangavel Alphonse, Alsmadi, Osama

“…Despite a high prevalence of metabolic trait related diseases in Arabian Peninsula, there is a lack of convincingly identified genetic determinants for…”
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Mitochondrial haplogroup R offers protection against obesity in Kuwaiti and Qatari populations by Dashti, Mohammed, Ali, Naser M, Alsaleh, Hussain, John, Sumi Elsa, Nizam, Rasheeba, Al-Mulla, Fahd, Thanaraj, Thangavel Alphonse

“…The Kuwaiti and Qatari populations have a high prevalence of obesity, a major risk factor for various metabolic disorders. Previous studies have independently…”
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Prognostic Genetic Markers for Thrombosis in COVID-19 Patients: A Focused Analysis on D-Dimer, Homocysteine and Thromboembolism by Abu-Farha, Mohamed, Al-Sabah, Salman, Hammad, Maha M, Hebbar, Prashantha, Channanath, Arshad Mohamed, John, Sumi Elsa, Taher, Ibrahim, Almaeen, Abdulrahman, Ghazy, Amany, Mohammad, Anwar, Abubaker, Jehad, Arefanian, Hossein, Al-Mulla, Fahd, Thanaraj, Thangavel Alphonse

“…COVID-19 is caused by Severe Acute Respiratory Syndrome Coronavirus-2, which has infected over thirty eight million individuals worldwide. Emerging evidence…”
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ONECUT1 variants beyond type 1 and type 2 diabetes: exploring clinical diversity and epigenetic associations in Arab cohorts by Dashti, Mohammed, Nizam, Rasheeba, John, Sumi Elsa, Melhem, Motasem, Channanath, Arshad, Alkandari, Hessa, Thanaraj, Thangavel Alphonse, Al-Mulla, Fahd

“…gene, encoding hepatocyte nuclear factor 6, is involved in pancreas and liver development. mutations impair the function of pancreatic β-cells and control a…”
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Assessment of coding region variants in Kuwaiti population: implications for medical genetics and population genomics by John, Sumi Elsa, Antony, Dinu, Eaaswarkhanth, Muthukrishnan, Hebbar, Prashantha, Channanath, Arshad Mohamed, Thomas, Daisy, Devarajan, Sriraman, Tuomilehto, Jaakko, Al-Mulla, Fahd, Alsmadi, Osama, Thanaraj, Thangavel Alphonse

“…Consanguineous populations of the Arabian Peninsula have been underrepresented in global efforts that catalogue human exome variability. We sequenced 291 whole…”
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Genome-wide association study identifies novel risk variants from RPS6KA1, CADPS, VARS, and DHX58 for fasting plasma glucose in Arab population by Hebbar, Prashantha, Abu-Farha, Mohamed, Alkayal, Fadi, Nizam, Rasheeba, Elkum, Naser, Melhem, Motasem, John, Sumi Elsa, Channanath, Arshad, Abubaker, Jehad, Bennakhi, Abdullah, Al-Ozairi, Ebaa, Tuomilehto, Jaakko, Pitkaniemi, Janne, Alsmadi, Osama, Al-Mulla, Fahd, Thanaraj, Thangavel Alphonse

“…Consanguineous populations of the Arabian Peninsula, which has seen an uncontrolled rise in type 2 diabetes incidence, are underrepresented in global studies…”
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ACE2 and FURIN variants are potential predictors of SARS-CoV-2 outcome: A time to implement precision medicine against COVID-19 by Al-Mulla, Fahd, Mohammad, Anwar, Al Madhoun, Ashraf, Haddad, Dania, Ali, Hamad, Eaaswarkhanth, Muthukrishnan, John, Sumi Elsa, Nizam, Rasheeba, Channanath, Arshad, Abu-Farha, Mohamed, Ahmad, Rasheed, Abubaker, Jehad, Thanaraj, Thangavel Alphonse

“…The severity of the new COVID-19 pandemic caused by the SARS-CoV-2 virus is strikingly variable in different global populations. SARS-CoV-2 uses ACE2 as a cell…”
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Disruption in the regulation of casein kinase 2 in circadian rhythm leads to pathological states: cancer, diabetes and neurodegenerative disorders by Malik, Md Zubbair, Dashti, Mohammed, Fatima, Yasmin, Channanath, Arshad, John, Sumi Elsa, Singh, R K Brojen, Al-Mulla, Fahd, Thanaraj, Thangavel Alphonse

“…Circadian rhythm maintains the sleep-wake cycle in biological systems. Various biological activities are regulated and modulated by the circadian rhythm,…”
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Relevance between COVID-19 and host genetics of immune response by Taher, Ibrahim, Almaeen, Abdulrahman, Ghazy, Amany, Abu-Farha, Mohamed, Mohamed Channanath, Arshad, Elsa John, Sumi, Hebbar, Prashantha, Arefanian, Hossein, Abubaker, Jehad, Al-Mulla, Fahd, Alphonse Thanaraj, Thangavel

“…The outbreak of coronavirus disease 2019 (COVID-19) was caused by the newly emerged corona virus (2019-nCoV alias SARS-CoV-2) that resembles the severe acute…”
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Genetic variants associated with warfarin dosage in Kuwaiti population by John, Sumi Elsa, Antony, Dinu, Eaaswarkhanth, Muthukrishnan, Hebbar, Prashantha, Alkayal, Fadi, Tuomilehto, Jaakko, Alsmadi, Osama, Thanaraj, Thangavel Alphonse

“…Assessing the distinct prevalence or absence of genetic variants associated with differential response to the anticoagulant medication of warfarin in different…”
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Delineation of Mitochondrial DNA Variants From Exome Sequencing Data and Association of Haplogroups With Obesity in Kuwait by Dashti, Mohammed, Alsaleh, Hussain, Eaaswarkhanth, Muthukrishnan, John, Sumi Elsa, Nizam, Rasheeba, Melhem, Motasem, Hebbar, Prashantha, Sharma, Prem, Al-Mulla, Fahd, Thanaraj, Thangavel Alphonse

“…Whole-exome sequencing is a valuable tool to determine genetic variations that are associated with rare and common health conditions. A limited number of…”
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Genetic landscape and clinical outcomes of autosomal recessive polycystic kidney disease in Kuwait by Alhaddad, Mariam E., Mohammad, Anwar, Dashti, Khadija M., John, Sumi Elsa, Bahbahani, Yousif, Abu-Farha, Mohamed, Abubaker, Jehad, Thanaraj, Thangavel Alphonse, Bastaki, Laila, Al-Mulla, Fahd, Al-Ali, Mohammad, Ali, Hamad

“…Autosomal recessive polycystic kidney disease (ARPKD), a rare genetic disorder characterized by kidney cysts, shows complex clinical and genetic heterogeneity…”
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Kuwaiti population subgroup of nomadic Bedouin ancestry—Whole genome sequence and analysis by John, Sumi Elsa, Thareja, Gaurav, Hebbar, Prashantha, Behbehani, Kazem, Thanaraj, Thangavel Alphonse, Alsmadi, Osama

“…Kuwaiti native population comprises three distinct genetic subgroups of Persian, “city-dwelling” Saudi Arabian tribe, and nomadic “tent-dwelling” Bedouin…”
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