Search Results - "John, S D"

Nrf2 Deficiency Upregulates Intrarenal Angiotensin-Converting Enzyme-2 and Angiotensin 1-7 Receptor Expression and Attenuates Hypertension and Nephropathy in Diabetic Mice by Zhao, Shuiling, Ghosh, Anindya, Lo, Chao-Sheng, Chenier, Isabelle, Scholey, James W, Filep, Janos G, Ingelfinger, Julie R, Zhang, Shao-Ling, Chan, John S D

“…Abstract We investigated the role of nuclear factor erythroid 2–related factor 2 (Nrf2) in renin-angiotensin system (RAS) gene expression in renal proximal…”
Get full text

Comparative Analysis and Fusion of Spatiotemporal Information for Footstep Recognition by Vera-Rodriguez, R., Mason, J. S. D., Fierrez, J., Ortega-Garcia, J.

“…Footstep recognition is a relatively new biometric which aims to discriminate people using walking characteristics extracted from floor-based sensors. This…”
Get full text

Hedgehog interacting protein activates sodium–glucose cotransporter 2 expression and promotes renal tubular epithelial cell senescence in a mouse model of type 1 diabetes by Zhao, Xin-Ping, Chang, Shiao-Ying, Pang, Yuchao, Liao, Min-Chun, Peng, Junzheng, Ingelfinger, Julie R., Chan, John S. D., Zhang, Shao-Ling

“…Aims/hypothesis Senescent renal tubular cells may be linked to diabetic kidney disease (DKD)-related tubulopathy. We studied mice with or without diabetes in…”
Get full text

Deletion of heterogeneous nuclear ribonucleoprotein F in renal tubules downregulates SGLT2 expression and attenuates hyperfiltration and kidney injury in a mouse model of diabetes by Miyata, Kana N., Lo, Chao-Sheng, Zhao, Shuiling, Zhao, Xin-Ping, Chenier, Isabelle, Yamashita, Michifumi, Filep, Janos G., Ingelfinger, Julie R., Zhang, Shao-Ling, Chan, John S. D.

“…Aims/hypothesis We previously reported that renal tubule-specific deletion of heterogeneous nuclear ribonucleoprotein F ( Hnrnpf ) results in upregulation of…”
Get full text

AT2R deficiency in mice accelerates podocyte dysfunction in diabetic progeny in a sex-dependent manner by Liao, Min-Chun, Pang, Yu-Chao, Chang, Shiao-Ying, Zhao, Xin-Ping, Chenier, Isabelle, Ingelfinger, Julie R., Chan, John S. D., Zhang, Shao-Ling

“…Aims/hypothesis The angiotensin II receptor type 2 (AT 2 R) may be a potential therapeutic target for the treatment of hypertension and chronic kidney disease…”
Get full text

Attenuation of Interstitial Fibrosis and Tubular Apoptosis in db/db Transgenic Mice Overexpressing Catalase in Renal Proximal Tubular Cells by BREZNICEANU, Marie-Luise, FANG LIU, WEI, Chih-Chang, CHENIER, Isabelle, GODIN, Nicolas, ZHANG, Shao-Ling, FILEP, Janos G, INGELFINGER, Julie R, CHAN, John S. D

“…Attenuation of Interstitial Fibrosis and Tubular Apoptosis in db/db Transgenic Mice Overexpressing Catalase in Renal Proximal Tubular Cells Marie-Luise…”
Get full text

Reactive Oxygen Species Promote Caspase-12 Expression and Tubular Apoptosis in Diabetic Nephropathy by BREZNICEANU, Marie-Luise, LAU, Cara J, GODIN, Nicolas, CHENIER, Isabelle, DUCLOS, Alain, THIER, Jean E, FILEP, Janos G, INGELFINGER, Julie R, ZHANG, Shao-Ling, CHAN, John S. D

“…Apoptosis of tubular epithelial cells contributes to the tubular atrophy that accompanies diabetic nephropathy. Reactive oxygen species (ROS) promote tubular…”
Get full text

Heterogeneous Nuclear Ribonucleoprotein F Mediates Insulin Inhibition of Bcl2-Modifying Factor Expression and Tubulopathy in Diabetic Kidney by Ghosh, Anindya, Zhao, Shuiling, Lo, Chao-Sheng, Maachi, Hasna, Chenier, Isabelle, Lateef, Muhammad Abdul, Abdo, Shaaban, Filep, Janos G., Ingelfinger, Julie R., Zhang, Shao-Ling, Chan, John S. D.

“…We investigated the molecular mechanism(s) by which insulin prevents Bcl2-modifying factor (Bmf)-induced renal proximal tubular cell (RPTC) apoptosis and loss…”
Get full text

Heterogeneous Nuclear Ribonucleoprotein F Stimulates Sirtuin-1 Gene Expression and Attenuates Nephropathy Progression in Diabetic Mice by Lo, Chao-Sheng, Shi, Yixuan, Chenier, Isabelle, Ghosh, Anindya, Wu, Chin-Han, Cailhier, Jean-Francois, Ethier, Jean, Lattouf, Jean-Baptiste, Filep, Janos G, Ingelfinger, Julie R, Zhang, Shao-Ling, Chan, John S D

“…We investigated the mechanism of heterogeneous nuclear ribonucleoprotein F (hnRNP F) renoprotective action in a type 2 diabetes (T2D) mouse model ( / )…”
Get full text

Overexpression of Nrf2 in Renal Proximal Tubular Cells Stimulates Sodium-Glucose Cotransporter 2 Expression and Exacerbates Dysglycemia and Kidney Injury in Diabetic Mice by Zhao, Shuiling, Lo, Chao-Sheng, Miyata, Kana N, Ghosh, Anindya, Zhao, Xin-Ping, Chenier, Isabelle, Cailhier, Jean-Francois, Ethier, Jean, Lattouf, Jean-Baptiste, Filep, Janos G, Ingelfinger, Julie R, Zhang, Shao-Ling, Chan, John S D

“…We investigated the impact of nuclear factor erythroid 2-related factor 2 (Nrf2) overexpression in renal proximal tubular cells (RPTCs) on blood glucose,…”
Get full text

NRF2 Deficiency Attenuates Diabetic Kidney Disease in Db/Db Mice via Down-Regulation of Angiotensinogen, SGLT2, CD36, and FABP4 Expression and Lipid Accumulation in Renal Proximal Tubular Cells by Su, Ke, Zhao, Shui-Ling, Yang, Wen-Xia, Lo, Chao-Sheng, Chenier, Isabelle, Liao, Min-Chun, Pang, Yu-Chao, Peng, Jun-Zheng, Miyata, Kana N, Cailhier, Jean-Francois, Ethier, Jean, Lattouf, Jean-Baptiste, Filep, Janos G, Ingelfinger, Julie R, Zhang, Shao-Ling, Chan, John S. D

“…The role(s) of nuclear factor erythroid 2-related factor 2 (NRF2) in diabetic kidney disease (DKD) is/are controversial. We hypothesized that Nrf2 deficiency…”
Get full text

Overexpression of catalase prevents hypertension and tubulointerstitial fibrosis and normalization of renal angiotensin-converting enzyme-2 expression in Akita mice by Shi, Yixuan, Lo, Chao-Sheng, Chenier, Isabelle, Maachi, Hasna, Filep, Janos G, Ingelfinger, Julie R, Zhang, Shao-Ling, Chan, John S D

“…We investigated the relationship among oxidative stress, hypertension, renal injury, and angiotensin-converting enzyme-2 (ACE2) expression in type 1 diabetic…”
Get more information

Signal crayfish (Pacifastacus leniusculus) predation upon Atlantic salmon (Salmo salar) eggs by Findlay, John D. S, Riley, William D, Lucas, Martyn C

“…The signal crayfish (Pacifastacus leniusculus) is a large, polytrophic crustacean which has invaded waterways across much of Europe. Crayfish prey on the eggs…”
Get full text

Catalase overexpression prevents nuclear factor erythroid 2-related factor 2 stimulation of renal angiotensinogen gene expression, hypertension, and kidney injury in diabetic mice by Abdo, Shaaban, Shi, Yixuan, Otoukesh, Abouzar, Ghosh, Anindya, Lo, Chao-Sheng, Chenier, Isabelle, Filep, Janos G, Ingelfinger, Julie R, Zhang, Shao Ling, Chan, John S D

“…This study investigated the impact of catalase (Cat) overexpression in renal proximal tubule cells (RPTCs) on nuclear factor erythroid 2-related factor 2…”
Get full text

Systemic oxidative–nitrosative–inflammatory stress during acute exercise in hypoxia; implications for microvascular oxygenation and aerobic capacity by Woodside, John D. S., Gutowski, Mariusz, Fall, Lewis, James, Philip E., McEneny, Jane, Young, Ian S., Ogoh, Shigehiko, Bailey, Damian M.

“…New Findings What is the central question of this study? Exercise performance is limited during hypoxia by a critical reduction in cerebral and skeletal tissue…”
Get full text

Bcl-2―Modifying Factor Induces Renal Proximal Tubular Cell Apoptosis in Diabetic Mice by LAU, Garnet J, GODIN, Nicolas, ETHIER, Jean, FILEP, Janos G, INGELFINGER, Julie R, NAIR, Viji, KRETZLER, Matthias, COHEN, Clemens D, ZHANG, Shao-Ling, CHAN, John S. D, MAACHI, Hasna, LO, Chao-Sheng, WU, Shyh-Jong, ZHU, Jian-Xin, BREZNICEANU, Marie-Luise, CHENIER, Isabelle, FRAGASSO-MARQUIS, Joelle, LATTOUF, Jean-Baptiste

“…This study investigated the mechanisms underlying tubular apoptosis in diabetes by identifying proapoptotic genes that are differentially upregulated by…”
Get full text

Heterogeneous Nuclear Ribonucleoprotein F Suppresses Angiotensinogen Gene Expression and Attenuates Hypertension and Kidney Injury in Diabetic Mice by LO, Chao-Sheng, CHANGE, Shiao-Ying, CHENIER, Isabelle, FILEP, Janos G, INGELFINGER, Julie R, SHAO LING ZHANG, CHAN, John S. D

“…We investigated the impact of heterogeneous nuclear ribonucleoprotein F (hnRNP F) overexpression on angiotensinogen (Agt) gene expression, hypertension, and…”
Get full text

High Glucose Stimulates Angiotensinogen Gene Expression via Reactive Oxygen Species Generation in Rat Kidney Proximal Tubular Cells by Hsieh, Tusty-Jiuan, Zhang, Shao-Ling, Filep, Janos G, Tang, Shiow-Shih, Ingelfinger, Julie R, Chan, John S. D

“…The present studies investigated whether the effect of high glucose levels on angiotensinogen (ANG) gene expression in kidney proximal tubular cells is…”
Get full text

Advancing Discovery Research in Nephrology in Canada: A Conference Report From the 2021 Molecules and Mechanisms Mediating Kidney Health and Disease (M3K) Scientific Meeting and Investigator Summit by Burger, Dylan, Abdelrasoul, Amira, Alexander, R. Todd, Ballermann, Barbara, Bridgewater, Darren, Chan, John S. D., Cunanan, Joanna, Cybulsky, Andrey V., Gerarduzzi, Casimiro, Gunaratnam, Lakshman, Hartwig, Sunny, Kapus, Andras, Kennedy, Christopher R. J., Lamarche, Caroline, Myette, Robert L., Nmecha, Ifeanyi Kennedy, Stalker, Leanne, Szaszi, Katalin, Torban, Elena, Zhang, Shao Ling, Takano, Tomoko

“…Purpose of conference: New discoveries arising from investigations into fundamental aspects of kidney development and function in health and disease are…”
Get full text

Overexpression of Angiotensinogen Increases Tubular Apoptosis in Diabetes by FANG LIU, BREZNICEANU, Marie-Luise, WEI, Chih-Chang, CHENIER, Isabelle, SACHETELLI, Sébastien, ZHANG, Shao-Ling, FILEP, Janos G, INGELFINGER, Julie R, CHAN, John S. D

“…The intrarenal renin-angiotensin system (RAS) plays an important role in the progression of diabetic nephropathy. We have previously reported that mice…”
Get full text