Search Results - "John, P M"

Update on the pharmacology of selective inhibitors of MAO-A and MAO-B: Focus on modulation of CNS monoamine neurotransmitter release by FINBERG, John P. M

“…Inhibitors of monoamine oxidase (MAO) were initially used in medicine following the discovery of their antidepressant action. Subsequently their ability to…”
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TRPV4: Molecular Conductor of a Diverse Orchestra by White, John P M, Cibelli, Mario, Urban, Laszlo, Nilius, Bernd, McGeown, J Graham, Nagy, Istvan

“…Transient receptor potential vanilloid type 4 (TRPV4) is a calcium-permeable nonselective cation channel, originally described in 2000 by research teams led by…”
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Inhibitors of MAO-A and MAO-B in Psychiatry and Neurology by Finberg, John P M, Rabey, Jose M

“…Inhibitors of MAO-A and MAO-B are in clinical use for the treatment of psychiatric and neurological disorders respectively. Elucidation of the molecular…”
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The optic nerve head is the site of axonal transport disruption, axonal cytoskeleton damage and putative axonal regeneration failure in a rat model of glaucoma by Chidlow, Glyn, Ebneter, Andreas, Wood, John P. M., Casson, Robert J.

“…The neurodegenerative disease glaucoma is characterised by the progressive death of retinal ganglion cells (RGCs) and structural damage to the optic nerve…”
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A review of the mechanisms of cone degeneration in retinitis pigmentosa by Narayan, Daniel S., Wood, John P. M., Chidlow, Glyn, Casson, Robert J.

“…Retinitis pigmentosa (RP) is an inherited condition that features degeneration of rod and cone photoreceptors. In all forms of RP, the genetic mutation is…”
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Investigations into Hypoxia and Oxidative Stress at the Optic Nerve Head in a Rat Model of Glaucoma by Chidlow, Glyn, Wood, John P M, Casson, Robert J

“…The vascular hypothesis of glaucoma proposes that retinal ganglion cell axons traversing the optic nerve head (ONH) undergo oxygen and nutrient insufficiency…”
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Definition of glaucoma: clinical and experimental concepts by Casson, Robert J, Chidlow, Glyn, Wood, John PM, Crowston, Jonathan G, Goldberg, Ivan

“…Glaucoma is a term describing a group of ocular disorders with multi‐factorial etiology united by a clinically characteristic intraocular pressure‐associated…”
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Wolfram syndrome 1 gene regulates pathways maintaining beta-cell health and survival by Abreu, Damien, Asada, Rie, Revilla, John M. P., Lavagnino, Zeno, Kries, Kelly, Piston, David W., Urano, Fumihiko

“…Wolfram Syndrome 1 (WFS1) protein is an endoplasmic reticulum (ER) factor whose deficiency results in juvenile-onset diabetes secondary to cellular dysfunction…”
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Validation of temperature‐controlled rheo‐MRI measurements in a submillimeter‐gap Couette geometry by Milc, Klaudia W., Serial, Maria R., Philippi, John, Dijksman, Joshua A., Duynhoven, John P. M., Terenzi, Camilla

“…A temperature‐controlled submillimeter‐gap (500 μm) rheo‐magnetic resonance imaging (MRI) Couette cell has been developed to measure confined flow of soft…”
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Unravelling the effect of droplet size on lipid oxidation in O/W emulsions by using microfluidics by ten Klooster, Sten, Boerkamp, Vincent J. P., Hennebelle, Marie, van Duynhoven, John P. M., Schroën, Karin, Berton-Carabin, Claire C.

“…Lipid oxidation in emulsions is hypothesised to increase with decreasing droplet size, as this increases the specific oil–water interfacial area, where lipid…”
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Expression of inducible heat shock proteins Hsp27 and Hsp70 in the visual pathway of rats subjected to various models of retinal ganglion cell injury by Chidlow, Glyn, Wood, John P M, Casson, Robert J

“…Inducible heat shock proteins (Hsps) are upregulated in the central nervous system in response to a wide variety of injuries. Surprisingly, however, no…”
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Prognostic significance of tumor budding in rectal cancer biopsies before neoadjuvant therapy by Rogers, Ailín C, Gibbons, David, Hanly, Ann M, Hyland, John MP, O'Connell, P Ronan, Winter, Desmond C, Sheahan, Kieran

“…Tumor budding is an increasingly important prognostic feature for pathologists to recognize. The aim of this study was to correlate intra-tumoral budding in…”
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Systemic inflammation enhances surgery-induced cognitive dysfunction in mice by Fidalgo, António Rei, Cibelli, Mario, White, John P.M., Nagy, Istvan, Maze, Mervyn, Ma, Daqing

“…► LPS-induced inflammation causes hippocampal memory deficits. ► Tibia surgery induces systemic and central inflammation shown with IL-1β increase. ► A…”
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Differential Effects of Experimental Retinal Detachment on S- and M/L-Cones in Rats by Chidlow, Glyn, Chan, Weng Onn, Wood, John P. M., Casson, Robert J.

“…Retinal detachment is a vision-threatening condition, which occurs when the neurosensory retina is separated from its blood supply. The main purpose of this…”
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Assessment of PLSDA cross validation by Westerhuis, Johan A, Hoefsloot, Huub C. J, Smit, Suzanne, Vis, Daniel J, Smilde, Age K, van Velzen, Ewoud J. J, van Duijnhoven, John P. M, van Dorsten, Ferdi A

“…Classifying groups of individuals based on their metabolic profile is one of the main topics in metabolomics research. Due to the low number of individuals…”
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Is Operative Time Associated With Obesity-related Outcomes in TKA? by Abella, Maveric K I L, Angeles, John P M, Finlay, Andrea K, Amanatullah, Derek F

“…Obesity-based cutoffs in TKA are premised on higher rates of postoperative complications. However, operative time may be associated with postoperative…”
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Does Operative Time Modify Obesity-related Outcomes in THA? by Abella, Maveric K. I. L., Angeles, John P. M., Finlay, Andrea K., Amanatullah, Derek F.

“…Most orthopaedic surgeons refuse to perform arthroplasty on patients with morbid obesity, citing the higher rate of postoperative complications. However, that…”
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Non-Invasive Rheo-MRI Study of Egg Yolk-Stabilized Emulsions: Yield Stress Decay and Protein Release by Serial, Maria R, Arnaudov, Luben N, Stoyanov, Simeon, Dijksman, Joshua A, Terenzi, Camilla, van Duynhoven, John P M

“…A comprehensive understanding of the time-dependent flow behavior of concentrated oil-in-water emulsions is of considerable industrial importance. Along with…”
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Practical Use of the Raw Electroencephalogram Waveform During General Anesthesia: The Art and Science by Bennett, Cambell, Voss, Logan J., Barnard, John P. M., Sleigh, James W.

“…Quantitative electroencephalogram (qEEG) monitors are often used to estimate depth of anesthesia and intraoperative recall during general anesthesia. As with…”
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Recharacterization of the RGC-5 Retinal Ganglion Cell Line by Van Bergen, Nicole J, Wood, John P. M, Chidlow, Glyn, Trounce, Ian A, Casson, Robert J, Ju, Won-Kyu, Weinreb, Robert N, Crowston, Jonathan G

“…The transformed RGC-5 retinal ganglion cell line is used widely in glaucoma research. Increased resistance to glutamate was noted in published literature and…”
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