Search Results - "John, Matthias J"

Chemical modifications on siRNAs avoid Toll-like-receptor-mediated activation of the hepatic immune system in vivo and in vitro by Broering, Ruth, Real, Catherine I, John, Matthias J, Jahn-Hofmann, Kerstin, Ickenstein, Ludger M, Kleinehr, Kathrin, Paul, Andreas, Gibbert, Kathrin, Dittmer, Ulf, Gerken, Guido, Schlaak, Joerg F

“…The therapeutic application of small interfering RNAs (siRNAs) is limited by the induction of severe off-target effects, especially in the liver. Therefore, we…”
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Identification of proteins that mediate the pro-viral functions of the interferon stimulated gene 15 in hepatitis C virus replication by Real, Catherine I., Megger, Dominik A., Sitek, Barbara, Jahn-Hofmann, Kerstin, Ickenstein, Ludger M., John, Matthias J., Walker, Andreas, Timm, Joerg, Kuhlmann, Katja, Eisenacher, Martin, Meyer, Helmut E., Gerken, Guido, Broering, Ruth, Schlaak, Joerg F.

“…•RNA interference-mediated Isg15 knockdown results in HCV suppression in vitro.•Isg15 attenuates the response to endogenous and exogenous…”
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Inhibition of drug-resistant HIV-1 by RNA interference by Huelsmann, Peter M., Rauch, Pia, Allers, Kristina, John, Matthias J., Metzner, Karin J.

“…RNA interference is a powerful tool used to inhibit human immunodeficiency virus type 1 (HIV-1) replication in vitro. Almost all HIV-1 genes have been targets…”
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