Search Results - "John, L C"

Synthesis of human amyloid restricted to liver results in an Alzheimer disease–like neurodegenerative phenotype by Lam, Virginie, Takechi, Ryusuke, Hackett, Mark J, Francis, Roslyn, Bynevelt, Michael, Celliers, Liesl M, Nesbit, Michael, Mamsa, Somayra, Arfuso, Frank, Das, Sukanya, Koentgen, Frank, Hagan, Maree, Codd, Lincoln, Richardson, Kirsty, O'Mara, Brenton, Scharli, Rainer K, Morandeau, Laurence, Gauntlett, Jonathan, Leatherday, Christopher, Boucek, Jan, Mamo, John C. L

“…Several lines of study suggest that peripheral metabolism of amyloid beta (Aß) is associated with risk for Alzheimer disease (AD). In blood, greater than 90%…”
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Sodium alginate microencapsulation improves the short-term oral bioavailability of cannabidiol when administered with deoxycholic acid by Majimbi, Maimuna, Brook, Emily, Galettis, Peter, Eden, Edward, Al-Salami, Hani, Mooranian, Armin, Al-Sallami, Hesham, Lam, Virginie, Mamo, John C L, Takechi, Ryusuke

“…Cannabidiol (CBD) confers therapeutic effects in some neurological disorders via modulation of inflammatory, oxidative and cell-signalling pathways. However,…”
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Spectral Accuracy of Molecular Ions in an LTQ/Orbitrap Mass Spectrometer and Implications for Elemental Composition Determination by Erve, John C.L., Gu, Ming, Wang, Yongdong, DeMaio, William, Talaat, Rasmy E.

“…In addition to mass accuracy, the ability of a mass spectrometer to faithfully measure the isotopic distribution of an ion, defined as spectral accuracy, is…”
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Blood-Brain Barrier Dysfunction Precedes Cognitive Decline and Neurodegeneration in Diabetic Insulin Resistant Mouse Model: An Implication for Causal Link by Takechi, Ryusuke, Lam, Virginie, Brook, Emily, Giles, Corey, Fimognari, Nicholas, Mooranian, Armin, Al-Salami, Hani, Coulson, Stephanie H, Nesbit, Michael, Mamo, John C L

“…Diabetic insulin resistance and pro-diabetic diet are reported to increase dementia risk through unknown mechanisms. Emerging evidence suggests that the…”
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Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate by Zhang, Yong-Kang, Plattner, Jacob J, Easom, Eric E, Jacobs, Robert T, Guo, Denghui, Freund, Yvonne R, Berry, Pamela, Ciaravino, Vic, Erve, John C. L, Rosenthal, Philip J, Campo, Brice, Gamo, Francisco-Javier, Sanz, Laura M, Cao, Jianxin

“…Carboxamide pyrazinyloxy benzoxaboroles were investigated with the goal to identify a molecule with satisfactory antimalarial activity, physicochemical…”
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Blood–brain barrier disruption and ventricular enlargement are the earliest neuropathological changes in rats with repeated sub-concussive impacts over 2 weeks by Hiles-Murison, Bailey, Lavender, Andrew P., Hackett, Mark J., Armstrong, Joshua J., Nesbit, Michael, Rawlings, Samuel, McGonigle, Terrence, Warnock, Andrew, Lam, Virginie, Mamo, John C. L., Fitzgerald, Melinda, Takechi, Ryu

“…Repeated sub-concussive impact (e.g . soccer ball heading), a significantly lighter form of mild traumatic brain injury, is increasingly suggested to…”
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Peripheral Administration of the Kv1.3-Blocking Peptide HsTX1[R14A] Improves Cognitive Performance in Senescence Accelerated SAMP8 Mice by Pan, Yijun, Kagawa, Yoshiteru, Sun, Jiaqi, Lucas, Deanna S. Deveson, Takechi, Ryusuke, Mamo, John C.L., Wai, Dorothy C.C., Norton, Raymond S., Jin, Liang, Nicolazzo, Joseph A.

“…Increased expression of the voltage-gated potassium channel Kv1.3 in activated microglia, and the subsequent release of pro-inflammatory mediators, are closely…”
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The differential effects of fatty acids on enterocytic abundance of amyloid-beta by Galloway, Susan, Takechi, Ryusuke, Nesbit, Michael, Pallebage-Gamarallage, Menuka M, Lam, Virginie, Mamo, John C L

“…Consumption of a Western-styled diet enriched in saturated fatty acids (SFA) relative to polyunsaturated fatty acids is positively associated with risk for…”
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Exposure to biodiesel exhaust is less harmful than exposure to mineral diesel exhaust on blood-brain barrier integrity in a murine model by Nesbit, Michael, Ko, Colleen Kah Ling, Mamo, John C L, Lam, Virginie, Landwehr, Katherine R, Larcombe, Alexander N, Takechi, Ryu

“…Emerging data suggest that air pollution is a persistent source of neuroinflammation, reactive oxygen species (ROS), and neuropathology that contributes to…”
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Using optical coherence tomography and optical coherence tomography angiography to delineate neurovascular homeostasis in migraine: a review by Chaliha, Devahuti R, Vaccarezza, Mauro, Charng, Jason, Chen, Fred K, Lim, Amy, Drummond, Peter, Takechi, Ryusuke, Lam, Virginie, Dhaliwal, Satvinder S, Mamo, John C L

“…Migraine is one of the world's most debilitating disorders, and it has recently been shown that changes in the retina can be a potential biomarker for the…”
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Serum 25-hydroxyvitamin D is associated with reduced verbal episodic memory in healthy, middle-aged and older adults by Lam, Virginie, Albrecht, Matthew A., Takechi, Ryusuke, Prasopsang, Prachya, Lee, Ya Ping, Foster, Jonathan K., Mamo, John C. L.

“…Background There is increasing evidence supporting an association of higher serum vitamin D concentration with better cognitive performance in older…”
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Chronic Intake of Energy Drinks and Their Sugar Free Substitution Similarly Promotes Metabolic Syndrome by Graneri, Liam T, Mamo, John C L, D'Alonzo, Zachary, Lam, Virginie, Takechi, Ryusuke

“…Energy drinks containing significant quantities of caffeine, taurine and sugar are increasingly consumed, particularly by adolescents and young adults. The…”
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The vitamin D, ionised calcium and parathyroid hormone axis of cerebral capillary function: therapeutic considerations for vascular-based neurodegenerative disorders by Lam, Virginie, Takechi, Ryusuke, Pallabage-Gamarallage, Menuka, Giles, Corey, Mamo, John C L

“…Blood-brain barrier dysfunction characterised by brain parenchymal extravasation of plasma proteins may contribute to risk of neurodegenerative disorders,…”
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Chronic high fat feeding paradoxically attenuates cerebral capillary dysfunction and neurovascular inflammation in Senescence-Accelerated-Murine-Prone Strain 8 mice by Lam, Virginie, Stephenson, Andrea, Nesbit, Michael, Mamsa, Somayra, Hackett, Mark, Takechi, Ryusuke, Mamo, John C. L.

“…Background: A body of epidemiological, clinical and preclinical studies suggest increased risk for cerebro- and cardio-vascular disease associated with dietary…”
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Hypertriglyceridemia and Alzheimer Disease: Opening the Mind to New Therapeutic Opportunities by Watts, Gerald F, Mamo, John C.L.

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Biospectroscopic Imaging Provides Evidence of Hippocampal Zn Deficiency and Decreased Lipid Unsaturation in an Accelerated Aging Mouse Model by Fimognari, Nicholas, Hollings, Ashley, Lam, Virginie, Tidy, Rebecca J, Kewish, Cameron M, Albrecht, Matthew A, Takechi, Ryu, Mamo, John C. L, Hackett, Mark J

“…Western society is facing a health epidemic due to the increasing incidence of dementia in aging populations, and there are still few effective diagnostic…”
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Is type 2 diabetes associated dementia a microvascular early-Alzheimer's phenotype induced by aberrations in the peripheral metabolism of lipoprotein-amyloid? by Takechi, Ryusuke, Sharif, Arazu, Brook, Emily, Majimbi, Maimuna, Chan, Dick C, Lam, Virginie, Watts, Gerald F, Mamo, John C L

“…There is increasing evidence of a positive association of type 2 diabetes with Alzheimer's disease (AD), the most prevalent form of dementia. Suggested…”
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Bioactivation of Sitaxentan in Liver Microsomes, Hepatocytes, and Expressed Human P450s with Characterization of the Glutathione Conjugate by Liquid Chromatography Tandem Mass Spectrometry by Erve, John C. L, Gauby, Shawn, Maynard, John W, Svensson, Mats A, Tonn, George, Quinn, Kevin P

“…Sitaxentan is a selective endothelin-A receptor antagonist that was marketed as Thelin in several European countries and Canada for pulmonary arterial…”
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The Effects of Chronic Consumption of Lipid-Rich and Delipidated Bovine Dairy Milk on Brown Adipose Tissue Volume in Wild-Type Mice by D'Alonzo, Zachary J, Mamo, John C L, Graneri, Liam T, Takechi, Ryusuke, Lam, Virginie

“…Brown adipose tissue (BAT) activation is associated with increased energy expenditure by inducing non-shivering thermogenesis. The ingestion of a milk fat…”
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Revealing differences in the chemical form of zinc in brain tissue using K-edge X-ray absorption near-edge structure spectroscopy by Hollings, Ashley L, Lam, Virginie, Takechi, Ryu, Mamo, John C. L, Reinhardt, Juliane, de Jonge, Martin D, Kappen, Peter, Hackett, Mark J

“…Zinc is a prominent trace metal required for normal memory function. Memory loss and cognitive decline during natural ageing and neurodegenerative disease have…”
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