Search Results - "John, Christy S"

Phase-0/microdosing studies using PET, AMS, and LC-MS/MS: a range of study methodologies and conduct considerations. Accelerating development of novel pharmaceuticals through safe testing in humans - a practical guide by Burt, Tal, John, Christy S, Ruckle, Jon L, Vuong, Le T

“…Phase-0 studies, including microdosing, also called Exploratory Investigational New Drug (eIND) or exploratory clinical trials, are a regulatory framework for…”
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FDA Approval Summary: Mylotarg for Treatment of Patients with Relapsed or Refractory CD33‐Positive Acute Myeloid Leukemia by Norsworthy, Kelly J., Ko, Chia‐Wen, Lee, Jee Eun, Liu, Jiang, John, Christy S., Przepiorka, Donna, Farrell, Ann T., Pazdur, Richard

“…On September 2, 2017, the U.S. Food and Drug Administration approved gemtuzumab ozogamicin (GO; Mylotarg; Pfizer, New York City, NY) for treatment of relapsed…”
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Myasthenia Gravis by Indraratna, Praveen, Matar, Walid, Priola, Adriano M, Veltri, Andrea, Priola, Sandro M, Miranda, Sabina, Reid, Derrece K, John, Christy S, Gilhus, Nils E

“…To the Editor: In his review on myasthenia gravis, Gilhus (Dec. 29 issue) 1 recommends against prescribing muscle relaxants, penicillamine, and certain…”
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Synthesis and Characterization of [125I]-N-(N-Benzylpiperidin-4-yl)-4-iodobenzamide, a New .sigma. Receptor Radiopharmaceutical: High-Affinity Binding to MCF-7 Breast Tumor Cells by John, Christy S, Vilner, Bertold J, Bowen, Wayne D

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Sigma-1 and sigma-2 receptors are expressed in a wide variety of human and rodent tumor cell lines by VILNER, B. J, JOHN, C. S, BOWEN, W. D

“…Thirteen tumor-derived cell lines of human and nonhuman origin and from various tissues were examined for the presence and density of sigma-1 and sigma-2…”
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Sigma receptor scintigraphy with N-[2-(1'-piperidinyl)ethyl]-3-(123)I-iodo-4-methoxybenzamide of patients with suspected primary breast cancer: first clinical results by Caveliers, Vicky, Everaert, Hendrik, John, Christy S, Lahoutte, Tony, Bossuyt, Axel

“…The aim of this study was to investigate the potential of a new iodobenzamide, N-[2-(1'-piperidinyl)ethyl]-3-(123)I-iodo-4-methoxybenzamide (P-(123)I-MBA), to…”
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Targeting sigma receptor-binding benzamides as in vivo diagnostic and therapeutic agents for human prostate tumors by JOHN, C. S, VILNER, B. J, GEYER, B. C, MOODY, T, BOWEN, W. D

“…Sigma receptors are known to be expressed in a variety of human tumor cells, including breast, neural, and melanoma tumors. A very high density (1.0-1.5…”
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Substituted Halogenated Arylsulfonamides:  A New Class of σ Receptor Binding Tumor Imaging Agents by John, Christy S, Lim, Benjamin B, Vilner, Bertold J, Geyer, Brian C, Bowen, Wayne D

“…The discovery of a series of novel halogenated arylsulfonamides (HAS) as new σ receptor binding tumor imaging agents is described. Several substituted…”
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Myasthenia Gravis by Indraratna, Praveen, Matar, Walid

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Synthesis, in vitro pharmacologic characterization, and preclinical evaluation of N-[2-(1′-piperidinyl)ethyl]-3-[ 125I]iodo-4-methoxybenzamide (P[ 125I]MBA) for imaging breast cancer by John, Christy S, Bowen, Wayne D, Fisher, Susan J, Lim, Benjamin B, Geyer, Brian C, Vilner, Bertold J, Wahl, Richard L

“…The goal of this study was to investigate the potential use of a radioiodinated benzamide, N-[2-(1′-piperidinyl)ethyl]-3-iodo[ 125I]-4-methoxybenzamide (P[…”
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Synthesis, In Vitro Binding, and Tissue Distribution of Radioiodinated 2-[ 125I] N-( N-Benzylpiperidin-4-yl)-2-Iodo Benzamide, 2-[ 125I]BP: A Potential σ Receptor Marker for Human Prostate Tumors by John, Christy S, Gulden, Mary E, Li, Jinghua, Bowen, Wayne D, McAfee, John G, Thakur, Mathew L

“…The preclinical evaluation of a σ receptor–specific radiopharmaceutical that binds to human prostate tumor cells with a high affinity is described. We have…”
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Synthesis, in vitro validation and in vivo pharmacokinetics of [ 125I]N-[2-(4-Iodophenyl)Ethyl]- N-Methyl-2-(1-Piperidinyl) ethylamine: A high-affinity ligand for imaging sigma receptor positive tumors by John, Christy S., Gulden, Mary E., Vilner, Bertold J., Bowen, Wayne D.

“…N-[2-(4-iodophenyl)ethyl]- N-methyl-2-(1-piperidinyl)ethylamine, IPEMP, and the corresponding bromo derivative, BrPEMP, have been synthesized and…”
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Myasthenia Gravis by Miranda, Sabina, Reid, Derrece K, John, Christy S

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99mTc-Labeled σ-Receptor-Binding Complex:  Synthesis, Characterization, and Specific Binding to Human Ductal Breast Carcinoma (T47D) Cells by John, Christy S, Lim, Benjamin B, Geyer, Brian C, Vilner, Bertold J, Bowen, Wayne D

“…σ-Receptors have recently been shown to be expressed in a variety of human tumor cells. In an attempt to prepare 99mTc chelates that would bind to σ-receptors…”
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Sigma Receptor Scintigraphy with N-[2-(1'-Piperidinyl)Ethyl]-3-123I-Iodo-4-Methoxybenzamide of Patients with Suspected Primary Breast Cancer: First Clinical Results by Caveliers, Vicky, Everaert, Hendrik, John, Christy S, Lahoutte, Tony, Bossuyt, Axel

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Labelled sigma receptor ligands: can their role in neurology and oncology be extended? by Caveliers, V, Everaert, H, Lahoutte, T, Dierickx, L O, John, C S, Bossuyt, A

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Sigma receptors are expressed in human non-small cell lung carcinoma by John, C S, Bowen, W D, Varma, V M, McAfee, J G, Moody, T W

“…N-(2-piperidinoethyl)4-iodobenzamide), IPAB, was used to characterize sigma receptors in non-small cell lung cancer (NSCLC) cell lines. 125IPAB bound with high…”
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Synthesis and evaluation of [ 18F] labeled benzamides: High affinity sigma receptor ligands for PET imaging by Dence, Carmen S., John, Christy S., Bowen, Wayne D., Welch, Michael J.

“…We have synthesized and characterized four new fluorinated halobenzamides as sigma receptor ligands for use with positron emission tomography (PET). All the…”
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99m Tc-Labeled σ-Receptor-Binding Complex:  Synthesis, Characterization, and Specific Binding to Human Ductal Breast Carcinoma (T47D) Cells by John, Christy S., Lim, Benjamin B., Geyer, Brian C., Vilner, Bertold J., Bowen, Wayne D.

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N,N′-Ethylene-di- l-Cysteine (EC) complexes of Ga(III) and In(III): Molecular modeling, thermodynamic stability and in vivo studies by Anderson, Carolyn J., John, Christy S., Li, Yuejin J., Hancock, Robert D., Mccarthy, Timothy J., Martell, Arthur E., Welch, Michael J.

“…There are several reports in the literature on the evaluation of chelates containing two nitrogens and two sulfurs (N 2S 2) as four coordinate ligands (in…”
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