Search Results - "John, Chandy C."

Something Big that Matters: The American Society of Tropical Medicine and Hygiene's Commitment to Combat Climate Change by John, Chandy C

“…Climate change has had and will have profound effects on human health, including the health issues most important to the members of the American Society of…”
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Multiplexed and High-Throughput Label-Free Detection of RNA/Spike Protein/IgG/IgM Biomarkers of SARS-CoV‑2 Infection Utilizing Nanoplasmonic Biosensors by Masterson, Adrianna N, Muhoberac, Barry B, Gopinadhan, Adnan, Wilde, David J, Deiss, Frédérique T, John, Chandy C, Sardar, Rajesh

“…To tackle the COVID-19 outbreak, which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is an unmet need for highly accurate…”
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Cerebral Malaria: Mechanisms of Brain Injury and Strategies for Improved Neurocognitive Outcome by Idro, Richard, Marsh, Kevin, John, Chandy C, Newton, Charles R J

“…Cerebral malaria is the most severe neurological complication of infection with Plasmodium falciparum . With >575,000 cases annually, children in sub-Saharan…”
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Acute kidney injury is associated with impaired cognition and chronic kidney disease in a prospective cohort of children with severe malaria by Conroy, Andrea L, Opoka, Robert O, Bangirana, Paul, Idro, Richard, Ssenkusu, John M, Datta, Dibyadyuti, Hodges, James S, Morgan, Catherine, John, Chandy C

“…Acute kidney injury (AKI) is a recognized complication of pediatric severe malaria, but its long-term consequences are unknown. Ugandan children with cerebral…”
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The impact of delayed treatment of uncomplicated P. falciparum malaria on progression to severe malaria: A systematic review and a pooled multicentre individual-patient meta-analysis by Mousa, Andria, Al-Taiar, Abdullah, Anstey, Nicholas M, Badaut, Cyril, Barber, Bridget E, Bassat, Quique, Challenger, Joseph D, Cunnington, Aubrey J, Datta, Dibyadyuti, Drakeley, Chris, Ghani, Azra C, Gordeuk, Victor R, Grigg, Matthew J, Hugo, Pierre, John, Chandy C, Mayor, Alfredo, Migot-Nabias, Florence, Opoka, Robert O, Pasvol, Geoffrey, Rees, Claire, Reyburn, Hugh, Riley, Eleanor M, Shah, Binal N, Sitoe, Antonio, Sutherland, Colin J, Thuma, Philip E, Unger, Stefan A, Viwami, Firmine, Walther, Michael, Whitty, Christopher J M, William, Timothy, Okell, Lucy C

“…Delay in receiving treatment for uncomplicated malaria (UM) is often reported to increase the risk of developing severe malaria (SM), but access to treatment…”
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What causes severe malaria and its complications in children? Lessons learned over the past 15 years by Conroy, Andrea L, Datta, Dibyadyuti, John, Chandy C

“…Over the past 15 years, malaria mortality has reduced by approximately 50%. However, malaria still causes more than 400,000 deaths annually, most of which…”
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Plasmodium falciparum EPCR-binding PfEMP1 expression increases with malaria disease severity and is elevated in retinopathy negative cerebral malaria by Shabani, Estela, Hanisch, Benjamin, Opoka, Robert O, Lavstsen, Thomas, John, Chandy C

“…Expression of group A and the A-like subset of group B Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is associated with severe malaria (SM)…”
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Gut Bacteroides act in a microbial consortium to cause susceptibility to severe malaria by Mandal, Rabindra K., Mandal, Anita, Denny, Joshua E., Namazii, Ruth, John, Chandy C., Schmidt, Nathan W.

“…Malaria is caused by Plasmodium species and remains a significant cause of morbidity and mortality globally. Gut bacteria can influence the severity of…”
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Clinical Features of Critical Coronavirus Disease 2019 in Children by Bhumbra, Samina, Malin, Stefan, Kirkpatrick, Lindsey, Khaitan, Alka, John, Chandy C., Rowan, Courtney M., Enane, Leslie A.

“…We sought to describe the presentation, course, and outcomes of hospitalized pediatric coronavirus disease 2019 patients, with detailed description of those…”
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Acute kidney injury in Ugandan children with severe malaria is associated with long-term behavioral problems by Hickson, Meredith R, Conroy, Andrea L, Bangirana, Paul, Opoka, Robert O, Idro, Richard, Ssenkusu, John M, John, Chandy C

“…Acute kidney injury (AKI) is a risk factor for neurocognitive impairment in severe malaria (SM), but the impact of AKI on long-term behavioral outcomes…”
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Developing mentorship in a resource-limited context: a qualitative research study of the experiences and perceptions of the makerere university student and faculty mentorship programme by Ssemata, Andrew S, Gladding, Sophia, John, Chandy C, Kiguli, Sarah

“…The aim of mentorship is to build the mentees capacity, enhance their skills and improve their ability to produce desired outcomes. However, the mentoring…”
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Xanthine oxidase levels and immune dysregulation are independently associated with anemia in Plasmodium falciparum malaria by Vasquez, Marilyn, Sica, Margaux, Namazzi, Ruth, Opoka, Robert O., Sherman, Julian, Datta, Dibyadyuti, Duran-Frigola, Miquel, Ssenkusu, John M., John, Chandy C., Conroy, Andrea L., Rodriguez, Ana

“…Severe anemia is an important contributor to mortality in children with severe malaria. Anemia in malaria is a multi-factorial complication, since…”
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Serum angiopoietin-1 and -2 levels discriminate cerebral malaria from uncomplicated malaria and predict clinical outcome in African children by Lovegrove, Fiona E, Tangpukdee, Noppadon, Opoka, Robert O, Lafferty, Erin I, Rajwans, Nimerta, Hawkes, Michael, Krudsood, Srivicha, Looareesuwan, Sornchai, John, Chandy C, Liles, W Conrad, Kain, Kevin C

“…Limited tools exist to identify which individuals infected with Plasmodium falciparum are at risk of developing serious complications such as cerebral malaria…”
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Evaluation of an ultrasensitive HRP2-based rapid diagnostic test for detection of asymptomatic Plasmodium falciparum parasitaemia among children in western Kenya by Turnbull, Lindsey B, Ayodo, George, Knight, Veronicah, John, Chandy C, McHenry, Megan S, Tran, Tuan M

“…Accurate detection of asymptomatic malaria parasitaemia in children living in high transmission areas is important for malaria control and reduction programmes…”
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Intestinal Injury Biomarkers Predict Mortality in Pediatric Severe Malaria by Sarangam, Maithri L, Namazzi, Ruth, Datta, Dibyadyuti, Bond, Caitlin, Vanderpool, Charles P B, Opoka, Robert O, John, Chandy C, Conroy, Andrea L

“…Severe malaria (SM) increases the risk of invasive bacterial infection, and there is evidence to suggest increased gastrointestinal permeability. Studies have…”
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Cerebrospinal fluid biomarkers provide evidence for kidney-brain axis involvement in cerebral malaria pathogenesis by Conroy, Andrea L, Datta, Dibyadyuti, Opoka, Robert O, Batte, Anthony, Bangirana, Paul, Gopinadhan, Adnan, Mellencamp, Kagan A, Akcan-Arikan, Ayse, Idro, Richard, John, Chandy C

“…Cerebral malaria is one of the most severe manifestations of malaria and is a leading cause of acquired neurodisability in African children. Recent studies…”
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Blackwater fever and acute kidney injury in children hospitalized with an acute febrile illness: pathophysiology and prognostic significance by Conroy, Andrea L, Hawkes, Michael T, Leligdowicz, Aleksandra, Mufumba, Ivan, Starr, Michelle C, Zhong, Kathleen, Namasopo, Sophie, John, Chandy C, Opoka, Robert O, Kain, Kevin C

“…Abstract Background Acute kidney injury (AKI) and blackwater fever (BWF) are related but distinct renal complications of acute febrile illness in East Africa…”
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Slow Clearance of Plasmodium falciparum in Severe Pediatric Malaria, Uganda, 2011-2013 by Hawkes, Michael, Conroy, Andrea L, Opoka, Robert O, Namasopo, Sophie, Zhong, Kathleen, Liles, W Conrad, John, Chandy C, Kain, Kevin C

“…Plasmodium falciparum resistance to artemisinin derivatives is emerging in Asia. We examined molecular markers of resistance in 78 children in Uganda who had…”
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Towards the use of a smartphone imaging-based tool for point-of-care detection of asymptomatic low-density malaria parasitaemia by Colbert, Ashlee J, Co, Katrina, Lima-Cooper, Giselle, Lee, Dong Hoon, Clayton, Katherine N, Wereley, Steven T, John, Chandy C, Linnes, Jacqueline C, Kinzer-Ursem, Tamara L

“…Globally, there are over 200 million cases of malaria annually and over 400,000 deaths. Early and accurate detection of low-density parasitaemia and…”
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Hydroxyurea to lower transcranial Doppler velocities and prevent primary stroke: the Uganda NOHARM sickle cell anemia cohort by Opoka, Robert O, Hume, Heather A, Latham, Teresa S, Lane, Adam, Williams, Olatundun, Tymon, Jennifer, Nakafeero, Maria, Kasirye, Phillip, Ndugwa, Christopher M, John, Chandy C, Ware, Russell E

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