Search Results - "Joharapurkar, Amit"

Prolyl Hydroxylase Inhibitors: A Breakthrough in the Therapy of Anemia Associated with Chronic Diseases by Joharapurkar, Amit A., Pandya, Vrajesh B., Patel, Vishal J., Desai, Ranjit C., Jain, Mukul R.

“…Chronic kidney disease, cancer, chronic inflammatory disorders, nutritional, and genetic deficiency can cause anemia. Hypoxia causes induction of…”
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Prolyl hydroxylase inhibitor desidustat attenuates autoimmune hemolytic anemia in mice by Patel, Vishal J., Joharapurkar, Amit A., Kshirsagar, Samadhan G., Patel, Maulik S., Savsani, Hardikkumar H., Rakhasiya, Milan H., Dodiya, Harshad S., Jain, Mukul R.

“…[Display omitted] •Prolyl hydroxylase inhibitor desidustat increased hemoglobin in autoimmune anemia.•Desidustat increased RBC lifespan and decreased antibody…”
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Desidustat: a novel PHD inhibitor for the treatment of CKD-induced anemia by Joharapurkar, Amit, Pandya, Vrajesh, Patel, Harilal, Jain, Mukul, Desai, Ranjit

“…Desidustat is a small molecule inhibitor of hypoxia-inducible factor-prolyl hydroxylase (HIF-PH) discovered and developed by Zydus Lifesciences for the…”
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Prolyl hydroxylase inhibitor desidustat protects against acute and chronic kidney injury by reducing inflammatory cytokines and oxidative stress by Joharapurkar, Amit A., Patel, Vishal J., Kshirsagar, Samadhan G., Patel, Maulik S., Savsani, Hardikkumar H., Jain, Mukul R.

“…Chronic kidney disease (CKD) is associated with activated inflammatory responses. Desidustat, a prolyl hydroxylase (PHD) inhibitor is useful for treatment of…”
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HIF Stabilizer Desidustat Protects against Complement-Mediated Diseases by Patel, Vishal J, Joharapurkar, Amit A, Kshirsagar, Samadhan G, Patel, Maulik S, Savsani, Hardikkumar H, Dodiya, Harshad S, Rakhasiya, Milan H, Patel, Ashvin K, Sundar, Rajesh, Jain, Mukul R

“…Complement cascade is a defence mechanism useful for eliminating pathogenic microorganisms and damaged cells. However, activation of alternative complement…”
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Inhibition of the methionine aminopeptidase 2 enzyme for the treatment of obesity by Joharapurkar, Amit A, Dhanesha, Nirav A, Jain, Mukul R

“…Worldwide prevalence of obesity has nearly doubled since 1980. Obesity is the result of interactions among the environmental factors, genetic predisposition,…”
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Effect of GLP-1 based therapies on diabetic dyslipidemia by Patel, Vishal J, Joharapurkar, Amit A, Shah, Gaurang B, Jain, Mukul R

“…Glucagon-like peptide-1 (GLP-1), is a hormone secreted by small intestine. Consumption of food or glucose stimulates synthesis and secretion of GLP-1 in the…”
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Selective Thyromimetics Using Receptor and Tissue Selectivity Approaches: Prospects for Dyslipidemia by Joharapurkar, Amit A, Dhote, Vipin V, Jain, Mukul R

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Age-related changes in hematological and biochemical profiles of Wistar rats by Patel, Suresh, Patel, Satish, Kotadiya, Ashvin, Patel, Samir, Shrimali, Bhavesh, Joshi, Nikita, Patel, Tushar, Trivedi, Harshida, Patel, Jitendra, Joharapurkar, Amit, Jain, Mukul

“…Wistar rats are extensively used as the model for assessing toxicity and efficacy in preclinical research. Hematological and biochemical laboratory data are…”
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ZY15557, a novel, long acting inhibitor of dipeptidyl peptidase‐4, for the treatment of Type 2 diabetes mellitus by Jain, Mukul R, Joharapurkar, Amit A, Kshirsagar, Samadhan G, Patel, Vishal J, Bahekar, Rajesh H, Patel, Harilal V, Jadav, Pradip A, Patel, Pankaj R, Desai, Ranjit C

“…Background and Purpose Dipeptidyl peptidase (DPP)‐4 inhibitors increase levels of glucagon‐like peptide‐1 (GLP‐1) and provide clinical benefit in the treatment…”
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Repurposing dimethyl fumarate for gastric ulcer and ulcerative colitis: Evidence of local efficacy without systemic side effect by Patel, Vishal, Joharapurkar, Amit, Kshirsagar, Samadhan, Patel, Maulik, Savsani, Hardikkumar, Patel, Ashvinkumar, Ranvir, Ramchandra, Jain, Mukul

“…•Dimethyl Fumarate (DMF) prevented development of ethanol-induced gastric ulcer.•Oral and intracecal DMF reduced disease acitivity score in DSS-induced…”
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Co-agonist of glucagon and GLP-1 reduces cholesterol and improves insulin sensitivity independent of its effect on appetite and body weight in diet-induced obese C57 mice by Patel, Vishal, Joharapurkar, Amit, Dhanesha, Nirav, Kshirsagar, Samadhan, Patel, Kartik, Bahekar, Rajesh, Shah, Gaurang, Jain, Mukul

“…Dual agonism of glucagon and glucagon-like peptide-1 (GLP-1) receptors reduce body weight without inducing hyperglycemia in rodents. However, the effect of a…”
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Prolyl hydroxylase inhibitor desidustat improves anemia in erythropoietin hyporesponsive state by Joharapurkar, Amit A., Patel, Vishal J., Kshirsagar, Samadhan G., Patel, Maulik S., Savsani, Hardikkumar H., Kajavadara, Chetan, Valani, Darshan, Jain, Mukul R.

“…Many anemic chronic kidney disease (CKD) patients are refractory to erythropoietin (EPO) effects due to inflammation, deranged iron utilization, and generation…”
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Coagonist of GLP-1 and Glucagon Receptor Ameliorates Development of Non-Alcoholic Fatty Liver Disease by Patel, Vishal, Joharapurkar, Amit, Kshirsagar, Samadhan, Sutariya, Brijesh, Patel, Maulik, Patel, Hiren, Pandey, Dheerendra, Patel, Dipam, Ranvir, Ramchandra, Kadam, Shekhar, Bahekar, Rajesh, Jain, Mukul

“…Obesity, diabetes and dyslipidemica are the key pathogenic stimulus that enhances progression of Non-Alcoholic Fatty Liver Disease (NAFLD). Coagonist of…”
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Optimization of 1,2,5-Thiadiazole Carbamates as Potent and Selective ABHD6 Inhibitors by Patel, Jayendra Z., Nevalainen, Tapio J., Savinainen, Juha R., Adams, Yahaya, Laitinen, Tuomo, Runyon, Robert S., Vaara, Miia, Ahenkorah, Stephen, Kaczor, Agnieszka A., Navia-Paldanius, Dina, Gynther, Mikko, Aaltonen, Niina, Joharapurkar, Amit A., Jain, Mukul R., Haka, Abigail S., Maxfield, Frederick R., Laitinen, Jarmo T., Parkkari, Teija

“…At present, inhibitors of α/β‐hydrolase domain 6 (ABHD6) are viewed as a promising approach to treat inflammation and metabolic disorders. This article…”
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Exendin-4 reduces glycemia by increasing liver glucokinase activity: an insulin independent effect by Dhanesha, Nirav, Joharapurkar, Amit, Shah, Gaurang, Dhote, Vipin, Kshirsagar, Samadhan, Bahekar, Rajesh, Jain, Mukul

“…Exendin-4 is a stable peptide agonist of GLP-1 receptor that exhibits insulinotropic actions. Some in vivo studies indicated insulin-independent…”
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Antinociceptive activity of alcoholic extract of Hemidesmus indicus R.Br. in mice by Verma, Prashant R., Joharapurkar, Amit A., Chatpalliwar, Vivekanand A., Asnani, Alpana J.

“…The ethanolic extract of roots of Hemidesmus indicus R.Br. (family: Asclepiadaceae) was investigated for possible antinociceptive effect in mice. Three models…”
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Therapeutic potential of coagonists of glucagon and GLP-1 by Patel, Vishal J, Joharapurkar, Amit A, Kshirsagar, Samadhan G, Patel, Kartikkumar N, Shah, Gaurang B, Jain, Mukul R

“…Dual agonism of glucagon and glucagon-like peptide-1 (GLP-1) receptors reduces body weight without inducing hyperglycemia. In addition, coagonists have…”
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Is the Inhibition of Dipeptidyl Peptidase-4 (DDP-4) Enzyme Route Dependent and/or Driven by High Peak Concentration?- Seeking Answers with ZYDPLA1, a Novel Long Acting DPP-4 Inhibitor, in a Rodent Model by Patel, Harilal, Joharapurkar, Amit A, Bahekar, Rajesh, Patel, Prakash, Kshirsagar, Samadhan G, Modi, Nirav, Ghoghari, Ashok, Patel, Vishal J, Jain, Mukul R, Srinivas, Nuggehally R, Patel, Pankaj R, Desai, Ranjit C

“…ZYDPLA1 is a long acting enzyme dipeptidyl peptidase-4 (DPP-4) inhibitor. The comparative effect of DPP-4 inhibition after intravenous (IV) and oral…”
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Coagonist of glucagon-like peptide-1 and glucagon receptors ameliorates kidney injury in murine models of obesity and diabetes mellitus by Patel, Vishal J, Joharapurkar, Amit A, Kshirsagar, Samadhan G, Sutariya, Brijesh K, Patel, Maulik S, Patel, Hiren M, Pandey, Dheerendra K, Bahekar, Rajesh H, Jain, Mukul R

“…To investigate the role of glucagon-like peptide-1 (GLP-1)/glucagon receptors coagonist on renal dysfunction associated with diabetes and obesity. Chronic…”
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