Search Results - "Johansson, Maria C"

Hypoxia triggers a proangiogenic pathway involving cancer cell microvesicles and PAR-2-mediated heparin-binding EGF signaling in endothelial cells by Svensson, Katrin J, Kucharzewska, Paulina, Christianson, Helena C, Sköld, Stefan, Löfstedt, Tobias, Johansson, Maria C, Mörgelin, Matthias, Bengzon, Johan, Ruf, Wolfram, Belting, Mattias

“…Highly malignant tumors, such as glioblastomas, are characterized by hypoxia, endothelial cell (EC) hyperplasia, and hypercoagulation. However, how these…”
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Multiregion Whole-Exome Sequencing Uncovers the Genetic Evolution and Mutational Heterogeneity of Early-Stage Metastatic Melanoma by Harbst, Katja, Lauss, Martin, Cirenajwis, Helena, Isaksson, Karolin, Rosengren, Frida, Törngren, Therese, Kvist, Anders, Johansson, Maria C, Vallon-Christersson, Johan, Baldetorp, Bo, Borg, Åke, Olsson, Håkan, Ingvar, Christian, Carneiro, Ana, Jönsson, Göran

“…Cancer genome sequencing has shed light on the underlying genetic aberrations that drive tumorigenesis. However, current sequencing-based strategies, which…”
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Metastasis Stimulation by Hypoxia and Acidosis-Induced Extracellular Lipid Uptake Is Mediated by Proteoglycan-Dependent Endocytosis by Menard, Julien A, Christianson, Helena C, Kucharzewska, Paulina, Bourseau-Guilmain, Erika, Svensson, Katrin J, Lindqvist, Eva, Indira Chandran, Vineesh, Kjellén, Lena, Welinder, Charlotte, Bengzon, Johan, Johansson, Maria C, Belting, Mattias

“…Hypoxia and acidosis are inherent stress factors of the tumor microenvironment and have been linked to increased tumor aggressiveness and treatment resistance…”
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Extracellular lipid loading augments hypoxic paracrine signaling and promotes glioma angiogenesis and macrophage infiltration by Offer, Svenja, Menard, Julien A, Pérez, Julio Enríquez, de Oliveira, Kelin G, Indira Chandran, Vineesh, Johansson, Maria C, Bång-Rudenstam, Anna, Siesjö, Peter, Ebbesson, Anna, Hedenfalk, Ingrid, Sundgren, Pia C, Darabi, Anna, Belting, Mattias

“…Primary brain tumors, in particular glioblastoma (GBM), remain among the most challenging cancers. Like most malignant tumors, GBM is characterized by hypoxic…”
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Decoding of the surfaceome and endocytome in primary glioblastoma cells identifies potential target antigens in the hypoxic tumor niche by de Oliveira, Kelin Gonçalves, Bång-Rudenstam, Anna, Beyer, Sarah, Boukredine, Axel, Talbot, Hugo, Governa, Valeria, Johansson, Maria C, Månsson, Ann-Sofie, Forsberg-Nilsson, Karin, Bengzon, Johan, Malmström, Johan, Welinder, Charlotte, Belting, Mattias

“…Immunotherapies with antibody-drug-conjugates (ADC) and CAR-T cells, targeted at tumor surface antigens (surfaceome), currently revolutionize clinical…”
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Magnetic nanoparticle-based isolation of endocytic vesicles reveals a role of the heat shock protein GRP75 in macromolecular delivery by Wittrup, Anders, Zhang, Si-He, Svensson, Katrin J., Kucharzewska, Paulina, Johansson, Maria C., Mörgelin, Matthias, Belting, Mattias, Ruoslahti, Erkki

“…An increased understanding of cellular uptake mechanisms of macromolecules remains an important challenge in cell biology with implications for viral infection…”
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Mesenchymal stromal cells from primary osteosarcoma are non‐malignant and strikingly similar to their bone marrow counterparts by Brune, Jan C., Tormin, Ariane, Johansson, Maria C., Rissler, Pehr, Brosjö, Otte, Löfvenberg, Richard, von Steyern, Fredrik Vult, Mertens, Fredrik, Rydholm, Anders, Scheding, Stefan

“…Mesenchymal stromal cells (MSC) are multipotent cells that can be isolated from a number of human tissues. In cancer, MSC have been implicated with tumor…”
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Ultrasensitive Immunoprofiling of Plasma Extracellular Vesicles Identifies Syndecan-1 as a Potential Tool for Minimally Invasive Diagnosis of Glioma by Indira Chandran, Vineesh, Welinder, Charlotte, Månsson, Ann-Sofie, Offer, Svenja, Freyhult, Eva, Pernemalm, Maria, Lund, Sigrid M, Pedersen, Shona, Lehtiö, Janne, Marko-Varga, Gyorgy, Johansson, Maria C, Englund, Elisabet, Sundgren, Pia C, Belting, Mattias

“…Liquid biopsy has great potential to improve the management of brain tumor patients at high risk of surgery-associated complications. Here, the aim was to…”
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Tracing and separating plasma components causing matrix effects in hydrophilic interaction chromatography–electrospray ionization mass spectrometry by Ekdahl, Anja, Johansson, Maria C., Ahnoff, Martin

“…► Polar endogenous compounds in plasma identified to interfere in HILIC–ESI-MS. ► Both enhancement and suppression of the analyte signal was observed. ►…”
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Landscape of surfaceome and endocytome in human glioma is divergent and depends on cellular spatial organization by Governa, Valeria, Talbot, Hugo, Gonçalves de Oliveira, Kelin, Cerezo-Magaña, Myriam, Bång-Rudenstam, Anna, Johansson, Maria C, Månsson, Ann-Sofie, Forsberg-Nilsson, Karin, Marko-Varga, György, Enríquez Pérez, Julio, Darabi, Anna, Malmström, Johan, Bengzon, Johan, Welinder, Charlotte, Belting, Mattias

“…Therapeutic strategies directed at the tumor surfaceome (TS), including checkpoint inhibitor blocking antibodies, antibody drug conjugates (ADCs), and chimeric…”
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Institutionalisation of validation and the transformation of vocational knowledge - the case of admission into the vocational teacher education in Sweden by Johansson, Maria C.

“…The aim of this thesis was to understand the validation of vocational knowledge prior to entry into vocational teacher education in Sweden. From this aim the…”
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Global extracellular vesicle proteomic signature defines U87-MG glioma cell hypoxic status with potential implications for non-invasive diagnostics by Indira Chandran, Vineesh, Welinder, Charlotte, Gonçalves de Oliveira, Kelin, Cerezo-Magaña, Myriam, Månsson, Ann-Sofie, Johansson, Maria C., Marko-Varga, Gyorgy, Belting, Mattias

“…Purpose Glioblastoma multiforme (GBM) is the most common and lethal of primary malignant brain tumors. Hypoxia constitutes a major determining factor for the…”
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Protumoral lipid droplet-loaded macrophages are enriched in human glioblastoma and can be therapeutically targeted by Governa, Valeria, de Oliveira, Kelin Gonçalves, Bång-Rudenstam, Anna, Offer, Svenja, Cerezo-Magaña, Myriam, Li, Jiaxin, Beyer, Sarah, Johansson, Maria C, Månsson, Ann-Sofie, Edvardsson, Charlotte, Durmo, Faris, Gustafsson, Emma, Boukredine, Axel, Jeannot, Pauline, Schmidt, Katja, Gezelius, Emelie, Menard, Julien A, Garza, Raquel, Jakobsson, Johan, de Neergaard, Therese, Sundgren, Pia C, Tiihonen, Aliisa M, Haapasalo, Hannu, Rautajoki, Kirsi J, Nordenfelt, Pontus, Darabi, Anna, Forsberg-Nilsson, Karin, Pietras, Alexander, Talbot, Hugo, Bengzon, Johan, Belting, Mattias

“…Glioblastoma presents a formidable clinical challenge because of its complex microenvironment. Here, we characterized tumor-associated foam cells (TAFs), a…”
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The Citizen in Light of the Mathematics Curriculum by Dahl, Jonas, Johansson, Maria C.

“…In this article, the mathematics needed for citizenship is discussed in relation to the Swedish curriculum. The article considers two approaches for discussing…”
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Normal-like breast cells, but not breast cancer cells, recovered from treatment with N′,N′′-diethylnorspermine by Myhre, Louise, Alm, Kersti, Johansson, Maria C, Oredsson, Stina M

“…A number of polyamine analogs are currently used in various clinical trials as cancer treatment and it is important to investigate their effects not only on…”
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ScFv Antibody-induced Translocation of Cell-surface Heparan Sulfate Proteoglycan to Endocytic Vesicles: EVIDENCE FOR HEPARAN SULFATE EPITOPE SPECIFICITY AND ROLE OF BOTH SYNDECAN AND GLYPICAN by Wittrup, Anders, Zhang, Si-He, ten Dam, Gerdy B, van Kuppevelt, Toin H, Bengtson, Per, Johansson, Maria, Welch, Johanna, Mörgelin, Matthias, Belting, Mattias

“…Cellular uptake of several viruses and polybasic macromolecules requires the expression of cell-surface heparan sulfate proteoglycan (HSPG) through as yet ill…”
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Energy transfer between fluorescein isothiocyanate and propidium iodide--a problem in the estimation of Tpot with the bromodeoxyuridine-DNA flow cytometry technique? by Johansson, M C, Baldetorp, B, Oredsson, S M

“…Energy transfer in flow cytometry can occur when two fluorochromes are bound in close proximity (generally within 100 A) and the emission spectrum of one…”
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Abstract 506: Mechanisms of microvesicle-mediated communication in cancer by Svensson, Katrin J., Christianson, Helena C., Wittrup, Anders, Johansson, Maria C., Mörgelin, Matthias, Belting, Mattias

“…Abstract The many functional roles of microvesicles (MVs) in tumor development and progression have lately become a subject of intense investigation. Cancer…”
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Radiation effects on S-phase duration, labelling index, potential doubling time and DNA distribution in head and neck cancer xenografts by Zätterström, U K, Engellau, J, Johansson, M C, Wennerberg, J, Kjellén, E

“…The effect of irradiation on S-phase duration (Ts), labelling index (LI), potential doubling time (Tpot), and cell cycle phase distributions was determined by…”
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Estimating the Total Rate of DNA Replication Using Branching Processes by Larsson, Sara, Rydén, Tobias, Holst, Ulla, Oredsson, Stina, Johansson, Maria

“…Increasing the knowledge of various cell cycle kinetic parameters, such as the length of the cell cycle and its different phases, is of considerable importance…”
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