Search Results - "Johansson, Malin E.V"

Normalization of Host Intestinal Mucus Layers Requires Long-Term Microbial Colonization by Johansson, Malin E.V., Jakobsson, Hedvig E., Holmén-Larsson, Jessica, Schütte, André, Ermund, Anna, Rodríguez-Piñeiro, Ana M., Arike, Liisa, Wising, Catharina, Svensson, Frida, Bäckhed, Fredrik, Hansson, Gunnar C.

“…The intestinal mucus layer provides a barrier limiting bacterial contact with the underlying epithelium. Mucus structure is shaped by intestinal location and…”
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Goblet cells need some stress by Johansson, Malin E.V, Hansson, Gunnar C

“…The intestinal tract is protected by epithelium-covering mucus, which Is constantly renewed by goblet cells, a specialized type of epithelial cell. Mucus is…”
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Transient Inability to Manage Proteobacteria Promotes Chronic Gut Inflammation in TLR5-Deficient Mice by Carvalho, Frederic A., Koren, Omry, Goodrich, Julia K., Johansson, Malin E.V., Nalbantoglu, Ilke, Aitken, Jesse D., Su, Yueju, Chassaing, Benoit, Walters, William A., González, Antonio, Clemente, Jose C., Cullender, Tyler C., Barnich, Nicolas, Darfeuille-Michaud, Arlette, Vijay-Kumar, Matam, Knight, Rob, Ley, Ruth E., Gewirtz, Andrew T.

“…Colitis results from breakdown of homeostasis between intestinal microbiota and the mucosal immune system, with both environmental and genetic influencing…”
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Is the Intestinal Goblet Cell a Major Immune Cell? by Johansson, Malin E.V., Hansson, Gunnar C.

“…Recent reports indicate that both the inflammasome (Wlodarska et al., 2014) and autophagy (Patel et al., 2013) pathways in goblet cells control mucin…”
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Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus Deterioration by Schroeder, Bjoern O., Birchenough, George M.H., Ståhlman, Marcus, Arike, Liisa, Johansson, Malin E.V., Hansson, Gunnar C., Bäckhed, Fredrik

“…Diet strongly affects gut microbiota composition, and gut bacteria can influence the colonic mucus layer, a physical barrier that separates trillions of gut…”
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The gastrointestinal mucus system in health and disease by Johansson, Malin E. V., Sjövall, Henrik, Hansson, Gunnar C.

“…Gastrointestinal mucus is the first line of defence against bac-teria; the organization of this protective system varies markedly along the digestive tract. In…”
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two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions by Johansson, Malin E.V, Larsson, Jessica M. Holmén, Hansson, Gunnar C

“…The normal intestinal microbiota inhabits the colon mucus without triggering an inflammatory response. The reason for this and how the intestinal mucus of the…”
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inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria by Johansson, Malin E.V, Phillipson, Mia, Petersson, Joel, Velcich, Anna, Holm, Lena, Hansson, Gunnar C

“…We normally live in symbiosis with ~10¹³ bacteria present in the colon. Among the several mechanisms maintaining the bacteria/host balance, there is limited…”
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Study of mucin turnover in the small intestine by in vivo labeling by Schneider, Hannah, Pelaseyed, Thaher, Svensson, Frida, Johansson, Malin E. V.

“…Mucins are highly glycosylated proteins which protect the epithelium. In the small intestine, the goblet cell-secreted Muc2 mucin constitutes the main…”
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Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice by Fu, Jianxin, Wei, Bo, Wen, Tao, Johansson, Malin E V, Liu, Xiaowei, Bradford, Emily, Thomsson, Kristina A, McGee, Samuel, Mansour, Lilah, Tong, Maomeng, McDaniel, J Michael, Sferra, Thomas J, Turner, Jerrold R, Chen, Hong, Hansson, Gunnar C, Braun, Jonathan, Xia, Lijun

“…Mucin-type O-linked oligosaccharides (O-glycans) are primary components of the intestinal mucins that form the mucus gel layer overlying the gut epithelium…”
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The central exons of the human MUC2 and MUC6 mucins are highly repetitive and variable in sequence between individuals by Svensson, Frida, Lang, Tiange, Johansson, Malin E. V., Hansson, Gunnar C.

“…The DNA sequence of the two human mucin genes MUC2 and MUC6 have not been completely resolved due to the repetitive nature of their central exon coding for…”
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Calcium-activated chloride channel regulator 1 (CLCA1) forms non-covalent oligomers in colonic mucus and has mucin 2–processing properties by Nyström, Elisabeth E.L., Arike, Liisa, Ehrencrona, Erik, Hansson, Gunnar C., Johansson, Malin E.V.

“…Calcium-activated chloride channel regulator 1 (CLCA1) is one of the major nonmucin proteins found in intestinal mucus. It is part of a larger family of CLCA…”
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Keeping Bacteria at a Distance by Johansson, Malin E.V., Hansson, Gunnar C.

“…An antibacterial peptide is essential for restricting contact between the intestinal microbiota and host. The human intestine harbors enormous amounts of…”
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Protein Turnover in Epithelial Cells and Mucus along the Gastrointestinal Tract Is Coordinated by the Spatial Location and Microbiota by Arike, Liisa, Seiman, Andrus, van der Post, Sjoerd, Rodriguez Piñeiro, Ana M., Ermund, Anna, Schütte, André, Bäckhed, Fredrik, Johansson, Malin E.V., Hansson, Gunnar C.

“…The gastrointestinal tract is covered by a single layer of epithelial cells that, together with the mucus layers, protect the underlying tissue from microbial…”
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Gram-Positive Bacteria are held at a Distance in the Colon Mucus by the Lectin-Like Protein Zg16 by Bergström, Joakim, Birchenough, George, Johansson, Malin E.V, Hansson, Gunnar C

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Mucus and the goblet cell by Johansson, Malin E V, Hansson, Gunnar C

“…The discovery of an inner mucus layer normally impervious to bacteria has changed our way of understanding the interaction between commensal bacteria and the…”
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The structure of the second CysD domain of MUC2 and role in mucin organization by transglutaminase-based cross-linking by Recktenwald, Christian V., Karlsson, Göran, Garcia-Bonete, Maria-Jose, Katona, Gergely, Jensen, Maja, Lymer, Richard, Bäckström, Malin, Johansson, Malin E.V., Hansson, Gunnar C., Trillo-Muyo, Sergio

“…The MUC2 mucin protects the colonic epithelium by a two-layered mucus with an inner attached bacteria-free layer and an outer layer harboring commensal…”
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The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria by Hansson, Gunnar C., Johansson, Malin E.V.

“…We have recently shown that the colon is protected by an inner mucus layer that efficiently separates the bacteria in the outer mucus from the epithelial…”
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The Colonic Surface Goblet Cells Secrete Mucus Important for Proper Protective Mucus Layer Formation by Nyström, Elisabeth E, Martínez-Abad, Beatriz, Arike, Liisa, Birchenough, George, Johansson, Malin E.V

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GLP-1R signaling modulates colonic energy metabolism, goblet cell number and survival in the absence of gut microbiota by Greiner, Thomas U., Koh, Ara, Peris, Eduard, Bergentall, Mattias, Johansson, Malin E.V., Hansson, Gunnar C., Drucker, Daniel J., Bäckhed, Fredrik

“…Gut microbiota increases energy availability through fermentation of dietary fibers to short-chain fatty acids in conventionally raised mice. Energy deficiency…”
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