Search Results - "Johansen, T N"

Resolution, absolute stereochemistry and molecular pharmacology of the enantiomers of ATPA by Stensbøl, Tine B, Borre, Lars, Johansen, Tommy N, Egebjerg, Jan, Madsen, Ulf, Ebert, Bjarke, Krogsgaard-Larsen, Povl

“…( RS)-2-Amino-3-(5- tert-butyl-3-hydroxy-4-isoxazolyl)propionic acid (ATPA), an analogue of ( RS)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid…”
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(S)-Homo-AMPA, a Specific Agonist at the mGlu6 Subtype of Metabotropic Glutamic Acid Receptors by Ahmadian, Haleh, Nielsen, Birgitte, Bräuner-Osborne, Hans, Johansen, Tommy N, Stensbøl, Tine B, Sløk, Frank A, Sekiyama, Naohiro, Nakanishi, Shigetada, Krogsgaard-Larsen, Povl, Madsen, Ulf

“…Our previous publication (J. Med. Chem. 1996, 39, 3188−3194) described (RS)-2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid (Homo-AMPA) as a highly…”
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Synthesis and Pharmacology of the Baclofen Homologues 5-Amino-4-(4-chlorophenyl)pentanoic Acid and the R- and S-Enantiomers of 5-Amino-3-(4-chlorophenyl)pentanoic Acid by Karla, Rolf, Ebert, Bjarke, Thorkildsen, Christian, Herdeis, Claus, Johansen, Tommy N, Nielsen, Birgitte, Krogsgaard-Larsen, Povl

“…(RS)-5-Amino-4-(4-chlorophenyl)pentanoic acid (10) and the R-form (11) and S-form (12) of (RS)-5-amino-3-(4-chlorophenyl)pentanoic acid, which are homologues…”
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Heteroaryl Analogues of AMPA. 2. Synthesis, Absolute Stereochemistry, Photochemistry, and Structure−Activity Relationships by Falch, Erik, Brehm, Lotte, Mikkelsen, Ivan, Johansen, Tommy N, Skjærbæk, Niels, Nielsen, Birgitte, Stensbøl, Tine B, Ebert, Bjarke, Krogsgaard-Larsen, Povl

“…We have previously shown that (S)-2-amino-3-(3-hydroxy-5-phenyl-4-isoxazolyl)propionic acid [(S)-APPA, 2] is a weak agonist at…”
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Synthesis and Pharmacology of 3-Isoxazolol Amino Acids as Selective Antagonists at Group I Metabotropic Glutamic Acid Receptors by Madsen, Ulf, Bräuner-Osborne, Hans, Frydenvang, Karla, Hvene, Lise, Johansen, Tommy N, Nielsen, Birgitte, Sánchez, Connie, Stensbøl, Tine B, Bischoff, Francois, Krogsgaard-Larsen, Povl

“…Using ibotenic acid (2) as a lead, two series of 3-isoxazolol amino acid ligands for (S)-glutamic acid (Glu, 1) receptors have been developed. Whereas…”
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Structural basis for 2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) receptor activation by Johansen, T. N., Greenwood, J. R., Vogensen, S. B., Krogsgaard-Larsen, Povl

“…)-Glutamic acid (Glu), the major excitatory neurotransmitter in the central nervous system, operates through ionotropic as well as metabotropic receptors and…”
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Excitatory Amino Acid Receptor Ligands:  Resolution, Absolute Stereochemistry, and Enantiopharmacology of 2-Amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)propionic Acid by Johansen, Tommy N, Ebert, Bjarke, Bräuner-Osborne, Hans, Didriksen, Michael, Christensen, Inge T, Søby, Karina K, Madsen, Ulf, Krogsgaard-Larsen, Povl, Brehm, Lotte

“…(RS)-2-Amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)propionic acid (Bu-HIBO, 6) has previously been shown to be an agonist at…”
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Design of excitatory amino acid receptor agonists, partial agonists and antagonists: ibotenic acid as a key lead structure by Krogsgaard-Larsen, P, Ebert, B, Lund, TM, Bräuner-Osborne, H, Sløk, FA, Johansen, TN, Brehm, L, Madsen, U

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Molecular pharmacology of 4-substituted glutamic acid analogues at ionotropic and metabotropic excitatory amino acid receptors by Bräuner-Osborne, Hans, Nielsen, Birgitte, Stensbøl, Tine B, Johansen, Tommy N, Skjærbæk, Niels, Krogsgaard-Larsen, Povl

“…The pharmacology of (2 S,4 R)-4-methylglutamic acid, (2 S,4 S)-4-methylglutamic acid and ( S)- and ( R)-4-methyleneglutamic acids (obtained in high chemical…”
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N-Methyl-d-aspartic Acid Receptor Agonists:  Resolution, Absolute Stereochemistry, and Pharmacology of the Enantiomers of 2-Amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic Acid by Madsen, Ulf, Frydenvang, Karla, Ebert, Bjarke, Johansen, Tommy N, Brehm, Lotte, Krogsgaard-Larsen, Povl

“…(R,S)-2-Amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid [(R,S)-AMAA, 4] is a potent and selective agonist at the N-methyl-d-aspartic acid (NMDA) subtype…”
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Stereochemistry and molecular pharmacology of ( S)-thio-ATPA, a new potent and selective GluR5 agonist by Stensbøl, Tine B., Jensen, Henrik S., Nielsen, Birgitte, Johansen, Tommy N., Egebjerg, Jan, Frydenvang, Karla, Krogsgaard-Larsen, Povl

“…( RS)-2-Amino-3-(5- tert-butyl-3-hydroxy-4-isothiazolyl)propionic acid (thio-ATPA), a 3-isothiazolol analogue of ( RS)-2-amino-3-(5-…”
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Excitatory amino acid receptor ligands: Asymmetric synthesis, absolute stereochemistry and pharmacology of ( R)- and ( S)-homoibotenic acid by Bischoff, F., Johansen, T.N., Ebert, B., Krogsgaard-Larsen, P., Madsen, U.

“…The ( R)- and ( S)-forms of 2-amino-3-(3-hydroxyisoxazol-5-yl)propionic acid (homoibotenic acid, HIBO) were synthesized, using ( S)-BOC-phenylalanine as a…”
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NMDA receptor agonists derived from ibotenic acid. Preparation, neuroexcitation and neurotoxicity by Madsen, U, Ferkany, J W, Jones, B E, Ebert, B, Johansen, T N, Holm, T, Krogsgaard-Larsen, P

“…The two heterocyclic aspartic acid and glutamic acid analogues derived from ibotenic acid, (RS)-2-amino-2-(3-hydroxy-5-methylisoxazol-4-yl)acetic acid (AMAA)…”
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Synthesis of tritiated (RS)-2-amino-2-(3-hydroxy-5-methylisoxazol-4-yl)acetic acid (AMAA), a potent and selective NMDA agonist by Johansen, Tommy N., Balasubramanian, Venkataraman, Madsen, Ulf, Ferkany, John W., Krogsgaard-Larsen, Povl

“…(RS)‐2‐Amino‐2‐(3‐hydroxy‐5‐methylisoxazol‐4‐yl)acetic acid (AMAA) is a potent and selective agonist at the NMDA subgroup of excitatory amino acid receptors…”
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Stereostructure-activity studies on agonists at the AMPA and kainate subtypes of ionotropic glutamate receptors by Johansen, Tommy N., Greenwood, Jeremy R., Frydenvang, Karla, Madsen, Ulf, Krogsgaard-Larsen, Povl

“…(S)‐Glutamic acid (Glu), the major excitatory neurotransmitter in the central nervous system, operates through ionotropic as well as metabotropic receptors and…”
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Synthesis and receptor binding affinity of new selective GluR5 ligands by Bunch, Lennart, Johansen, Tina H., Bräuner-Osborne, Hans, Stensbøl, Tine B., Johansen, Tommy N., Krogsgaard-Larsen, Povl, Madsen, Ulf

“…Two hybrid analogues of the kainic acid receptor agonists, 2-amino-3-(5-tert-butyl-3-hydroxy-4-isoxazolyl)propionic acid (ATPA) and (2S,4R)-4-methylglutamic…”
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A new structural class of subtype-selective inhibitor of cloned excitatory amino acid transporter, EAAT2 by Bräuner-Osborne, Hans, Hermit, Mette B, Nielsen, Birgitte, Krogsgaard-Larsen, Povl, Johansen, Tommy N

“…We have studied the pharmacological effects of ( RS)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) and the enantiomers of (…”
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3-Pyrazolone analogues of the 3-isoxazolol metabotropic excitatory amino acid receptor agonist homo-AMPA. Synthesis and pharmacological testing by Zimmermann, Diane, Janin, Yves Louis, Brehm, Lotte, Bräuner-Osborne, Hans, Ebert, Bjarke, Johansen, Tommy Nørskov, Madsen, Ulf, Krogsgaard-Larsen, Povl

“…We have previously shown that the higher homologue of ( S)-glutamic acid [( S)-Glu], ( S)-α-aminoadipic acid [( S)-α-AA] is selectively recognized by the mGlu…”
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Resolution, configurational assignment, and enantiopharmacology of 2-amino-3-[3-hydroxy-5-(2-methyl-2H-tetrazol-5-yl)isoxazol-4-yl]propionic acid, a potent GluR3- and GluR4-preferring AMPA receptor agonist by Vogensen, Stine B., Jensen, Henrik S., Stensbøl, Tine B., Frydenvang, Karla, Bang-Andersen, Benny, Johansen, Tommy N., Egebjerg, Jan, Krogsgaard-Larsen, Povl

“…We have previously shown that (RS)‐2‐amino‐3‐[3‐hydroxy‐5‐(2‐methyl‐2H‐tetrazol‐5‐yl)isoxazol‐4‐yl]propionic acid (2‐Me‐Tet‐AMPA) is a selective agonist at…”
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Resolution, absolute stereochemistry, and enantiopharmacology of the GluR1-4 and GluR5 antagonist 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid by Møller, Eva H., Egebjerg, Jan, Brehm, Lotte, Stensbøl, Tine B., Johansen, Tommy N., Madsen, Ulf, Krogsgaard-Larsen, Povl

“…The phosphono amino acid, (RS)‐2‐amino‐3‐[5‐tert‐butyl‐3‐(phosphonomethoxy)‐4‐isoxazolyl]propionic acid (ATPO), is a structural hybrid between the NMDA…”
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