Search Results - "Johansen, P. B."

Lower Blood Glucose, Hyperglucagonemia, and Pancreatic α Cell Hyperplasia in Glucagon Receptor Knockout Mice by Gelling, R. W., Du, X. Q., Dichmann, D. S., Rømer, J., Huang, H., Cui, L., Obici, S., Tang, B., Holst, J. J., Fledelius, C., Johansen, P. B., Rossetti, L., Jelicks, L. A., Serup, P., Nishimura, E., Charron, M. J.

“…Glucagon, the counter-regulatory hormone to insulin, is secreted from pancreatic α cells in response to low blood glucose. To examine the role of glucagon in…”
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Influence of a selective histamine H3 receptor antagonist on hypothalamic neural activity, food intake and body weight by MALMLÖF, K, ZARAGOZA, F, GOLOZOUBOVA, V, REFSGAARD, H. H. F, CREMERS, T, RAUN, K, WULFF, B. S, JOHANSEN, P. B, WESTERINK, B, RIMVALL, K

“…This study was conducted to elucidate whether antagonistic targeting of the histamine H3 receptor increases hypothalamic histamine levels, in parallel with…”
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Danish, national cross-sectional observational study on the prevalence of prior major osteoporotic fractures in adults presenting with hip fracture—limitations and scope for fracture liaison services in prevention of hip fracture by Frederiksen, A., Abrahamsen, B., Johansen, P. B., Sørensen, H. A.

“…Summary Fracture liaison services prevent hip fractures by identifying other osteoporotic fractures that generally debut at a younger age. However, this study…”
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Development of a tail vein transection bleeding model in fully anaesthetized haemophilia A mice - characterization of two novel FVIII molecules by Johansen, P. B., Tranholm, M., Haaning, J., Knudsen, T.

“…Introduction The tail tip bleeding model and the tail vein transection survival model in mice are important tools for assessment of in vivo effect in…”
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Preclinical pharmacokinetics and biodistribution of subcutaneously administered glycoPEGylated recombinant factor VIII (N8‐GP) and development of a human pharmacokinetic prediction model by Rode, F., Almholt, K., Petersen, M., Kreilgaard, M., Kjalke, M., Karpf, D. M., Groth, A. V., Johansen, P. B., Larsen, L. F., Loftager, M., Haaning, J.

“…Essentials N8‐GP is an extended half‐life recombinant factor VIII (FVIII) for the treatment of hemophilia A. Subcutaneous (SC) FVIII dosing might reduce the…”
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Factor VIII with a 237 amino acid B‐domain has an extended half‐life in F8‐knockout mice by Bloem, E., Karpf, D. M., Nørby, P. L., Johansen, P. B., Loftager, M., Rahbek‐Nielsen, H., Petersen, H. H., Blouse, G. E., Thim, L., Kjalke, M., Bolt, G.

“…Essentials Factor (F)VIII with an intermediate‐length B‐domain showed higher levels in murine gene therapy. FVIII with different B‐domain lengths were…”
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Adipogenic and orexigenic effects of the ghrelin-receptor ligand tabimorelin are diminished in leptin-signalling-deficient ZDF rats by Holm, AM, Johansen, PB, Ahnfelt-Ronne, I, Romer, J

“…OBJECTIVE: The aim was to investigate the possible interactions of the two peripheral hormones, leptin and ghrelin, that regulate the energy balance in…”
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Ototoxicity due to hydroxychloroquine: report of two cases by Johansen, P B, Gran, J T

“…We report two cases of irreversible sensineuronal hearing loss due to hydroxychloroquine treatment. The first patient was a 44-year-old woman with…”
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Recombinant human factor VIIa and a factor VIIa‐analogue reduces heparin and low molecular weight heparin (LMWH)‐induced bleeding in rats by LAURITZEN, B., HEDNER, U., JOHANSEN, P. B., TRANHOLM, M., EZBAN, M.

“…Background: Heparin and low molecular weight heparin (LMWH) are widely used for prevention and treatment of thromboemobolic events, but may occasionally cause…”
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Pharmacological characterisation of a new oral GH secretagogue, NN703 by Hansen, BS, Raun, K, Nielsen, KK, Johansen, PB, Hansen, TK, Peschke, B, Lau, J, Andersen, PH, Ankersen, M

“…NN703 is a novel orally active GH secretagogue (GHS) derived from ipamorelin. NN703 stimulates GH release from rat pituitary cells in a dose-dependent manner…”
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Pharmacokinetic evaluation of ipamorelin and other peptidyl growth hormone secretagogues with emphasis on nasal absorption by JOHANSEN, P. B.

“…1. The pharmacokinetics of three new peptidyl growth hormone secretagogues, ipamorelin (NNC 26-0161), NNC 26-0194 and NNC 26-0235, were compared with two…”
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Methylprednisolone does not inhibit the release of growth hormone after intravenous injection of a novel growth hormone secretagogue in rats by Malmlöf, K., Johansen, P.B., Haahr, P-M., Wilken, M., Oxlund, H.

“…The present study was undertaken to study the growth hormone-releasing properties and growth-promoting effect of a GH secretagogue ipamorelin (IPA) in rats…”
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Absorption and Metabolism of the Absorption Enhancer Didecanoylphosphatidylcholine in Rabbit Nasal Epithelium In Vivo by VERMEHREN, C, JOHANSEN, P. B, HANSEN, H. S

“…The absorption enhancer, didecanoylphosphatidylcholine (DDPC), improves the nasal absorption of human growth hormone in rabbits. We elucidated the uptake and…”
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Effects of heparin and aminoguanidine on glomerular basement membrane thickening in diabetic rats by Oturai, P S, Rasch, R, Hasselager, E, Johansen, P B, Yokoyama, H, Thomsen, M K, Myrup, B, Kofoed-Enevoldsen, A, Deckert, T

“…The effects of heparin and aminoguanidine on glomerular basement membrane thickening were studied in streptozotocin diabetic Sprague-Dawley rats. A…”
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Antibiotic activity in serum following single and repeated oral administration of sodium fusidate in volunteers by MUNKHOLM, P, HEY, H, RASMUSSEN, S. N, JOHANSEN, P. B

“…The pharmacokinetics of antibiotic activity were investigated in 10 healthy, female volunteers receiving a single oral dose of sodium fusidate (500 mg)…”
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Prophylactic treatment of adult nocturia with bumetanide by Pedersen, P A, Johansen, P B

“…The efficacy of 1 mg bumetanide on nocturia was compared with placebo in a randomised double-blind cross-over study in general practice. Twenty-eight patients,…”
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Pharmacokinetics of tinzaparin (Logiparin)--a low molecular weight heparin--after single and repeated intravenous administration in rats by Johansen, P B, Rasmussen, S N, Ostergaard, P B

“…After a single and repeated i.v. injections of 1 mg/kg 3H-radiolabelled tinzaparin once daily to rats for 7, 14, and 21 days, drug-related radioactivity in…”
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Prosthetic rehabilitation in unilateral high above-elbow amputation and brachial plexus lesion: case report by Thyberg, M, Johansen, P B

“…Rehabilitation in persons with high above-elbow amputation presents a considerable prosthetic problem, especially in those who also have brachial plexus…”
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The growth hormone secretagogue ipamorelin counteracts glucocorticoid-induced decrease in bone formation of adult rats by Andersen, N.B., Malmlöf, K., Johansen, P.B., Andreassen, T.T., Ørtoft, G., Oxlund, H.

“…The ability of the growth hormone secretagogue (GHS) Ipamorelin to counteract the catabolic effects of glucocorticoid (GC) on skeletal muscles and bone was…”
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Continuous Monitoring of Detrusor Pressure in Patients With a Reflex Urinary Bladder After Spinal Cord Injury by Thyberg, M, Gedda, S, B Johansen, P, Lassvik, C, Spångberg, A, Engberg, A

“…In spinal cord injury, the detrusor pressure, as a parameter of urinary bladder dysfunction, is related to incontinence and renal complications. In order to…”
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