Search Results - "Johansen, Lene E"
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Co-targeting CDK4/6 and AKT with endocrine therapy prevents progression in CDK4/6 inhibitor and endocrine therapy-resistant breast cancer
Published in Nature communications (25-08-2021)“…CDK4/6 inhibitors (CDK4/6i) combined with endocrine therapy have shown impressive efficacy in estrogen receptor-positive advanced breast cancer. However, most…”
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Co-targeting CDK2 and CDK4/6 overcomes resistance to aromatase and CDK4/6 inhibitors in ER+ breast cancer
Published in NPJ precision oncology (24-09-2022)“…Resistance to aromatase inhibitor (AI) treatment and combined CDK4/6 inhibitor (CDK4/6i) and endocrine therapy (ET) are crucial clinical challenges in treating…”
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Triple combination targeting PI3K, ER, and CDK4/6 inhibits growth of ER‐positive breast cancer resistant to fulvestrant and CDK4/6 or PI3K inhibitor
Published in Cancer communications (London, England) (01-06-2023)“…List of abbreviations CDK4/6 Cyclin-dependent kinase 4/6 CDK4/6i CDK4/6-inhibitor ER Estrogen receptor ERBB2 Erb-B2 receptor tyrosine kinase 2 ES Enrichment…”
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MCM3 upregulation confers endocrine resistance in breast cancer and is a predictive marker of diminished tamoxifen benefit
Published in NPJ breast cancer (04-01-2021)“…Resistance to endocrine therapy in estrogen receptor-positive (ER + ) breast cancer is a major clinical problem with poorly understood mechanisms. There is an…”
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Discriminating Isogenic Cancer Cells and Identifying Altered Unsaturated Fatty Acid Content as Associated with Metastasis Status, Using K-Means Clustering and Partial Least Squares-Discriminant Analysis of Raman Maps
Published in Analytical chemistry (Washington) (01-04-2010)“…Raman spectroscopy is a label-free, real-time diagnostic tool that shows great promise in identifying cell differences. We have evaluated the discriminatory…”
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Identification of genes with altered expression in medullary breast cancer vs. ductal breast cancer and normal breast epithelia
Published in International journal of oncology (01-06-2006)“…Medullary breast cancer (MCB) is a morphologically and biologically distinct subtype that, despite cytologically highly malignant characteristics, has a…”
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