Search Results - "Johansen, Harald T"

Nuclear legumain activity in colorectal cancer by Haugen, Mads H, Johansen, Harald T, Pettersen, Solveig J, Solberg, Rigmor, Brix, Klaudia, Flatmark, Kjersti, Maelandsmo, Gunhild M

“…The cysteine protease legumain is involved in several biological and pathological processes, and the protease has been found over-expressed and associated with…”
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Cystatin E/M suppresses legumain activity and invasion of human melanoma by Briggs, Jon J, Haugen, Mads H, Johansen, Harald T, Riker, Adam I, Abrahamson, Magnus, Fodstad, Øystein, Maelandsmo, Gunhild M, Solberg, Rigmor

“…High activity of cysteine proteases such as legumain and the cathepsins have been shown to facilitate growth and invasion of a variety of tumor types. In…”
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Legumain in Acute Coronary Syndromes: A Substudy of the PLATO (Platelet Inhibition and Patient Outcomes) Trial by Gregersen, Ida, Michelsen, Annika E, Lunde, Ngoc Nguyen, Åkerblom, Axel, Lakic, Tatevik G, Skjelland, Mona, Ryeng Skagen, Karolina, Becker, Richard C, Lindbäck, Johan, Himmelmann, Anders, Solberg, Rigmor, Johansen, Harald T, James, Stefan K, Siegbahn, Agneta, Storey, Robert F, Kontny, Frederic, Aukrust, Pål, Ueland, Thor, Wallentin, Lars, Halvorsen, Bente

“…Background The cysteine protease legumain is increased in patients with atherosclerosis, but its causal role in atherogenesis and cardiovascular disease is…”
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Correction: Nuclear Legumain Activity in Colorectal Cancer by Haugen, Mads H., Johansen, Harald T., Pettersen, Solveig J., Solberg, Rigmor, Brix, Klaudia, Flatmark, Kjersti, Maelandsmo, Gunhild M.

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Characterization of cysteine proteases in Malian medicinal plants by Bah, Sékou, Paulsen, Berit S., Diallo, Drissa, Johansen, Harald T.

“…Extracts form 10 different Malian medicinal plants with a traditional use against schistosomiasis were investigated for their possible content of proteolytic…”
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Intra- and extracellular regulation of activity and processing of legumain by cystatin E/M by Smith, Robert, Johansen, Harald T., Nilsen, Hilde, Haugen, Mads H., Pettersen, Solveig J., Mælandsmo, Gunhild M., Abrahamson, Magnus, Solberg, Rigmor

“…Legumain, an asparaginyl endopeptidase, is up-regulated in tumour and tumour-associated cells, and is linked to the processing of cathepsin B, L, and proMMP-2…”
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Bradykinin analysis revived – A validated method for determination of its stable metabolite in whole blood by LC–MS/MS by Seip, Knut F., Bjerknes, Kari C., Johansen, Harald T., Nielsen, Erik W., Landrø, Linn, Reubsaet, Léon

“…•A validated method for determination of the metabolite, bradykinin 1–5 (BK1–5), has been developed.•The validation confirms good linearity, repeatability…”
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Marasmius oreades agglutinin (MOA) is a chimerolectin with proteolytic activity by Cordara, Gabriele, Egge-Jacobsen, Wolfgang, Johansen, Harald T., Winter, Harry C., Goldstein, Irwin J., Sandvig, Kirsten, Krengel, Ute

“…► Marasmius oreades agglutinin (MOA) is a calcium-dependent cysteine protease. ► Cys215 is the catalytic nucleophile in the putative C215-H257-E274 catalytic…”
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Collagen I regulates matrix metalloproteinase-2 activation in osteosarcoma cells independent of S100A4 by Elenjord, Renate, Allen, Jasmine B, Johansen, Harald T, Kildalsen, Hanne, Svineng, Gunbjørg, Mælandsmo, Gunhild M, Loennechen, Thrina, Winberg, Jan-Olof

“…This work investigates the effect of cell-collagen I interactions on the synthesis and activation of MMP-2, as well as synthesis of MT1-MMP and TIMP-1, by…”
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Evidence that unrestricted legumain activity is involved in disturbed epidermal cornification in cystatin M/E deficient mice by Zeeuwen, Patrick L.J.M., van Vlijmen-Willems, Ivonne M.J.J., Olthuis, Diana, Johansen, Harald T., Hitomi, Kiyotaka, Hara-Nishimura, Ikuko, Powers, James C., James, Karen E., op den Camp, Huub J., Lemmens, Rob, Schalkwijk, Joost

“…Homozygosity for Cst6 null alleles causes the phenotype of the ichq mouse, which is a model for human harlequin ichthyosis (OMIM 242500), a genetically…”
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Antigen levels of urokinase plasminogen activator and its receptor at the tumor-host interface of colorectal adenocarcinomas are related to tumor aggressiveness by Buø, Laila, Meling, Gunn Iren, Karlsrud, Tove S, Johansen, Harald T, Aasen, Ansgar O

“…The distributions of urokinase and tissue plasminogen activators (uPA, tPA), uPA receptor (uPAR), and plasminogen activator inhibitors (PA1-1, PAI-2) were…”
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Expression of matrix metalloproteinases and the metastasis-associated gene S100A4 in human neuroblastoma and primitive neuroectodermal tumor cells by Bjørnland, Kristin, Bratland, Åse, Rugnes, Elin, Pettersen, Solveig, Johansen, Harald T., Aasen, Ansgar O., Fodstad, Øystein, Ree, Anne H., Mælandsmo, Gunhild M.

“…Background: Matrix metalloproteinases (MMPs) and their endogenous inhibitors (tissue inhibitors of MMPs; TIMPs) have been shown to correlate with in vitro…”
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C1-inhibitor attenuates hyperacute rejection and inhibits complement, leukocyte and platelet activation in an ex vivo pig-to-human perfusion model by Fiane, Arnt E, Videm, Vibeke, Johansen, Harald T, Mellbye, Ove J, Nielsen, Erik W, Mollnes, Tom E

“…Xenotransplantation may be a future alternative due to increased shortage of organs. Classical complement activation is central in hyperacute rejection in…”
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Abstract 1093: Legumain in colorectal cancer: Unorthodox localization and trafficking by Haugen, Mads H., Flatmark, Kjersti, Damgaard, Ingrid, Tamhane, Tripti, Engesæter, Birgit, Tveito, Siri, Egeland, Eivind V., Solberg, Rigmor, Johansen, Harald T., Pettersen, Solveig J., Boye, Kjetil, Brix, Klaudia, Mælandsmo, Gunhild M.

“…Abstract The cysteine proteinase legumain is unique in cleaving substrates N-terminally of asparagine, and recent observations also revealed carboxypeptidase…”
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Quantification of kininogens in plasma. A functional method based on the cysteine proteinase inhibitor activity by Karlsrud, Tove S., Buø, Laila, Aasen, Ansgar O., Johansen, Harald T.

“…We have previously reported on a microassay based on human kininogens as cysteine proteinase inhibitors (CPIs), which could quantify partially purified…”
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Activation of the plasma Kallikrein-Kinin system in respiratory distress syndrome by SAUGSTAD, O. D, BUØ, L, JOHANSEN, H. T, RØISE, O, AASEN, A. O

“…Components of the plasma kallikrein-kinin and fibrinolytic systems together with antithrombin III were measured the first days postpartum in 13 premature…”
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Correction: Nuclear Legumain Activity in Colorectal Cancer by Mads H. Haugen, Harald T. Johansen, Solveig J. Pettersen, Rigmor Solberg, Klaudia Brix, Kjersti Flatmark, Gunhild M. Maelandsmo

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Colorimetric and Fluorimetric Microplate Assays for Legumain and a Staining Reaction for Detection of the Enzyme after Electrophoresis by Johansen, Harald T., Knight, C.Graham, Barrett, Alan J.

“…The cysteine endopeptidase legumain was recently discovered in mammalian cells, predominantly localized in the lysosomal system where it is believed to…”
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Polymorphonuclear elastase in human colorectal carcinoma by Bjørnland, K, Buø, L, Scott, H, Konttinen, Y, Johansen, H T, Aasen, A O

“…proteinases are required for invasion through the extracellular matrix (ECM) during tumor invasion and metastasis. Polymorphonuclear (PMN) elastase can degrade…”
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Activation of the plasma contact system and hemodynamic changes after graft revascularization in liver transplantation by Scholz, T, Backman, L, Mathisen, O, Buø, L, Karlsrud, T, Johansen, H T, Bergan, A, Klintmalm, G B, Aasen, A O

“…In this study, the relation between activation of the plasma contact system and hemodynamic changes during orthotopic liver transplantation was evaluated…”
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