Search Results - "Johansen, Dan"

Genetic Variations in the Human G Protein-coupled Receptor Class C, Group 6, Member A (GPRC6A) Control Cell Surface Expression and Function by Jørgensen, Stine, Have, Christian Theil, Underwood, Christina Rye, Dan Johansen, Lars, Wellendorph, Petrine, Gjesing, Anette Prior, Jørgensen, Christinna V., Quan, Shi, Rui, Gao, Inoue, Asuka, Linneberg, Allan, Grarup, Niels, Jun, Wang, Pedersen, Oluf, Hansen, Torben, Bräuner-Osborne, Hans

“…GPRC6A is a G protein-coupled receptor activated by l-amino acids, which, based on analyses of knock-out mice, has been suggested to have physiological…”
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LDL-cholesterol goal achievement, cardiovascular disease, and attributed risk of Lp(a) in a large cohort of predominantly genetically verified familial hypercholesterolemia by Bogsrud, Martin P., Græsdal, Asgeir, Johansen, Dan, Langslet, Gisle, Hovland, Anders, Arnesen, Kjell-Erik, Mundal, Liv J., Retterstøl, Kjetil, Wium, Cecilie, Holven, Kirsten B.

“…Current treatment goals for familial hypercholesterolemia (FH) recommended by the European Atherosclerosis Society (EAS) are LDL-C ≤2.5 mmol/L (∼100 mg/dL) or…”
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Molecular pharmacology of promiscuous seven transmembrane receptors sensing organic nutrients by Wellendorph, Petrine, Johansen, Lars Dan, Bräuner-Osborne, Hans

“…A number of highly promiscuous seven transmembrane (7TM) receptors have been cloned and characterized within the last few years. It is noteworthy that many of…”
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No evidence for a bone phenotype in GPRC6A knockout mice under normal physiological conditions by Wellendorph, Petrine, Johansen, Lars Dan, Jensen, Anders A, Casanova, Emilio, Gassmann, Martin, Deprez, Pierre, Clément-Lacroix, Philippe, Bettler, Bernhard, Bräuner-Osborne, Hans

“…GPRC6A is a seven-transmembrane receptor mediating signaling by a wide range of l-α-amino acids, a signaling augmented by the divalent cations Ca2+ and Mg2+…”
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REAL-LIFE PCSK9 EXPERIENCE: 65% TREATMENT TARGET ATTAINMENT IN FAMILIAL HYPERCHOLESTEROLEMIA PATIENTS by Graesdal, Asgeir, Bogsrud, Martin, Johansen, Dan, Dybvig, Ane, Holven, Kirsten

“…Background: LDL-cholesterol (LDL-C) treatment targets for patients with familial hypercholesterolemia (FH) is < 2.5 mmol/L, or < 1.8 mmol/L in high-risk-FH…”
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Treatment goal attainment in children with familial hypercholesterolemia: A cohort study of 302 children in Norway by Bogsrud, Martin P., Langslet, Gisle, Wium, Cecilie, Johansen, Dan, Svilaas, Arne, Holven, Kirsten B.

“…Consensus statements recommend that statin treatment in children with heterozygous familial hypercholesterolemia (FH) should be considered from 8 to 10 years…”
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ONLY EIGHT PERCENT OF VERY HIGH-RISK FAMILIAL HYPERCHOLESTEROLEMIA PATIENTS ACHIEVE LDL-CHOLESTEROL TARGET DESPITE BEING ON MAXIMAL CONVENTIONAL LIPID-LOWERING THERAPY by Bogsrud, Martin Prøven, Græsdal, Asgeir, Johansen, Dan, Langslet, Gisle, Hovland, Anders, Holven, Kirsten

“…Background: LDL-cholesterol (LDL-C) treatment targets for patients with familial hypercholesterolemia (FH) is defined by the European Atherosclerosis Society…”
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Some children with a familial hypercholesterolemia mutation may exhibit persistent low LDL levels by Langslet, Gisle, Bogsrud, Martin P., Wium, Cecilie, Johansen, Dan, Svilaas, Arne, Holven, Kirsten B.

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LDL-cholesterol goal achievement, cardiovascular disease, and attributed risk of Lp(a)in a large cohort of predominantly genetically verified familial hypercholesterolemia by Bogsrud, Martin Prøven, Græsdal, Asgeir, Johansen, Dan, Langslet, Gisle, Hovland, Anders, Arnesen, Kjell Erik, Mundal, Liv, Retterstøl, Kjetil, Wium, Cecilie, Holven, Kirsten Bjørklund

“…Current treatment goals for familial hypercholesterolemia (FH) recommended by the European Atherosclerosis Society (EAS) are LDL-C ≤2.5 mmol/L (∼100 mg/dL) or…”
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Abstract 19363: Elevated Lp(a) Levels Strongly Increase the Risk for Cardiovascular Disease in Patients With Familial Hypercholesterolemia by Holven, Kirsten B, Græsdal, Asgeir, Langslet, Gisle, Hovland, Anders, Retterstøl, Kjetil, Mundal, Liv, Johansen, Dan, Bogsrud, Martin P

“…IntroductionSeveral studies have suggested that elevated levels of Lp(a) is a strong and independent risk factor for cardiovascular disease (CVD) in the…”
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The l-α-amino acid receptor GPRC6A is expressed in the islets of Langerhans but is not involved in l-arginine-induced insulin release by Smajilovic, Sanela, Clemmensen, Christoffer, Johansen, Lars Dan, Wellendorph, Petrine, Holst, Jens Juul, Thams, Peter Grevsen, Ogo, Egbuna, Bräuner-Osborne, Hans

“…GPRC6A is a seven-transmembrane receptor activated by a wide range of l -α-amino acids, most potently by l -arginine and other basic amino acids. The receptor…”
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IKAP localizes to membrane ruffles with filamin A and regulates actin cytoskeleton organization and cell migration by Johansen, Lars Dan, Naumanen, Tiina, Knudsen, Astrid, Westerlund, Nina, Gromova, Irina, Junttila, Melissa, Nielsen, Christina, Bøttzauw, Trine, Tolkovsky, Aviva, Westermarck, Jukka, Coffey, Eleanor T, Jäättelä, Marja, Kallunki, Tuula

“…Loss-of-function mutations in the IKBKAP gene, which encodes IKAP (ELP1), cause familial dysautonomia (FD), with defective neuronal development and…”
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The l-[alpha]-amino acid receptor GPRC6A is expressed in the islets of Langerhans but is not involved in l-arginine-induced insulin release by Smajilovic, Sanela, Clemmensen, Christoffer, Johansen, Lars Dan, Wellendorph, Petrine, Holst, Jens Juul, Thams, Peter Grevsen, Ogo, Egbuna, Bräuner-osborne, Hans

“…GPRC6A is a seven-transmembrane receptor activated by a wide range of l-[alpha]-amino acids, most potently by l-arginine and other basic amino acids. The…”
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The Emerging Role of Promiscuous 7TM Receptors as Chemosensors for Food Intake by Wellendorph, Petrine, Johansen, Lars Dan, Bräuner-Osborne, Hans

“…In recent years, several highly promiscuous seven transmembrane (7TM) receptors have been cloned and characterized of which many are activated broadly by amino…”
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THE EMERGING ROLE OF PROMISCUOUS 7TM RECEPTORS AS CHEMOSENSORS FOR FOOD INTAKE: Incretins and Insulin Secretion by WELLENDORPH, Petrine, JOHANSEN, Lars Dan, BRÄUNER-OSBORNE, Hans

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