Search Results - "Johannsson, Oskar T."

Hsa-miR-21-3p associates with breast cancer patient survival and targets genes in tumor suppressive pathways by Amirfallah, Arsalan, Knutsdottir, Hildur, Arason, Adalgeir, Hilmarsdottir, Bylgja, Johannsson, Oskar T, Agnarsson, Bjarni A, Barkardottir, Rosa B, Reynisdottir, Inga

“…Breast cancer is the cancer most often diagnosed in women. MicroRNAs (MIRs) are short RNA molecules that bind mRNA resulting in their downregulation. MIR21 has…”
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The BARD1 Cys557Ser variant and breast cancer risk in Iceland by Stacey, Simon N, Sulem, Patrick, Johannsson, Oskar T, Helgason, Agnar, Gudmundsson, Julius, Kostic, Jelena P, Kristjansson, Kristleifur, Jonsdottir, Thora, Sigurdsson, Helgi, Hrafnkelsson, Jon, Johannsson, Jakob, Sveinsson, Thorarinn, Myrdal, Gardar, Grimsson, Hlynur Niels, Bergthorsson, Jon T, Amundadottir, Laufey T, Gulcher, Jeffrey R, Thorsteinsdottir, Unnur, Kong, Augustine, Stefansson, Kari

“…Most, if not all, of the cellular functions of the BRCA1 protein are mediated through heterodimeric complexes composed of BRCA1 and a related protein, BARD1…”
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Niraparib for Advanced Breast Cancer with Germline BRCA1 and BRCA2 Mutations: the EORTC 1307-BCG/BIG5-13/TESARO PR-30-50-10-C BRAVO Study by Turner, Nicholas C, Balmaña, Judith, Poncet, Coralie, Goulioti, Theodora, Tryfonidis, Konstantinos, Honkoop, Aafke H, Zoppoli, Gabriele, Razis, Evangelia, Johannsson, Oskar T, Colleoni, Marco, Tutt, Andrew N, Audeh, William, Ignatiadis, Michail, Mailliez, Audrey, Trédan, Olivier, Musolino, Antonino, Vuylsteke, Peter, Juan-Fita, Maria Jose, Macpherson, Iain R J, Kaufman, Bella, Manso, Luis, Goldstein, Lori J, Ellard, Susan L, Láng, István, Jen, Kai Yu, Adam, Virginie, Litière, Saskia, Erban, John, Cameron, David A

“…To investigate the activity of niraparib in patients with germline-mutated (g m) advanced breast cancer. BRAVO was a randomized, open-label phase III trial…”
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Oestrogen receptor status, treatment and breast cancer prognosis in Icelandic BRCA2 mutation carriers by Jonasson, Jon G, Stefansson, Olafur A, Johannsson, Oskar T, Sigurdsson, Helgi, Agnarsson, Bjarni A, Olafsdottir, Gudridur H, Alexiusdottir, Kristin K, Stefansdottir, Hrefna, Munoz Mitev, Rodrigo, Olafsdottir, Katrin, Olafsdottir, Kristrun, Arason, Adalgeir, Stefansdottir, Vigdis, Olafsdottir, Elinborg J, Barkardottir, Rosa B, Eyfjord, Jorunn E, Narod, Steven A, Tryggvadóttir, Laufey

“…Background: The impact of an inherited BRCA2 mutation on the prognosis of women with breast cancer has not been well documented. We studied the effects of…”
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Association of BRCA2 K3326 With Small Cell Lung Cancer and Squamous Cell Cancer of the Skin by Rafnar, Thorunn, Sigurjonsdottir, Gudbjorg R, Stacey, Simon N, Halldorsson, Gisli, Sulem, Patrick, Pardo, Luba M, Helgason, Hannes, Sigurdsson, Stefan T, Gudjonsson, Thorkell, Tryggvadottir, Laufey, Olafsdottir, Gudridur H, Jonasson, Jon G, Alexiusdottir, Kristin, Sigurdsson, Asgeir, Gudmundsson, Julius, Saemundsdottir, Jona, Sigurdsson, Jon K, Johannsdottir, Hrefna, Uitterlinden, Andre, Vermeulen, Sita H, Galesloot, Tessel E, Allain, Dawn C, Lacko, Martin, Sigurgeirsson, Bardur, Thorisdottir, Kristin, Johannsson, Oskar T, Sigurdsson, Fridbjorn, Ragnarsson, Gunnar B, Isaksson, Helgi, Hardardottir, Hronn, Gudbjartsson, Tomas, Gudbjartsson, Daniel F, Masson, Gisli, Kiemeney, Lambertus A M L, Ewart Toland, Amanda, Nijsten, Tamar, Peters, Wilbert H M, Olafsson, Jon H, Jonsson, Steinn, Thorsteinsdottir, Unnur, Thorleifsson, Gudmar, Stefansson, Kari

“…Most pathogenic mutations in the BRCA2 gene carry a high risk of hereditary breast and ovarian cancer (HBOC). However, a stop-gain mutation, K3326*…”
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Genome-wide search for breast cancer linkage in large Icelandic non-BRCA1/2 families by Arason, Adalgeir, Gunnarsson, Haukur, Johannesdottir, Gudrun, Jonasson, Kristjan, Bendahl, Pär-Ola, Gillanders, Elizabeth M, Agnarsson, Bjarni A, Jönsson, Göran, Pylkäs, Katri, Mustonen, Aki, Heikkinen, Tuomas, Aittomäki, Kristiina, Blomqvist, Carl, Melin, Beatrice, Johannsson, Oskar T H, Møller, Pål, Winqvist, Robert, Nevanlinna, Heli, Borg, Ake, Barkardottir, Rosa B

“…A significant proportion of high-risk breast cancer families are not explained by mutations in known genes. Recent genome-wide searches (GWS) have not revealed…”
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High risk of in-breast tumor recurrence after BRCA1/2-associated breast cancer by Nilsson, Martin P., Hartman, Linda, Kristoffersson, Ulf, Johannsson, Oskar T., Borg, Åke, Henriksson, Karin, Lanke, Elsa, Olsson, Håkan, Loman, Niklas

“…The purpose of the study was to compare breast-conserving therapy (BCT) and mastectomy (M) in BRCA1/2 mutation carriers. Women with invasive breast cancer and…”
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Breast cancer survival in Nordic BRCA2 mutation carriers—unconventional association with oestrogen receptor status by Olafsdottir, Elinborg J., Borg, Ake, Jensen, Maj-Britt, Gerdes, Anne-Marie, Johansson, Anna L. V., Barkardottir, Rosa B., Johannsson, Oskar T., Ejlertsen, Bent, Sønderstrup, Ida Marie Heeholm, Hovig, Eivind, Lænkholm, Anne-Vibeke, Hansen, Thomas van Overeem, Olafsdottir, Gudridur H., Rossing, Maria, Jonasson, Jon G., Sigurdsson, Stefan, Loman, Niklas, Nilsson, Martin P., Narod, Steven A., Tryggvadottir, Laufey

“…Background The natural history of breast cancer among BRCA2 carriers has not been clearly established. In a previous study from Iceland, positive ER status was…”
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Long-term prognosis of early-onset breast cancer in a population-based cohort with a known BRCA1/2 mutation status by Nilsson, Martin P., Hartman, Linda, Idvall, Ingrid, Kristoffersson, Ulf, Johannsson, Oskar T., Loman, Niklas

“…All women in the South Sweden Health Care Region with breast cancer diagnosed aged less than 41 during the period between 1990 and 1995 were contacted in 1996…”
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High Atlastin 2-2 (ATL2-2) Expression Associates with Worse Prognosis in Estrogen-Receptor-Positive Breast Cancer by Reynisdottir, Inga, Arason, Adalgeir, Freysteinsdottir, Edda S, Kristjansdottir, Sigrun B, Hilmarsdottir, Bylgja, Traustadottir, Gunnhildur A, Johannsson, Oskar T, Agnarsson, Bjarni A, Barkardottir, Rosa B

“…The disruption of endoplasmic reticulum (ER) homeostasis occurs in many human diseases. Atlastins (ATLs) maintain the branched network of the ER. The…”
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The Retinoblastoma Gene Undergoes Rearrangements in BRCA1-Deficient Basal-like Breast Cancer by JÖNSSON, Goran, STAAF, Johan, PERSSON, Camilla, GRABAU, Dorthe, JOHNSSON, Ellinor, LÖVGREN, Kristina, MAGNUSSON, Linda, HEIKKILÄ, Päivi, AGNARSSON, Bjarni A, JOHANNSSON, OskarT, MALMSTRÖM, Per, FERNÖ, Marten, VALLON-CHRISTERSSON, Johan, OLSSON, Håkan, LOMAN, Niklas, NEVANLINNA, Heli, BARKARDOTTIR, Rosa B, BORG, Ake, RINGNER, Markus, GRUVBERGER-SAAL, Sofia K, SAAL, Lao H, HOLM, Karolina, HEGARDT, Cecilia, ARASON, Adalgeir, FAGERHOLM, Rainer

“…Breast tumors from BRCA1 germ line mutation carriers typically exhibit features of the basal-like molecular subtype. However, the specific genes recurrently…”
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BRCA1 Promoter Methylation Status in 1031 Primary Breast Cancers Predicts Favorable Outcomes Following Chemotherapy by Stefansson, Olafur A, Hilmarsdottir, Holmfridur, Olafsdottir, Kristrun, Tryggvadottir, Laufey, Sverrisdottir, Asgerdur, Johannsson, Oskar T, Jonasson, Jon G, Eyfjord, Jorunn E, Sigurdsson, Stefan

“…Breast Cancer 1 gene ( ) is known to be inactivated in breast tumors by promoter methylation. Tumor cells in patients carrying a germline mutation in are…”
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Tumour diploidy and survival in breast cancer patients with BRCA2 mutations by Tryggvadottir, Laufey, Olafsdottir, Elinborg J., Olafsdottir, Gudridur H., Sigurdsson, Helgi, Johannsson, Oskar T., Bjorgvinsson, Einar, Alexiusdottir, Kristin, Stefansson, Olafur A., Agnarsson, Bjarni A., Narod, Steven A., Eyfjord, Jorunn E., Jonasson, Jon G.

“…It is not well known to what extent carrying a BRCA2 mutation affects the survival of women with breast cancer and prognostic factors among BRCA2 -positive…”
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Impact of teenage oral contraceptive use in a population-based series of early-onset breast cancer cases who have undergone BRCA mutation testing by Jernström, Helena, Loman, Niklas, Johannsson, Oskar T., Borg, Åke, Olsson, Håkan

“…Oral contraceptive (OC) use in young women has been associated with an increased risk of breast cancer. This matched case-control study aims to elucidate the…”
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High prevalence of the 999del5 mutation in Icelandic breast and ovarian cancer patients by JOHANNESDOTTIR, G, GUDMUNDSSON, J, EGILSSON, V, BARKARDOTTIR, R. B, BERGTHORSSON, J. T, ARASON, A, AGNARSSON, B. A, EIRIKSDOTTIR, G, JOHANSSON, O. T, BORG, A, INGVARSSON, S, EASTON, D. F

“…Studies on Icelandic breast cancer families have shown that most of them segregate a 999del5 BRCA2 mutation. Here, we report the frequency of the 999del5 BRCA2…”
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Characterization of a Novel Breast Carcinoma Xenograft and Cell Line Derived from a BRCA1 Germ-Line Mutation Carrier by Johannsson, Oskar T, Staff, Synnöve, Vallon-Christersson, Johan, Kytöla, Soili, Gudjonsson, Thorarinn, Rennstam, Karin, Hedenfalk, Ingrid A, Adeyinka, Adewale, Kjellén, Elisabeth, Wennerberg, Johan, Baldetorp, Bo, Petersen, Ole W, Olsson, Håkan, Oredsson, Stina, Isola, Jorma, Borg, Åke

“…A human tumor xenograft (L56Br-X1) was established from a breast cancer axillary lymph node metastasis of a 53-year-old woman with a BRCA1 germ-line nonsense…”
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Rapid caspase-dependent cell death in cultured human breast cancer cells induced by the polyamine analogue N(1),N(11)-diethylnorspermine by Hegardt, Cecilia, Johannsson, Oskar T, Oredsson, Stina M

“…The spermine analogue N(1),N(11)-diethylnorspermine (DENSPM) efficiently depletes the cellular pools of putrescine, spermidine and spermine by down-regulating…”
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Actionable Genotypes and Their Association with Life Span in Iceland by Jensson, Brynjar O., Arnadottir, Gudny A., Katrinardottir, Hildigunnur, Fridriksdottir, Run, Helgason, Hannes, Oddsson, Asmundur, Sveinbjornsson, Gardar, Eggertsson, Hannes P., Halldorsson, Gisli H., Atlason, Bjarni A., Jonsson, Hakon, Oskarsson, Gudjon R., Sturluson, Arni, Gudjonsson, Sigurjon A., Thorisson, Gudmundur A., Zink, Florian, Moore, Kristjan H.S., Palsson, Gunnar, Sigurdsson, Asgeir, Jonasdottir, Adalbjorg, Jonasdottir, Aslaug, Magnusson, Magnus K., Helgadottir, Anna, Steinthorsdottir, Valgerdur, Gudmundsson, Julius, Stacey, Simon N., Hilmarsson, Rafn, Olafsson, Isleifur, Johannsson, Oskar T., Arnar, David O., Saemundsdottir, Jona, Magnusson, Olafur T., Masson, Gisli, Halldorsson, Bjarni V., Helgason, Agnar, Stefansson, Hreinn, Jonsdottir, Ingileif, Holm, Hilma, Rafnar, Thorunn, Thorsteinsdottir, Unnur, Gudbjartsson, Daniel F., Stefansson, Kari, Sulem, Patrick

“…This study examines the relationship of pathogenic and likely pathogenic variants for which preventive or therapeutic measures are available to life span and…”
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Reproductive factors in hereditary breast cancer by JERNSTRÖM, H. C. B, JOHANNSSON, O. T, LOMAN, N, BORG, K, OLSSON, H

“…An early age at menarche, a short menstrual cycle length, and a high age at first full term pregnancy or nulliparity are known risk factors for breast cancer…”
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Genomic profiling of breast tumours in relation to BRCA abnormalities and phenotypes by Stefansson, Olafur Andri, Jonasson, Jon Gunnlaugur, Johannsson, Oskar Thor, Olafsdottir, Kristrun, Steinarsdottir, Margret, Valgeirsdottir, Sigridur, Eyfjord, Jorunn Erla

“…Germline mutations in the BRCA1 and BRCA2 genes account for a considerable fraction of familial predisposition to breast cancer. Somatic mutations in BRCA1 and…”
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