Search Results - "Johannsen, F R"

Toxicological profile of carboxymethyl inulin by Johannsen, F.R

“…Carboxymethylinulin (CMI), formed by carboxylation of a natural carbohydrate obtained from the chicory plant, is particularly effective in sequestration of…”
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Mutagenicity assessment of acrylate and methacrylate compounds and implications for regulatory toxicology requirements by Johannsen, F.R., Vogt, Barbara, Waite, Maureen, Deskin, Randy

“…Esters of acrylic acid and methacrylic acid, more commonly known as acrylates and methacrylates, respectively, are key raw materials in the coatings and…”
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Mixture risk assessment: A case study of monsanto experiences by Nair, R.S., Dudek, B.R., Grothe, D.R., Johannsen, F.R., Lamb, I.C., Martens, M.A., Sherman, J.H., Stevens, M.W.

“…Monsanto employs several pragmatic approaches for evaluating the toxicity of mixtures. These approaches are similar to those recommended by many national and…”
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A scheme for classifying carcinogens by Ashby, J, Doerrer, N G, Flamm, F G, Harris, J E, Hughes, D H, Johannsen, F R, Lewis, S C, Krivanek, N D, McCarthy, J F, Moolenaar, R J

“…We present a scheme for classifying chemical carcinogens according to the weight of the evidence that each substance poses a human cancer hazard. The approach…”
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Toxicity and uptake potential of an acrylic polymer comonomer and its biological degradation products by JOHANNSEN, F. R, LEVINSKAS, G. J, ADAMS, W. J

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Effects of formaldehyde in the rat and dog following oral exposure by Johannsen, F R, Levinskas, G J, Tegeris, A S

“…Formaldehyde was administered orally (p.o.) to groups of rats and dogs at dosages up to 150 and 100 mg/kg/day, respectively, for 91 consecutive days…”
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Hepatic involvement of two chlorinated propenes following repeated oral exposure in the rat by Johannsen, F R, Levinskas, G J, Goldenthal, E I

“…The comparative toxicity of two chlorinated propene isomers, 1,2,3-trichloropropene (TRCP) and 1,1,2,3-tetrachloropropene (TECP), was investigated via…”
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Toxicological profile of orally administered 1,6-hexane diamine in the rat by Johannsen, F R, Levinskas, G J

“…The industrial chemical 1,6-Hexane Diamine, or hexamethylenediamine (HMD), has an acute oral LD50 of 980 mg kg-1 in rats. Dietary administration of HMD to…”
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Subchronic inhalation toxicity and reproductive assessment in rats of three chlorinated propenes by Johannsen, F R, Levinskas, G J, Rusch, G M, Schroeder, R E

“…Groups of 15 male and 15 female Sprague-Dawley rats were exposed to 1 of 3 chloropropene (2,3-Di = DCP; 1,2,3-Tri = TRCP; and 1,1,2,3-Tetra = TECP) vapors to…”
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Acute and subchronic toxicity of tetramethylcyclohexanes by Johannsen, F R, Levinskas, G J

“…The acute oral toxicity in rats was estimated for seven isomers or isomeric ratios of tetramethylcyclohexane (TMCH). Lack of sufficient mortality at the…”
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Oral toxicity of trichlorobenzyl chloride and its acid derivative by Johannsen, F R, Levinskas, G J

“…The acute rat oral LD50 of 2,4,6-Trichlorobenzyl chloride (TCBC) was determined to be 3075 mg/kg. When male and female rats were administered 1500 and 3000 ppm…”
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Evaluation of the subchronic and reproductive effects of a series of chlorinated propanes in the rat. I. Toxicity of 1,2,3-trichloropropane by Johannsen, F R, Levinskas, G J, Rusch, G M, Terrill, J B, Schroeder, R E

“…Repeated inhalation exposure and 1-generation reproduction studies have been conducted in the rat to address the adequacy of the 10 ppm occupational exposure…”
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A two-generation reproduction study in rats receiving diets containing hexamethylenediamine by Short, R D, Johannsen, F R, Schardein, J L

“…Rats received diets containing average daily doses of 0, 50, 150, and 500 mg/kg/day of hexamethylenediamine over two generations. Although no treatment-related…”
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Risk assessment of carcinogenic and noncarcinogenic chemicals by Johannsen, F R

“…"Risk Assessment" is a general term used with increasing frequency by both scientists and regulators. Scientifically based risk assessments consider available…”
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Subchronic toxicity of tetramethylsuccinonitrile by Johannsen, F R, Levinskas, G J

“…The acute rat oral LD50 for tetramethylsuccinonitrile (TMSN) is 38.9 +/- 7.4 mg/kg. A series of three 90-day subchronic toxicity studies were conducted with…”
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Toxicity of calcium sodium metaphosphate fiber. II. Chronic inhalation and oncogenicity study by Nair, R S, Johannsen, F R, Bolte, H F, Newton, P E, Rinehart, W E

“…Male and female Fischer 344 rats (80/sex/group) were exposed to CSM fiber 6 hr/day, 5 days/week at target-exposure levels of 0, 1, 5, or 25 mg/m3 for 24…”
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Chronic toxicity, oncogenic potential, and reproductive toxicity of p-nitroaniline in rats by Nair, R S, Auletta, C S, Schroeder, R E, Johannsen, F R

“…Dose levels for these studies were selected mainly on the basis of subchronic studies, although consideration was also given to workplace exposure levels and…”
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Evaluation of the teratogenic potential of three aliphatic nitriles in the rat by Johannsen, F R, Levinskas, G J, Berteau, P E, Rodwell, D E

“…Acetonitrile (ACN), adiponitrile (ADN), and propionitrile (PN), were evaluated for embryotoxic and teratogenic potential in rats. Mated Sprague-Dawley rats…”
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Teratogenic response of dimethylacetamide in rats by Johannsen, F R, Levinskas, G J, Schardein, J L

“…Pregnant CD rats (25/group) were used to determine the teratogenic potential of dimethylacetamide (DMAC). DMAC was administered in deionized water once a day…”
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Assessment of toxicity of o-nitrochlorobenzene in rats following a 4-week inhalation exposure by Nair, R S, Johannsen, F R, Levinskas, G J, Terrill, J B

“…o-Nitrochlorobenzene (ONCB) is a chemical intermediate used for the synthesis of various industrial chemicals. To evaluate the subchronic toxicity of this…”
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