Search Results - "Johannsen, Eric C."

An Epigenetic Journey: Epstein-Barr Virus Transcribes Chromatinized and Subsequently Unchromatinized Templates during Its Lytic Cycle by Chakravorty, Adityarup, Sugden, Bill, Johannsen, Eric C

“…The Epstein-Barr virus (EBV) lytic phase, like those of all herpesviruses, proceeds via an orderly cascade that integrates DNA replication and gene expression…”
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Epstein-Barr Virus Oncoprotein Super-enhancers Control B Cell Growth by Zhou, Hufeng, Schmidt, Stefanie C.S., Jiang, Sizun, Willox, Bradford, Bernhardt, Katharina, Liang, Jun, Johannsen, Eric C., Kharchenko, Peter, Gewurz, Benjamin E., Kieff, Elliott, Zhao, Bo

“…Super-enhancers are clusters of gene-regulatory sites bound by multiple transcription factors that govern cell transcription, development, phenotype, and…”
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A cancer-associated Epstein-Barr virus BZLF1 promoter variant enhances lytic infection by Bristol, Jillian A, Djavadian, Reza, Albright, Emily R, Coleman, Carrie B, Ohashi, Makoto, Hayes, Mitchell, Romero-Masters, James C, Barlow, Elizabeth A, Farrell, Paul J, Rochford, Rosemary, Kalejta, Robert F, Johannsen, Eric C, Kenney, Shannon C

“…Latent Epstein-Barr virus (EBV) infection contributes to both B-cell and epithelial-cell malignancies. However, whether lytic EBV infection also contributes to…”
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Hippo signaling effectors YAP and TAZ induce Epstein-Barr Virus (EBV) lytic reactivation through TEADs in epithelial cells by Van Sciver, Nicholas, Ohashi, Makoto, Pauly, Nicholas P, Bristol, Jillian A, Nelson, Scott E, Johannsen, Eric C, Kenney, Shannon C

“…The Epstein-Barr virus (EBV) human herpesvirus is associated with B-cell and epithelial-cell malignancies, and both the latent and lytic forms of viral…”
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Epstein—Barr Virus Nuclear Antigen 3C binds to BATF/IRF4 or SPI1/IRF4 composite sites and recruits Sin3A to repress CDKN2A by Jiang, Sizun, Willox, Bradford, Zhou, Hufeng, Holthaus, Amy M., Wang, Anqi, Shi, Tommy T., Maruo, Seiji, Kharchenko, Peter V., Johannsen, Eric C., Kieff, Elliott, Zhao, Bo

“…Epstein—Barr virus nuclear antigen 3C (EBNA3C) repression of CDKN2A p14ARF and p16INK4A is essential for immortal human B-lymphoblastoid cell line (LCL)…”
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Differentiation-Dependent KLF4 Expression Promotes Lytic Epstein-Barr Virus Infection in Epithelial Cells by Nawandar, Dhananjay M, Wang, Anqi, Makielski, Kathleen, Lee, Denis, Ma, Shidong, Barlow, Elizabeth, Reusch, Jessica, Jiang, Ru, Wille, Coral K, Greenspan, Deborah, Greenspan, John S, Mertz, Janet E, Hutt-Fletcher, Lindsey, Johannsen, Eric C, Lambert, Paul F, Kenney, Shannon C

“…Epstein-Barr virus (EBV) is a human herpesvirus associated with B-cell and epithelial cell malignancies. EBV lytically infects normal differentiated oral…”
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Restricted TET2 Expression in Germinal Center Type B Cells Promotes Stringent Epstein-Barr Virus Latency by Wille, Coral K, Li, Yangguang, Rui, Lixin, Johannsen, Eric C, Kenney, Shannon C

“…Epstein-Barr virus (EBV) latently infects normal B cells and contributes to the development of certain human lymphomas. Newly infected B cells support a highly…”
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Latent Epstein-Barr virus infection collaborates with Myc over-expression in normal human B cells to induce Burkitt-like Lymphomas in mice by Bristol, Jillian A, Nelson, Scott E, Ohashi, Makoto, Casco, Alejandro, Hayes, Mitchell, Ranheim, Erik A, Pawelski, Abigail S, Singh, Deo R, Hodson, Daniel J, Johannsen, Eric C, Kenney, Shannon C

“…Epstein-Barr virus (EBV) is an important cause of human lymphomas, including Burkitt lymphoma (BL). EBV+ BLs are driven by Myc translocation and have stringent…”
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Hypoxia-inducible factor-1α plays roles in Epstein-Barr virus's natural life cycle and tumorigenesis by inducing lytic infection through direct binding to the immediate-early BZLF1 gene promoter by Kraus, Richard J, Yu, Xianming, Cordes, Blue-Leaf A, Sathiamoorthi, Saraniya, Iempridee, Tawin, Nawandar, Dhananjay M, Ma, Shidong, Romero-Masters, James C, McChesney, Kyle G, Lin, Zhen, Makielski, Kathleen R, Lee, Denis L, Lambert, Paul F, Johannsen, Eric C, Kenney, Shannon C, Mertz, Janet E

“…When confronted with poor oxygenation, cells adapt by activating survival signaling pathways, including the oxygen-sensitive transcriptional regulators called…”
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EBNA2-deleted Epstein-Barr virus (EBV) isolate, P3HR1, causes Hodgkin-like lymphomas and diffuse large B cell lymphomas with type II and Wp-restricted latency types in humanized mice by Li, Chunrong, Romero-Masters, James C, Huebner, Shane, Ohashi, Makoto, Hayes, Mitchell, Bristol, Jillian A, Nelson, Scott E, Eichelberg, Mark R, Van Sciver, Nicholas, Ranheim, Erik A, Scott, Rona S, Johannsen, Eric C, Kenney, Shannon C

“…EBV transforms B cells in vitro and causes human B-cell lymphomas including classical Hodgkin lymphoma (CHL), Burkitt lymphoma (BL) and diffuse large B-cell…”
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Reduced IRF4 expression promotes lytic phenotype in Type 2 EBV-infected B cells by Bristol, Jillian A, Brand, Joshua, Ohashi, Makoto, Eichelberg, Mark R, Casco, Alejandro, Nelson, Scott E, Hayes, Mitchell, Romero-Masters, James C, Baiu, Dana C, Gumperz, Jenny E, Johannsen, Eric C, Dinh, Huy Q, Kenney, Shannon C

“…Humans are infected with two types of EBV (Type 1 (T1) and Type 2 (T2)) that differ substantially in their EBNA2 and EBNA 3A/B/C latency proteins and have…”
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ΔNp63α promotes Epstein-Barr virus latency in undifferentiated epithelial cells by Van Sciver, Nicholas, Ohashi, Makoto, Nawandar, Dhananjay M, Pauly, Nicholas P, Lee, Denis, Makielski, Kathleen R, Bristol, Jillian A, Tsao, Sai Wah, Lambert, Paul F, Johannsen, Eric C, Kenney, Shannon C

“…Epstein-Barr virus (EBV) is a human herpesvirus that causes infectious mononucleosis and contributes to both B-cell and epithelial-cell malignancies…”
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Epstein–Barr virus nuclear antigen 3A partially coincides with EBNA3C genome-wide and is tethered to DNA through BATF complexes by Schmidt, Stefanie C. S., Jiang, Sizun, Zhou, Hufeng, Willox, Bradford, Holthaus, Amy M., Kharchenko, Peter V., Johannsen, Eric C., Kieff, Elliott, Zhao, Bo

“…Significance Epstein–Barr Virus (EBV)-infected lymphoblasts can give rise to non-Hodgkin’s lymphomas, Hodgkin’s disease, and lymphoproliferative disorders,…”
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B cells infected with Type 2 Epstein-Barr virus (EBV) have increased NFATc1/NFATc2 activity and enhanced lytic gene expression in comparison to Type 1 EBV infection by Romero-Masters, James C, Huebner, Shane M, Ohashi, Makoto, Bristol, Jillian A, Benner, Bayleigh E, Barlow, Elizabeth A, Turk, Gail L, Nelson, Scott E, Baiu, Dana C, Van Sciver, Nicholas, Ranheim, Erik A, Gumperz, Jenny, Sherer, Nathan M, Farrell, Paul J, Johannsen, Eric C, Kenney, Shannon C

“…Humans are infected with two distinct strains (Type 1 (T1) and Type 2 (T2)) of Epstein-Barr virus (EBV) that differ substantially in their EBNA2 and EBNA…”
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Type 1 and Type 2 Epstein-Barr viruses induce proliferation, and inhibit differentiation, in infected telomerase-immortalized normal oral keratinocytes by Singh, Deo R, Nelson, Scott E, Pawelski, Abigail S, Cantres-Velez, Juan A, Kansra, Alisha S, Pauly, Nicholas P, Bristol, Jillian A, Hayes, Mitchell, Ohashi, Makoto, Casco, Alejandro, Lee, Denis, Fogarty, Stuart A, Lambert, Paul F, Johannsen, Eric C, Kenney, Shannon C

“…Differentiated epithelial cells are an important source of infectious EBV virions in human saliva, and latent Epstein-Barr virus (EBV) infection is strongly…”
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5-hydroxymethylation of the EBV genome regulates the latent to lytic switch by Wille, Coral K., Nawandar, Dhananjay M., Henning, Amanda N., Ma, Shidong, Oetting, Kayla M., Lee, Dennis, Lambert, Paul, Johannsen, Eric C., Kenney, Shannon C.

“…Latent Epstein–Barr virus (EBV) infection and cellular hypermethylation are hallmarks of undifferentiated nasopharyngeal carcinoma (NPC). However, EBV…”
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Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection by Price, Alexander M, Dai, Joanne, Bazot, Quentin, Patel, Luv, Nikitin, Pavel A, Djavadian, Reza, Winter, Peter S, Salinas, Cristina A, Barry, Ashley Perkins, Wood, Kris C, Johannsen, Eric C, Letai, Anthony, Allday, Martin J, Luftig, Micah A

“…Latent Epstein-Barr virus (EBV) infection is causally linked to several human cancers. EBV expresses viral oncogenes that promote cell growth and inhibit the…”
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An EBNA3C-deleted Epstein-Barr virus (EBV) mutant causes B-cell lymphomas with delayed onset in a cord blood-humanized mouse model by Romero-Masters, James C, Ohashi, Makoto, Djavadian, Reza, Eichelberg, Mark R, Hayes, Mitch, Bristol, Jillian A, Ma, Shidong, Ranheim, Erik A, Gumperz, Jenny, Johannsen, Eric C, Kenney, Shannon C

“…EBV causes human B-cell lymphomas and transforms B cells in vitro. EBNA3C, an EBV protein expressed in latently-infected cells, is required for EBV…”
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Epstein-Barr virus LMP1 protein promotes proliferation and inhibits differentiation of epithelial cells via activation of YAP and TAZ by Singh, Deo R, Nelson, Scott E, Pawelski, Abigail S, Kansra, Alisha S, Fogarty, Stuart A, Bristol, Jillian A, Ohashi, Makoto, Johannsen, Eric C, Kenney, Shannon C

“…Latent Epstein-Barr virus (EBV) infection promotes undifferentiated nasopharyngeal carcinomas (NPCs) in humans, but the mechanism(s) for this effect has been…”
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Human CD4+ iNKT cell adoptive immunotherapy induces anti‐tumour responses against CD1d‐negative EBV‐driven B lymphoma by Baiu, Dana C., Sharma, Akshat, Schehr, Jennifer L., Basu, Jayati, Smith, Kelsey A., Ohashi, Makoto, Johannsen, Eric C., Kenney, Shannon C., Gumperz, Jenny E.

“…Invariant natural killer T (iNKT) cells are a conserved population of innate T lymphocytes that are uniquely suitable as off‐the‐shelf cellular immunotherapies…”
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