Search Results - "Johannesen, L"

Differentiating Drug-Induced Multichannel Block on the Electrocardiogram: Randomized Study of Dofetilide, Quinidine, Ranolazine, and Verapamil by Johannesen, L, Vicente, J, Mason, J W, Sanabria, C, Waite-Labott, K, Hong, M, Guo, P, Lin, J, Sørensen, J S, Galeotti, L, Florian, J, Ugander, M, Stockbridge, N, Strauss, D G

“…Block of the hERG potassium channel and prolongation of the QT interval are predictors of drug‐induced torsade de pointes. However, drugs that block the hERG…”
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Late sodium current block for drug-induced long QT syndrome: Results from a prospective clinical trial by Johannesen, L, Vicente, J, Mason, JW, Erato, C, Sanabria, C, Waite-Labott, K, Hong, M, Lin, J, Guo, P, Mutlib, A, Wang, J, Crumb, WJ, Blinova, K, Chan, D, Stohlman, J, Florian, J, Ugander, M, Stockbridge, N, Strauss, DG

“…Drug‐induced long QT syndrome has resulted in many drugs being withdrawn from the market. At the same time, the current regulatory paradigm for screening new…”
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Results From the IQ-CSRC Prospective Study Support Replacement of the Thorough QT Study by QT Assessment in the Early Clinical Phase by Darpo, B, Benson, C, Dota, C, Ferber, G, Garnett, C, Green, CL, Jarugula, V, Johannesen, L, Keirns, J, Krudys, K, Liu, J, Ortemann-Renon, C, Riley, S, Sarapa, N, Smith, B, Stoltz, RR, Zhou, M, Stockbridge, N

“…The QT effects of five “QT‐positive” and one negative drug were tested to evaluate whether exposure–response analysis can detect QT effects in a small study…”
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Improving the Assessment of Heart Toxicity for All New Drugs Through Translational Regulatory Science by Johannesen, L, Vicente, J, Gray, R A, Galeotti, L, Loring, Z, Garnett, C E, Florian, J, Ugander, M, Stockbridge, N, Strauss, D G

“…Fourteen drugs have been removed from the market worldwide because they cause torsade de pointes. Most drugs that cause torsade can be identified by assessing…”
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Assessing ECG signal quality indices to discriminate ECGs with artefacts from pathologically different arrhythmic ECGs by Daluwatte, C, Johannesen, L, Galeotti, L, Vicente, J, Strauss, D G, Scully, C G

“…False and non-actionable alarms in critical care can be reduced by developing algorithms which assess the trueness of an arrhythmia alarm from a bedside…”
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A prospective study of pain and psychological functioning following traumatic spinal cord injury by Finnerup, N B, Jensen, M P, Norrbrink, C, Trok, K, Johannesen, I L, Jensen, T S, Werhagen, L

“…Study design: Longitudinal study. Objectives: To study prospectively pain characteristics, change in pain over time and the associations between pain and…”
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Can adenosine triphosphate be a proxy measure in evaluation of hand disinfection effect? by Breidablik, H.J., Lysebo, D.E., Johannesen, L., Skare, Å., Andersen, J.R., Kleiven, O.T.

“…Contaminated hands may contribute to the transmission of pathogens. In the prevention of healthcare-associated infections the effect of disinfection methods…”
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Commentary on: “Levofloxacin‐Induced QTc Prolongation Depends on the Time of Drug Administration” by Garnett, C, Johannesen, L

“…Circadian variations in the corrected QT (QTc) interval have been documented in clinical trials. Animal models show circadian variations in expression of the…”
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Sensory function in spinal cord injury patients with and without central pain by Finnerup, N. B., Johannesen, I. L., Fuglsang‐Frederiksen, A., Bach, F. W., Jensen, T. S.

“…Spinal cord injury (SCI) frequently results in neuropathic pain. However, the pathophysiology underlying this pain is unclear. In this study, we compared…”
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Adjunctive Techniques for Repair of Ischaemic Mitral Regurgitation by Johannesen, Sigrid L, Barker, Colin M, Levack, Melissa M

“…Ischaemic mitral regurgitation is a complex process with debate in the literature as to the optimal treatment pathway. Multiple therapies are available to…”
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Immediately restored one-piece single-tooth implants with reduced diameter: one-year results of a multi-center study by Zembić, A., Johannesen, L. H., Schou, S., Malo, P., Reichert, T., Farella, M., Hämmerle, C. H. F.

“…Objectives: The aim of the present multi‐center study was to evaluate the treatment outcome of immediately restored one‐piece single‐tooth implants with a…”
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Intravenous lidocaine relieves spinal cord injury pain : A randomized controlled trial by FINNERUP, Nanna B, BIERING-SØRENSEN, Fin, JOHANNESEN, Inger L, TERKELSEN, Astrid J, JUHL, Gitte I, KRISTENSEN, Anders D, SINDRUP, Søren H, BACH, Flemming W, JENSEN, Troels S

“…Neuropathic pain in spinal cord injury is a common challenging therapeutic condition. The current study examines the analgesic effect of the sodium channel…”
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Levetiracetam in spinal cord injury pain: a randomized controlled trial by Finnerup, N B, Grydehøj, J, Bing, J, Johannesen, I L, Biering-Sørensen, F, Sindrup, S H, Jensen, T S

“…Study design: A randomized, double-blind, placebo-controlled, crossover, multicenter trial. A 1-week baseline period was followed by two treatment periods of 5…”
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Pain and dysesthesia in patients with spinal cord injury : A postal survey by FINNERUP, N. B, JOHANNESEN, I. L, SINDRUP, S. H, BACH, F. W, JENSEN, T. S

“…A postal survey. To assess the prevalence and characteristics of pain and dysesthesia in a community based sample of patients with spinal cord injury (SCI)…”
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Estimating the glomerular filtration rate using serum cystatin C levels in patients with spinal cord injuries by Erlandsen, E J, Hansen, R M, Randers, E, Petersen, L E, Abrahamsen, J, Johannesen, I L

“…Study design: Prospective cohort study. Objectives: To investigate the relationship between 51 chromium-ethylene-diamine-tetra-acetate ( 51 Cr-EDTA) clearance,…”
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Segmental hypersensitivity and spinothalamic function in spinal cord injury pain by Finnerup, Nanna B., Sørensen, Leif, Biering-Sørensen, Fin, Johannesen, Inger L., Jensen, Troels S.

“…The mechanisms underlying central pain following spinal cord injury (SCI) are unsettled. The purpose of the present study was to examine differences in…”
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Reliability of the International Spinal Cord Injury Bowel Function Basic and Extended Data Sets by Juul, T, Bazzocchi, G, Coggrave, M, Johannesen, I L, Hansen, R B M, Thiyagarajan, C, Poletti, E, Krogh, K, Christensen, P

“…Study design: This study was designed as an international validation study. Objective: The objective of this study was to assess the inter-rater reliability of…”
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Conservative Management of Spontaneous Pneumomediastinum by Blotevogel, Phillip W, Johannesen, Sigrid L, Deb, Subrato J

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Serum cystatin C as a marker of the renal function in patients with spinal cord injury by THOMASSEN, S. A, JOHANNESEN, I. L, ERLANDSEN, E. J, ABRAHAMSEN, J, RANDERS, E

“…To investigate the relationship between serum cystatin C, serum creatinine, and (51)Cr-EDTA-clearance in patients with spinal cord injury. The Spinal Cord…”
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Ultramicronized palmitoylethanolamide in spinal cord injury neuropathic pain: a randomized, double-blind, placebo-controlled trial by Andresen, Sven R., Bing, Jette, Hansen, Rikke M., Biering-Sørensen, Fin, Johannesen, Inger L., Hagen, Ellen Merete, Rice, Andrew S. C., Nielsen, Jørgen F., Bach, Flemming W., Finnerup, Nanna B.

“…Neuropathic pain and spasticity after spinal cord injury (SCI) represent significant problems. Palmitoylethanolamide (PEA), a fatty acid amide that is produced…”
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