Search Results - "Jogl, Gerwald"

Identification and characterization of small molecule inhibitors of the LINE-1 retrotransposon endonuclease by D’Ordine, Alexandra M., Jogl, Gerwald, Sedivy, John M.

“…The long interspersed nuclear element-1 (LINE-1 or L1) retrotransposon is the only active autonomously replicating retrotransposon in the human genome. L1…”
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Allosteric Motions of the CRISPR–Cas9 HNH Nuclease Probed by NMR and Molecular Dynamics by East, Kyle W, Newton, Jocelyn C, Morzan, Uriel N, Narkhede, Yogesh B, Acharya, Atanu, Skeens, Erin, Jogl, Gerwald, Batista, Victor S, Palermo, Giulia, Lisi, George P

“…CRISPR–Cas9 is a widely employed genome-editing tool with functionality reliant on the ability of the Cas9 endonuclease to introduce site-specific breaks in…”
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Phase separation of the LINE-1 ORF1 protein is mediated by the N-terminus and coiled-coil domain by Newton, Jocelyn C., Naik, Mandar T., Li, Grace Y., Murphy, Eileen L., Fawzi, Nicolas L., Sedivy, John M., Jogl, Gerwald

“…Long interspersed nuclear element-1 (L1) is a retrotransposable element that autonomously replicates in the human genome, resulting in DNA damage and genomic…”
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The Cytochrome P450-Catalyzed Oxidative Rearrangement in the Final Step of Pentalenolactone Biosynthesis: Substrate Structure Determines Mechanism by Duan, Lian, Jogl, Gerwald, Cane, David E

“…The final step in the biosynthesis of the sesquiterpenoid antibiotic pentalenolactone (1) is the highly unusual cytochrome P450-catalyzed, oxidative…”
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Structural and Biochemical Studies of TIGAR (TP53-induced Glycolysis and Apoptosis Regulator) by Li, Hua, Jogl, Gerwald

“…Activation of the p53 tumor suppressor by cellular stress leads to variable responses ranging from growth inhibition to apoptosis. TIGAR is a novel…”
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Disruption of electrostatic contacts in the HNH nuclease from a thermophilic Cas9 rewires allosteric motions and enhances high-temperature DNA cleavage by Belato, Helen B, Norbrun, Carmelissa, Luo, Jinping, Pindi, Chinmai, Sinha, Souvik, D'Ordine, Alexandra M, Jogl, Gerwald, Palermo, Giulia, Lisi, George P

“…Allosteric signaling within multidomain proteins is a driver of communication between spatially distant functional sites. Understanding the mechanism of…”
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A structural basis for streptomycin-induced misreading of the genetic code by Demirci, Hasan, Murphy, Frank, Murphy, Eileen, Gregory, Steven T., Dahlberg, Albert E., Jogl, Gerwald

“…During protein synthesis, the ribosome selects aminoacyl-transfer RNAs with anticodons matching the messenger RNA codon present in the A site of the small…”
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Cryo-electron microscopy structure of the 70S ribosome from Enterococcus faecalis by Murphy, Eileen L., Singh, Kavindra V., Avila, Bryant, Kleffmann, Torsten, Gregory, Steven T., Murray, Barbara E., Krause, Kurt L., Khayat, Reza, Jogl, Gerwald

“…Enterococcus faecalis is a gram-positive organism responsible for serious infections in humans, but as with many bacterial pathogens, resistance has rendered a…”
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Expansion of GA Dinucleotide Repeats Increases the Density of CLAMP Binding Sites on the X-Chromosome to Promote Drosophila Dosage Compensation by Kuzu, Guray, Kaye, Emily G, Chery, Jessica, Siggers, Trevor, Yang, Lin, Dobson, Jason R, Boor, Sonia, Bliss, Jacob, Liu, Wei, Jogl, Gerwald, Rohs, Remo, Singh, Nadia D, Bulyk, Martha L, Tolstorukov, Michael Y, Larschan, Erica

“…Dosage compensation is an essential process that equalizes transcript levels of X-linked genes between sexes by forming a domain of coordinated gene…”
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Modification of 16S ribosomal RNA by the KsgA methyltransferase restructures the 30S subunit to optimize ribosome function by Demirci, Hasan, Murphy, 4th, Frank, Belardinelli, Riccardo, Kelley, Ann C, Ramakrishnan, V, Gregory, Steven T, Dahlberg, Albert E, Jogl, Gerwald

“…All organisms incorporate post-transcriptional modifications into ribosomal RNA, influencing ribosome assembly and function in ways that are poorly understood…”
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Crystal Structure of Carnitine Acetyltransferase and Implications for the Catalytic Mechanism and Fatty Acid Transport by Jogl, Gerwald, Tong, Liang

“…Carnitine acyltransferases have crucial roles in the transport of fatty acids for β-oxidation. Dysregulation of these enzymes can lead to serious diseases in…”
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Tiamulin-Resistant Mutants of the Thermophilic Bacterium Thermus thermophilus by Killeavy, Erin E., Jogl, Gerwald, Gregory, Steven T.

“…Tiamulin is a semisynthetic pleuromutilin antibiotic that binds to the 50S ribosomal subunit A site and whose (((2-diethylamino)ethyl)thio)-acetic acid tail…”
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A Survey of Spontaneous Antibiotic-Resistant Mutants of the Halophilic, Thermophilic Bacterium Rhodothermus marinus by Silvia, Sophia, Donahue, Samantha A, Killeavy, Erin E, Jogl, Gerwald, Gregory, Steven T

“…is a halophilic extreme thermophile, with potential as a model organism for studies of the structural basis of antibiotic resistance. In order to facilitate…”
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The central role of protein S12 in organizing the structure of the decoding site of the ribosome by Demirci, Hasan, Wang, Leyi, Murphy, 4th, Frank V, Murphy, Eileen L, Carr, Jennifer F, Blanchard, Scott C, Jogl, Gerwald, Dahlberg, Albert E, Gregory, Steven T

“…The ribosome decodes mRNA by monitoring the geometry of codon-anticodon base-pairing using a set of universally conserved 16S rRNA nucleotides within the…”
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Crystal Structure of Inositol Phosphate Multikinase 2 and Implications for Substrate Specificity by Holmes, William, Jogl, Gerwald

“…Inositol polyphosphates perform essential functions as second messengers in eukaryotic cells, and their cellular levels are regulated by inositol phosphate…”
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Optimal Alignment for Enzymatic Proton Transfer: Structure of the Michaelis Complex of Triosephosphate Isomerase at 1.2-Å Resolution by Jogl, Gerwald, Rozovsky, Sharon, McDermott, Ann E., Tong, Liang

“…In enzyme catalysis, where exquisitely positioned functionality is the sine qua non, atomic coordinates for a Michaelis complex can provide powerful insights…”
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Structure and Function of Carnitine Acyltransferases by JOGL, GERWALD, HSIAO, YU-SHAN, TONG, LIANG

“…: Carnitine acyltransferases catalyze the exchange of acyl groups between carnitine and coenzyme A (CoA). These enzymes include carnitine acetyltransferase…”
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High-resolution neutron crystallographic studies of the hydration of the coenzyme cob(II)alamin by Jogl, Gerwald, Wang, Xiaoping, Mason, Sax A., Kovalevsky, Andrey, Mustyakimov, Marat, Fisher, Zöe, Hoffman, Christina, Kratky, Christoph, Langan, Paul

“…The hydration of the coenzyme cob(II)alamin has been studied using high‐resolution monochromatic neutron crystallographic data collected at room temperature to…”
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Crystal Structure of the Non-heme Iron Dioxygenase PtlH in Pentalenolactone Biosynthesis by You, Zheng, Omura, Satoshi, Ikeda, Haruo, Cane, David E., Jogl, Gerwald

“…The non-heme iron dioxygenase PtlH from the soil organism Streptomyces avermitilis is a member of the iron(II)/α-ketoglutarate-dependent dioxygenase…”
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Crystal structure of rat carnitine palmitoyltransferase II (CPT-II) by Hsiao, Yu-Shan, Jogl, Gerwald, Esser, Victoria, Tong, Liang

“…Carnitine palmitoyltransferase II (CPT-II) has a crucial role in the β-oxidation of long-chain fatty acids in mitochondria. We report here the crystal…”
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